Abstract: Received: 1 March 2021 | Revised: 22 June 2021 | Accepted: 24 June 2021 DOI: 10.1111/ijcp.14574 ORIG INAL PAPER Respiratory Medicine Variation in therapeutic strategies for the management of severe COVID-­19 in India: A nationwide cross-­sectional survey Bharat Jagiasi1 | Prashant Nasa2 | Gunjan Chanchalani3 | Ahsan Ahmed4 | Ajith Kumar AK5 | Kanwalpreet Sodhi6 | Kishore Mangal7 | Manoj K. Singh8 | Nitesh Gupta9 | Prasanna U. Bidkar10 | Ranvir S. Tyagi11 | Reshu G. Khanikar12 | Swagata Tripathy13 | Swapna Khanzode14 | Kesavarapu Subba Reddy15 | Saurabh Saigal16 | Vijay Anand Sivakumar17 | Yash Javeri18 | Seema S. Tekwani19 1 Critical Care Department, Reliance Hospital, Navi Mumbai, Maharashtra, India 2 Critical Care Medicine, NMC Specialty Hospital, Dubai, United Arab Emirates 3 Critical Care Medicine, Cumballa Hill Hospital, Mumbai, Maharashtra, India 4 Anesthesiology and Critical Care, KPC Medical College and Hospital, Kolkata, West Bengal, India 5 Critical Care Medicine, Manipal Hospitals, Bengaluru, Karnataka, India 6 Department of Critical Care, Deep Hospital, Ludhiana, Punjab, India 7 Critical Care, Eternal Hospital, Jaipur, Rajasthan, India 8 Critical Care & Sleep Medicine, Apollo Hospital, Ahmedabad, Gujarat, India 9 Department of Pulmonary, Critical Care and Sleep Medicine, VMMC and Safdarjung Hospital, New Delhi, India 10 Department of Anaesthesiology and Critical Care, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India 11 Department of Anaesthesia and Critical Care Medicine, Synergy Plus Hospital, Agra, Uttar Pradesh, India 12 Department of Critical Care Medicine, Health City Hospital, Guwahati, Assam, India 13 Anesthesia & Intensive Care, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India 14 Medicine and Critical Care, Wockhardt Multispecialty Hospital, Nagpur, Maharashtra, India 15 Department Of Critical Care Medicine, Apollo Health City, Hyderabad, Telangana, India 16 Anaesthesia and Intensive Care, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India 17 Velammal Medical college and Research Centre, Madurai, Tamil Nadu, India 18 Critical Care Medicine and Emergency Medicine, Regency Super Specialty Hospital, Lucknow, Uttar Pradesh, India 19 Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University School of Medicine, Atlanta, GA, USA Correspondence Prashant Nasa, Critical Care Medicine, NMC Specialty Hospital, PO box 7832, Al Nahda-­2, Dubai, United Arab Emirates. Email: dr.prashantnasa@hotmail.com Abstract Aim: During the pandemic of coronavirus disease 2019 (COVID-­19), the physicians are using various off-­label therapeutics to manage COVID-­19. We undertook a cross-­ sectional survey to study the current variation in therapeutic strategies for managing severe COVID-­19 in India. Methods: From January 4 to January 18, 2021, an online cross-­sectional survey was conducted among physicians involved in the management of severe COVID-­19. The survey had three sections: 1. Antiviral agents, 2. Immunomodulators, and 3. Adjuvant therapies. Results: 1055 respondents (from 24 states and five union territories), of which 64.2% were consultants, 54.3% working in private hospitals, and 39.1% were from critical care medicine completed the survey. Remdesivir (95.2%), antithrombotics (94.2%), Int J Clin Pract...