Conv. Plasma
Nigella Sativa

All ivermectin studies
Meta analysis
study COVID-19 treatment researchIvermectinIvermectin (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Medical Safety of Ivermectin

Descotes, J., ImmunoSafe Consultance
Mar 2021  
  Source   PDF   All Studies   Meta AnalysisMeta
Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
*, now known with p < 0.00000000001 from 103 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments.
Safety analysis of >350 articles showing that ivermectin has an excellent safety profile. The author notes that "no severe adverse event has been reported in dozens of completed or ongoing studies involving thousands of participants worldwide to evaluate the efficacy of ivermectin against COVID-19".
Descotes et al., 5 Mar 2021, preprint, 1 author.
This PaperIvermectinAll
As per the request of MedinCell SA (France), I the undersigned certify to have perused the publicly available information relevant to conduct an extensive analysis of ivermectin safety in human beings. The aim of the present review is to propose an independent, evaluative judgement of this information which includes original scientific publications and literature reviews, case reports, and any other source provided it can be undisputedly tracked down and freely accessed. The author personally collected and reviewed all the cited information from the beginning of September 2020 to the end of February 2021.
Other Publications (Index H = 42) 82 chapters in multi-authored books, 249 original scientific papers and 74 review papers in peerreviewed journals, 486 presentations and posters at scientific meetings on the preclinical and medical safety assessment, immunotoxicology and immunological safety, regulatory safety and risk evaluation of medicinal products and chemicals.
Addiss, Eberhard, Lammie, Hitch, Spencer, Tolerance of single high dose ivermectin for treatment of lymphatic filariasis, Trans R Soc Trop Med Hyg
Agbabiaka, Savović, Methods for causality assessment of adverse drug reactions: a systematic review, Drug Saf
Alam, Murshed, Gomes, Masud, Saber et al., Ivermectin as pre-exposure prophylaxis for COVID-19 among healthcare providers in a selected tertiary hospital in Dhakaan observational study, Eur J Med Health Sci
Alexander, Bockarie, Kastens, Kazura, Alpers, Absence of ivermectinassociated excess deaths, Trans R Soc Trop Med Hyg
Alvinerie, Dupuy, Kili-Mvouaka, Sutra, Lespine, Ketoconazole increases the plasma levels of ivermectin in sheep, Vet Parasitol
Areskoga, Samson-Himmel, Alvineriec, Sutrac, Höglunda, Dexamethasone treatment interferes with the pharmacokinetics of ivermectin in young cattle, Vet Parasitol
Aroke, Tchouakam, Awungla, Mapoh, Ngassa et al., Ivermectin induced Steven-Johnsons syndrome: a case report, BMC Res Notes
Ashour, Ivermectin: from theory to clinical application, Int J Antimicrob Ag
Atlam, Murshed, Bhiuyan, Saber, Alam et al., A case series of 100 COVID-19 positive patients treated with combination of ivermectin and doxycycline, Bangladesh Coll Phys Surg
Author, EDUCATION 1976
Awadzi, Edwards, Duke, Opoku, Attah et al., The co-administration of ivermectin and albendazole -safety, pharmacokinetics and efficacy against Onchocerca volvulus, Ann Trop Med Parasitol
Awadzi, Edwards, Opoku, Ardrey, Favager et al., The safety, tolerability and pharmacokinetics of levamisole alone, levamisole plus ivermectin, and levamisole plus albendazole, and their efficacy against Onchocerca volvulus, Ann Trop Med Parasitol
Awadzi, Gilles, Diethylcarbamazine in the treatment of patients with onchocerciasis, Br J Clin Pharmac
Aziz, Diallo, Diop, Lariviere, Porta, Efficacy and tolerance of ivermectin in human onchocerciasis, Lancet ii
Ballent, Lifschitz, Virkel, Mate, Lanusse, Pretreatment with the inducers rifampicin and phenobarbital alters ivermectin gastrointestinal disposition, J Vet Pharmacol Ther
Ballent, Lifschitz, Virkel, Sallovitz, Lanusse, Involvement of P-glycoprotein on ivermectin kinetic in sheep: itraconazole-mediated changes on gastrointestinal disposition, J Vet Pharmacol Ther
Ballent, Lifschitz, Virkel, Sallovitz, Lanusse, Modulation of the P-glycoproteinmediated intestinal secretion of ivermectin: in vitro and in vivo assessments, Drug Metab Dispos
Bansod, Kharkar, Raut, Choudalwar, Abamectin: an uncommon but potentially fatal cause of pesticide poisoning, Int J Res Med Sci
Barkwell, Shields, Deaths associated with ivermectin treatment of scabies, Lancet
Bartley, Mcallister, Bartley, Dupuy, Ménez et al., P-glycoprotein interfering agents potentiate ivermectin susceptibility in ivermectin sensitive and resistant isolates of Teladorsagia circumcincta and Haemonchus contortus, Parasitology
Baudou, Lespine, Durrieu, André, Gandia et al., Serious ivermectin toxicity and human ABCB1 nonsense mutations, N Engl J Med
Begley, ABC transporters and the blood-brain barrier, Curr Pharm Des
Blakley, Rousseaux, Effect of ivermectin on the immune response in mice, Am J Vet Res
Bof, Muteba, Mansiangi, Ilunga-Ilunga, Coppieters, Analysis of severe adverse effects following community-based ivermectin treatment in the Democratic Republic of Congo, BMC Pharmacol Toxicol
Bogoch, Khan, Abrams, Nott, Leung et al., Failure of ivermectin per rectum to achieve clinically meaningful serum levels in two cases of Strongyloides hyperinfection, Am J Trop Med Hyg
Bohlen, Burrows, Clarke, Burrows, Lack of effect of ivermectin on antipyrine and erythromycin disposition in calves, J Vet Pharmacol Ther
Bortolato, Yardley, Khoja, Godar, Asatryan et al., Pharmacological insights into the role of P2X4 receptors in behavioral regulation: lessons from ivermectin, Int J Neuropsychopharmacol
Boussinesq, Gardon, Gardon-Wendel, Kamgno, Ngoumou et al., Three probable cases of Loa loa encephalopathy following ivermectin treatment for onchocerciasis, Am J Trop Med Hyg
Budge, Herbert, Andersen, Weil, Adverse events following single dose treatment of lymphatic filariasis: observations from a review of the literature, PloS Negl Trop Dis
Burnham, Adverse reactions to ivermectin treatment for onchocerciasis. Results of a placebo-controlled, double-blind trial in Malawi, Trans R Soc Trop Med Hyg
Bécourt, Marguet, Balguerie, Joly, Treatment of scabies with oral ivermectin in 15 infants: a retrospective study on tolerance and efficacy, Br J Dermatol
Caly, Druce, Catton, Jans, Wagstaff, The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro, Antiviral Res
Campbell, Avermectin as an antiparasitic agent for use in humans, Annu Rev Microbiol
Campbell, De Lorimier, Mealey, Adverse reaction to apomorphine in a Collie homozygous for the ABCB1-1∆ (MDR1) mutation, J Small Anim Pract
Campbell, Ivermectin and Abamectin
Camprubí, Almuedo-Riera, Martí-Soler, Soriano, Hurtado et al., Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients, PloS One
Chandler, Serious neurological adverse events after ivermectin -Do they occur beyond the indication of onchocerciasis?, Trop Med Hyg
Changeux, Amoura, Rey, Miyara, A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications, CR Biol
Chedik, Mias-Lucquin, Bruyere, Fardel, In silico prediction for intestinal absorption and brain penetration of chemical pesticides in humans, Int J Environ Res Public Health
Chen, Kubo, Ivermectin and its target molecules: shared and unique modulation mechanisms of ion channels and receptors by ivermectin, J Physiol
Chesnais, Pion, Boullé, Gardon, Gardon-Wendel et al., Individual risk of post-ivermectin serious adverse events in subjects infected with Loa loa, Eclin Med
Chippaux, Gardon-Wendel, Gardon, Ernould, Absence of any adverse inadvertent effect of ivermectin during pregnancy, Trans Royal Soc Trop Med Hyg
Chosidow, Gendrel, Safety of oral ivermectin in children, Arch Pediatr
Chung, Yang, Wu, Deng, Tsai, Agricultural avermectins: an uncommon but potentially fatal cause of pesticide poisoning, Ann Emerg Med
Colebunders, Wafula, Hotterbeekx, Siewe-Fodjo, Ivermectin use in children below 15 kg: potential benefits for onchocerciasis and scabies elimination programmes, Br J Dermatol
Cordeiro, Jr, Moreira, Slobodticov, Andrade Galvão et al., Ivermectin acute administration impaired the spermatogenesis and spermiogenesis of adult rats, Res Vet Sci
Crat, Ivermectin -Pregnancy and breastfeeding
Daneman, Prat, The blood-brain barrier, Cold Spring Harb Perspect Biol
De Sole, Remme, Awadzi, Accorsi, Alley et al., Adverse reactions after large-scale treatment of onchocerciasis with ivermectin: combined results from eight community trials, Bull World Health Org
Degrees ; Gerhard, IPCS/WHO & CEE 1988-1996 Program "Poison Centers in the World" (INTOX), IPCS/WHO 1992-2007 High Council for Public Hygiene, French Ministry of Health 1992-2019 Founder and President of Summerschool in Immunotoxicology 1993-2002 National Committee for the Evaluation of Pesticides
Del Giudice, Marty, Gari-Toussaint, Fichoux, Ivermectin in elderly patients, Arch Dermatol
Deraemeker, Ferrao, Goosens, Mostin, Sindic, Encephalopathy due to prolonged misuse of ivermectin (Stromectol*) after scabies infection
Deshpande, Hill, Mealey, Chambers, Gieseg, The effect of the canine ABCB1-1Δ mutation on sedation after intravenous administration of acepromazine, J Vet Intern Med
Diazgranados, Costa, Deaths after ivermectin treatment, Lancet
Didier, Loor, Decreased biotolerability for ivermectin and cyclosporin A in mice exposed to potent P-glycoprotein inhibitors, Int J Cancer
Didier, Loor, The abamectin derivative ivermectin is a potent P-glycoprotein inhibitor, Anticancer Drugs
Djeunga, Azafack, Thotchum, Kamgno, Successful management of poisoning with ivermectin (Mectizan) in the Obala health district (Centre Region, Cameroon): A case report, Am J Trop Med Hyg
Dourmishev, Dourmishev, Schwartz, Ivermectin: pharmacology and application in dermatology, Int J Dermatol
Dukuly, Pacqué, Taylor, Williams, Greene, A prospective study in high-risk subjects of electrocardiographic changes with ivermectin, Trop Med Parasitol
Duthaler, Leisegang, Karlsson, Krähenbühl, Hammann, The effect of food on the pharmacokinetics of oral ivermectin, J Antimicrob Chemother
Edwards, Ivermectin: does P-glycoprotein play a role in neurotoxicity?, Filaria J
El-Saber, Alqahtani, Ilesanmi, Saati, El-Mleeh et al., Avermectin derivatives, pharmacokinetics, therapeutic and toxic dosages, mechanism of action, and their biological effects, Pharmaceuticals
El-Tahtawy, Glue, Andrews, Mardekian, Amsden et al., The effect of azithromycin on ivermectin pharmacokinetics -a population pharmacokinetic model analysis, PLoS Negl Trop Dis
Elmeliegy, Vourvahis, Guo, Wang, Effect of P-glycoprotein (P-gp) inducers on exposure of P-gp substrates: Review of clinical drug-drug interaction studies, Clin Pharmacokin
Erdő, Denes, De Lange, Age-associated physiological and pathological changes at the blood-brain barrier: A review, J Cereb Blood Flow Metab
Fernandez, Lee, Rahilly, Hovda, Brutlag et al., Tramadol effects on lameness score after inhibition of P-gp by ivermectin administration in horses: preliminary results, J Vet Emerg Crit Care
Fisher, Mrozik, Chemistry
Fodjo, Tatah, Tabah, Ngarka, Nfor et al., Epidemiology of onchocerciasis-associated epilepsy in the Mbam and Sanaga river valleys of Cameroon: impact of more than 13 years of ivermectin, Infect Dis Poverty
Fox, Ivermectin: uses and impact 20 years on, Curr Op Infect Dis
Fujimoto, Kawasaki, Morimoto, Kikuchi, Kawana, Treatment for crusted scabies: limitations and side effects of treatment with ivermectin, J Nippon Med Sch
Fusco, Downs, Satlin, Pahuja, Ramos et al., Non-oral treatment with ivermectin for disseminated strongyloidiasis, Am J Trop Med Hyg
Galvao De Castro, Gregianin, Burger, Continuous high-dose ivermectin appears to be safe in patients with acute myelogenous leukemia and could inform clinical repurposing for COVID-19 infection, Leuk Lymphoma
Gardon, Gardon-Wendel, Ngangue, Kamgno, Chippaux et al., Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection, Lancet
Geyer, Gavrilova, Petzinger, Brain penetration of ivermectin and selamectin in mdr1a,b P-glycoprotein-and bcrp-deficient knockout mice, J Vet Pharmacol Ther
Gilbert, Slechta, A case of ivermectin-induced warfarin toxicity: first published report, Hosp Pharm
Gokbulut, Cirak, Senlik, Aksit, Durmaz et al., Comparative plasma disposition, bioavailability and efficacy of ivermectin following oral and pour-on administrations in horses, Vet Parasitol
González, González, Ueno, Ivermectin in human medicine, an overview of the current status of its clinical applications, Curr Pharm Biotechnol
González-Canga, Fernández-Martínez, Sahagún-Prieto, Diez-Liébana, Vega et al., A review of the pharmacological interactions of ivermectin in several animal species, Curr Drug Metab
Goossens, Deraemaeker, Santos, Mostin, Sindic, Encephalopathy due to prolonged misuse of ivermectin (Stromectol R ) after scabies infection, Clin Toxicol
Graeme, Giancola, Curry, Visual changes after acute iatrogenic ivermectin poisoning, J Toxicol Clin Toxicol
Greene, Dukuly, Munoz, White, Pacque et al., A comparison of 6-, 12, and 24-monthly dosing with ivermectin for treatment of onchocerciasis, J Infect Dis
Grewal, Kukal, Kanojia, Madan, Saso et al., In vitro assessment of the effect of antiepileptic drugs on expression and function of ABC transporters and their interactions with ABCC2, Molecules
Guderian, Anselmi, Sempertegui, Cooper, Adverse reactions to ivermectin in reactive onchodermatitis, Lancet
Guzzo, Furtek, Porras, Chen, Tipping et al., Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects, J Clin Pharmacol
Guéniche, Bruyere, Vée, Fardel, Implication of human drug transporters to toxicity and toxicoketics of pesticides, Pest Manag Sci
Gyapong, Chinbuah, Gyapong, Inadvertent exposure of pregnant women to ivermectin and albendazole during mass drug administration for lymphatic filariasis, Med Int Health
Hall, Spoerke, Bronstein, Kulig, Rumack, Human ivermectin exposure, J Emerg Med
Hauber, Galle, Chiodini, Rupp, Birke et al., Fatal outcome of a hyperinfection syndrome despite successful eradication of Strongyloides with subcutaneous ivermectin, Infection
Hay, Arnott, Ivermectin and coagulation: an in vitro study, Ann Trop Med Parasitol
Heidary, Gharebaghi, Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen, J Antibiot
Hellwig, Mai, A COVID-19 Prophylaxis? Lower incidence associated with prophylactic administration of ivermectin, Inter J Antimicrob Ag
Hill, Preliminary meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection
Hirota, Toda, Morisawa, Mineshita, A case report of Ivermectin-induced prolonged liver dysfunction in an elderly patient with scabies, Rinsho Yakuri/Jap J Clin Pharmacol Ther
Homeida, Bagi, Ghalib, El Sheikh, Ismail et al., Prolongation of prothrombin time with ivermectin, Lancet
Hopper, Aldrich, Haskins, Ivermectin toxicity in 17 Collies, J Vet Intern Med
Horowitz, Freeman, Three novel prevention, diagnostic, and treatment options for COVID-19 urgently necessitating controlled randomized trials, Med Hypoth
Hugnet, Lespine, Alvinerie, Multiple oral dosing of ketoconazole increases dog exposure to ivermectin, J Pharm Pharm Sci
Ich, Guidance S2(R1) on genotoxicity testing and data interpretation for pharmaceuticals intended for human use
Ito, Mazzotti reaction with eosinophilia after undergoing oral ivermectin for scabies, J Dermatol
Jans, Wagstaff, Ivermectin as a broad-spectrum host-directed antiviral: the real deal?, Cells
Jecfa, Toxicological evaluation of certain veterinary drug residues in food: ivermectin
Juarez, Scholnik-Cabrera, Dueñas-Gonzalez, The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug, Am J Cancer Res
Kamgno, Gardon, Gardon-Wendel, Demanga-Ngangue, Duke et al., Adverse systemic reactions to treatment of onchocerciasis with ivermectin at normal and high doses given annually or three-monthly, Trans R Soc Trop Med Hyg
Kerneuzet, Blind, Darrieux, Moreau, Safa, Ivermectin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, JAAD Case Rep
Kinyanjui, Middleton, Güttel, Cassell, Ross et al., Scabies in residential care homes: Modelling, inference and interventions for well-connected population sub-units, PLoS Comput Biol
Kipp, Burnham, Kamugisha, Improvement in seizures after ivermectin, Lancet
Kircik, Rosso, Layton, Schauber, Over 25 years of clinical experience with ivermectin: an overview of safety for an increasing number of indications, J Drugs Dermatol
Klotz, Ogbuokiri, Okonkwo, Ivermectin binds avidly to plasma proteins, Eur J Clin Pharmacol
Krause, Buisson, Bertrand, Corringer, Galzi et al., Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor, Mol Pharmacol
Kumaraswami, Ottesen, Vijayasekaran, Devi, Swaminathan et al., Ivermectin for the treatment of Wuchereria bancrofti filariasis. Efficacy and adverse reactions, JAMA
Lacher, Skagen, Veit, Dalton, Woodahl, P-glycoprotein transport of neurotoxic pesticides, J Pharmacol Exp Ther
Laing, Devaney, Ivermectin -Old drug, new tricks?, Trends Parasitol
Lankas, Minsker, Robertson, Effects of ivermectin on reproduction and neonatal toxicity in rats, Food Chem Toxicol
Lehrer, Rheinstein, Ivermectin docks to the SARS-CoV-2 spike receptor-binding domain attached to ACE2, vivo
Lespine, Dupuy, Alvinerie, Comera, Nagy et al., Interaction of macrocyclic lactones with the multidrug transporters: the bases of the pharmacokinetics of lipidlike drugs, Curr Drug Metab
Lespine, Dupuy, Orlowski, Nagy, Glavinas et al., Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3), Biol Interact
Lespine, Martin, Dupuy, Roulet, Pineau et al., Interaction of macrocyclic lactones with P-glycoprotein: structure-affinity relationship, Eur J Pharm Sci
Leung, Al-Rawahi, Grant, Fleckenstein, Bowie, Failure of subcutaneous ivermectin in treating Strongyloides hyperinfection, Am J Trop Med Hyg
Levy, Martin, Bursztejn, Chiaverini, Miquel et al., Group for Reseach of the French Society of Pediatric Dermatology (2020) Ivermectin safety in infants and children under 15 kg treated for scabies: a multicentric observational study, Br J Dermatol
Lifschitz, Virkel, Sallovitz, Pis, Imperiale et al., Loperamide modifies the tissue disposition kinetics of ivermectin in rats, J Pharm Pharmacol
Lind, Fidel, Gay, Mealey, Evaluation of vincristine-associated myelosuppression in Border Collies, Am J Vet Res
Little, Kosetti, A narrative review of pharmacologic treatments for COVID-19: safety considerations and ototoxicity, Laryngoscope
Lund, Petersen, Dalhoff, Clinical implications of P-glycoprotein modulation in drugdrug interactions, Drugs
Mackenzie, Geary, Gerlach, Possible pathogenic pathways in the adverse clinical events seen following ivermectin administration to onchocerciasis patients, Filaria J
Mahringer, Fricker, ABC transporters at the blood-brain barrier, Exp Op Drug Metab Toxicol
Mar, De Ocariz, Mckinster, Orozco-Covarrubias, Tamayo-Sánchez et al., Treatment of 18 children with scabies or cutaneous larva migrans using ivermectin, Clin Exp Dermatol
Mara, Sarrot-Reynauld, Mallaret, Raclot-Roy, Massot, Drug-induced eruption after treatment of hyperkeratotic crusted scabies with ivermectin, Rev Med Interne
Marques-Santos, Bernardo, De Paula, Rumjanek, Cyclosporin A and trifluoperazine, two resistance-modulating agents, increase ivermectin neurotoxicity in mice, Pharmacol Toxicol
Martin, Robertson, Choudhary, Ivermectin: an anthelmintic, an insecticide, and much more, Trends Parasitol
Martin-Prevel, Cosnefroy, Tshipamba, Ngari, Chodakewitz et al., Tolerance and efficacy of single high dose ivermectin for the treatment of loiasis, Am J Trop Med Hyg
Marty, Lowry, Rodriguez, Milner, Pieciak et al., Treatment of human disseminated strongyloidiasis with a parenteral veterinary formulation of ivermectin, Clin Infect Dis
Massi, Mansare, Traoré, Ndiaye, Diop et al., Post-ivermectin encephalopathy in Senegal: a case report, Pan Afr Med J
Mayhan, Arrick, The blood-brain barrier in health and disease, Morgan and Claypool Life Sciences
Mealey, Bentjen, Gay, Cantor, Ivermectin sensitivity in collies is associated with a deletion mutation of the MDR1 gene, Pharmacogenetics
Mealey, Bentjen, Waiting, Frequency of the mutant MDR1 allele associated with ivermectin sensitivity in a sample population of collies from the northwestern United States, Am J Vet Res
Mealey, Burke, Identification of a nonsense mutation in feline ABCB1, J Vet Pharmacol Ther
Merola, Eubig, Toxicology of avermectins and milbemycins (macrocylic lactones) and the role of P-glycoprotein in dogs and cats, Vet Clin North Am Small Anim Pract
Miyajima, Hirota, Sugioka, Fukuzawa, Sekine et al., Effect of high-fat meal intake on the pharmacokinetic profile of ivermectin in Japanese patients with scabies, J Dermatol
Molento, Lifschitz, Sallovitz, Lanusse, Prichard, Influence of verapamil on the pharmacokinetics of the antiparasitic drugs ivermectin and moxidectin in sheep, Parasitol Res
Molinari, Soloneski, Reigosa, Larramendy, In vitro genotoxic and cytotoxic effects of ivermectin and its formulation ivomec ® on Chinese hamster ovary (CHO K1) cells, J Hazard Mat
Momekov, Momekova, Ivermectin as a potential COVID-19 treatment from the pharmacokinetic point of view, doi:10.1101/2020.04.11.20061804
Moreira, Bernardi, Spinosa, Ivermectin reduces sexual behavior in female rats, Neurotoxicol Teratol
Muñoz, Ballester, Antonijoan, Gich, Rodríguez et al., Safety and pharmacokinetic profile of fixed dose ivermectin with an innovative 18mg tablet in healthy adult volunteers, PLoS Negl Trop Dis
Nakamura, Taniguchi, Ohtaki, A case of crusted scabies with a bullous pemphigoidlike eruption and nail involvement, J Dermatol
Navarro, Camprubí, Requena-Méndez, Buonfrate, Giorli et al., Safety of high-dose ivermectin: a systematic review and meta-analysis, J Antimicrob Chemother
Ngwasiri, Abanda, Aminde, Ivermectin-induced fixed drug eruption in an elderly Cameroonian: a case report, J Med Case Rep
Nicolas, Maia, Bassat, Kobylinski, Monteiro et al., Safety of oral ivermectin during pregnancy: a systematic review and metaanalysis, Lancet Glob Health
Nzolo, Anto, Hailemariam, Bakajika, Muteba et al., Central and peripheral nervous system disorders following ivermectin mass administration: a descriptive study based on the Democratic Republic of Congo Pharmacovigilance System, Drugs Real World Outcomes
Ogbuokiri, Ozumba, Okonkwo, Ivermectin levels in human breastmilk, Eur J Clin Pharmacol
Olsén, Ingvast-Larsson, Bondesson, Broström, Tjälve et al., Cetirizine in horses: pharmacokinetics and effect of ivermectin pretreatment, J Vet Pharmacol Ther
Olsén, Ingvast-Larsson, Larsson, Broström, Bondesson et al., Fexofenadine in horses: pharmacokinetics, pharmacodynamics and effect of ivermectin pretreatment, Vet Pharmacol Ther
Omura, A splendid gift from the earth: the origins and impact of the avermectins (Nobel Lecture), Angew Chem Int Ed
Oshikoya, Ogunyinka, Ogar, Abiola, Ibrahim et al., Severe cutaneous adverse drug reactions manifesting as Stevens-Johnson syndrome and toxic epidermal necrolysis reported to the national pharmacovigilance center in Nigeria: a database review from 2004 to 2017, Ther Adv Drug Saf
Pacanowski, Santos, Roux, Le Maignan, Guillot et al., Subcutaneous ivermectin as a safe salvage therapy in Strongyloides stercoralis hyperinfection syndrome: a case report, Am J Trop Med Hyg
Pacqué, Munoz, Poetschke, Foose, Greene et al., Pregnancy outcome after inadvertent ivermectin treatment during community-based distribution, Lancet
Pacqué, Munoz, White, Williams, Greene et al., Ivermectin and prothrombin times, Lancet
Pacqué, Muñoz, Greene, Taylor, Community-based treatment of onchocerciasis with ivermectin: safety, efficacy, and acceptability of yearly treatment, J Infect Dis
Pacqué, Muñoz, Greene, White, Dukuly et al., Safety of and compliance with community-based ivermectin therapy, Lancet
Peña-Silva, Duffull, Steer, Jaramillo-Rincon, Gwee et al., Pharmacokinetic considerations on the repurposing of ivermectin for treatment of COVID-19, Br J Clin Pharmacol
Raffi, Suresh, Butler, Reviews of scabies in the elderly, Dermatol Ther
Rajter, Sherman, Fatteh, Vogel, Sacks et al., Use of ivermectin is associated with lower mortality in hospitalized patients with COVID-19. The ICON study, Chest
Richards, Mcneely, Bryan, Eberhard, Mcneely et al., Ivermectin and prothrombin time, Lancet i
Rizzo, Ivermectin, antiviral properties and COVID-19: a possible new mechanism of action, Naunyn Schmiedebergs Arch Pharmacol
Rodari, Buonfrate, Pomari, Lunardi, Bon et al., Ivermectin concentration in breastmilk of a woman with Strongyloides stercoralis and human Tlymphotropic virus-I co-infection, Acta Trop
Sajid, Iqbal, Muhammad, Sandhu, Khan et al., Effect of ivermectin on the cellular and humoral immune responses of rabbits, Life Sci
Sartor, Bentjen, Trepanier, Maeley, Loperamide toxicity in a collie with the MDR1 mutation associated with ivermectin sensitivity, J Vet Intern Med
Schinkel, Wagenaar, Mol, Van Deemter, P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs, J Clin Invest
Schmith, Zhou, Lohmer, The approved dose of ivermectin alone is not the ideal dose for the treatment of COVID-19, Clin Pharmacol Ther
Schulz, Coulibaly, Schindler, Wimmersberger, Keiser, Pharmacokinetics of ascending doses of ivermectin in Trichuris trichiura-infected children aged 2-12 years, J Antimicrob Chemother
Seegobin, Bueno, Maharaj, Ashby, Brown et al., Toxic epidermal necrolysis after ivermectin, Am J Emerg Med
Shouman, Hegazi, Nafae, Ragab, Samra et al., Use of ivermectin as a potential chemoprophylaxis for COVID-19 in Egypt: a randomized clinical trial, J Clin Diag Res
Sousa, Morais, Vieirac, Maranho, Machado et al., Genotoxicity and carcinogenicity of ivermectin and amoxicillin in vivo systems, Environ Toxicol Pharmacol
Soyuncu, Oktay, Berk, Eken, Abamectin intoxication with coma and hypotension, Clin Toxicol
Sparsa, Bonnetblanc, Peyrot, Loustaud-Ratti, Vidal et al., Systemic adverse reactions with ivermectin treatment of scabies, Ann Dermatol Venereol
Stankiewicz, Cabaj, Moore, Millar, Ng Chie, Influence of ivermectin on cellular and humoral immune responses of lambs, Vet Immunol Immunopathol
Ständer, Kirschstein, Kohl-Sobania, Zillikens, Ludwig et al., Effectiveness and adverse events of ivermectin treatment for scabies in 30 infant patients: report from a German single center, J Eur Acad Dermatol Venereol
Sung, Huang, Fan, Lin, Lin, Avermectin intoxication with coma, myoclonus, and polyneuropathy, Clin Toxicol
Tarr, Miele, Peregoy, Smith, Neva et al., Case report: rectal administration of ivermectin to a patient with Strongyloides hyperinfection syndrome, Am J Trop Med Hyg
Thylefors, The Mectizan Donation Program (MDP), Ann Trop Med Parasitol
Tipthara, Kobylinski, Godejohann, Hanboonkunupakarn, Roth et al., Identification of the metabolites of ivermectin in humans, Pharmacol Res Perspect
Trailović, Nedeljkovic, Central and peripheral neurotoxic effects of ivermectin in rats, J Vet Med Sci
Trailović, Varagić, The effect of ivermectin on convulsions in rats produced by lidocaine and strychnine, Vet Res Commun
Turner, Maclean, Fleckenstein, Greenaway, Parenteral administration of ivermectin in a patient with disseminated strongyloidiasis, Am J Trop Med Hyg
Twum-Danso, Loa loa encephalopathy temporally related to ivermectin administration reported from onchocerciasis mass treatment programs from 1989 to 2001: implications for the future, Filaria J
Twum-Danso, Serious adverse events following treatment with ivermectin for onchocerciasis control: a review of reported cases, Filaria J
Uhlir, Volf, Ivermectin: its effect on the immune system of rabbits and rats infested with ectoparasites, Vet Immunol Immunopathol
Van Amstel, Portmann, Cox, Doherty, Newman, Ivermectin concentrations in blood and cerebrospinal fluid following intravenous administration to healthy llamas
Van Hees, Raimon, Fodjo, Colebunders, Safety of ivermectin during pregnancy, Lancet Glob Health
Vanapalli, Chen, Ellingrod, Kitzman, Lee et al., Orange juice decreases the oral bioavailability of ivermectin in healthy volunteers, Clin Pharmacol Ther
Veit, Beck, Steuerwald, Hatz, First case of ivermectin-induced severe hepatitis, Trans R Soc Trop Med Hyg
Ventre, Rozières, Lenief, Albert, Rossio et al., Topical ivermectin improves allergic skin inflammation, Allergy
Wagstaff, Sivakumaran, Heaton, Harrich, Jans, Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus, Biochem J
Westlake, Aronoff, Evaluating the risks of systemic maternal ivermectin exposure during pregnancy in human and vertebrate animals: a scoping review, Curr Drug Saf
Whitworth, Hay, Mcnicholas, Morgan, Maude et al., Coagulation abnormalities and ivermectin, Ann Trop Med Parasitol
Whitworth, Morgan, Maude, Downham, Taylor, A community trial of ivermectin for onchocerciasis in Sierra Leone: adverse reactions after the first five treatment rounds, Trans R Soc Trop Med Hyg
Who, World Health Organization's List of Essential Medicines, 21 st List
Wilkins, Steer, Cranswick, Gwee, Is it safe to use ivermectin in children less than five years of age and weighing less than 15 kg?, Arch Dis Child
Wimmersberger, Coulibaly, Schulz, Puchkow, Huwyler et al., Efficacy and safety of ivermectin against Trichuris trichiura in preschool-aged and school-aged children: a randomized controlled dose-finding trial, Clin Infect Dis
Yung, Acute human toxicity of macrocyclic lactones, Curr Pharm Biotechnol
Zargari, Aghazadeh, Moeineddin, Clinical applications of topical ivermectin in dermatology, Dermatol Online J
Zeng, Andrew, Arison, Luffer-Atlas, Wang, Identification of cytochrome P4503A4 as the major enzyme responsible for the metabolism of ivermectin by human liver microsomes, Xenobiotica
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop