Ivermectin: an award-winning drug with expected antiviral activity against COVID-19

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Res.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0015', 'doi-asserted-by': 'crossref', 'first-page': '80', 'DOI': '10.1016/j.virusres.2019.01.010', 'article-title': 'Ivermectin treatment inhibits the replication of porcine circovirus 2 ' '(PCV2) in vitro and mitigates the impact of viral infection in piglets', 'volume': '263', 'author': 'Wang', 'year': '2019', 'journal-title': 'Virus Res.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0020', 'doi-asserted-by': 'crossref', 'DOI': '10.1371/journal.pntd.0006934', 'article-title': 'Antivirus effectiveness of ivermectin on dengue virus type 2 in Aedes ' 'albopictus', 'volume': '12', 'author': 'Xu', 'year': '2018', 'journal-title': 'PLoS Negl. Trop. Dis.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0025', 'doi-asserted-by': 'crossref', 'first-page': '117', 'DOI': '10.1016/j.antiviral.2015.12.012', 'article-title': 'Discovery of berberine, abamectin and ivermectin as antivirals against ' 'chikungunya and other alphaviruses', 'volume': '126', 'author': 'Varghese', 'year': '2016', 'journal-title': 'Antivir. Res.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0030', 'doi-asserted-by': 'crossref', 'first-page': '104760', 'DOI': '10.1016/j.antiviral.2020.104760', 'article-title': 'The broad spectrum antiviral ivermectin targets the host nuclear ' 'transport importin alpha/beta1 heterodimer', 'volume': '177', 'author': 'Yang', 'year': '2020', 'journal-title': 'Antivir. Res.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0035', 'doi-asserted-by': 'crossref', 'first-page': '259', 'DOI': '10.1016/j.chom.2016.07.004', 'article-title': 'A screen of FDA-approved drugs for inhibitors of Zika virus infection', 'volume': '20', 'author': 'Barrows', 'year': '2016', 'journal-title': 'Cell Host Microbe'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0040', 'doi-asserted-by': 'crossref', 'first-page': '38', 'DOI': '10.1016/j.diagmicrobio.2019.03.012', 'article-title': 'Lack of efficacy of ivermectin for prevention of a lethal Zika virus ' 'infection in a murine system', 'volume': '95', 'author': 'Ketkar', 'year': '2019', 'journal-title': 'Diagn. Microbiol. Infect. Dis.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0045', 'doi-asserted-by': 'crossref', 'first-page': '104787', 'DOI': '10.1016/j.antiviral.2020.104787', 'article-title': 'The FDA-approved drug Ivermectin inhibits the replication of SARS-CoV-2 ' 'in vitro', 'volume': '178', 'author': 'Caly', 'year': '2020', 'journal-title': 'Antivir. Res.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0050', 'doi-asserted-by': 'crossref', 'first-page': '4399', 'DOI': '10.1128/JVI.75.9.4399-4401.2001', 'article-title': 'Measles viruses on throat swabs from measles patients use signaling ' 'lymphocytic activation molecule (CDw150) but not CD46 as a cellular ' 'receptor', 'volume': '75', 'author': 'Ono', 'year': '2001', 'journal-title': 'J. Virol.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0055', 'first-page': 'M20', 'article-title': 'Histopathologic changes and SARS-CoV-2 imunostaining in the lung of a ' 'patient with COVID-19', 'author': 'Zhang', 'year': '2020', 'journal-title': 'Ann. Intern. Med.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0060', 'doi-asserted-by': 'crossref', 'first-page': '762', 'DOI': '10.1002/cpt.1889', 'article-title': 'The approved dose of ivermectin alone is not the Ideal dose for the ' 'treatment of COVID-19', 'volume': '108', 'author': 'Schmith', 'year': '2020', 'journal-title': 'Clin. Pharmacol. Ther.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0065', 'doi-asserted-by': 'crossref', 'first-page': '1153', 'DOI': '10.1007/s00210-020-01902-5', 'article-title': 'Ivermectin, antiviral properties and COVID-19: a possible new mechanism ' 'of action', 'volume': '393', 'author': 'Rizzo', 'year': '2020', 'journal-title': 'Naunyn Schmiedeberg’s Arch. Pharmacol.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0070', 'doi-asserted-by': 'crossref', 'DOI': '10.1128/AAC.00086-20', 'article-title': 'Novel ionophores active against La Crosse virus identified through ' 'rapid antiviral screening', 'volume': '64', 'author': 'Sandler', 'year': '2020', 'journal-title': 'Antimicrob. Agents Chemother.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0075', 'doi-asserted-by': 'crossref', 'first-page': '2202', 'DOI': '10.1172/JCI137647', 'article-title': 'SARS-CoV-2: a storm is raging', 'volume': '130', 'author': 'Pedersen', 'year': '2020', 'journal-title': 'J. Clin. Invest.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0080', 'doi-asserted-by': 'crossref', 'first-page': '270', 'DOI': '10.1038/s41586-020-2012-7', 'article-title': 'A pneumonia outbreak associated with a new coronavirus of probable bat ' 'origin', 'volume': '579', 'author': 'Zhou', 'year': '2020', 'journal-title': 'Nature.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0085', 'doi-asserted-by': 'crossref', 'first-page': '465', 'DOI': '10.1038/s41586-020-2196-x', 'article-title': 'Virological assessment of hospitalized patients with COVID-2019', 'volume': '581', 'author': 'Wölfel', 'year': '2020', 'journal-title': 'Nature.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0090', 'doi-asserted-by': 'crossref', 'first-page': '1177', 'DOI': '10.1056/NEJMc2001737', 'article-title': 'SARS-CoV-2 viral load in upper respiratory specimens of infected ' 'patients', 'volume': '382', 'author': 'Zou', 'year': '2020', 'journal-title': 'N. Engl. J. Med.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0095', 'doi-asserted-by': 'crossref', 'first-page': 'm1443', 'DOI': '10.1136/bmj.m1443', 'article-title': 'Viral load dynamics and disease severity in patients infected with ' 'SARS-CoV-2 in Zhejiang Province, China, January-march 2020: ' 'retrospective cohort study', 'volume': '369', 'author': 'Zheng', 'year': '2020', 'journal-title': 'BMJ.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0100', 'doi-asserted-by': 'crossref', 'first-page': '379', 'DOI': '10.1007/s13555-018-0249-y', 'article-title': 'Topical ivermectin in the treatment of Papulopustular rosacea: a ' 'systematic review of evidence and clinical guideline recommendations', 'volume': '8', 'author': 'Ebbelaar', 'year': '2018', 'journal-title': 'Dermatol. Ther. (Heidelb).'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0105', 'doi-asserted-by': 'crossref', 'first-page': '589', 'DOI': '10.1007/s00011-011-0307-8', 'article-title': 'Anti-inflammatory effects of ivermectin in mouse model of allergic ' 'asthma', 'volume': '60', 'author': 'Yan', 'year': '2011', 'journal-title': 'Inflamm. Res.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0110', 'doi-asserted-by': 'crossref', 'first-page': '524', 'DOI': '10.1007/s00011-008-8007-8', 'article-title': 'Ivermectin inhibits LPS-induced production of inflammatory cytokines ' 'and improves LPS-induced survival in mice', 'volume': '57', 'author': 'Zhang', 'year': '2008', 'journal-title': 'Inflamm. Res.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0115', 'doi-asserted-by': 'crossref', 'first-page': '498', 'DOI': '10.1186/s13063-020-04421-z', 'volume': '21', 'author': 'Chaccour', 'year': '2020', 'journal-title': 'Trials.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0120', 'doi-asserted-by': 'crossref', 'first-page': '110', 'DOI': '10.1016/j.ejpb.2019.09.002', 'article-title': 'Challenges and strategies in drug delivery systems for treatment of ' 'pulmonary infections', 'volume': '144', 'author': 'Ho', 'year': '2019', 'journal-title': 'Eur. J. Pharm. Biopharm.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0125', 'doi-asserted-by': 'crossref', 'first-page': '83', 'DOI': '10.1016/j.addr.2014.10.022', 'article-title': 'Inhaled formulations and pulmonary drug delivery systems for ' 'respiratory infections', 'volume': '85', 'author': 'Zhou', 'year': '2015', 'journal-title': 'Adv. Drug Deliv. Rev.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0130', 'doi-asserted-by': 'crossref', 'first-page': '113', 'DOI': '10.3390/pharmaceutics11030113', 'article-title': 'Strategies to enhance drug absorption via nasal and pulmonary routes', 'volume': '11', 'author': 'Ghadiri', 'year': '2019', 'journal-title': 'Pharmaceutics.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0140', 'doi-asserted-by': 'crossref', 'first-page': '1144', 'DOI': '10.1007/s11095-006-0162-4', 'article-title': 'Oral absorption of poorly water-soluble drugs: computer simulation of ' 'fraction absorbed in humans from a miniscale dissolution test', 'volume': '23', 'author': 'Takano', 'year': '2006', 'journal-title': 'Pharm. Res.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0145', 'doi-asserted-by': 'crossref', 'first-page': '11034', 'DOI': '10.1021/acsnano.9b02807', 'article-title': 'Orally administrable therapeutic synthetic nanoparticle for Zika virus', 'volume': '13', 'author': 'Surnar', 'year': '2019', 'journal-title': 'ACS Nano'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0150', 'doi-asserted-by': 'crossref', 'first-page': '1025', 'DOI': '10.2147/IJN.S38378', 'article-title': 'Nanodrugs: pharmacokinetics and safety', 'volume': '9', 'author': 'Onoue', 'year': '2014', 'journal-title': 'Int. J. Nanomedicine'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0155', 'doi-asserted-by': 'crossref', 'first-page': '2111', 'DOI': '10.1007/s00436-017-5510-2', 'article-title': 'Ivermectin lipid-based nanocarriers as novel formulations against head ' 'lice', 'volume': '116', 'author': 'Ullio-Gamboa', 'year': '2017', 'journal-title': 'Parasitol. Res.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0160', 'doi-asserted-by': 'crossref', 'first-page': '2933', 'DOI': '10.1007/s00436-013-3466-4', 'article-title': 'Improved antifilarial activity of ivermectin in chitosan-alginate ' 'nanoparticles against human lymphatic filarial parasite, Brugia malayi', 'volume': '112', 'author': 'Ali', 'year': '2013', 'journal-title': 'Parasitol. Res.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0165', 'doi-asserted-by': 'crossref', 'first-page': '681', 'DOI': '10.1007/s00436-013-3696-5', 'article-title': 'Therapeutic efficacy of poly (lactic-co-glycolic acid) nanoparticles ' 'encapsulated ivermectin (nano-ivermectin) against brugian filariasis in ' 'experimental rodent model', 'volume': '113', 'author': 'Ali', 'year': '2014', 'journal-title': 'Parasitol. Res.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0170', 'doi-asserted-by': 'crossref', 'first-page': '609', 'DOI': '10.3109/02652048.2010.501397', 'article-title': 'Ivermectin-loaded microparticles for parenteral sustained release: in ' 'vitro characterization and effect of some formulation variables', 'volume': '27', 'author': 'Camargo', 'year': '2010', 'journal-title': 'J. Microencapsul.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0175', 'article-title': 'Liposomal systems as nanocarriers for the antiviral agent Ivermectin', 'volume': '8043983', 'author': 'Croci', 'year': '2016', 'journal-title': 'Int. J. Biomater.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0180', 'doi-asserted-by': 'crossref', 'first-page': '150', 'DOI': '10.1016/j.drudis.2019.09.023', 'article-title': 'Physicochemical properties affecting the fate of nanoparticles in ' 'pulmonary drug delivery', 'volume': '25', 'author': 'Liu', 'year': '2020', 'journal-title': 'Drug Discov. Today'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0185', 'doi-asserted-by': 'crossref', 'first-page': '647', 'DOI': '10.4155/tde-2017-0037', 'article-title': 'Drug delivery to the lungs: challenges and opportunities', 'volume': '8', 'author': 'Newman', 'year': '2017', 'journal-title': 'Ther. Deliv.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0190', 'doi-asserted-by': 'crossref', 'first-page': '5852', 'DOI': '10.3390/ijms15045852', 'article-title': 'Nanoparticle-mediated pulmonary drug delivery: a review', 'volume': '15', 'author': 'Paranjpe', 'year': '2014', 'journal-title': 'Int. J. Mol. Sci.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0195', 'doi-asserted-by': 'crossref', 'first-page': '171', 'DOI': '10.3390/pharmaceutics12020171', 'article-title': 'Nanomaterials designed for antiviral drug delivery transport across ' 'biological barriers', 'volume': '12', 'author': 'Cojocaru', 'year': '2020', 'journal-title': 'Pharmaceutics.'}, { 'key': '10.1016/j.jconrel.2020.10.009_bb0200', 'doi-asserted-by': 'crossref', 'first-page': '3719', 'DOI': '10.1021/acsnano.0c02540', 'article-title': 'Nano research for COVID-19', 'volume': '14', 'author': 'Chan', 'year': '2020', 'journal-title': 'ACS Nano'}], 'container-title': 'Journal of Controlled Release', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S0168365920305800?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S0168365920305800?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2022, 6, 26]], 'date-time': '2022-06-26T11:46:04Z', 'timestamp': 1656243964000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S0168365920305800'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 1]]}, 'references-count': 39, 'alternative-id': ['S0168365920305800'], 'URL': 'http://dx.doi.org/10.1016/j.jconrel.2020.10.009', 'relation': {}, 'ISSN': ['0168-3659'], 'subject': [], 'container-title-short': 'Journal of Controlled Release', 'published': {'date-parts': [[2021, 1]]}, 'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'}, { 'value': 'Ivermectin: an award-winning drug with expected antiviral activity against ' 'COVID-19', 'name': 'articletitle', 'label': 'Article Title'}, {'value': 'Journal of Controlled Release', 'name': 'journaltitle', 'label': 'Journal Title'}, { 'value': 'https://doi.org/10.1016/j.jconrel.2020.10.009', 'name': 'articlelink', 'label': 'CrossRef DOI link to publisher maintained version'}, {'value': 'article', 'name': 'content_type', 'label': 'Content Type'}, { 'value': '© 2020 Elsevier B.V. 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