Ivermectin inhibits importin-α/β-dependent nuclear import of viral proteins
Götz, Kosyna, Wagstaff, Wagstaff (B), shows spike-ACE2 disruption at 1nM with microfluidic diffusional sizing
Fauquet, binds to glycan sites on the SARS-CoV-2 spike protein preventing interaction with blood and epithelial cells and inhibiting hemagglutination
Boschi, Scheim, shows dose-dependent inhibition of wildtype and omicron variants
Shahin, exhibits dose-dependent inhibition of lung injury
Abd-Elmawla, Ma, may inhibit SARS-CoV-2 via IMPase inhibition
Jitobaom, may inhibit SARS-CoV-2 induced formation of fibrin clots resistant to degradation
Vottero, inhibits SARS-CoV-2 3CL
pro Mody, may inhibit SARS-CoV-2 RdRp activity
Parvez (B), may minimize viral myocarditis by inhibiting NF-κB/p65-mediated inflammation in macrophages
Gao, may be beneficial for COVID-19 ARDS by blocking GSDMD and NET formation
Liu (C), shows protection against inflammation, cytokine storm, and mortality in an LPS mouse model sharing key pathological features of severe COVID-19
DiNicolantonio, Zhang, may be beneficial in severe COVID-19 by binding IGF1 to inhibit the promotion of inflammation, fibrosis, and cell proliferation that leads to lung damage
Zhao, may minimize SARS-CoV-2 induced cardiac damage
Liu, Liu (B), increases Bifidobacteria which play a key role in the immune system
Hazan, has immunomodulatory
Munson and anti-inflammatory
DiNicolantonio (B), Yan properties, and has an extensive and very positive safety profile
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