Central effects of Ivermectin in alleviation of Covid-19-induced dysautonomia

{ 'indexed': {'date-parts': [[2022, 8, 11]], 'date-time': '2022-08-11T06:41:10Z', 'timestamp': 1660200070142}, 'reference-count': 0, 'publisher': 'Bentham Science Publishers Ltd.', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2022, 8, 10]]}, 'abstract': '<jats:sec>\n' '<jats:title>Abstract:</jats:title>\n' '<jats:p>Covid-19 may be associated with various neurological disorders, including ' 'dysautonomia, a dysfunction of the autonomic nervous system (ANS). In Covid-19, hypoxia, ' 'immuno-inflammatory abnormality, and deregulation of the renin-angiotensin system (RAS) may ' 'increase sympathetic discharge with dysautonomia development. Direct SARS-CoV-2 cytopathic ' 'effects and associated inflammatory reaction may lead to neuroinflammation, affecting ' 'different parts of the central nervous system (CNS), including the autonomic center in the ' 'hypothalamus, causing dysautonomia. High circulating AngII and hypoxia, oxidative stress, ' 'high pro-inflammatory cytokines, and emotional stress can also provoke autonomic deregulation ' 'and high sympathetic outflow with the development of the sympathetic storm. During SARS-CoV-2 ' 'infection with neuro-invasion, GABA-ergic neurons and nicotinic acetylcholine receptor ' '(nAChR) are inhibited in the hypothalamic pre-sympathetic neurons leading to sympathetic ' 'storm and dysautonomia. Different therapeutic modalities are applied to treat SARS-CoV-2 ' 'infection, like antiviral and anti-inflammatory drugs. One robust repurposed one is ' 'Ivermectin (IVM), widely used to prevent and manage mild-moderate Covid-19. IVM activates ' 'both GABA-ergic neurons and nAChRs to mitigate SARS-CoV-2 infection-induced dysautonomia. ' 'Therefore, in this brief report, we try to identify the potential role of IVM in the ' 'management of Covid-19-induced dysautonomia.</jats:p>\n' '</jats:sec>', 'DOI': '10.2174/1389450123666220810102406', 'type': 'journal-article', 'created': {'date-parts': [[2022, 8, 11]], 'date-time': '2022-08-11T06:24:24Z', 'timestamp': 1660199064000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Central effects of Ivermectin in alleviation of Covid-19-induced dysautonomia', 'prefix': '10.2174', 'volume': '23', 'author': [ { 'given': 'Hayder M.', 'family': 'Al-kuraishy', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of clinical pharmacology and medicine, college of ' 'medicine, ALmustansiriyia University, Baghdad, Iraq'}]}, { 'given': 'Ali I.', 'family': 'Al-Gareeb', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of clinical pharmacology and medicine, college of ' 'medicine, ALmustansiriyia University, Baghdad, Iraq'}]}, { 'given': 'Athanasios', 'family': 'Alexiou', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Science and Engineering, Novel Global Community ' 'Educational Foundation, Hebersham, Australia and AFNP Med, Wien, ' 'Austria'}]}, { 'given': 'Gaber El-Saber', 'family': 'Batiha', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Pharmacology and Therapeutics, Faculty of ' 'Veterinary Medicine, Damanhour University, Damanhour 22511, ' 'AlBeheira, Egypt'}]}], 'member': '965', 'container-title': 'Current Drug Targets', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.eurekaselect.com/article/download?doi=10.2174/1389450123666220810102406', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://www.eurekaselect.com/207352/article', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://www.eurekaselect.com/article/download?doi=10.2174/1389450123666220810102406', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 8, 11]], 'date-time': '2022-08-11T06:24:30Z', 'timestamp': 1660199070000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.eurekaselect.com/207352/article'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 8, 10]]}, 'references-count': 0, 'alternative-id': ['LiveAll1'], 'URL': 'http://dx.doi.org/10.2174/1389450123666220810102406', 'relation': {}, 'ISSN': ['1389-4501'], 'subject': ['Clinical Biochemistry', 'Drug Discovery', 'Pharmacology', 'Molecular Medicine'], 'container-title-short': 'CDT', 'published': {'date-parts': [[2022, 8, 10]]}}