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Ivermectin contributes to attenuating the severity of acute lung injury in mice

Ma et al., Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113706
Nov 2022  
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Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
*, now known with p < 0.00000000001 from 102 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Animal study showing dose dependent inhibition of lung injury with ivermectin. In lipopolysaccharide and bleomycin-induced mouse models of acute lung injury, treatment with ivermectin improved survival rates, body weight loss, lung injury scores, and other measures of disease severity. Ivermectin reduced inflammatory cell infiltration, pro-inflammatory cytokine levels (TNF-α and IL-6), and activity of the neutrophil enzyme myeloperoxidase in the lungs of ALI mice. Mechanistically, ivermectin appeared to inhibit activation of MAPK and NF-kB signaling pathways involved in inflammation. Ivermectin may be beneficial treating acute lung injury or acute respiratory distress syndrome from COVID-19 or other causes.
Ivermectin, better known for antiparasitic activity, is a broad spectrum antiviral with activity against many viruses including H7N7 Götz, Dengue Jitobaom, Tay, Wagstaff, HIV-1 Wagstaff, Simian virus 40 Wagstaff (B), Zika Barrows, Jitobaom, Yang, West Nile Yang, Yellow Fever Mastrangelo, Varghese, Japanese encephalitis Mastrangelo, Chikungunya Varghese, Semliki Forest virus Varghese, Human papillomavirus Li, Epstein-Barr Li, BK Polyomavirus Bennett, and Sindbis virus Varghese.
Ivermectin inhibits importin-α/β-dependent nuclear import of viral proteins Götz, Kosyna, Wagstaff, Wagstaff (B), inhibits SARS-CoV-2 3CLpro Mody, shows spike-ACE2 disruption at 1nM with microfluidic diffusional sizing Fauquet, binds to glycan sites on the SARS-CoV-2 spike protein preventing interaction with blood and epithelial cells and inhibiting hemagglutination Boschi, Scheim, exhibits dose-dependent inhibition of lung injury Abd-Elmawla, Ma, may inhibit SARS-CoV-2 via IMPase inhibition Jitobaom, may inhibit SARS-CoV-2 induced formation of fibrin clots resistant to degradation Vottero, may inhibit SARS-CoV-2 RdRp activity Parvez (B), may be beneficial for COVID-19 ARDS by blocking GSDMD and NET formation Liu (C), shows protection against inflammation, cytokine storm, and mortality in an LPS mouse model sharing key pathological features of severe COVID-19 DiNicolantonio, Zhang, may be beneficial in severe COVID-19 by binding IGF1 to inhibit the promotion of inflammation, fibrosis, and cell proliferation that leads to lung damage Zhao, may minimize SARS-CoV-2 induced cardiac damage Liu, Liu (B), increases Bifidobacteria which play a key role in the immune system Hazan, has immunomodulatory Munson and anti-inflammatory DiNicolantonio (B), Yan properties, and has an extensive and very positive safety profile Descotes.
Ma et al., 30 Nov 2022, China, peer-reviewed, 11 authors. Contact:
This PaperIvermectinAll
Ivermectin contributes to attenuating the severity of acute lung injury in mice
Yuanqiao Ma, Xiaoxiao Xu, Hang Wu, Changbo Li, Peijie Zhong, Zejin Liu, Chuang Ma, Wenhua Liu, Chenyu Wang, Yijie Zhang, Junpeng Wang
Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2022.113706
Ivermectin has been proposed as a potential anti-inflammatory drug in addition to its antiparasitic activity. Here we investigated the potential role of ivermectin in the pathogenesis of acute lung injury (ALI) using the lipopolysaccharide (LPS)-or bleomycin (BLM)-induced mice models. Male C57BL/6 mice were given ivermectin orally every day for the remainder of the experiment at doses of 1 or 2 mg/kg after 24 h of LPS or BLM treatment. Ivermectin reversed severe lung injury caused by LPS or BLM challenge, including mortality, changes in diffuse ground-glass and consolidation shadows on lung CT imaging, lung histopathological scores, lung wet/dry ratio, and protein content in the bronchoalveolar lavage fluid (BALF). Furthermore, ivermectin also reduced total lung BALF inflammatory cells, infiltrating neutrophils, myeloperoxidase activity, and plasma TNF-α and IL-6 levels in mice treated with LPS or BLM. Finally, the mechanism study showed that LPS or BLM administration increased JNK, Erk1/2, and p38 MAPK phosphorylation while decreasing IκBα expression, an inhibitor of NF-κB. However, ivermectin increased IκBα expression but blocked elevated phosphorylated JNK and p38 MAPK, not Erk1/2, in both ALI mice. These findings suggested that ivermectin may alleviate ALI caused by LPS or BLM in mice, partly via lowering the inflammatory response, which is mediated at least by the inhibition of MAPK and NF-κB signaling. Collectively, ivermectin might be used to treat acute lung injury/acute respiratory distress syndrome.
Conflict of interest statement The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Appendix A. Supporting information Supplementary data associated with this article can be found in the online version at doi:10.1016/j.biopha.2022.113706.
Alharthy, Faqihi, Memish, Karakitsos, Lung injury in COVID-19-an emerging hypothesis, ACS Chem. Neurosci
Aratani, Myeloperoxidase: its role for host defense, inflammation, and neutrophil function, Arch. Biochem. Biophys
Aryannejad, Tabary, Noroozi, Mashinchi, Iranshahi et al., Anti-inflammatory Effects of ivermectin in the treatment of acetic acid-induced colitis in rats: involvement of GABAB receptors, Dig. Dis. Sci
Biber, Harmelin, Lev, Ram, Shaham et al., The effect of ivermectin on the viral load and culture viability in early treatment of non-hospitalized patients with mild COVID-19 -A double-blind, randomized placebo-controlled trial, Int. J. Infect. Dis. IJID Off. Publ. Int. Soc. Infect. Dis
Biber, Harmelin, Lev, Ram, Shaham et al., The effect of ivermectin on the viral load and culture viability in early treatment of non-hospitalized patients with mild COVID-19 -a double-blind, randomized placebo-controlled trial, Int. J. Infect. Dis. IJID Off. Publ. Int. Soc. Infect. Dis
Borges, Pithon-Curi, Curi, Hatanaka, COVID-19 and neutrophils: the relationship between hyperinflammation and neutrophil extracellular traps, Mediat. Inflamm
Buonfrate, Chesini, Martini, Roncaglioni, Fernandez et al., High-dose ivermectin for early treatment of COVID-19 (COVER study): a randomised, doubleblind, multicentre, phase II, dose-finding, proof-of-concept clinical trial, Int. J. Antimicrob. Agents
Castro, Gregianin, Burger, Continuous high-dose ivermectin appears to be safe in patients with acute myelogenous leukemia and could inform clinical repurposing for COVID-19 infection, Leuk. Lymphoma
Chang, Karin, Mammalian MAP kinase signalling cascades, Nature
Chen, Kubo, Ivermectin and its target molecules: shared and unique modulation mechanisms of ion channels and receptors by ivermectin, J. Physiol
Chen, Wan, Zhou, Li, Wei, Ursolic acid attenuates lipopolysaccharideinduced acute lung injury in a mouse model, Immunotherapy
Dushianthan, Grocott, Postle, Cusack, Acute respiratory distress syndrome and acute lung injury, Postgrad. Med. J
El-Benna, Hurtado-Nedelec, Marzaioli, Marie, Gougerot-Pocidalo et al., Priming of the neutrophil respiratory burst: role in host defense and inflammation, Immunol. Rev
Fan, Brodie, Slutsky, Acute respiratory distress syndrome: advances in diagnosis and treatment, JAMA
Gong, Guo, Li, Yuan, Shang et al., BML-111, a lipoxin receptor agonist, protects haemorrhagic shock-induced acute lung injury in rats, Resuscitation
Gorial, Mashhadani, Sayaly, Dakhil, Almashhadani et al., Effectiveness of ivermectin as add-on therapy in COVID-19 management
He, Zhou, Yu, Wang, Deng et al., Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms, Pharmacol. Res
Huang, Xiu, Zhang, Zhang, The Role of Macrophages in the Pathogenesis of ALI/ARDS, Mediat. Inflamm
Huppert, Matthay, Ware, Pathogenesis of acute respiratory distress syndrome, Semin. Respir. Crit. Care Med
Jagrosse, Dean, Rahman, Nilsson, RNAi therapeutic strategies for acute respiratory distress syndrome, Transl. Res. J. Lab. Clin. Med
Khongthaw, Dulta, Chauhan, Kumar, Ighalo, Lycopene: a therapeutic strategy against coronavirus disease 19 (COVID-19), Inflammopharmacology
Kim, Lee, Yang, Lee, Effenberger et al., Immunopathogenesis and treatment of cytokine storm in COVID-19, Theranostics
Kumar, Page, Peti, The interaction of p38 with its upstream kinase MKK6, Protein Sci
Kyriakis, Avruch, Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update, Physiol. Rev
Laing, Gillan, Devaney, Ivermectin -old drug, new tricks? Trends Parasitol
Lee, Na, Surh, Resolution of inflammation as a novel chemopreventive strategy, Semin. Immunopathol
Lewis, Pritchard, Thomas, Smith, Pharmacological agents for adults with acute respiratory distress syndrome, Cochrane Database Syst. Rev
Li, Zhan, Anti-parasite drug ivermectin can suppress ovarian cancer by regulating lncRNA-EIF4A3-mRNA axes, EPMA J
Ma, None
Martin, Jans, Antivirals that target the host IMPα/β1-virus interface, Biochem. Soc. Trans
Martin, Robertson, Choudhary, Ivermectin: an anthelmintic, an insecticide, and much more, Trends Parasitol
Matute-Bello, Downey, Moore, Groshong, Matthay et al., Acute Lung Injury in Animals Study Group, An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals, Am. J. Respir. Cell Mol. Biol
Mowery, Terzian, Nelson, Acute lung injury, Curr. Probl. Surg
Nair, Chauhan, Saha, Kubatzky, Conceptual evolution of cell signaling, Int J. Mol. Sci
Nambara, Masuda, Nishio, Kuramitsu, Tobo et al., Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer, Oncotarget
Nathan, Ding, Nonresolving inflammation, Cell
Nishio, Sugimachi, Goto, Wang, Morikawa et al., Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice, Proc. Natl. Acad. Sci. USA
Nova, Skovierova, Calkovska, Alveolar-capillary membrane-related pulmonary cells as a target in endotoxin-induced acute lung injury, Int. J. Mol. Sci
Rai, Yadav, Singh, Singh, Ursolic acid attenuates oxidative stress in nigrostriatal tissue and improves neurobehavioral activity in MPTP-induced Parkinsonian mouse model, J. Chem. Neuroanat
Rai, Zahra, Singh, Birla, Keswani et al., Anti-inflammatory activity of ursolic acid in MPTP-induced Parkinsonian mouse model, Neurotox. Res
Rajter, Sherman, Fatteh, Vogel, Sacks et al., Use of ivermectin is associated with lower mortality in hospitalized patients with coronavirus disease 2019: the ivermectin in COVID nineteen study, Chest
Raza, Shahin, Zhai, Li, Alvisi et al., Ivermectin inhibits bovine herpesvirus 1 DNA polymerase nuclear import and interferes with viral replication, Microorganisms
Reusch, Domenico, Bonaguro, Schulte-Schrepping, Baßler et al., Neutrophils in COVID-19
Saguil, Fargo, Acute respiratory distress syndrome: diagnosis and management, Am. Fam. Physician
Sanchez, Mechanical ventilation in patients subjected to extracorporeal membrane oxygenation (ECMO), Med. Intensiv
Singh, Rai, Birla, Zahra, Kumar et al., Effect of chlorogenic acid supplementation in MPTP-intoxicated mouse, Front. Pharmacol
Singh, Rai, Birla, Zahra, Rathore et al., Neuroprotective effect of chlorogenic acid on mitochondrial dysfunctionmediated apoptotic death of DA neurons in a parkinsonian mouse model, Oxid. Med. Cell. Longev
Taniguchi, Karin, NF-kappaB, inflammation, immunity and cancer: coming of age, Nat. Rev. Immunol
Ventre, Rozières, Lenief, Albert, Rossio et al., Topical ivermectin improves allergic skin inflammation
Wilkins, Steer, Cranswick, Gwee, Question 1: is it safe to use ivermectin in children less than five years of age and weighing less than 15 kg?, Arch. Dis. Child
Williams, Berg, Reskallah, Yuan, Eltzschig, Acute respiratory distress syndrome, Anesthesiology
Yan, Ci, Chen, Chen, Li et al., Anti-inflammatory effects of ivermectin in mouse model of allergic asthma, Inflamm. Res. Off. J. Eur. Histamine Res. Soc
Ye, Wang, Mao, The pathogenesis and treatment of the `Cytokine Storm' in COVID-19, J. Infect
Yong, Koh, Moon, The p38 MAPK inhibitors for the treatment of inflammatory diseases and cancer, Expert Opin. Investig. Drugs
Zahra, Rai, Birla, Singh, Rathore et al., Neuroprotection of rotenone-induced Parkinsonism by ursolic acid in PD mouse model, CNS Neurol. Disord. Drug Targets
Zhang, Song, Ci, An, Ju et al., Ivermectin inhibits LPS-induced production of inflammatory cytokines and improves LPS-induced survival in mice, Inflamm. Res. Off. J. Eur. Histamine Res. Soc
Zhang, Song, Xiong, Ci, Li et al., Inhibitory effects of ivermectin on nitric oxide and prostaglandin E2 production in LPS-stimulated RAW 264.7 macrophages, Int. Immunopharmacol
Zhou, Dai, Huang, Neutrophils in acute lung injury
Zhou, Wu, Ning, Wu, Xu et al., Ivermectin has new application in inhibiting colorectal cancer cell growth, Front. Pharmacol
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