analysis identifying strong or moderate affinity bindings for ivermectin to multiple sites on the spike protein, CD147 and α7nAChr, which may provide effective competitive binding for all variants of SARS-CoV-2.
Ivermectin had the highest affinity to the α7nAChr receptor. Analysis showed a potential direct binding of SARS-CoV-2 spike protein to α7nAChr, suggesting mediation of SARS-CoV-2 cellular entry, and potentially shedding light on aspects of COVID-19 including the loss of smell and taste, cytokine storm, and impairment of endothelium-dependent acetylcholine-induced vasodilation.
Aminpour et al., 25 Mar 2022, peer-reviewed, 12 authors.
In Silico studies are an important part of preclinical research, however results may be very different in vivo.