The Nucleolus and Its Interactions with Viral Proteins Required for Successful Infection
José Manuel Ulloa-Aguilar, Luis Herrera Moro Huitron, Rocío Yazmin Benítez-Zeferino, Jorge Francisco Cerna-Cortes, Julio García-Cordero, Guadalupe León-Reyes, Edgar Rodrigo Guzman-Bautista, Carlos Noe Farfan-Morales, José Manuel Reyes-Ruiz, Roxana U Miranda-Labra, Luis Adrián De Jesús-González, Moises León-Juárez
Cells, doi:10.3390/cells13181591
Nuclear bodies are structures in eukaryotic cells that lack a plasma membrane and are considered protein condensates, DNA, or RNA molecules. Known nuclear bodies include the nucleolus, Cajal bodies, and promyelocytic leukemia nuclear bodies. These bodies are involved in the concentration, exclusion, sequestration, assembly, modification, and recycling of specific components involved in the regulation of ribosome biogenesis, RNA transcription, and RNA processing. Additionally, nuclear bodies have been shown to participate in cellular processes such as the regulation of transcription of the cell cycle, mitosis, apoptosis, and the cellular stress response. The dynamics and functions of these bodies depend on the state of the cell. It is now known that both DNA and RNA viruses can direct their proteins to nuclear bodies, causing alterations in their composition, dynamics, and functions. Although many of these mechanisms are still under investigation, it is well known that the interaction between viral and nuclear body proteins is necessary for the success of the viral infection cycle. In this review, we concisely describe the interaction between viral and nuclear body proteins. Furthermore, we focus on the role of the nucleolus in RNA virus infections. Finally, we discuss the possible implications of the interaction of viral proteins on cellular transcription and the formation/degradation of non-coding RNAs.
Conflicts of Interest: The authors declare no conflicts of interest.
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'abstract': '<jats:p>Nuclear bodies are structures in eukaryotic cells that lack a plasma membrane and are '
'considered protein condensates, DNA, or RNA molecules. Known nuclear bodies include the '
'nucleolus, Cajal bodies, and promyelocytic leukemia nuclear bodies. These bodies are involved '
'in the concentration, exclusion, sequestration, assembly, modification, and recycling of '
'specific components involved in the regulation of ribosome biogenesis, RNA transcription, and '
'RNA processing. Additionally, nuclear bodies have been shown to participate in cellular '
'processes such as the regulation of transcription of the cell cycle, mitosis, apoptosis, and '
'the cellular stress response. The dynamics and functions of these bodies depend on the state '
'of the cell. It is now known that both DNA and RNA viruses can direct their proteins to '
'nuclear bodies, causing alterations in their composition, dynamics, and functions. Although '
'many of these mechanisms are still under investigation, it is well known that the interaction '
'between viral and nuclear body proteins is necessary for the success of the viral infection '
'cycle. In this review, we concisely describe the interaction between viral and nuclear body '
'proteins. Furthermore, we focus on the role of the nucleolus in RNA virus infections. '
'Finally, we discuss the possible implications of the interaction of viral proteins on '
'cellular transcription and the formation/degradation of non-coding RNAs.</jats:p>',
'DOI': '10.3390/cells13181591',
'type': 'journal-article',
'created': {'date-parts': [[2024, 9, 23]], 'date-time': '2024-09-23T07:36:38Z', 'timestamp': 1727076998000},
'page': '1591',
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'is-referenced-by-count': 0,
'title': 'The Nucleolus and Its Interactions with Viral Proteins Required for Successful Infection',
'prefix': '10.3390',
'volume': '13',
'author': [ { 'given': 'José Manuel',
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'affiliation': [ { 'name': 'Laboratorio de Virología Perinatal y Diseño Molecular de '
'Antígenos y Biomarcadores, Departamento de Inmunobioquímica, '
'Instituto Nacional de Perinatología, Mexico City 11000, Mexico'},
{ 'name': 'Posgrado en Biología Experimental, Departamento de Ciencias '
'Biológicas y de la Salud (DCBS), Universidad Autónoma '
'Metropolitana-Iztapalapa, Mexico City 09310, Mexico'}]},
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'given': 'Luis',
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{ 'name': 'Laboratorio de Microbiología Molecular, Departamento de '
'Microbiología, Escuela Nacional de Ciencias Biologícas, '
'Instituto Politécnico Nacional, Mexico City 11340, Mexico'}]},
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'affiliation': [ { 'name': 'Laboratorio de Virología Perinatal y Diseño Molecular de '
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{ 'name': 'Laboratorio de Microbiología Molecular, Departamento de '
'Microbiología, Escuela Nacional de Ciencias Biologícas, '
'Instituto Politécnico Nacional, Mexico City 11340, Mexico'}]},
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'affiliation': [ { 'name': 'Laboratorio de Microbiología Molecular, Departamento de '
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'Instituto Politécnico Nacional, Mexico City 11340, Mexico'}]},
{ 'given': 'Julio',
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'affiliation': [ { 'name': 'Departamento de Biomedicina Molecular, Centro de Investigación y '
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'(CINVESTAV-IPN), Mexico City 07360, Mexico'}]},
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'given': 'Guadalupe',
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'affiliation': [ { 'name': 'Laboratorio de Nutrigenética y Nutrigenómica, Instituto Nacional '
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{ 'given': 'Edgar Rodrigo',
'family': 'Guzman-Bautista',
'sequence': 'additional',
'affiliation': [ { 'name': 'Laboratorio de Virología Perinatal y Diseño Molecular de '
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'Mexico'}]},
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'given': 'Carlos Noe',
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'affiliation': [ { 'name': 'Departamento de Ciencias Naturales, Universidad Autonoma '
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'Mexico'}]},
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