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Anti-inflammatory activity of ivermectin in late-stage COVID-19 may reflect activation of systemic glycine receptors

DiNicolantonio et al., Open Heart, doi:10.1136/openhrt-2021-001655
Apr 2021  
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Review suggesting that the effectiveness of ivermectin in the cytokine storm phase of COVID-19 may be, at least in part, an anti-inflammatory effect mediated by increased activation of glycine receptors on leukocytes and possibly vascular endothelium.
DiNicolantonio et al., 19 Apr 2021, peer-reviewed, 3 authors.
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Anti-inflammatory activity of ivermectin in late-stage COVID-19 may reflect activation of systemic glycine receptors
Dr James J Dinicolantonio, Jorge Barroso-Aranda, Mark F Mccarty
Open Heart, doi:10.1136/openhrt-2021-001655
somewhat analogous anti-inflammatory protection in COVID-19, as has previously been suggested. 26 27 However, in light of accumulating evidence that ivermectin may have important utility for the primary prevention of COVID-19, it is likely that it also exerts an antiviral effect with respect to SARS-CoV-2, as suggested by in vitro studies. 3 28 It is not clear whether glycine receptor agonism might have anything to do with this effect.
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