Ivermectin: an award-winning drug with expected antiviral activity against COVID-19

Formiga et al., J. Control Release, doi:10.1016/j.jconrel.2020.10.009

Jan 2021

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Review hypothesizing that micro- and nanotechnology-based formulations of ivermectin for the pulmonary delivery of ivermectin may be beneficial for use with COVID-19.

6 studies investigate novel formulations of ivermectin for improved efficacy Albariqi, Albariqi (B), Chaccour, Errecalde, Mansour, Saha

1. Albariqi et al., Pharmacokinetics and Safety of Inhaled Ivermectin in Mice as a Potential COVID-19 Treatment, International Journal of Pharmaceutics, doi:10.1016/j.ijpharm.2022.121688.sciencedirect.com, doi.org.

2. Albariqi (B) et al., Preparation and Characterization of Inhalable Ivermectin Powders as a Potential COVID-19 Therapy, Journal of Aerosol Medicine and Pulmonary Drug Delivery, doi:10.1089/jamp.2021.0059.liebertpub.com, doi.org.

3. Chaccour et al., Nebulized ivermectin for COVID-19 and other respiratory diseases, a proof of concept, dose-ranging study in rats, Scientific Reports, doi:10.1038/s41598-020-74084-y.nature.com, doi.org.

4. Errecalde et al., Safety and Pharmacokinetic Assessments of a Novel Ivermectin Nasal Spray Formulation in a Pig Model, Journal of Pharmaceutical Sciences, doi:10.1016/j.xphs.2021.01.017.sciencedirect.com, doi.org.

5. Mansour et al., Safety of inhaled ivermectin as a repurposed direct drug for treatment of COVID-19: A preclinical tolerance study, International Immunopharmacology, doi:10.1016/j.intimp.2021.108004.sciencedirect.com, doi.org.

6. Saha et al., Manipulation of Spray-Drying Conditions to Develop an Inhalable Ivermectin Dry Powder, Pharmaceutics, doi:10.3390/pharmaceutics14071432.mdpi.com, doi.org.

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Formiga et al., 10 Jan 2021, peer-reviewed, 6 authors.

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Ivermectin: an award-winning drug with expected antiviral activity against COVID-19

Fabio Rocha Formiga, Roger Leblanc, Juliana De Souza Rebouças, Leonardo Paiva Farias, Ronaldo Nascimento De Oliveira, Lindomar Pena

Journal of Controlled Release, doi:10.1016/j.jconrel.2020.10.009

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

Declaration of Competing Interest The authors deny the existence of any conflicts of interest.

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