Conv. Plasma
Nigella Sativa

All ivermectin studies
Meta analysis
study COVID-19 treatment researchIvermectinIvermectin (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Anti-inflammatory activity of ivermectin in late-stage COVID-19 may reflect activation of systemic glycine receptors

DiNicolantonio et al., Open Heart, doi:10.1136/openhrt-2021-001655
Apr 2021  
  Source   PDF   All Studies   Meta AnalysisMeta
Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
*, now known with p < 0.00000000001 from 102 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Review suggesting that the effectiveness of ivermectin in the cytokine storm phase of COVID-19 may be, at least in part, an anti-inflammatory effect mediated by increased activation of glycine receptors on leukocytes and possibly vascular endothelium.
DiNicolantonio et al., 19 Apr 2021, peer-reviewed, 3 authors.
This PaperIvermectinAll
Anti-inflammatory activity of ivermectin in late-stage COVID-19 may reflect activation of systemic glycine receptors
Dr James J Dinicolantonio, Jorge Barroso-Aranda, Mark F Mccarty
Open Heart, doi:10.1136/openhrt-2021-001655
somewhat analogous anti-inflammatory protection in COVID-19, as has previously been suggested. 26 27 However, in light of accumulating evidence that ivermectin may have important utility for the primary prevention of COVID-19, it is likely that it also exerts an antiviral effect with respect to SARS-CoV-2, as suggested by in vitro studies. 3 28 It is not clear whether glycine receptor agonism might have anything to do with this effect.
Baudou, Lespine, Durrieu, Serious Ivermectin Toxicity and Human ABCB1 Nonsense Mutations, N Engl J Med, doi:10.1056/NEJMc1917344
Caly, Druce, Catton, The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro, Antiviral Res, doi:10.1016/j.antiviral.2020.104787
Didier, Loor, Decreased biotolerability for ivermectin and cyclosporin A in mice exposed to potent P-glycoprotein inhibitors, Int J Cancer, doi:10.1002/ijc.2910630220
Ding, Svingen, Pedersen, Plasma glycine and risk of acute myocardial infarction in patients with suspected stable angina pectoris, J Am Heart Assoc, doi:10.1161/JAHA.115.002621
Dinicolantonio, Barroso, Mccarty, Ivermectin may be a clinically useful anti-inflammatory agent for late-stage COVID-19, Open Heart, doi:10.1136/openhrt-2020-001350
Dinicolantonio, Mccarty, Thrombotic complications of COVID-19 may reflect an upregulation of endothelial tissue factor expression that is contingent on activation of endosomal NADPH oxidase, Open Heart, doi:10.1136/openhrt-2020-001337
Froh, Thurman, Wheeler, Molecular evidence for a glycine-gated chloride channel in macrophages and leukocytes, Am J Physiol Gastrointest Liver Physiol, doi:10.1152/ajpgi.00503.2001
Ikejima, Iimuro, Forman, A diet containing glycine improves survival in endotoxin shock in the rat, Am J Physiol, doi:10.1152/ajpgi.1996.271.1.G97
Ikejima, Qu, Stachlewitz, Kupffer cells contain a glycine-gated chloride channel, Am J Physiol, doi:10.1152/ajpgi.1997.272.6.G1581
Li, Bradford, Wheeler, Dietary glycine prevents peptidoglycan polysaccharide-induced reactive arthritis in the rat: role for glycine-gated chloride channel, Infect Immun, doi:10.1128/IAI.69.9.5883-5891.2001
Li, Can glycine mitigate COVID-19 associated tissue damage and cytokine storm?, Radiat Res, doi:10.1667/RADE-20-00146.1
Lynagh, Webb, Dixon, Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channel, J Biol Chem, doi:10.1074/jbc.M111.262634
Lynch, Molecular structure and function of the glycine receptor chloride channel, Physiol Rev, doi:10.1152/physrev.00042.2003
Mccarty, Iloki-Assanga, Lujan, Activated glycine receptors may decrease endosomal NADPH oxidase activity by opposing ClC-3-mediated efflux of chloride from endosomes, Med Hypotheses, doi:10.1016/j.mehy.2019.01.012
Mealey, Bentjen, Gay, Ivermectin sensitivity in collies is associated with a deletion mutation of the MDR1 gene, Pharmacogenetics, doi:10.1097/00008571-200111000-00012
Rodrigues, De Sá, Ishimoto, Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients, J Exp Med, doi:10.1084/jem.20201707
Schmith, Zhou, Lohmer, The Approved dose of ivermectin alone is not the ideal dose for the treatment of COVID-19, Clin Pharmacol Ther, doi:10.1002/cpt.1889
Shan, Haddrill, Lynch, Ivermectin, Ivermectin, an unconventional agonist of the glycine receptor chloride channel, J Biol Chem, doi:10.1074/jbc.M011264200
Viktorov, Ivermectin inhibits activation of Kupffer cells induced by lipopolysaccharide toxin
Wang, Lynch, A comparison of glycine-and ivermectinmediated conformational changes in the glycine receptor ligandbinding domain, Int J Biochem Cell Biol, doi:10.1016/j.biocel.2011.11.005
Wheeler, Ikejema, Enomoto, Glycine: a new antiinflammatory immunonutrient, Cell Mol Life Sci, doi:10.1007/s000180050030
Wheeler, Rose, Yamashima, Dietary glycine blunts lung inflammatory cell influx following acute endotoxin, Am J Physiol Lung Cell Mol Physiol, doi:10.1152/ajplung.2000.279.2.L390
Wheeler, Stachlewitz, Yamashina, Glycine-gated chloride channels in neutrophils attenuate calcium influx and superoxide production, Faseb J, doi:10.1096/fasebj.14.3.476
Wheeler, Thurman, Production of superoxide and TNF-alpha from alveolar macrophages is blunted by glycine, Am J Physiol, doi:10.1152/ajplung.1999.277.5.L952
Yamashina, Konno, Wheeler, Endothelial cells contain a glycine-gated chloride channel, Nutr Cancer, doi:10.1207/S15327914NC402_17
Zhang, Ma, Jiang, Glycine attenuates lipopolysaccharideinduced acute lung injury by regulating NLRP3 inflammasome and NRF2 signaling, Nutrients, doi:10.3390/nu12030611
Zhang, Song, Ci, Ivermectin inhibits LPS-induced production of inflammatory cytokines and improves LPS-induced survival in mice, Inflamm Res, doi:10.1007/s00011-008-8007-8
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop