Conv. Plasma
Nigella Sativa

All ivermectin studies
Meta analysis
study COVID-19 treatment researchIvermectinIvermectin (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Attenuation of clinical and immunological outcomes during SARS-CoV-2 infection by ivermectin

de Melo et al., EMBO Mol. Med., doi:10.15252/emmm.202114122 (date from preprint)
Nov 2020  
  Source   PDF   All Studies   Meta AnalysisMeta
Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
*, now known with p < 0.00000000001 from 103 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments.
Animal study showing that standard doses of ivermectin prevented clinical deterioration, reduced olfactory deficit, and limited inflammation in the upper and lower respiratory tracts of SARS-CoV-2-infected hamsters.
Ivermectin, better known for antiparasitic activity, is a broad spectrum antiviral with activity against many viruses including H7N7 Götz, Dengue Jitobaom, Tay, Wagstaff, HIV-1 Wagstaff, Simian virus 40 Wagstaff (B), Zika Barrows, Jitobaom, Yang, West Nile Yang, Yellow Fever Mastrangelo, Varghese, Japanese encephalitis Mastrangelo, Chikungunya Varghese, Semliki Forest virus Varghese, Human papillomavirus Li, Epstein-Barr Li, BK Polyomavirus Bennett, and Sindbis virus Varghese.
Ivermectin inhibits importin-α/β-dependent nuclear import of viral proteins Götz, Kosyna, Wagstaff, Wagstaff (B), shows spike-ACE2 disruption at 1nM with microfluidic diffusional sizing Fauquet, binds to glycan sites on the SARS-CoV-2 spike protein preventing interaction with blood and epithelial cells and inhibiting hemagglutination Boschi, Scheim, shows dose-dependent inhibition of wildtype and omicron variants Shahin, exhibits dose-dependent inhibition of lung injury Abd-Elmawla, Ma, may inhibit SARS-CoV-2 via IMPase inhibition Jitobaom, may inhibit SARS-CoV-2 induced formation of fibrin clots resistant to degradation Vottero, inhibits SARS-CoV-2 3CLpro Mody, may inhibit SARS-CoV-2 RdRp activity Parvez (B), may minimize viral myocarditis by inhibiting NF-κB/p65-mediated inflammation in macrophages Gao, may be beneficial for COVID-19 ARDS by blocking GSDMD and NET formation Liu (C), shows protection against inflammation, cytokine storm, and mortality in an LPS mouse model sharing key pathological features of severe COVID-19 DiNicolantonio, Zhang, may be beneficial in severe COVID-19 by binding IGF1 to inhibit the promotion of inflammation, fibrosis, and cell proliferation that leads to lung damage Zhao, may minimize SARS-CoV-2 induced cardiac damage Liu, Liu (B), increases Bifidobacteria which play a key role in the immune system Hazan, has immunomodulatory Munson and anti-inflammatory DiNicolantonio (B), Yan properties, and has an extensive and very positive safety profile Descotes.
de Melo et al., 22 Nov 2020, peer-reviewed, 11 authors.
This PaperIvermectinAll
Attenuation of clinical and immunological outcomes during SARS‐CoV‐2 infection by ivermectin
Guilherme Dias Melo, Françoise Lazarini, Florence Larrous, Lena Feige, Etienne Kornobis, Sylvain Levallois, Agnès Marchio, Lauriane Kergoat, David Hardy, Thomas Cokelaer, Pascal Pineau, Marc Lecuit, Pierre‐marie Lledo, Jean‐pierre Changeux, Hervé Bourhy
EMBO Molecular Medicine, doi:10.15252/emmm.202114122
The devastating pandemic due to SARS-CoV-2 and the emergence of antigenic variants that jeopardize the efficacy of current vaccines create an urgent need for a comprehensive understanding of the pathophysiology of COVID-19, including the contribution of inflammation to disease. It also warrants for the search of immunomodulatory drugs that could improve disease outcome. Here, we show that standard doses of ivermectin (IVM), an antiparasitic drug with potential immunomodulatory activities through the cholinergic anti-inflammatory pathway, prevent clinical deterioration, reduce olfactory deficit, and limit the inflammation of the upper and lower respiratory tracts in SARS-CoV-2infected hamsters. Whereas it has no effect on viral load in the airways of infected animals, transcriptomic analyses of infected lungs reveal that IVM dampens type I interferon responses and modulates several other inflammatory pathways. In particular, IVM dramatically reduces the Il-6/Il-10 ratio in lung tissue and promotes macrophage M2 polarization, which might account for the more favorable clinical presentation of IVM-treated animals. Altogether, this study supports the use of immunomodulatory drugs such as IVM, to improve the clinical condition of SARS-CoV-2-infected patients.
Author contributions JPC and HB conceived the experimental hypothesis. GDM, FLaz, FLar, and HB designed the experiments. GDM, FLaz, FLar, LF, LK, SL, AM, and DH performed the experiments. GDM, FLaz, FLar, LF, EK, SL, AM, TC, PP, ML, and P-ML analyzed the data. GDM, J-PC, and HB wrote the manuscript, and all authors edited it. Conflict of interest The authors declare that they have no conflict of interest. For more information • COVID-19 section of the WHO website: References Aamir K, Khan HU, Sethi G, Hossain MA, Arya A (2020) Wnt signaling mediates TLR pathway and promote unrestrained adipogenesis and The paper explained Problem The current pandemic of COVID-19 has caused more than 3.5 million deaths and more than 150 million laboratory-confirmed cases worldwide since December 2019 (as of May 2021). COVID-19, caused by SARS-CoV-2, commonly brings about upper airways and pulmonary symptoms and in severe cases can lead to respiratory distress and death. Different therapeutic approaches have been proposed to fight this disease but comprehensive therapeutic studies are still lacking. Results We report that ivermectin, used at the standard anti-parasitic dose of 400 µg/kg, protects infected hamsters from developing clinical signs and from losing the sense of smell during SARS-CoV-2 infection. The treated animals exhibited a specific inflammatory response, presenting a reduced type I/III interferon stimulation and a modulation in several..
Ar Evalo, Pagotto, Orfido Jl, Daghero, Segovia et al., Ivermectin reduces in vivo coronavirus infection in a mouse experimental model, Sci Rep
Bastard, Rosen, Zhang, Michailidis, Hoffmann et al., Autoantibodies against type I IFNs in patients with life-threatening COVID-19, Science
Batalha, Forezi, Lima, Pauli, Boechat et al., Drug repurposing for the treatment of COVID-19: Pharmacological aspects and synthetic approaches, Bioorg Chem
Beco, Petite, Olivry, Comparison of subcutaneous ivermectin and oral moxidectin for the treatment of notoedric acariasis in hamsters, Veterinary Record
Bernigaud, Guillemot, Ahmed-Belkacem, Grimaldi-Bensouda, Lespine et al., Oral ivermectin for a scabies outbreak in a long-term-care facility: potential value in preventing COVID-19 and associated mortality?, Br J Dermatol
Bhaskar, Sinha, Banach, Mittoo, Weissert et al., Cytokine storm in COVID-19-immunopathological mechanisms. Clinical considerations, and therapeutic approaches: the REPROGRAM consortium position paper, Front Immunol
Boudewijns, Thibaut, Kaptein, Li, Vergote et al., STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters, Nat Commun
Bray, Rayner, El, Jans, Wagstaff, Ivermectin and COVID-19: a report in antiviral research, widespread interest, an FDA warning, two letters to the editor and the authors' responses, Antiviral Res
Calabrese, Kozumbo, Kapoor, Dhawan, Jimenez et al., NRF2 activation putatively mediates clinical benefits of low-dose radiotherapy in COVID-19 pneumonia and acute respiratory distress syndrome (ards): novel mechanistic considerations, Radiother Oncol
Caly, Druce, Catton, Jans, Wagstaff, The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro, Antiviral Res
Camprubí, Almuedo-Riera, Mart I-Soler, Soriano, Hurtado et al., Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients, PLoS One
Cerdan, Sisquellas, Pereira, Gomes, Changeux et al., The glycine receptor allosteric ligands library (GRALL), Bioinformatics
Cereda, Tirani, Rovida, Demicheli, Ajelli et al., The early phase of the COVID-19 outbreak in Lombardy
Chaccour, Casellas, Blanco-Di Matteo, Pineda, Fernandez-Montero et al., The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with non-severe COVID-19: a pilot, double-blind, placebo-controlled, randomized clinical trial, EClinicalMedicine
Chaccour, Hammann, On-Garc Ia, Rabinovich, Ivermectin and COVID-19: keeping rigor in times of urgency, Am J Trop Med Hyg
Chan, Zhang, Yuan, Poon, Chan et al., Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility, Clin Infect Dis
Changeux, Amoura, Rey, Miyara, A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications, CR Biol
Chen, Pan, Anatomical and pathological observation and analysis of SARS and COVID-19: microthrombosis is the main cause of death, Biol Proced Online
Chen, Tan, Kou, Duan, Wang et al., Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool, BMC Bioinformatics
Cokelaer, Desvillechabrol, Legendre, Cardon, Sequana': a set of snakemake NGS pipelines, J Open Source Softw
Cokelaer, Pultz, Harder, Serra-Musach, Saez-Rodriguez, BioServices: a common Python package to access biological Web Services programmatically, Bioinformatics
Cross, Linker, Leslie, Sex-dependent effects of nicotine on the developing brain, J Neurosci Res
De Melo, Lazarini, Levallois, Hautefort, Michel et al., COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters, Sci Transl Med
Dey, Sen, Maulik, Unveiling COVID-19-associated organ-specific cell types and cell-specific pathway cascade, Brief Bioinform
Dobin, Davis, Schlesinger, Drenkow, Zaleski et al., STAR: ultrafast universal RNA-seq aligner, Bioinformatics
Ewels, Magnusson, Lundin, MultiQC: summarize analysis results for multiple tools and samples in a single report, Bioinformatics
Gahring, Myers, Dunn, Weiss, Rogers, Nicotinic alpha 7 receptor expression and modulation of the lung epithelial response to lipopolysaccharide, PLoS One
Galani, Triantafyllia, Eleminiadou, Koltsida, Stavropoulos et al., Interferon-λ mediates non-redundant front-line antiviral protection against influenza virus infection without compromising host fitness, Immunity
Gianchandani, Esfandiari, Ang, Iyengar, Knotts et al., Managing hyperglycemia in the COVID-19 inflammatory storm, Diabetes
Guzzo, Furtek, Porras, Chen, Tipping et al., Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects, J Clin Pharmacol
Han, Mukdad, Long, Lopez, Anosmia in COVID-19: mechanisms and significance, Chem Senses
Hanafi, Szumlas, Fryauff, El-Hossary, Singer et al., Effects of ivermectin on bloodfeeding Phlebotomus papatasi, and the promastigote stage of Leishmania major, Vector Borne Zoonotic Dis
Hasanoglu, Korukluoglu, Asilturk, Cosgun, Kalem et al., Higher viral loads in asymptomatic COVID-19 patients might be the invisible part of the iceberg, Infection
Heidary, Gharebaghi, Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen, J Antibiot
Hibbs, Gouaux, Principles of activation and permeation in an anion-selective Cys-loop receptor, Nature
Hill, Abdulamir, Ahmed, Asghar, Babalola et al., Meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection, Res Squ, doi:10.21203/
Hoagland, Møller, Uhl, Oishi, Frere et al., Leveraging the antiviral type-I interferon system as a first line defense against SARS-CoV-2 pathogenicity, Immunity
Horby, Lim, Emberson, Mafham, Bell et al., Dexamethasone in hospitalized patients with Covid-19 -preliminary report, N Engl J Med
Hu, Cai, Song, Li, Zhao et al., Possible SARS-coronavirus 2 inhibitor revealed by simulated molecular docking to viral main protease and host toll-like receptor, Future Virol
Huntley, Sawford, Mutowo-Meullenet, Shypitsyna, Bonilla et al., The GOA database: gene ontology annotation updates for 2015, Nucleic Acids Res
Isidori, Giannetta, Pofi, Venneri, Gianfrilli et al., Targeting the NO-cGMP-PDE5 pathway in COVID-19 infection. The DEDALO project, Andrology
Islam, Rahman, Aydin, Beklen, Arga et al., Integrative transcriptomics analysis of lung epithelial cells and identification of repurposable drug candidates for COVID-19, Eur J Pharmacol
Jermain, Hanafin, Cao, Lifschitz, Lanusse et al., Development of a minimal physiologically-based pharmacokinetic model to simulate lung exposure in humans following oral administration of ivermectin for COVID-19 drug repurposing, J Pharm Sci
Jin, Bai, He, Wu, Liu et al., Gender differences in patients with COVID-19: focus on severity and mortality, Frontiers in Public Health
Kanehisa, Goto, KEGG: kyoto encyclopedia of genes and genomes, Nucleic Acids Res
Kaur, Shekhar, Sharma, Sarma, Prakash et al., Ivermectin as a potential drug for treatment of COVID-19: an in-sync review with clinical and computational attributes, Pharmacol Rep
Klinkhammer, Schnepf, Ye, Schwaderlapp, Gad et al., IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission, eLife
Kory, Meduri, Varon, Iglesias, Marik, Review of the emerging evidence demonstrating the efficacy of ivermectin in the prophylaxis and treatment of COVID-19, Am J Ther
Krause, Buisson, Bertrand, Corringer, Galzi et al., Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor, Mol Pharmacol
Köster, Rahmann, Snakemake-a scalable bioinformatics workflow engine, Bioinformatics
Laing, Devaney, Ivermectin -old drug, new tricks?, Trends Parasitol
Lazarini, Gabellec, Torquet, Lledo, Early activation of microglia triggers long-lasting impairment of adult neurogenesis in the olfactory bulb, The Journal of Neuroscience
Li, Zhao, Zhan, Quantitative proteomics reveals a broadspectrum antiviral property of ivermectin, benefiting for COVID-19 treatment, J Cell Physiol
Liao, Smyth, Shi, featureCounts: an efficient general purpose program for assigning sequence reads to genomic features, Bioinformatics
Lifschitz, Virkel, Sallovitz, Sutra, Galtier et al., Comparative distribution of ivermectin and doramectin to parasite location tissues in cattle, Vet Parasitol
Love, Huber, Anders, Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2, Genome Biol
Martin, Cutadapt removes adapter sequences from high-throughput sequencing reads, EMBnet J
Masood, Mahmood, Shahid, Nasir, Ghanchi et al., Transcriptomic profiling of disease severity in patients with COVID-19 reveals role of blood clotting and vasculature related genes, doi:10.1101/2020.06.18.20132571
Mcelvaney, Hobbs, Qiao, Mcelvaney, Moll et al., A linear prognostic score based on the ratio of interleukin-6 to interleukin-10 predicts outcomes in COVID-19, EBioMedicine
Mcelvaney, Mcevoy, Mcelvaney, Carroll, Murphy et al., Characterization of the inflammatory response to severe COVID-19 illness, Am J Respir Crit Care Med
Melotti, Mas, Kuciak, Lorente-Trigos, Borges et al., The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer, EMBO Mol Med
Mi, Muruganujan, Ebert, Huang, Thomas, PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools, Nucleic Acids Res
Muñoz-Fontela, Dowling, Funnell, Gsell, Ax et al., Animal models for COVID-19, Nature
Oczypok, Perkins, Oury, All the "RAGE" in lung disease: The receptor for advanced glycation endproducts (RAGE) is a major mediator of pulmonary inflammatory responses, Paediatr Respir Rev
Okabayashi, Kojima, Masaki, Yokota, Imaizumi et al., Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells, Virus Res
Oliviero, De Castro, Coperchini, Chiovato, Rotondi, COVID-19 pulmonary and olfactory dysfunctions: is the chemokine CXCL10 the common denominator?, The Neuroscientist
Pavlov, Tracey, The vagus nerve and the inflammatory reflexlinking immunity and metabolism, The Authors EMBO Molecular Medicine
Pei, Xiao, Guo, Pei, Wei et al., Sustained stimulation of β(2)AR inhibits insulin signaling in H9C2 cardiomyoblast cells through the PKA-dependent signaling pathway, Diabetes Metab Syndr Obes
Pfaffl, A new mathematical model for relative quantification in real-time RT-PCR, Nucleic Acids Res
Potus, Mai, Lebret, Malenfant, Breton-Gagnon et al., Novel insights on the pulmonary vascular consequences of COVID-19, Am J Physiol Lung Cell Mol Physiol
Qiu, Cui, Hautefort, Haehner, Zhao et al., Olfactory and gustatory dysfunction as an early identifier of COVID-19 in adults and children: an international multicenter study, Otolaryngol Head Neck Surg
Rajter, Sherman, Fatteh, Vogel, Sacks et al., Use of ivermectin is associated with lower mortality in hospitalized patients with COVID-19 (ICON study), Chest
Raker, Becker, Steinbrink, The cAMP pathway as therapeutic target in autoimmune and inflammatory diseases, Front Immunol
Raslan, Yoon, WNT signaling in lung repair and regeneration, Mol Cells
Rossotti, Travi, Ughi, Corradin, Baiguera et al., Safety and efficacy of anti-il6-receptor tocilizumab use in severe and critical patients affected by coronavirus disease 2019: A comparative analysis, J Infect
Said, Glutamate receptors and asthmatic airway disease, Trends Pharmacol Sci
Sajid, Iqbal, Muhammad, Iqbal, Immunomodulatory effect of various anti-parasitics: a review, Parasitology
Samuel, Majd, Richter, Ghazizadeh, Zekavat et al., Androgen signaling regulates SARS-CoV-2 receptor levels and is associated with severe COVID-19 symptoms in men, Cell Stem Cell
Sang, Miller, Blecha, Macrophage polarization in virus-host interactions, J Clin Cell Immunol
Scully, Haverfield, Ursin, Tannenbaum, Klein, Considering how biological sex impacts immune responses and COVID-19 outcomes, Nat Rev Immunol
Sia, Yan, Chin, Fung, Choy et al., Pathogenesis and transmission of SARS-CoV-2 in golden hamsters, Nature
Stanifer, Guo, Doldan, Boulant, Importance of type I and III interferons at respiratory and intestinal barrier surfaces, Front Immunol
Sun, Zhuang, Zheng, Li, Wong et al., Generation of a broadly useful model for COVID-19 pathogenesis, vaccination, and treatment, Cell
Suo, Liu, Feng, Guo, Hu et al., ddPCR: a more accurate tool for SARS-CoV-2 detection in low viral load specimens, Emerg Microbes Infect
Takahashi, Ellingson, Wong, Israelow, Lucas et al., Sex differences in immune responses that underlie COVID-19 disease outcomes, Nature
Tizabi, Getachew, Copeland, Aschner, Nicotine and the nicotinic cholinergic system in COVID-19, FEBS J
Vaduganathan, Vardeny, Michel, Mcmurray, Pfeffer et al., Renin-angiotensin-aldosterone system inhibitors in patients with covid-19, N Engl J Med
Van Den Eynden, Sahebali, Horwood, Carmans, Brône et al., Glycine and glycine receptor signalling in non-neuronal cells, Front Mol Neurosci
Varet, Brillet-Gu Eguen, Copp Ee, Dillies, SARTools: A DESeq2-and EdgeR-based R pipeline for comprehensive differential analysis of RNA-Seq data
Virgiliis, Giovanni, Lung innervation in the eye of a cytokine storm: neuroimmune interactions and COVID-19, Nat Rev Neurol
Vom Steeg, Klein, Sex and sex steroids impact influenza pathogenesis across the life course, Semin Immunopathol
Xydakis, Dehgani-Mobaraki, Holbrook, Geisthoff, Bauer et al., Smell and taste dysfunction in patients with COVID-19, Lancet Infect Dis
Zemkova, Tvrdonova, Bhattacharya, Jindrichova, Allosteric modulation of ligand gated ion channels by ivermectin, Physiol Res
Zhang, Bastard, Liu, Pen, Velez et al., Inborn errors of type I IFN immunity in patients with life-threatening COVID-19, Science
Zhang, Liu, Wang, Yang, Li et al., SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19, J Hematol Oncol
Zhao, Yu, Lv, Meng, Xu et al., Activation of alpha-7 nicotinic acetylcholine receptors (α7nAchR) promotes the protective autophagy in LPS-induced acute lung injury (ALI) in vitro and in vivo, Inflammation
Zhe, Hongyuan, Wenjuan, Peng, Xiaowei et al., Blockade of glutamate receptor ameliorates lipopolysaccharide-induced sepsis through regulation of neuropeptides, Biosci Rep
{ 'DOI': '10.15252/emmm.202114122', 'ISSN': ['1757-4676', '1757-4684'], 'URL': '', 'alternative-id': ['10.15252/emmm.202114122'], 'assertion': [ { 'group': {'label': 'Publication History', 'name': 'publication_history'}, 'label': 'Received', 'name': 'received', 'order': 0, 'value': '2021-02-11'}, { 'group': {'label': 'Publication History', 'name': 'publication_history'}, 'label': 'Accepted', 'name': 'accepted', 'order': 1, 'value': '2021-06-23'}, { 'group': {'label': 'Publication History', 'name': 'publication_history'}, 'label': 'Published', 'name': 'published', 'order': 2, 'value': '2021-07-12'}], 'author': [ { 'ORCID': '', 'affiliation': [ { 'name': 'Lyssavirus Epidemiology and Neuropathology Unit Institut Pasteur ' 'Paris France'}], 'authenticated-orcid': False, 'family': 'de Melo', 'given': 'Guilherme Dias', 'sequence': 'first'}, { 'ORCID': '', 'affiliation': [ { 'name': 'Perception and Memory Unit Institut Pasteur CNRS UMR 3571 Paris ' 'France'}], 'authenticated-orcid': False, 'family': 'Lazarini', 'given': 'Françoise', 'sequence': 'additional'}, { 'ORCID': '', 'affiliation': [ { 'name': 'Lyssavirus Epidemiology and Neuropathology Unit Institut Pasteur ' 'Paris France'}], 'authenticated-orcid': False, 'family': 'Larrous', 'given': 'Florence', 'sequence': 'additional'}, { 'affiliation': [ { 'name': 'Lyssavirus Epidemiology and Neuropathology Unit Institut Pasteur ' 'Paris France'}], 'family': 'Feige', 'given': 'Lena', 'sequence': 'additional'}, { 'affiliation': [ { 'name': 'Biomics Technological Platform Center for Technological ' 'Resources and Research (C2RT) Institut Pasteur Paris France'}, { 'name': 'Bioinformatics and Biostatistics Hub Computational Biology ' 'Department Institut Pasteur Paris France'}], 'family': 'Kornobis', 'given': 'Etienne', 'sequence': 'additional'}, { 'ORCID': '', 'affiliation': [ { 'name': 'Biology of Infection Unit Institut Pasteur Inserm U1117 Paris ' 'France'}], 'authenticated-orcid': False, 'family': 'Levallois', 'given': 'Sylvain', 'sequence': 'additional'}, { 'affiliation': [ { 'name': 'Nuclear Organization and Oncogenesis Unit Institut Pasteur Paris ' 'France'}], 'family': 'Marchio', 'given': 'Agnès', 'sequence': 'additional'}, { 'ORCID': '', 'affiliation': [ { 'name': 'Lyssavirus Epidemiology and Neuropathology Unit Institut Pasteur ' 'Paris France'}], 'authenticated-orcid': False, 'family': 'Kergoat', 'given': 'Lauriane', 'sequence': 'additional'}, { 'ORCID': '', 'affiliation': [{'name': 'Experimental Neuropathology Unit Institut Pasteur Paris France'}], 'authenticated-orcid': False, 'family': 'Hardy', 'given': 'David', 'sequence': 'additional'}, { 'ORCID': '', 'affiliation': [ { 'name': 'Biomics Technological Platform Center for Technological ' 'Resources and Research (C2RT) Institut Pasteur Paris France'}, { 'name': 'Bioinformatics and Biostatistics Hub Computational Biology ' 'Department Institut Pasteur Paris France'}], 'authenticated-orcid': False, 'family': 'Cokelaer', 'given': 'Thomas', 'sequence': 'additional'}, { 'affiliation': [ { 'name': 'Nuclear Organization and Oncogenesis Unit Institut Pasteur Paris ' 'France'}], 'family': 'Pineau', 'given': 'Pascal', 'sequence': 'additional'}, { 'ORCID': '', 'affiliation': [ { 'name': 'Biology of Infection Unit Institut Pasteur Inserm U1117 Paris ' 'France'}, { 'name': 'Division of Infectious Diseases and Tropical Medicine Institut ' 'Imagine Université de Paris Necker‐Enfants Malades University ' 'Hospital AP‐HP Paris France'}], 'authenticated-orcid': False, 'family': 'Lecuit', 'given': 'Marc', 'sequence': 'additional'}, { 'affiliation': [ { 'name': 'Perception and Memory Unit Institut Pasteur CNRS UMR 3571 Paris ' 'France'}], 'family': 'Lledo', 'given': 'Pierre‐Marie', 'sequence': 'additional'}, { 'ORCID': '', 'affiliation': [ { 'name': 'Neuroscience Department Institut Pasteur Collège de France Paris ' 'France'}], 'authenticated-orcid': False, 'family': 'Changeux', 'given': 'Jean‐Pierre', 'sequence': 'additional'}, { 'ORCID': '', 'affiliation': [ { 'name': 'Lyssavirus Epidemiology and Neuropathology Unit Institut Pasteur ' 'Paris France'}], 'authenticated-orcid': False, 'family': 'Bourhy', 'given': 'Hervé', 'sequence': 'additional'}], 'container-title': 'EMBO Molecular Medicine', 'container-title-short': 'EMBO Mol Med', 'content-domain': {'crossmark-restriction': False, 'domain': ['']}, 'created': {'date-parts': [[2021, 6, 25]], 'date-time': '2021-06-25T12:02:32Z', 'timestamp': 1624622552000}, 'deposited': { 'date-parts': [[2023, 12, 18]], 'date-time': '2023-12-18T20:56:16Z', 'timestamp': 1702932976000}, 'funder': [{'DOI': '10.13039/501100003762', 'doi-asserted-by': 'publisher', 'name': 'Institut Pasteur'}], 'indexed': {'date-parts': [[2024, 5, 12]], 'date-time': '2024-05-12T01:15:22Z', 'timestamp': 1715476522203}, 'is-referenced-by-count': 37, 'issue': '8', 'issued': {'date-parts': [[2021, 7, 12]]}, 'journal-issue': {'issue': '8', 'published-print': {'date-parts': [[2021, 8, 9]]}}, 'language': 'en', 'license': [ { 'URL': '', 'content-version': 'vor', 'delay-in-days': 0, 'start': { 'date-parts': [[2021, 7, 12]], 'date-time': '2021-07-12T00:00:00Z', 'timestamp': 1626048000000}}], 'link': [ { 'URL': '', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': '', 'content-type': 'application/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': '', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'member': '297', 'original-title': [], 'prefix': '10.1038', 'published': {'date-parts': [[2021, 7, 12]]}, 'published-online': {'date-parts': [[2021, 7, 12]]}, 'published-print': {'date-parts': [[2021, 8, 9]]}, 'publisher': 'Springer Science and Business Media LLC', 'reference': [ {'DOI': '10.1016/j.phrs.2019.104602', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_2_1'}, {'DOI': '10.1038/s41598-021-86679-0', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_3_1'}, { 'author': 'AVMA', 'key': 'e_1_2_11_4_1', 'volume-title': 'AVMA guidelines for the euthanasia of animals: 2020 edition*', 'year': '2020'}, { 'article-title': 'Viral concentration determination through plaque assays: using ' 'traditional and novel overlay systems', 'author': 'Baer A', 'first-page': 'e52065', 'journal-title': 'J Vis Exp', 'key': 'e_1_2_11_5_1', 'year': '2014'}, {'DOI': '10.1126/science.abd4585', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_6_1'}, { 'DOI': '10.1016/j.bioorg.2020.104488', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_7_1'}, {'DOI': '10.1136/vr.149.11.324', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_8_1'}, {'DOI': '10.1111/bjd.19821', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_9_1'}, {'DOI': '10.3389/fimmu.2020.01648', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_10_1'}, { 'DOI': '10.1038/s41467-020-19684-y', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_11_1'}, { 'DOI': '10.1016/j.antiviral.2020.104805', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_12_1'}, { 'DOI': '10.1016/j.radonc.2021.04.015', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_13_1'}, { 'DOI': '10.1016/j.antiviral.2020.104787', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_14_1'}, { 'DOI': '10.1371/journal.pone.0242184', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_15_1'}, { 'DOI': '10.1093/bioinformatics/btaa170', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_16_1'}, { 'article-title': 'The early phase of the COVID‐19 outbreak in Lombardy, Italy', 'author': 'Cereda D', 'journal-title': 'arXiv', 'key': 'e_1_2_11_17_1', 'year': '2020'}, {'DOI': '10.4269/ajtmh.20-0271', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_18_1'}, { 'DOI': '10.1016/j.eclinm.2020.100720', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_19_1'}, { 'article-title': 'Simulation of the clinical and pathological manifestations of ' 'Coronavirus Disease 2019 (COVID‐19) in golden Syrian hamster model: ' 'implications for disease pathogenesis and transmissibility', 'author': 'Chan JF', 'first-page': '2428', 'journal-title': 'Clin Infect Dis', 'key': 'e_1_2_11_20_1', 'volume': '9', 'year': '2020'}, {'DOI': '10.5802/crbiol.8', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_21_1'}, {'DOI': '10.1186/1471-2105-14-128', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_22_1'}, { 'DOI': '10.1186/s12575-021-00142-y', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_23_1'}, { 'DOI': '10.1093/bioinformatics/btt547', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_24_1'}, {'DOI': '10.21105/joss.00352', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_25_1'}, {'DOI': '10.1002/jnr.23878', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_26_1'}, {'DOI': '10.1038/s41582-020-0402-y', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_27_1'}, {'DOI': '10.1093/bib/bbaa214', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_28_1'}, { 'DOI': '10.1093/bioinformatics/bts635', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_29_1'}, { 'DOI': '10.1093/bioinformatics/btw354', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_30_1'}, { 'DOI': '10.1371/journal.pone.0175367', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_31_1'}, { 'DOI': '10.1016/j.immuni.2017.04.025', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_32_1'}, {'DOI': '10.2337/dbi20-0022', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_33_1'}, {'DOI': '10.1177/009127002237994', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_34_1'}, {'DOI': '10.1093/chemse/bjaa040', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_35_1'}, {'DOI': '10.1089/vbz.2009.0030', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_36_1'}, { 'DOI': '10.1007/s15010-020-01548-8', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_37_1'}, {'DOI': '10.1038/s41429-020-0336-z', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_38_1'}, {'DOI': '10.1038/nature10139', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_39_1'}, { 'article-title': 'Meta‐analysis of randomized trials of ivermectin to treat SARS‐CoV‐2 ' 'infection', 'author': 'Hill A', 'journal-title': 'Res Squ', 'key': 'e_1_2_11_40_1', 'year': '2021'}, { 'DOI': '10.1016/j.immuni.2021.01.017', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_41_1'}, { 'article-title': 'Dexamethasone in hospitalized patients with Covid‐19 ‐ preliminary ' 'report', 'author': 'Horby P', 'first-page': '693', 'journal-title': 'N Engl J Med', 'key': 'e_1_2_11_42_1', 'volume': '384', 'year': '2020'}, {'DOI': '10.2217/fvl-2020-0099', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_43_1'}, {'DOI': '10.1093/nar/gku1113', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_44_1'}, {'DOI': '10.1111/andr.12837', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_45_1'}, { 'DOI': '10.1016/j.ejphar.2020.173594', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_46_1'}, { 'DOI': '10.1016/j.xphs.2020.08.024', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_47_1'}, {'DOI': '10.3389/fpubh.2020.00152', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_48_1'}, {'DOI': '10.1093/nar/28.1.27', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_49_1'}, { 'DOI': '10.1007/s43440-020-00195-y', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_50_1'}, {'DOI': '10.7554/eLife.33354', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_51_1'}, { 'DOI': '10.1097/MJT.0000000000001377', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_52_1'}, { 'DOI': '10.1093/bioinformatics/bts480', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_53_1'}, {'DOI': '10.1124/mol.53.2.283', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_54_1'}, {'DOI': '10.1016/', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_55_1'}, { 'DOI': '10.1523/JNEUROSCI.6394-11.2012', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_56_1'}, {'DOI': '10.1002/jcp.30055', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_57_1'}, { 'DOI': '10.1093/bioinformatics/btt656', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_58_1'}, { 'DOI': '10.1016/S0304-4017(99)00175-2', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_59_1'}, {'DOI': '10.1186/s13059-014-0550-8', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_60_1'}, {'DOI': '10.14806/ej.17.1.200', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_61_1'}, { 'article-title': 'Transcriptomic profiling of disease severity in patients with COVID‐19 ' 'reveals role of blood clotting and vasculature related genes', 'author': 'Masood KI', 'journal-title': 'medRxiv', 'key': 'e_1_2_11_62_1', 'year': '2020'}, { 'DOI': '10.1016/j.ebiom.2020.103026', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_63_1'}, { 'DOI': '10.1164/rccm.202005-1583OC', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_64_1'}, { 'DOI': '10.1126/scitranslmed.abf8396', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_65_1'}, {'DOI': '10.15252/emmm.201404084', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_66_1'}, {'DOI': '10.1093/nar/gky1038', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_67_1'}, {'DOI': '10.1038/s41586-020-2787-6', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_68_1'}, { 'DOI': '10.1016/j.prrv.2017.03.012', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_69_1'}, { 'DOI': '10.1016/j.virusres.2011.07.011', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_70_1'}, {'DOI': '10.1177/1073858420939033', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_71_1'}, {'DOI': '10.1038/nrendo.2012.189', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_72_1'}, {'DOI': '10.2147/DMSO.S268028', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_73_1'}, {'DOI': '10.1093/nar/29.9.e45', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_74_1'}, { 'DOI': '10.1152/ajplung.00195.2020', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_75_1'}, {'DOI': '10.1177/0194599820934376', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_76_1'}, { 'DOI': '10.1016/j.chest.2020.10.009', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_77_1'}, {'DOI': '10.3389/fimmu.2016.00123', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_78_1'}, { 'article-title': 'WNT signaling in lung repair and regeneration', 'author': 'Raslan AA', 'first-page': '774', 'journal-title': 'Mol Cells', 'key': 'e_1_2_11_79_1', 'volume': '43', 'year': '2020'}, { 'DOI': '10.1016/j.jinf.2020.07.008', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_80_1'}, { 'DOI': '10.1016/S0165-6147(98)01275-9', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_81_1'}, {'DOI': '10.1017/S0031182005009108', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_82_1'}, { 'DOI': '10.1016/j.stem.2020.11.009', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_83_1'}, { 'article-title': 'Macrophage polarization in virus‐host interactions', 'author': 'Sang Y', 'first-page': '311', 'journal-title': 'J Clin Cell Immunol', 'key': 'e_1_2_11_84_1', 'volume': '6', 'year': '2015'}, {'DOI': '10.1038/s41577-020-0348-8', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_85_1'}, {'DOI': '10.1038/s41586-020-2342-5', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_86_1'}, {'DOI': '10.3389/fimmu.2020.608645', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_87_1'}, {'DOI': '10.1007/s00281-018-0718-5', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_88_1'}, { 'DOI': '10.1016/j.cell.2020.06.010', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_89_1'}, { 'DOI': '10.1080/22221751.2020.1772678', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_90_1'}, {'DOI': '10.1038/s41586-020-2700-3', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_91_1'}, {'DOI': '10.1111/febs.15521', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_92_1'}, {'DOI': '10.1056/NEJMsr2005760', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_93_1'}, {'DOI': '10.3389/neuro.02.009.2009', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_94_1'}, { 'DOI': '10.1371/journal.pone.0157022', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_95_1'}, { 'author': 'WHO', 'key': 'e_1_2_11_96_1', 'volume-title': 'Protocol: real‐time RT‐PCR assays for the detection of SARS‐CoV‐2', 'year': '2020'}, { 'DOI': '10.1016/S1473-3099(20)30293-0', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_97_1'}, { 'DOI': '10.33549/physiolres.932711', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_98_1'}, {'DOI': '10.1126/science.abd4570', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_99_1'}, { 'DOI': '10.1186/s13045-020-00954-7', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_100_1'}, { 'DOI': '10.1007/s10753-019-01088-w', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_101_1'}, {'DOI': '10.1042/BSR20171629', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_102_1'}], 'reference-count': 101, 'references-count': 101, 'relation': { 'has-preprint': [ { 'asserted-by': 'object', 'id': '10.1101/2020.11.21.392639', 'id-type': 'doi'}]}, 'resource': {'primary': {'URL': ''}}, 'score': 1, 'short-title': [], 'source': 'Crossref', 'subject': [], 'subtitle': [], 'title': 'Attenuation of clinical and immunological outcomes during SARS‐CoV‐2 infection by\xa0ivermectin', 'type': 'journal-article', 'update-policy': '', 'volume': '13'}
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop