Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment
Li et al.,
Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19..,
J. Cellular Physiology, doi:10.1002/jcp.30055 (In Vitro)
In Vitro study showing Ivermectin is a safe wide-spectrum antiviral against SARS-CoV-2, human papillomavirus (HPV), Epstein–Barr virus (EBV), and HIV.
Authors note that the combination of ivermectin and other drugs might result in more favorable prognoses for patients with COVID-19, for example ivermerctin and HCQ.
15 In Vitro studies support the efficacy of ivermectin
[Boschi, Caly, Croci, De Forni, Delandre, Jeffreys, Jitobaom, Jitobaom (B), Li, Liu, Mody, Mountain Valley MD, Segatori, Surnar, Yesilbag].
Li et al., 22 Sep 2020, peer-reviewed, 3 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
Abstract: |
Received: 21 July 2020
|
Revised: 31 August 2020
Accepted: 7 September 2020
DOI: 10.1002/jcp.30055
ORIGINAL RESEARCH ARTICLE
Quantitative proteomics reveals a broad‐spectrum antiviral
property of ivermectin, benefiting for COVID‐19 treatment
Na Li1,2,3 |
Lingfeng Zhao4
1
University Creative Research Initiatives
Center, Shandong First Medical University,
Jinan, Shandong, China
| Xianquan Zhan1,2,3,5,6
Abstract
Viruses such as human cytomegalovirus (HCMV), human papillomavirus (HPV),
2
Key Laboratory of Cancer Proteomics of
Chinese Ministry of Health, Xiangya Hospital,
Central South University, Changsha, Hunan,
China
3
State Local Joint Engineering Laboratory for
Anticancer Drugs, Xiangya Hospital, Central
South University, Changsha, Hunan, China
4
Epstein–Barr virus (EBV), human immunodeficiency virus (HIV), and coronavirus
(severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2]) represent a great
burden to human health worldwide. FDA‐approved anti‐parasite drug ivermectin is
also an antibacterial, antiviral, and anticancer agent, which offers more potentiality
to improve global public health, and it can effectively inhibit the replication of
Department of Obstetrics and Gynecology,
The Third Affiliated Hospital, Sothern Medical
University, Tianhe, Guangzhou, Guangdong,
China
SARS‐CoV‐2 in vitro. This study sought to identify ivermectin‐related virus infection
5
ovarian cancer cells TOV‐21G treated with and without ivermectin (20 μmol/L) for
Department of Oncology, Xiangya Hospital,
Central South University, Changsha, Hunan,
China
6
National Clinical Research Center for
Geriatric Disorders, Xiangya Hospital, Central
South University, Changsha, Hunan, China
pathway alterations in human ovarian cancer cells. Stable isotope labeling by amino
acids in cell culture (SILAC) quantitative proteomics was used to analyze human
24 h, which identified 4447 ivermectin‐related proteins in ovarian cancer cells.
Pathway network analysis revealed four statistically significant antiviral pathways,
including HCMV, HPV, EBV, and HIV1 infection pathways. Interestingly, compared
with the reported 284 SARS‐CoV‐2/COVID‐19‐related genes from GencLip3, we
Correspondence
Xianquan Zhan, University Creative Research
Initiatives Center, Shandong First Medical
University, 6699 Qingdao Rd, Jinan, 250117
Shandong, China.
Email:yjzhan2011@gmail.com
identified 52 SARS‐CoV‐2/COVID‐19‐related protein alterations when treated with
and without ivermectin. Protein–protein network (PPI) was constructed based on
the interactions between 284 SARS‐CoV‐2/COVID‐19‐related genes and between
52 SARS‐CoV‐2/COVID‐19‐related proteins regulated by ivermectin. Molecular
complex detection analysis of PPI network identified three hub modules, including
Funding information
Hunan Provincial Hundred Talent Plan
(to X.Z.); Shandong First Medical University
Talent Introduction Funds (to X.Z.)
cytokines and growth factor family, MAP kinase and G‐protein family, and HLA class
proteins. Gene Ontology analysis revealed 10 statistically significant cellular components, 13 molecular functions, and 11 biological processes. These findings
demonstrate the broad‐spectrum antiviral property of ivermectin benefiting for
COVID‐19 treatment in the context of predictive, preventive, and personalized
medicine in virus‐related diseases.
KEYWORDS
ivermectin, quantitative proteomics, SARS‐CoV‐2/COVID‐19, stable isotope labeling by amino
acids in cell culture, virus‐related..
Please send us corrections, updates, or comments. Vaccines and
treatments are complementary. All practical, effective, and safe means should
be used based on risk/benefit analysis. No treatment, vaccine, or intervention
is 100% available and effective for all current and future variants. We do not
provide medical advice. Before taking any medication, consult a qualified
physician who can provide personalized advice and details of risks and
benefits based on your medical history and situation.
FLCCC and
WCH
provide treatment protocols.
Submit