Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All ivermectin studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19ivm.org COVID-19 treatment researchIvermectinIvermectin (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

A review of the anti-viral effects of ivermectin

Adegboro et al., African Journal of Clinical and Experimental Microbiology, doi:10.4314/ajcem.v22i3.2
Jul 2021  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
 
*, now with p < 0.00000000001 from 104 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19ivm.org
Review of the antiviral effects of ivermectin.
Reviews covering ivermectin for COVID-19 include1-38.
Adegboro et al., 2 Jul 2021, peer-reviewed, 4 authors.
This PaperIvermectinAll
A review of the anti-viral effects of ivermectin
B Adegboro, O A Lawani, S E Oriaifo, S A Abayomi
African Journal of Clinical and Experimental Microbiology, doi:10.4314/ajcem.v22i3.2
Ivermectin is an avermectin which is a group of pentacyclic sixteen-membered lactone (macrocyclic lactone disaccharide) derived from the soil bacterium Streptomyces avermitilis. It is a semi-synthetic broad-spectrum antihelminthic, anti-viral and anti-cancer agent. It has a wide safety margin with low adverse effects when it is used orally. It has, however, so far only been approved by the Food and Drug Administration (FDA) as a broad spectrum anti-parasitic agent. Because ivermectin also has broad activities as an anti-viral agent, we herein review its pharmacokinetic and pharmacodynamic activities, as well as the in vitro and in vivo studies conducted on the drug. It is hoped that this work will pave way for ivermectin being seriously considered as an addition to the drugs available for the management of patients with COVID-19.
References
Azeem, Ashraff, Rasheed, Anjum, Hameed, Evaluation of cytotoxic and antiviral activity of ivermectin against Newcastle disease virus, Pak J Pharm Sci
Banerjee, Nandy, Dalai, Ahmed, The battle against COVID-19 pandemic: What we need to know before we "test fire" ivermectin, Drug Res (Stuttg.)
Barrows, Campos, Powell, A screen of FDA-drugs, for inhibitors of Zika virus infection, Cell Host Microbe
Basanez, Pion, Boakes, Effect of single-dose ivermectin on Onchocerca volvulus: A systematic review and meta-analysis, Lancet Infect Dis
Bennet, Zhao, Bosard, Imperiale, Role of a nuclear localization signal on the minor capsid proteins VP2 and VP3 in BKPyV nuclear entry, Virology
Berthomme, Monahan, Parris, Jacquemont, Epstein, Cloning, sequencing, and functional characterization of the two subunits of the pseudorabies virus DNA polymerase holoenzyme: evidence for specificity of interaction, J Virol
Borst, Schinkel, What have learnt thus far from mice with disrupted p-glycoprotein genes?, Eur J Cancer
Bray, Rayner, Noel, Jans, None
Caly, Druce, Catton, Jans, Wagstaff, The FDA approved drug Ivermectin inhibit replication of SARS-CoV-2 in vitro, Antiviral Res
Caly, Druce, Catton, Jans, Wagstaff, The FDA-approved drug ivermectin inhibits the replication of SARS-COV-2 in vitro, Antivir Res
Caly, Druce, Catton, Jans, Wagstaff, The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro, Antivir Res
Caly, Wagstaff, Jans, Nuclear trafficking of proteins from RNA viruses: Potential target for antivirals?, Antivir Res
Canga, Prieto, Liebana, Martinez, Vega, The pharmacokinetics and interactions of ivermectin-a minireview, AAPS J
Carmona-Guttierrez, Bauer, Zimmermann, Digesting the crisis: Autophagy and coronavirus, Microb Cell, doi:.10.15698/.05.715
Didier, Loor, The abamectin derivative ivermectin is a potent p-glycoprotein inhibitor, Anti-Cancer Drugs
Dou, Chen, Wang, Ivermectin induces cytostatic autophagy by blocking the PAK/AKT axis in breast cancer, Cancer Res
González Canga, Sahagún Prieto, Diez Liébana, The pharmacokinetics and interaction of ivermectin in humans: a mini-review, AAPS J, doi:10.1208/s12248-007-9000-9
Gotz, Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import, Sci Rep
Gotz, Magar, Dornfeld, Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import, Sci Rep
Heidary, Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen, J Antibiot, doi:10.1038/s41429-%09020-0336-z
Juarez, Schcolnik-Cabrera, Duenas-Gonzalez, The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug, Am J Cancer Res
Laing, Gillan, Daveney, Ivermectin-Old Drug, New Tricks?, Trends Parasitol, doi:10.1016/j.pt.2017.02.004
Lundberg, Pinkham, Baer, Nuclear import and export inhibitors alter capsid protein distribution in mammalian cells and reduce Venezuelan Equine Encephalitis Virus replication, Antivir Res
Lv, Liu, Wang, Ivermectin inhibits DNA polymerase UL42 of pseudorabies virus entrance into the nucleus and proliferation of the virus in vitro and vivo, Antivir Res
Lv, Liu, Wang, Ivermectin inhibits DNA polymerase UL42 of pseudorabies virus entrance into the nucleus and proliferation of the virus in vitro and vivo, Antivir Res
Mudatsir, Yufika, Nainu, Antiviral activity of ivermectin against SARS-CoV-2: An old-fashioned dog with a new trick -a literature review, Scientia Pharmaceutica, doi:10.3390/scipharm88030036
Nicolas, Maia, Bassat, Safety of oral ivermectin during pregnancy: A systematic review and meta-analysis, Lancet Glob Health
Rajter, Sherman, Fatteh, Ivermectin in COVID Nineteen) study: Use of ivermectin is associated with lower mortality in hospitalized patients with COVID-19, MedRxiv, doi:10.1101/2020.06.06.2012446
Raza, Shahin, Zhai, Ivermectin inhibits bovine herpesvirus-1 DNA polymerase nuclear import and interferes with viral replication, Microorganisms, doi:10.3390/microorganisms8030409
Rizzo, Ivermectin, antiviral properties and COVID-19: A possible new mechanism of action, Nauyn-Schmeid Acta Pharmacol
Schmith, Zhou, Lohmer, The approved dose of ivermectin alone is not the ideal dose for the treatment of COVID-19, Clin Pharmacol Ther
Slonska, Cymerys, Skwarska, Golke, Banbura, Influence of importin alpha/beta and exportin 1 on Equine herpesvirus type 1 (EHV-1) replication in primary murine neurons, Pol J Vet Sci
Tay, Fraser, Chan, Nuclear localization of dengue virus (DENV) 1-4 non -structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin, Antivir Res
Velthuis, Van Den Worm, Sims, Zn 2+ inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture, PLoS Pathol
Wagstaff, Ivermectin and COVID-19: A report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors' responses, Antivir. Res
Wagstaff, Rawlinson, Hearps, Jans, An Alpha Screen (R)-based assay for high throughput screening for specific inhibitor of nuclear import, J Biomol Screen
Wagstaff, Sivakumaran, Heaton, Harrich, Jans, Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import to inhibit replication of HIV-1 and dengue virus, Biochem J
Wagstaff, Sivakumaran, Heaton, Harrich, Jans, Ivermectin is a specific inhibitor of importinα/β -mediated nuclear import able to inhibit replication of HIV-1 and dengue virus, Biochem J
Wang, Du, Huang, The pseudorabies virus DNA polymerase accessory subunit UL42 directs nuclear transport of the holoenzyme, Front Microbiol
Yang, Atkinson, Wang, The broad spectrum antiviral ivermectin targets the host nuclear transport import α/β1 heterodimer, Antivir Res
Yang, Atkinson, Wang, The broad-spectrum anti-viral ivermectin targets the host nuclear transport importin α/βI heterodimer, Antivir Res
Yang, Qi, Farias-Pereira, Permethrin and ivermectin modulate lipid metabolism in steatosis-induced HepG2 hepatocyte, Food Chem Toxicol
Yates, Wolstenholme, An ivermectin sensitive glutamate-gated chloride channel subunit from Dirafilaria immitis, Int J Parasitol
Zhang, Ni, Zhang, Ivermectin confers its cytostatic effect by inducing AMPK/ mTOR-mediated autophagy and DNA damage, Chemosph
Ōmura, Crump, The life and times of ivermectin: A success story, Nat Rev Microbiol
{ 'indexed': {'date-parts': [[2024, 4, 1]], 'date-time': '2024-04-01T15:51:26Z', 'timestamp': 1711986686424}, 'reference-count': 0, 'publisher': 'African Journals Online (AJOL)', 'issue': '3', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p>Ivermectin is an avermectin which is a group of pentacyclic sixteen-membered lactone ' '(macrocyclic lactone disaccharide) derived from the soil bacterium Streptomyces avermitilis. ' 'It is a semi-synthetic broad-spectrum anti-helminthic, anti-viral and anti-cancer agent. It ' 'has a wide safety margin with low adverse effects when it is used orally. It has, however, so ' 'far only been approved by the Food and Drug Administration (FDA) as a broad spectrum ' 'anti-parasitic agent. Because ivermectin also has broad activities as an anti-viral agent, we ' 'herein review its pharmacokinetic and pharmacodynamic activities, as well as the in vitro and ' 'in vivo studies conducted on the drug. It is hoped that this work will pave way for ' 'ivermectin being seriously considered as an addition to the drugs available for the ' 'management of patients with COVID-19.&#x0D;\n' 'Keywords: ivermectin; pharmacokinetics; pharmacodynamics; broad-spectrum anti-viral; ' 'COVID-19</jats:p>', 'DOI': '10.4314/ajcem.v22i3.2', 'type': 'journal-article', 'created': {'date-parts': [[2021, 7, 5]], 'date-time': '2021-07-05T14:41:18Z', 'timestamp': 1625496078000}, 'page': '322-329', 'source': 'Crossref', 'is-referenced-by-count': 1, 'title': 'A review of the anti-viral effects of ivermectin', 'prefix': '10.4314', 'volume': '22', 'author': [ {'given': 'B.', 'family': 'Adegboro', 'sequence': 'first', 'affiliation': []}, {'given': 'O.A.', 'family': 'Lawani', 'sequence': 'additional', 'affiliation': []}, {'given': 'S.E.', 'family': 'Oriaifo', 'sequence': 'additional', 'affiliation': []}, {'given': 'S.A.', 'family': 'Abayomi', 'sequence': 'additional', 'affiliation': []}], 'member': '2895', 'published-online': {'date-parts': [[2021, 7, 2]]}, 'container-title': 'African Journal of Clinical and Experimental Microbiology', 'original-title': [], 'link': [ { 'URL': 'https://www.ajol.info/index.php/ajcem/article/download/209853/197857', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://www.ajol.info/index.php/ajcem/article/download/209853/197857', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2021, 7, 5]], 'date-time': '2021-07-05T14:41:32Z', 'timestamp': 1625496092000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.ajol.info/index.php/ajcem/article/view/209853'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 7, 2]]}, 'references-count': 0, 'journal-issue': {'issue': '3', 'published-online': {'date-parts': [[2021, 7, 2]]}}, 'URL': 'http://dx.doi.org/10.4314/ajcem.v22i3.2', 'relation': {}, 'ISSN': ['1595-689X'], 'subject': [], 'container-title-short': 'Af J Clin Exp Micro', 'published': {'date-parts': [[2021, 7, 2]]}}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit