Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All ivermectin studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19ivm.org COVID-19 treatment researchIvermectinIvermectin (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

Ivermectin ameliorates acute myocarditis via the inhibition of importin-mediated nuclear translocation of NF-κB/p65

Gao et al., International Immunopharmacology, doi:10.1016/j.intimp.2024.112073
Apr 2024  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020, now with p < 0.00000000001 from 105 studies, recognized in 23 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 109 treatments. c19ivm.org
Mouse study showing that ivermectin improves cardiac function and reduces inflammation in models of viral and autoimmune myocarditis. Authors found that ivermectin inhibited the nuclear translocation of NF-κB/p65 in macrophages by targeting importin β, thereby reducing levels of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. These effects were confirmed in both Coxsackie B3 virus (CVB3)-induced myocarditis and experimental autoimmune myocarditis (EAM) in BALB/c mice, as well as in CVB3-infected RAW264.7 macrophages treated with ivermectin or a selective NF-κB/p65 nuclear translocation inhibitor, cTN50. While not directly tested against SARS-CoV-2, these findings suggest that ivermectin's ability to suppress NF-κB/p65-mediated inflammation in macrophages may be beneficial in the context of COVID-19-associated myocarditis and cytokine storm.
69 preclinical studies support the efficacy of ivermectin for COVID-19:
Ivermectin, better known for antiparasitic activity, is a broad spectrum antiviral with activity against many viruses including H7N767, Dengue33,68,69, HIV-169, Simian virus 4070, Zika33,71,72, West Nile72, Yellow Fever73,74, Japanese encephalitis73, Chikungunya74, Semliki Forest virus74, Human papillomavirus53, Epstein-Barr53, BK Polyomavirus75, and Sindbis virus74.
Ivermectin inhibits importin-α/β-dependent nuclear import of viral proteins67,69,70,76, shows spike-ACE2 disruption at 1nM with microfluidic diffusional sizing34, binds to glycan sites on the SARS-CoV-2 spike protein preventing interaction with blood and epithelial cells and inhibiting hemagglutination37,77, shows dose-dependent inhibition of wildtype and omicron variants32, exhibits dose-dependent inhibition of lung injury57,62, may inhibit SARS-CoV-2 via IMPase inhibition33, may inhibit SARS-CoV-2 induced formation of fibrin clots resistant to degradation6, inhibits SARS-CoV-2 3CLpro50, may inhibit SARS-CoV-2 RdRp activity25, may minimize viral myocarditis by inhibiting NF-κB/p65-mediated inflammation in macrophages56, may be beneficial for COVID-19 ARDS by blocking GSDMD and NET formation78, may interfere with SARS-CoV-2's immune evasion via ORF8 binding1, may inhibit SARS-CoV-2 by disrupting CD147 interaction79-82, shows protection against inflammation, cytokine storm, and mortality in an LPS mouse model sharing key pathological features of severe COVID-1955,83, may be beneficial in severe COVID-19 by binding IGF1 to inhibit the promotion of inflammation, fibrosis, and cell proliferation that leads to lung damage5, may minimize SARS-CoV-2 induced cardiac damage36,44, increases Bifidobacteria which play a key role in the immune system84, has immunomodulatory47 and anti-inflammatory66,85 properties, and has an extensive and very positive safety profile86.
Gao et al., 17 Apr 2024, peer-reviewed, 6 authors.
This PaperIvermectinAll
{ 'indexed': {'date-parts': [[2024, 4, 18]], 'date-time': '2024-04-18T02:20:52Z', 'timestamp': 1713406852190}, 'reference-count': 67, 'publisher': 'Elsevier BV', 'license': [ { 'start': { 'date-parts': [[2024, 5, 1]], 'date-time': '2024-05-01T00:00:00Z', 'timestamp': 1714521600000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'}, { 'start': { 'date-parts': [[2024, 5, 1]], 'date-time': '2024-05-01T00:00:00Z', 'timestamp': 1714521600000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.elsevier.com/legal/tdmrep-license'}, { 'start': { 'date-parts': [[2024, 5, 1]], 'date-time': '2024-05-01T00:00:00Z', 'timestamp': 1714521600000}, 'content-version': 'stm-asf', 'delay-in-days': 0, 'URL': 'https://doi.org/10.15223/policy-017'}, { 'start': { 'date-parts': [[2024, 5, 1]], 'date-time': '2024-05-01T00:00:00Z', 'timestamp': 1714521600000}, 'content-version': 'stm-asf', 'delay-in-days': 0, 'URL': 'https://doi.org/10.15223/policy-037'}, { 'start': { 'date-parts': [[2024, 5, 1]], 'date-time': '2024-05-01T00:00:00Z', 'timestamp': 1714521600000}, 'content-version': 'stm-asf', 'delay-in-days': 0, 'URL': 'https://doi.org/10.15223/policy-012'}, { 'start': { 'date-parts': [[2024, 5, 1]], 'date-time': '2024-05-01T00:00:00Z', 'timestamp': 1714521600000}, 'content-version': 'stm-asf', 'delay-in-days': 0, 'URL': 'https://doi.org/10.15223/policy-029'}, { 'start': { 'date-parts': [[2024, 5, 1]], 'date-time': '2024-05-01T00:00:00Z', 'timestamp': 1714521600000}, 'content-version': 'stm-asf', 'delay-in-days': 0, 'URL': 'https://doi.org/10.15223/policy-004'}], 'content-domain': {'domain': ['elsevier.com', 'sciencedirect.com'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2024, 5]]}, 'DOI': '10.1016/j.intimp.2024.112073', 'type': 'journal-article', 'created': {'date-parts': [[2024, 4, 17]], 'date-time': '2024-04-17T22:12:54Z', 'timestamp': 1713391974000}, 'page': '112073', 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Ivermectin ameliorates acute myocarditis via the inhibition of importin-mediated nuclear ' 'translocation of NF-κB/p65', 'prefix': '10.1016', 'volume': '133', 'author': [ { 'ORCID': 'http://orcid.org/0009-0009-8016-8025', 'authenticated-orcid': False, 'given': 'Xu', 'family': 'Gao', 'sequence': 'first', 'affiliation': []}, {'given': 'Yunling', 'family': 'Xuan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Zhou', 'family': 'Zhou', 'sequence': 'additional', 'affiliation': []}, {'given': 'Chen', 'family': 'Chen', 'sequence': 'additional', 'affiliation': []}, {'given': 'Dao', 'family': 'Wen Wang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Zheng', 'family': 'Wen', 'sequence': 'additional', 'affiliation': []}], 'member': '78', 'reference': [ { 'issue': '16', 'key': '10.1016/j.intimp.2024.112073_b0005', 'doi-asserted-by': 'crossref', 'first-page': '1488', 'DOI': '10.1056/NEJMra2114478', 'article-title': 'Myocarditis', 'volume': '387', 'author': 'Basso', 'year': '2022', 'journal-title': 'N. Engl. J. Med'}, { 'issue': '1', 'key': '10.1016/j.intimp.2024.112073_b0010', 'doi-asserted-by': 'crossref', 'first-page': '714', 'DOI': '10.1186/s12889-023-15539-5', 'article-title': 'Global, regional, and national burdens of myocarditis, 1990–2019: ' 'systematic analysis from GBD 2019: GBD for myocarditis', 'volume': '23', 'author': 'Wang', 'year': '2023', 'journal-title': 'BMC. Public. Health'}, { 'issue': '15', 'key': '10.1016/j.intimp.2024.112073_b0015', 'doi-asserted-by': 'crossref', 'first-page': '1123', 'DOI': '10.1161/CIRCULATIONAHA.121.058457', 'article-title': 'Genetic architecture of acute myocarditis and the overlap with ' 'inherited cardiomyopathy', 'volume': '146', 'author': 'Lota', 'year': '2022', 'journal-title': 'Circulation'}, { 'issue': '1', 'key': '10.1016/j.intimp.2024.112073_b0020', 'doi-asserted-by': 'crossref', 'first-page': '121', 'DOI': '10.1016/j.gheart.2014.01.007', 'article-title': 'The global burden of myocarditis: part 1: a systematic literature ' 'review for the Global Burden of Diseases, Injuries, and Risk Factors ' '2010 study', 'volume': '9', 'author': 'Cooper', 'year': '2014', 'journal-title': 'Glob. Heart'}, { 'issue': '11', 'key': '10.1016/j.intimp.2024.112073_b0025', 'doi-asserted-by': 'crossref', 'first-page': '670', 'DOI': '10.1038/nrcardio.2015.108', 'article-title': 'Viral myocarditis–diagnosis, treatment options, and current ' 'controversies', 'volume': '12', 'author': 'Pollack', 'year': '2015', 'journal-title': 'Nat. Rev. Cardiol'}, { 'issue': '3', 'key': '10.1016/j.intimp.2024.112073_b0030', 'doi-asserted-by': 'crossref', 'first-page': '496', 'DOI': '10.1161/CIRCRESAHA.115.306573', 'article-title': 'Myocarditis', 'volume': '118', 'author': 'Fung', 'year': '2016', 'journal-title': 'Circulat. Res.'}, { 'issue': '4', 'key': '10.1016/j.intimp.2024.112073_b0035', 'doi-asserted-by': 'crossref', 'first-page': '629', 'DOI': '10.2217/fmb.15.5', 'article-title': 'Coxsackievirus B3 replication and pathogenesis', 'volume': '10', 'author': 'Garmaroudi', 'year': '2015', 'journal-title': 'Future. Microbiol'}, { 'key': '10.1016/j.intimp.2024.112073_b0040', 'doi-asserted-by': 'crossref', 'first-page': '64', 'DOI': '10.3389/fcvm.2019.00064', 'article-title': 'Myocarditis in humans and in experimental animal models', 'volume': '6', 'author': 'Blyszczuk', 'year': '2019', 'journal-title': 'Front. Cardiovasc. Med.'}, { 'issue': '3', 'key': '10.1016/j.intimp.2024.112073_b0045', 'doi-asserted-by': 'crossref', 'first-page': '274', 'DOI': '10.1007/s000590050020', 'article-title': 'Experimental autoimmune myocarditis and its pathomechanism', 'volume': '25', 'author': 'Izumi', 'year': '2000', 'journal-title': 'Herz'}, { 'issue': '18', 'key': '10.1016/j.intimp.2024.112073_b0050', 'doi-asserted-by': 'crossref', 'first-page': '2498', 'DOI': '10.2174/1381612821666150316123711', 'article-title': 'Mouse models of autoimmune diseases - autoimmune myocarditis', 'volume': '21', 'author': 'Muller', 'year': '2015', 'journal-title': 'Curr. Pharm. Des'}, { 'key': '10.1016/j.intimp.2024.112073_b0055', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.antiviral.2023.105588', 'article-title': 'Importin alpha/beta-dependent nuclear transport of human parvovirus B19 ' 'nonstructural protein 1 is essential for viral replication', 'volume': '213', 'author': 'Alvisi', 'year': '2023', 'journal-title': 'Antiviral. Res'}, { 'issue': '3', 'key': '10.1016/j.intimp.2024.112073_b0060', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/cells8030281', 'article-title': 'Novel flavivirus antiviral that targets the host nuclear transport ' 'importin alpha/beta1 heterodimer', 'volume': '8', 'author': 'Yang', 'year': '2019', 'journal-title': 'Cells'}, { 'issue': '1', 'key': '10.1016/j.intimp.2024.112073_b0065', 'doi-asserted-by': 'crossref', 'first-page': 'e1006823', 'DOI': '10.1371/journal.ppat.1006823', 'article-title': 'Importin alpha1 is required for nuclear import of herpes simplex virus ' 'proteins and capsid assembly in fibroblasts and neurons', 'volume': '14', 'author': 'Dohner', 'year': '2018', 'journal-title': 'PLoS. Pathog'}, { 'issue': '3', 'key': '10.1016/j.intimp.2024.112073_b0070', 'doi-asserted-by': 'crossref', 'first-page': '301', 'DOI': '10.1016/j.antiviral.2013.06.002', 'article-title': 'Nuclear localization of dengue virus (DENV) 1–4 non-structural protein ' '5; protection against all 4 DENV serotypes by the inhibitor Ivermectin', 'volume': '99', 'author': 'Tay', 'year': '2013', 'journal-title': 'Antiviral. Res'}, { 'issue': '1', 'key': '10.1016/j.intimp.2024.112073_b0075', 'doi-asserted-by': 'crossref', 'first-page': '515', 'DOI': '10.1186/s13071-020-04391-w', 'article-title': 'Systemic profile of immune factors in an elderly Italian population ' 'affected by chronic strongyloidiasis', 'volume': '13', 'author': 'Tiberti', 'year': '2020', 'journal-title': 'Parasit. Vectors'}, { 'issue': '5', 'key': '10.1016/j.intimp.2024.112073_b0080', 'doi-asserted-by': 'crossref', 'first-page': 'e0010340', 'DOI': '10.1371/journal.pntd.0010340', 'article-title': 'Onchocerca volvulus-specific antibody and cellular responses in ' 'onchocerciasis patients treated annually with ivermectin for 30 years ' 'and exposed to parasite transmission in central Togo', 'volume': '16', 'author': 'Johanns', 'year': '2022', 'journal-title': 'PLoS. Negl. Trop. Dis'}, { 'key': '10.1016/j.intimp.2024.112073_b0085', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.antiviral.2020.104760', 'article-title': 'The broad spectrum antiviral ivermectin targets the host nuclear ' 'transport importin alpha/beta1 heterodimer', 'volume': '177', 'author': 'Yang', 'year': '2020', 'journal-title': 'Antiviral. Res'}, { 'issue': '3', 'key': '10.1016/j.intimp.2024.112073_b0090', 'doi-asserted-by': 'crossref', 'first-page': '851', 'DOI': '10.1042/BJ20120150', 'article-title': 'Ivermectin is a specific inhibitor of importin alpha/beta-mediated ' 'nuclear import able to inhibit replication of HIV-1 and dengue virus', 'volume': '443', 'author': 'Wagstaff', 'year': '2012', 'journal-title': 'Biochem. J.'}, { 'issue': '3', 'key': '10.1016/j.intimp.2024.112073_b0095', 'doi-asserted-by': 'crossref', 'first-page': '202', 'DOI': '10.1016/j.antiviral.2012.06.008', 'article-title': 'Nuclear trafficking of proteins from RNA viruses: potential target for ' 'antivirals?', 'volume': '95', 'author': 'Caly', 'year': '2012', 'journal-title': 'Antiviral. Res'}, { 'issue': '11', 'key': '10.1016/j.intimp.2024.112073_b0100', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/v14112468', 'article-title': 'Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2', 'volume': '14', 'author': 'Nakanishi', 'year': '2022', 'journal-title': 'Viruses'}, { 'issue': '1', 'key': '10.1016/j.intimp.2024.112073_b0105', 'doi-asserted-by': 'crossref', 'first-page': '38', 'DOI': '10.1016/j.diagmicrobio.2019.03.012', 'article-title': 'Lack of efficacy of ivermectin for prevention of a lethal Zika virus ' 'infection in a murine system', 'volume': '95', 'author': 'Ketkar', 'year': '2019', 'journal-title': 'Diagn. Microbiol. Infect. Dis'}, { 'issue': '1', 'key': '10.1016/j.intimp.2024.112073_b0110', 'doi-asserted-by': 'crossref', 'first-page': '23', 'DOI': '10.1186/s12941-020-00368-w', 'article-title': 'Ivermectin, a new candidate therapeutic against SARS-CoV-2/COVID-19', 'volume': '19', 'author': 'Sharun', 'year': '2020', 'journal-title': 'Ann. Clin. Microbiol. Antimicrob'}, { 'issue': '12', 'key': '10.1016/j.intimp.2024.112073_b0115', 'doi-asserted-by': 'crossref', 'first-page': '3443', 'DOI': '10.1093/jac/dkac339', 'article-title': 'Suppression of classical nuclear import pathway by importazole and ' 'ivermectin inhibits rotavirus replication', 'volume': '77', 'author': 'Sarkar', 'year': '2022', 'journal-title': 'J. Antimicrob. Chemother'}, { 'key': '10.1016/j.intimp.2024.112073_b0120', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.micpath.2021.104914', 'article-title': 'Antiviral potential of ivermectin against foot-and-mouth disease virus, ' 'serotype O, A and Asia-1', 'volume': '155', 'author': 'Naeem', 'year': '2021', 'journal-title': 'Microb. Pathog'}, { 'key': '10.1016/j.intimp.2024.112073_b0125', 'doi-asserted-by': 'crossref', 'first-page': '55', 'DOI': '10.1016/j.antiviral.2018.09.010', 'article-title': 'Ivermectin inhibits DNA polymerase UL42 of pseudorabies virus entrance ' 'into the nucleus and proliferation of the virus in vitro and vivo', 'volume': '159', 'author': 'Lv', 'year': '2018', 'journal-title': 'Antiviral. Res'}, { 'issue': '2', 'key': '10.1016/j.intimp.2024.112073_b0130', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.bbadis.2021.166294', 'article-title': 'Repositioning Ivermectin for Covid-19 treatment: Molecular mechanisms ' 'of action against SARS-CoV-2 replication', 'volume': '1868', 'author': 'Low', 'year': '2022', 'journal-title': 'Biochim. Biophys. Acta. Mol. Basis. Dis'}, { 'issue': '1', 'key': '10.1016/j.intimp.2024.112073_b0135', 'doi-asserted-by': 'crossref', 'first-page': '7132', 'DOI': '10.1038/s41598-021-86679-0', 'article-title': 'Ivermectin reduces in vivo coronavirus infection in a mouse ' 'experimental model', 'volume': '11', 'author': 'Arevalo', 'year': '2021', 'journal-title': 'Sci. Rep'}, { 'key': '10.1016/j.intimp.2024.112073_b0140', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fcimb.2021.700502', 'article-title': 'Combination treatment with remdesivir and ivermectin exerts highly ' 'synergistic and potent antiviral activity against murine coronavirus ' 'infection', 'volume': '11', 'author': 'Tan', 'year': '2021', 'journal-title': 'Front. Cell. Infect. Microbiol'}, { 'issue': '5', 'key': '10.1016/j.intimp.2024.112073_b0145', 'doi-asserted-by': 'crossref', 'first-page': '566', 'DOI': '10.1016/j.jiph.2022.03.014', 'article-title': 'Combined therapy with ivermectin and doxycycline can effectively ' 'alleviate the cytokine storm of COVID-19 infection amid vaccination ' 'drive: A narrative review', 'volume': '15', 'author': 'Sharma', 'year': '2022', 'journal-title': 'J. Infect. Public. Health'}, { 'issue': '4', 'key': '10.1016/j.intimp.2024.112073_b0150', 'doi-asserted-by': 'crossref', 'first-page': '2959', 'DOI': '10.1002/jcp.30055', 'article-title': 'Quantitative proteomics reveals a broad-spectrum antiviral property of ' 'ivermectin, benefiting for COVID-19 treatment', 'volume': '236', 'author': 'Li', 'year': '2021', 'journal-title': 'J. Cell. Physiol'}, { 'issue': '17', 'key': '10.1016/j.intimp.2024.112073_b0155', 'doi-asserted-by': 'crossref', 'first-page': '1717', 'DOI': '10.1016/j.jacc.2022.02.003', 'volume': '79', 'author': 'Writing', 'year': '2022', 'journal-title': 'J. Am. Coll. Cardiol'}, { 'issue': '11', 'key': '10.1016/j.intimp.2024.112073_b0160', 'doi-asserted-by': 'crossref', 'first-page': '524', 'DOI': '10.1007/s00011-008-8007-8', 'article-title': 'Ivermectin inhibits LPS-induced production of inflammatory cytokines ' 'and improves LPS-induced survival in mice', 'volume': '57', 'author': 'Zhang', 'year': '2008', 'journal-title': 'Inflamm. Res'}, { 'key': '10.1016/j.intimp.2024.112073_b0165', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.biopha.2022.113706', 'article-title': 'Ivermectin contributes to attenuating the severity of acute lung injury ' 'in mice', 'volume': '155', 'author': 'Ma', 'year': '2022', 'journal-title': 'Biomed. Pharmacother'}, { 'issue': '10', 'key': '10.1016/j.intimp.2024.112073_b0170', 'doi-asserted-by': 'crossref', 'first-page': 'e110183', 'DOI': '10.1371/journal.pone.0110183', 'article-title': 'The “genomic storm” induced by bacterial endotoxin is calmed by a ' 'nuclear transport modifier that attenuates localized and systemic ' 'inflammation', 'volume': '9', 'author': 'DiGiandomenico', 'year': '2014', 'journal-title': 'PLoS. One'}, { 'issue': '8', 'key': '10.1016/j.intimp.2024.112073_bib326', 'doi-asserted-by': 'crossref', 'DOI': '10.15252/emmm.201708743', 'article-title': 'P2X4 receptor controls microglia activation and favors remyelination in ' 'autoimmune encephalitis', 'volume': '10', 'author': 'Zabala', 'year': '2018', 'journal-title': 'Embo Mol Med'}, { 'issue': '5', 'key': '10.1016/j.intimp.2024.112073_bib327', 'doi-asserted-by': 'crossref', 'first-page': '1626', 'DOI': '10.1007/s10753-023-01829-y', 'article-title': 'Ivermectin Protects Against Experimental Autoimmune Encephalomyelitis ' 'in Mice by Modulating the Th17/Treg Balance Involved in the IL-2/STAT5 ' 'Pathway', 'volume': '46', 'author': 'Xie', 'year': '2023', 'journal-title': 'Inflammation'}, { 'issue': '5', 'key': '10.1016/j.intimp.2024.112073_bib328', 'doi-asserted-by': 'crossref', 'first-page': '971', 'DOI': '10.1111/fcp.12902', 'article-title': 'Evaluation of therapeutic potential of ivermectin against complete ' 'Freund’s adjuvant-induced arthritis in rats: Involvement of ' 'inflammatory mediators', 'volume': '37', 'author': 'Khan', 'year': '2023', 'journal-title': 'Fund Clin Pharmacol'}, { 'key': '10.1016/j.intimp.2024.112073_b0175', 'unstructured': 'C. National Research Council Committee for the Update of the Guide for ' 'the, A. Use of Laboratory, The National Academies Collection: Reports ' 'funded by National Institutes of Health, Guide for the Care and Use of ' 'Laboratory Animals, National Academies Press (US) Copyright © 2011, ' 'National Academy of Sciences., Washington (DC), 2011.'}, { 'issue': '2', 'key': '10.1016/j.intimp.2024.112073_b0180', 'doi-asserted-by': 'crossref', 'first-page': '213', 'DOI': '10.1007/s00203-019-01734-9', 'article-title': 'Antiviral activity of five filamentous cyanobacteria against ' 'coxsackievirus B3 and rotavirus', 'volume': '202', 'author': 'Deyab', 'year': '2020', 'journal-title': 'Arch. Microbiol'}, { 'key': '10.1016/j.intimp.2024.112073_b0185', 'doi-asserted-by': 'crossref', 'first-page': '47', 'DOI': '10.1016/j.yjmcc.2022.05.012', 'article-title': 'Standardised method for cardiomyocyte isolation and purification from ' 'individual murine neonatal, infant, and adult hearts', 'volume': '170', 'author': 'Nicks', 'year': '2022', 'journal-title': 'J. Mol. Cell. Cardiol'}, { 'issue': '1 Suppl', 'key': '10.1016/j.intimp.2024.112073_b0190', 'doi-asserted-by': 'crossref', 'first-page': '25', 'DOI': '10.2144/000112517', 'article-title': 'ImageJ for microscopy', 'volume': '43', 'author': 'Collins', 'year': '2007', 'journal-title': 'Biotechniques'}, { 'key': '10.1016/j.intimp.2024.112073_b0195', 'doi-asserted-by': 'crossref', 'first-page': '289', 'DOI': '10.1007/978-1-4939-7871-7_20', 'article-title': 'Analysis of protein-protein interaction by co-IP in human cells', 'volume': '1794', 'author': 'Tang', 'year': '2018', 'journal-title': 'Methods. Mol. Biol'}, { 'issue': '9', 'key': '10.1016/j.intimp.2024.112073_b0200', 'doi-asserted-by': 'crossref', 'first-page': '440', 'DOI': '10.4049/immunohorizons.1900064', 'article-title': 'Protection from endotoxin shock by selective targeting of ' 'proinflammatory signaling to the nucleus mediated by importin alpha 5', 'volume': '3', 'author': 'Liu', 'year': '2019', 'journal-title': 'Immunohorizons'}, { 'key': '10.1016/j.intimp.2024.112073_b0205', 'doi-asserted-by': 'crossref', 'unstructured': 'N. Lasrado, N. Borcherding, R. Arumugam, T.K. Starr, J. Reddy, ' 'Dissecting the cellular landscape and transcriptome network in viral ' 'myocarditis by single-cell RNA sequencing, iScience 25(3) (2022) 103865. ' 'doi: 10.1016/j.isci.2022.103865.', 'DOI': '10.1016/j.isci.2022.103865'}, { 'issue': '4', 'key': '10.1016/j.intimp.2024.112073_b0210', 'doi-asserted-by': 'crossref', 'first-page': '316', 'DOI': '10.1161/CIRCULATIONAHA.121.056730', 'article-title': 'Identification of pathogenic immune cell subsets associated with ' 'checkpoint inhibitor-induced myocarditis', 'volume': '146', 'author': 'Zhu', 'year': '2022', 'journal-title': 'Circulation'}, { 'key': '10.1016/j.intimp.2024.112073_b0220', 'doi-asserted-by': 'crossref', 'first-page': '193', 'DOI': '10.1016/j.intimp.2019.04.052', 'article-title': 'THE NF-kB AND IkB PROTEINS', 'volume': '73', 'author': 'Shen', 'year': '2019', 'journal-title': 'Int. Immunopharmacol'}, { 'issue': '24', 'key': '10.1016/j.intimp.2024.112073_b0225', 'doi-asserted-by': 'crossref', 'first-page': '14255', 'DOI': '10.1074/jbc.270.24.14255', 'article-title': 'Inhibition of nuclear translocation of transcription factor NF-kappa B ' 'by a synthetic peptide containing a cell membrane-permeable motif and ' 'nuclear localization sequence', 'volume': '270', 'author': 'Lin', 'year': '1995', 'journal-title': 'J. Biol. Chem'}, { 'key': '10.1016/j.intimp.2024.112073_b0230', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fcell.2022.760509', 'article-title': 'Identification of cardiac CircRNAs in mice with CVB3-induced ' 'myocarditis', 'volume': '10', 'author': 'Nie', 'year': '2022', 'journal-title': 'Front. Cell. Dev. Biol'}, { 'issue': '2', 'key': '10.1016/j.intimp.2024.112073_b0235', 'doi-asserted-by': 'crossref', 'first-page': 'e28473', 'DOI': '10.1002/jmv.28473', 'article-title': 'Analysis of long noncoding RNAs and messenger RNAs expression profiles ' 'in the hearts of mice with acute viral myocarditis', 'volume': '95', 'author': 'Xue', 'year': '2023', 'journal-title': 'J. Med. Virol'}, { 'issue': '1', 'key': '10.1016/j.intimp.2024.112073_b0240', 'doi-asserted-by': 'crossref', 'first-page': 'e014071', 'DOI': '10.1161/CIRCIMAGING.122.014071', 'article-title': 'Imaging targets to visualize the cardiac immune landscape in heart ' 'failure', 'volume': '16', 'author': 'Wienecke', 'year': '2023', 'journal-title': 'Circ. Cardiovasc. Imaging'}, { 'issue': '13', 'key': '10.1016/j.intimp.2024.112073_b0245', 'doi-asserted-by': 'crossref', 'first-page': '3050', 'DOI': '10.1039/D2LC01070D', 'article-title': 'Mitigating neutrophil trafficking and cardiotoxicity with DS-IkL in a ' 'microphysiological system of a cytokine storm', 'volume': '23', 'author': 'Shirure', 'year': '2023', 'journal-title': 'Lab. Chip'}, { 'issue': '11', 'key': '10.1016/j.intimp.2024.112073_b0250', 'doi-asserted-by': 'crossref', 'first-page': '1766', 'DOI': '10.1161/CIRCRESAHA.121.318005', 'article-title': 'Immune cells and immunotherapy for cardiac injury and repair', 'volume': '128', 'author': 'Rurik', 'year': '2021', 'journal-title': 'Circ. Res.'}, { 'key': '10.1016/j.intimp.2024.112073_b0255', 'doi-asserted-by': 'crossref', 'unstructured': 'R. Dhingra, I. Rabinovich-Nikitin, S. Rothman, M. Guberman, H. Gang, V. ' 'Margulets, D.S. Jassal, K.N. Alagarsamy, S. Dhingra, C. Valenzuela ' 'Ripoll, F. Billia, A. Diwan, A. Javaheri, L.A. Kirshenbaum, Proteasomal ' 'degradation of TRAF2 mediates mitochondrial dysfunction in ' 'doxorubicin-cardiomyopathy, Circulation 146(12) (2022) 934-954. doi: ' '10.1161/CIRCULATIONAHA.121.058411.', 'DOI': '10.1161/CIRCULATIONAHA.121.058411'}, { 'issue': '1', 'key': '10.1016/j.intimp.2024.112073_b0260', 'doi-asserted-by': 'crossref', 'first-page': '11907', 'DOI': '10.1038/s41598-021-91395-w', 'article-title': 'Hyperlipidemic hypersensitivity to lethal microbial inflammation and ' 'its reversal by selective targeting of nuclear transport shuttles', 'volume': '11', 'author': 'Liu', 'year': '2021', 'journal-title': 'Sci. Rep'}, { 'key': '10.1016/j.intimp.2024.112073_b0265', 'doi-asserted-by': 'crossref', 'first-page': '103', 'DOI': '10.1016/j.cellsig.2018.01.011', 'article-title': 'Importins α and β signaling mediates endothelial cell inflammation and ' 'barrier disruption', 'volume': '44', 'author': 'Leonard', 'year': '2018', 'journal-title': 'Cell. Signal'}, { 'key': '10.1016/j.intimp.2024.112073_b0270', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.bcp.2021.114501', 'article-title': 'Natural lactucopicrin alleviates importin-alpha3-mediated NF-kappaB ' 'activation in inflammated endothelial cells and improves sepsis in mice', 'volume': '186', 'author': 'Weng', 'year': '2021', 'journal-title': 'Biochem. Pharmacol'}, { 'issue': '3', 'key': '10.1016/j.intimp.2024.112073_b0275', 'doi-asserted-by': 'crossref', 'first-page': '747', 'DOI': '10.1007/s10620-015-3948-6', 'article-title': 'Karyopherin alpha 2 promotes the inflammatory response in rat ' 'pancreatic acinar cells via facilitating NF-κB activation', 'volume': '61', 'author': 'Cai', 'year': '2016', 'journal-title': 'Digest. Dis. Sci'}, { 'key': '10.1016/j.intimp.2024.112073_b0280', 'doi-asserted-by': 'crossref', 'first-page': '50', 'DOI': '10.1016/j.ceb.2019.01.001', 'article-title': 'Inhibitors of nuclear transport', 'volume': '58', 'author': 'Jans', 'year': '2019', 'journal-title': 'Curr. Opin. Cell. Biol'}, { 'issue': '2', 'key': '10.1016/j.intimp.2024.112073_b0285', 'doi-asserted-by': 'crossref', 'first-page': '223', 'DOI': '10.1038/cr.2011.13', 'article-title': 'NF-kappaB in immunobiology', 'volume': '21', 'author': 'Hayden', 'year': '2011', 'journal-title': 'Cell. Res'}, { 'issue': '6', 'key': '10.1016/j.intimp.2024.112073_b0290', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1002/rmv.2131', 'article-title': 'An overview of the immune mechanisms of viral myocarditis', 'volume': '30', 'author': 'Lasrado', 'year': '2020', 'journal-title': 'Rev. Med. Virol'}, { 'issue': '6', 'key': '10.1016/j.intimp.2024.112073_b0295', 'doi-asserted-by': 'crossref', 'first-page': 'e0179468', 'DOI': '10.1371/journal.pone.0179468', 'article-title': 'Survival, bacterial clearance and thrombocytopenia are improved in ' 'polymicrobial sepsis by targeting nuclear transport shuttles', 'volume': '12', 'author': 'Veach', 'year': '2017', 'journal-title': 'PLoS. One'}, { 'issue': '42', 'key': '10.1016/j.intimp.2024.112073_b0300', 'doi-asserted-by': 'crossref', 'first-page': '4389', 'DOI': '10.1093/eurheartj/ehab447', 'article-title': 'The JAK-STAT pathway: an emerging target for cardiovascular disease in ' 'rheumatoid arthritis and myeloproliferative neoplasms', 'volume': '42', 'author': 'Baldini', 'year': '2021', 'journal-title': 'Eur. Heart. J'}, { 'issue': '4', 'key': '10.1016/j.intimp.2024.112073_b0305', 'doi-asserted-by': 'crossref', 'first-page': '503', 'DOI': '10.1016/j.immuni.2012.03.013', 'article-title': 'The JAK-STAT pathway at twenty', 'volume': '36', 'author': 'Stark', 'year': '2012', 'journal-title': 'Immunity'}, { 'issue': '12', 'key': '10.1016/j.intimp.2024.112073_b0310', 'doi-asserted-by': 'crossref', 'first-page': '1760', 'DOI': '10.1161/CIRCRESAHA.119.316167', 'article-title': 'AP-1 Contributes to chromatin accessibility to promote sarcomere ' 'disassembly and cardiomyocyte protrusion during Zebrafish heart ' 'regeneration', 'volume': '126', 'author': 'Beisaw', 'year': '2020', 'journal-title': 'Circ. Res.'}, { 'issue': '9', 'key': '10.1016/j.intimp.2024.112073_b0315', 'doi-asserted-by': 'crossref', 'first-page': 'e73294', 'DOI': '10.1371/journal.pone.0073294', 'article-title': 'The AP-1 transcription factor c-Jun prevents stress-imposed maladaptive ' 'remodeling of the heart', 'volume': '8', 'author': 'Windak', 'year': '2013', 'journal-title': 'PLoS. One'}, { 'key': '10.1016/j.intimp.2024.112073_b0320', 'article-title': 'The mechanism of the NFAT transcription factor family involved in ' 'oxidative stress response', 'author': 'Zhang', 'year': '2023', 'journal-title': 'J. Cardiol'}, { 'issue': '32', 'key': '10.1016/j.intimp.2024.112073_b0325', 'doi-asserted-by': 'crossref', 'first-page': '13335', 'DOI': '10.1073/pnas.0812911106', 'article-title': 'NFAT isoforms control activity-dependent muscle fiber type ' 'specification', 'volume': '106', 'author': 'Calabria', 'year': '2009', 'journal-title': 'Proc. Natl. Acad. Sci. U. S. A'}], 'container-title': 'International Immunopharmacology', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S1567576924005915?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S1567576924005915?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2024, 4, 17]], 'date-time': '2024-04-17T22:13:16Z', 'timestamp': 1713391996000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S1567576924005915'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 5]]}, 'references-count': 67, 'alternative-id': ['S1567576924005915'], 'URL': 'http://dx.doi.org/10.1016/j.intimp.2024.112073', 'relation': {}, 'ISSN': ['1567-5769'], 'subject': ['Pharmacology', 'Immunology', 'Immunology and Allergy'], 'container-title-short': 'International Immunopharmacology', 'published': {'date-parts': [[2024, 5]]}, 'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'}, { 'value': 'Ivermectin ameliorates acute myocarditis via the inhibition of ' 'importin-mediated nuclear translocation of NF-κB/p65', 'name': 'articletitle', 'label': 'Article Title'}, { 'value': 'International Immunopharmacology', 'name': 'journaltitle', 'label': 'Journal Title'}, { 'value': 'https://doi.org/10.1016/j.intimp.2024.112073', 'name': 'articlelink', 'label': 'CrossRef DOI link to publisher maintained version'}, {'value': 'article', 'name': 'content_type', 'label': 'Content Type'}, { 'value': '© 2024 Elsevier B.V. All rights reserved.', 'name': 'copyright', 'label': 'Copyright'}], 'article-number': '112073'}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit