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All Studies   Meta Analysis   Recent: 
Favipiravir and Ivermectin Showed in Vitro Synergistic Antiviral Activity against SARS-CoV-2
Jitobaom et al., Research Square, doi:10.21203/rs.3.rs-941811/v1 (Preprint) (In Vitro)
14 Oct 2021    Source   PDF   Share   Tweet
In Vitro study showing a strong synergistic effect of ivermectin and favipiravir. Combining multiple antiviral drugs with different mechanisms of action helps to minimize drug resistance and toxicity.
For ivermectin alone, IC50 for Calu-3 was 0.2µM, supporting in vivo efficacy at 0.6 mg/kg.
14 In Vitro studies support the efficacy of ivermectin [Caly, Croci, De Forni, Delandre, Jeffreys, Jitobaom, Jitobaom (B), Li, Liu, Mody, Mountain Valley MD, Segatori, Surnar, Yesilbag].
Jitobaom et al., 14 Oct 2021, preprint, 8 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
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