Crosstalk between neutrophil extracellular traps and immune regulation: insights into pathobiology and therapeutic implications of transfusion-related acute lung injury
Yi Liu, Rong Wang, Congkuan Song, Song Ding, Yifan Zuo, Ke Yi, Ning Li, Bo Wang, Qing Geng
Frontiers in Immunology, doi:10.3389/fimmu.2023.1324021
Transfusion-related acute lung injury (TRALI) is the leading cause of transfusionassociated death, occurring during or within 6 hours after transfusion. Reports indicate that TRALI can be categorized as having or lacking acute respiratory distress syndrome (ARDS) risk factors. There are two types of TRALI in terms of its pathogenesis: antibody-mediated and non-antibody-mediated. The key initiation steps involve the priming and activation of neutrophils, with neutrophil extracellular traps (NETs) being established as effector molecules formed by activated neutrophils in response to various stimuli. These NETs contribute to the production and release of reactive oxygen species (ROS) and participate in the destruction of pulmonary vascular endothelial cells. The significant role of NETs in TRALI is well recognized, offering a potential pathway for TRALI treatment. Moreover, platelets, macrophages, endothelial cells, and complements have been identified as promoters of NET formation. Concurrently, studies have demonstrated that the storage of platelets and concentrated red blood cells (RBC) can induce TRALI through bioactive lipids. In this article, recent clinical and pre-clinical studies on the pathophysiology and pathogenesis of TRALI are reviewed to further illuminate the mechanism through which NETs induce TRALI. This review aims to propose new therapeutic strategies for TRALI, with the hope of effectively improving its poor prognosis.
Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Appendix The proteins/genes described in this review.
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'abstract': '<jats:p>Transfusion-related acute lung injury (TRALI) is the leading cause of '
'transfusion-associated death, occurring during or within 6 hours after transfusion. Reports '
'indicate that TRALI can be categorized as having or lacking acute respiratory distress '
'syndrome (ARDS) risk factors. There are two types of TRALI in terms of its pathogenesis: '
'antibody-mediated and non-antibody-mediated. The key initiation steps involve the priming and '
'activation of neutrophils, with neutrophil extracellular traps (NETs) being established as '
'effector molecules formed by activated neutrophils in response to various stimuli. These NETs '
'contribute to the production and release of reactive oxygen species (ROS) and participate in '
'the destruction of pulmonary vascular endothelial cells. The significant role of NETs in '
'TRALI is well recognized, offering a potential pathway for TRALI treatment. Moreover, '
'platelets, macrophages, endothelial cells, and complements have been identified as promoters '
'of NET formation. Concurrently, studies have demonstrated that the storage of platelets and '
'concentrated red blood cells (RBC) can induce TRALI through bioactive lipids. In this '
'article, recent clinical and pre-clinical studies on the pathophysiology and pathogenesis of '
'TRALI are reviewed to further illuminate the mechanism through which NETs induce TRALI. This '
'review aims to propose new therapeutic strategies for TRALI, with the hope of effectively '
'improving its poor prognosis.</jats:p>',
'DOI': '10.3389/fimmu.2023.1324021',
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'title': 'Crosstalk between neutrophil extracellular traps and immune regulation: insights into '
'pathobiology and therapeutic implications of transfusion-related acute lung injury',
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{'given': 'Song', 'family': 'Ding', 'sequence': 'additional', 'affiliation': []},
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