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A timeline of ivermectin-related events in the COVID-19 pandemic

Turkia, M., Research Gate
Apr 2021  
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Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
 
*, now with p < 0.00000000001 from 104 studies, recognized in 23 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19ivm.org
An extensive timeline of ivermectin-related events from April 2020 to March 2021 including studies, news, health authority decisions, biased news coverage, and censorship.
The author concludes that in a broader historical perspective, the timeline depicts rather dysfunctional societies unable to properly communicate and organize themselves, leading to misallocation of resources and decisions that may have conflicted with elementary ethical considerations, with this behavior rationalized by claiming adherence to mental paradigms that may have poorly matched the situation.
Reviews covering ivermectin for COVID-19 include1-41.
Turkia et al., 3 Apr 2021, preprint, 1 author.
This PaperIvermectinAll
A timeline of ivermectin-related events in the COVID-19 pandemic
M.Sc Mika Turkia
Background Ivermectin is a multifaceted medication invented in Japan in 1975 by professor Satoshi Ōmura, for which he won the 2015 Nobel Prize in medicine. Several billion doses of ivermectin have been administered since 1981. Currently, ivermectin preparations are available off-patent from many sources, with the production cost of a single dose estimated to be less than 0.1 US dollars. Review The interest in ivermectin with regard to COVID-19 was initiated by an Australian in vitro study published on April 3, 2020, indicating that a single treatment with ivermectin effectively eliminated the SARS-CoV-2 virus in cell culture. A few days later, two doctors in Peru begun treating a COVID-19 outbreak in a prison with ivermectin, later also treating the local police. In the second and third quarter of 2020 the use of ivermectin spread to other South and Central American countries, Egypt, India and Bangladesh, and later to Lebanon, Southern Africa and Southeastern Europe, with Slovakia being the first European Union country to adopt it. Ivermectin treatments raised controversy in many European Union countries and the United States which ignored ivermectin, referring to a lack of evidence of its efficacy and safety and demanding large-scale clinical trials. The World Health Organization (WHO) and the European Medicine Agency (EMA) advised against using ivermectin even after results of 26 randomized clinical trials were available in March 2021. In contrast, many developing countries adopted ivermectin with little evidence. In the United States, government funding was allocated to the development of a novel pharmaceutical estimated to possess an efficacy comparable to ivermectin but priced several magnitudes higher. Social media companies censored ivermectin researchers and research, with for example YouTube censoring results of a meta-analysis commissioned by the WHO. Traditional media appeared to either ignore ivermectin or publish negative commentaries only. Conclusion There was widespread disagreement on the fundamentals: which methods were appropriate as a basis for decision making, what counted as evidence, and what was ethical. Societies appeared disorganized, unable to transcend their current practices, financial structures and mindsets even when facing an obvious failure.
the most important pillar of response: early treatment. Risk/benefit assessment is fatally compromised by inaccurate, distorted, or absent data concerning the incidence and mortality of disease and the safety and efficacy of countermeasures" [399] ; [400] . On March 17, a systematic review and and an individual patient data meta-analysis of ivermectin use in children weighing less than 15 kg by Jittamala et al. concluded that existing limited data between January 1980 and October 2019 suggest that oral ivermectin in children weighing less than 15 kilograms is safe [17] ; [401] . Overall a total of 1.4% (15/1,088) of children experienced 18 adverse events all of which were mild and self-limiting. No serious adverse events were reported. On March 17, an interview of a Brazilian MD Adler Menezes described an ivermectin prophylaxis experiment in a factory with 12,000 employees [402] . Ivermectin was administered weekly to workers of one of two work shifts, with infections disappearing in the prophylaxis group. Ivermectin was then administered also to workers in the other shift, with the same result. On March 18, the Infectious Diseases Society of America (IDSA), citing very low certainty of evidence, gave a conditional recommendation against the use of ivermectin in hospitalized patients with severe COVID-19 and in outpatients with COVID-19, outside of the context of a clinical trial, adding that "adding that well-designed, adequately powered, and well-executed..
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