Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2
Jeffreys et al.,
Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro activity against..,
International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2022.106542 (date from earlier preprint) (In Vitro)
In Vitro study showing enhanced antiviral activity of ivermectin and remdesivir in combination.
15 In Vitro studies support the efficacy of ivermectin
[Boschi, Caly, Croci, De Forni, Delandre, Jeffreys, Jitobaom, Jitobaom (B), Li, Liu, Mody, Mountain Valley MD, Segatori, Surnar, Yesilbag].
Jeffreys et al., 24 Dec 2020, peer-reviewed, 17 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
Abstract: In vitro synergistic interaction of remdesivir and ivermectin against SARS-CoV-2
Editor: Dr Jim Gray
Journal Pre-proof
Remdesivir-ivermectin combination displays synergistic interaction
with improved in vitro activity against SARS-CoV-2
Laura N Jeffreys , Shaun H Pennington , Jack Duggan ,
Claire H Caygill , Rose C Lopeman , Alastair F Breen ,
Jessica B Jinks , Alison Ardrey , Samantha Donnellan ,
Edward I Patterson , Grant L Hughes , David W Hong ,
Paul M O’Neill , Ghaith Aljayyoussi , Andrew Owen ,
Stephen A Ward , Giancarlo A Biagini
PII:
DOI:
Reference:
S0924-8579(22)00030-9
https://doi.org/10.1016/j.ijantimicag.2022.106542
ANTAGE 106542
To appear in:
International Journal of Antimicrobial Agents
Received date:
Accepted date:
9 September 2021
20 January 2022
Please cite this article as: Laura N Jeffreys , Shaun H Pennington , Jack Duggan , Claire H Caygill ,
Rose C Lopeman , Alastair F Breen , Jessica B Jinks , Alison Ardrey , Samantha Donnellan ,
Edward I Patterson , Grant L Hughes , David W Hong , Paul M O’Neill , Ghaith Aljayyoussi ,
Andrew Owen , Stephen A Ward , Giancarlo A Biagini , Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2, International Journal
of Antimicrobial Agents (2022), doi: https://doi.org/10.1016/j.ijantimicag.2022.106542
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FULL TITLE
Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro
activity against SARS-CoV-2
SHORT TITLE
In vitro synergistic interaction of remdesivir and ivermectin against SARS-CoV-2
AUTHORS
Laura N Jeffreys1*, Shaun H Pennington1*‡, Jack Duggan1, Claire H Caygill, Rose C
Lopeman, Alastair F Breen1, Jessica B Jinks1, Alison Ardrey1, Samantha Donnellan1, Edward
I Patterson1,2, Grant L Hughes1,2, David W Hong3, Paul M O’Neill3, Ghaith Aljayyoussi1,
Andrew Owen4, Stephen A Ward1 and Giancarlo A Biagini1*‡
1
Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool
School of Tropical Medicine, Liverpool, L3 5QA, UK
2
Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, L3 5QA,
UK
3
Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, U.K.
4
Department of Pharmacology and Therapeutics, Centre of Excellence in Long-acting
Therapeutics (CELT), University of Liverpool, Liverpool, L69 3GE, UK.
1
*
JOINT FIRST AUTHORS
‡CO-CORRESPONDING AUTHORS
Giancarlo A Biagini
Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool
School of Tropical Medicine, Liverpool, L3 5QA, UK
+44151 705 3151
giancarlo.biagini@lstmed.ac.uk
Shaun H Pennington
Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool
School of Tropical Medicine, Liverpool, L3 5QA, UK
+44151 702 9427
shaun.pennington@lstmed.ac.uk
ABSTRACT WORD COUNT:
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MAIN DOCUMENT WORD..
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