Repositioning Ivermectin for Covid-19 treatment: Molecular mechanisms of action against SARS-CoV-2 replication

Low et al., Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, doi:10.1016/j.bbadis.2021.166294

Oct 2021

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Review of the antiviral characteristics of ivermectin and mechanisms of action. Authors note that ivermectin has proven effective for HIV-1, Adenovirus, flu, SARS-CoV, and more; due to genomic similarity between SARS-CoV-2 and SARS-CoV, the role of the IMPα/β1 complex for viral protein (NSP12-RdRp) shuttling between the nucleus and cytoplasm holds great potential; and that ivermectin exhibits great potential in reducing SARS-CoV-2 viral replication via numerous modes of action, such as the disruption of the Importin heterodimer complex (IMPα/β1).

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Low et al., 20 Oct 2021, peer-reviewed, 3 authors.

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