Safety of oral administration of high doses of ivermectin by means of biocompatible polyelectrolytes formulation

DOI record: { "DOI": "10.1016/j.heliyon.2020.e05820", "ISSN": [ "2405-8440" ], "URL": "http://dx.doi.org/10.1016/j.heliyon.2020.e05820", "alternative-id": [ "S2405844020326633" ], "article-number": "e05820", "assertion": [ { "label": "This article is maintained by", "name": "publisher", "value": "Elsevier" }, { "label": "Article Title", "name": "articletitle", "value": "Safety of oral administration of high doses of ivermectin by means of biocompatible polyelectrolytes formulation" }, { "label": "Journal Title", "name": "journaltitle", "value": "Heliyon" }, { "label": "CrossRef DOI link to publisher maintained version", "name": "articlelink", "value": "https://doi.org/10.1016/j.heliyon.2020.e05820" }, { "label": "Content Type", "name": "content_type", "value": "article" }, { "label": "Copyright", "name": "copyright", "value": "© 2020 The Author(s). Published by Elsevier Ltd." } ], "author": [ { "affiliation": [], "family": "Madrid", "given": "Rafael R.M.", "sequence": "first" }, { "affiliation": [], "family": "Mathews", "given": "Patrick D.", "sequence": "additional" }, { "affiliation": [], "family": "Patta", "given": "Ana C.M.F.", "sequence": "additional" }, { "affiliation": [], "family": "Gonzales-Flores", "given": "Anai P.", "sequence": "additional" }, { "affiliation": [], "family": "Ramirez", "given": "Carlos A.B.", "sequence": "additional" }, { "affiliation": [], "family": "Rigoni", "given": "Vera L.S.", "sequence": "additional" }, { "affiliation": [], "family": "Tavares-Dias", "given": "Marcos", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-5028-9215", "affiliation": [], "authenticated-orcid": false, "family": "Mertins", "given": "Omar", "sequence": "additional" } ], "container-title": "Heliyon", "container-title-short": "Heliyon", "content-domain": { "crossmark-restriction": true, "domain": [ "cell.com", "elsevier.com", "sciencedirect.com" ] }, "created": { "date-parts": [ [ 2020, 12, 31 ] ], "date-time": "2020-12-31T21:02:30Z", "timestamp": 1609448550000 }, "deposited": { "date-parts": [ [ 2021, 7, 30 ] ], "date-time": "2021-07-30T08:52:04Z", "timestamp": 1627635124000 }, "funder": [ { "DOI": "10.13039/501100001807", "doi-asserted-by": "publisher", "name": "Fundação de Amparo à Pesquisa do Estado de São Paulo" } ], "indexed": { "date-parts": [ [ 2024, 3, 18 ] ], "date-time": "2024-03-18T15:22:35Z", "timestamp": 1710775355152 }, "is-referenced-by-count": 11, "issue": "1", "issued": { "date-parts": [ [ 2021, 1 ] ] }, "journal-issue": { "issue": "1", "published-print": { "date-parts": [ [ 2021, 1 ] ] } }, "language": "en", "license": [ { "URL": "https://www.elsevier.com/tdm/userlicense/1.0/", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2021, 1, 1 ] ], "date-time": "2021-01-01T00:00:00Z", "timestamp": 1609459200000 } }, { "URL": "http://creativecommons.org/licenses/by-nc-nd/4.0/", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2020, 12, 19 ] ], "date-time": "2020-12-19T00:00:00Z", "timestamp": 1608336000000 } } ], "link": [ { "URL": "https://api.elsevier.com/content/article/PII:S2405844020326633?httpAccept=text/xml", "content-type": "text/xml", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://api.elsevier.com/content/article/PII:S2405844020326633?httpAccept=text/plain", "content-type": "text/plain", "content-version": "vor", "intended-application": "text-mining" } ], "member": "78", "original-title": [], "page": "e05820", "prefix": "10.1016", "published": { "date-parts": [ [ 2021, 1 ] ] }, "published-print": { "date-parts": [ [ 2021, 1 ] ] }, "publisher": "Elsevier BV", "reference": [ { "DOI": "10.1016/j.ejphar.2019.172784", "article-title": "Old wine in new bottles: drug repurposing in oncology", "author": "Antoszczak", "doi-asserted-by": "crossref", "first-page": "172784", "journal-title": "Eur. J. Pharmacol.", "key": "10.1016/j.heliyon.2020.e05820_bib1", "volume": "866", "year": "2020" }, { "DOI": "10.1038/nrd.2018.168", "article-title": "Drug repurposing: progress, challenges and recommendations", "author": "Pushpakom", "doi-asserted-by": "crossref", "first-page": "41", "journal-title": "Nat. Rev. Drug Discov.", "key": "10.1016/j.heliyon.2020.e05820_bib2", "volume": "18", "year": "2019" }, { "DOI": "10.1016/j.antiviral.2020.104787", "article-title": "The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro", "author": "Caly", "doi-asserted-by": "crossref", "first-page": "104787", "journal-title": "Antivir. Res.", "key": "10.1016/j.heliyon.2020.e05820_bib3", "volume": "178", "year": "2020" }, { "DOI": "10.1038/ncomms2924", "article-title": "The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism", "author": "Jin", "doi-asserted-by": "crossref", "first-page": "1937", "journal-title": "Nat. Commun.", "key": "10.1016/j.heliyon.2020.e05820_bib4", "volume": "4", "year": "2013" }, { "article-title": "The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug", "author": "Juarez", "first-page": "317", "journal-title": "Am. J. Canc. Res.", "key": "10.1016/j.heliyon.2020.e05820_bib5", "volume": "8", "year": "2018" }, { "DOI": "10.1038/s41429-020-0336-z", "article-title": "Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen", "author": "Heidary", "doi-asserted-by": "crossref", "journal-title": "J. Antibiot. (Tokyo)", "key": "10.1016/j.heliyon.2020.e05820_bib6", "year": "2020" }, { "DOI": "10.1016/j.ejphar.2004.08.009", "article-title": "Antitumor effect of avermectins", "author": "Drinyaev", "doi-asserted-by": "crossref", "first-page": "19", "journal-title": "Eur. J. Pharmacol.", "key": "10.1016/j.heliyon.2020.e05820_bib7", "volume": "501", "year": "2004" }, { "DOI": "10.1097/00001813-199609000-00005", "article-title": "The abamectin derivative ivermectin is a potent P-glycoprotein inhibitor", "author": "Didier", "doi-asserted-by": "crossref", "first-page": "745", "journal-title": "Anti Canc. Drugs", "key": "10.1016/j.heliyon.2020.e05820_bib8", "volume": "7", "year": "1996" }, { "DOI": "10.1038/ja.2017.11", "article-title": "Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations", "author": "Crump", "doi-asserted-by": "crossref", "first-page": "495", "journal-title": "J. Antibiot. (Tokyo)", "key": "10.1016/j.heliyon.2020.e05820_bib9", "volume": "70", "year": "2017" }, { "DOI": "10.1016/j.chemosphere.2016.03.113", "article-title": "Eco-toxicological effects of the avermectin family with a focus on abamectin and ivermectin", "author": "Bai", "doi-asserted-by": "crossref", "first-page": "204", "journal-title": "Chemosphere", "key": "10.1016/j.heliyon.2020.e05820_bib10", "volume": "154", "year": "2016" }, { "DOI": "10.1093/jac/dkz524", "article-title": "Safety of high-dose ivermectin: a systematic review and meta-analysis", "author": "Navarro", "doi-asserted-by": "crossref", "first-page": "827", "journal-title": "J. Antimicrob. Chemother.", "key": "10.1016/j.heliyon.2020.e05820_bib11", "volume": "75", "year": "2020" }, { "DOI": "10.1016/j.clindermatol.2005.11.008", "article-title": "Onchocerciasis: river blindness", "author": "Enk", "doi-asserted-by": "crossref", "first-page": "176", "journal-title": "Clin. Dermatol.", "key": "10.1016/j.heliyon.2020.e05820_bib12", "volume": "24", "year": "2006" }, { "article-title": "Adverse reactions after large-scale treatment of onchocerciasis with ivermectin: combined results from eight community trials", "author": "De Sole", "first-page": "707", "journal-title": "Bull. World Health Organ.", "key": "10.1016/j.heliyon.2020.e05820_bib13", "volume": "67", "year": "1989" }, { "DOI": "10.1016/j.ijbiomac.2020.01.160", "article-title": "Polyionic complexes of chitosan-N-arginine with alginate as pH responsive and mucoadhesive particles for oral drug delivery applications", "author": "Patta", "doi-asserted-by": "crossref", "first-page": "550", "journal-title": "Int. J. Biol. Macromol.", "key": "10.1016/j.heliyon.2020.e05820_bib14", "volume": "148", "year": "2020" }, { "DOI": "10.1590/S0100-40422012000300031", "article-title": "Development and application of methods for the determination of ivermectin in veterinarian medications", "author": "Costa", "doi-asserted-by": "crossref", "first-page": "616", "journal-title": "Quim. Nova", "key": "10.1016/j.heliyon.2020.e05820_bib15", "volume": "35", "year": "2012" }, { "DOI": "10.1021/acs.biomac.7b01630", "article-title": "Targeted drug delivery and treatment of endoparasites with biocompatible particles of pH-responsive structure", "author": "Mathews", "doi-asserted-by": "crossref", "first-page": "499", "journal-title": "Biomacromolecules", "key": "10.1016/j.heliyon.2020.e05820_bib16", "volume": "19", "year": "2018" }, { "DOI": "10.1111/jai.13086", "article-title": "Growth, parasitic infection and hematology in Colossoma macropomum Cuvier, 1818 fed diets containing Allium sativum", "author": "Inoue", "doi-asserted-by": "crossref", "first-page": "901", "journal-title": "J. Appl. Ichthyol.", "key": "10.1016/j.heliyon.2020.e05820_bib18", "volume": "32", "year": "2016" }, { "article-title": "Caracteristicas hematologicas da Tilapia rendalli Boulenger, 1896 (Osteichthyes: Cichlidae) capturada em ‘‘Pesque-Pague’’ de Franca, Sao Paulo", "author": "Tavares-Dias", "first-page": "103", "journal-title": "Bras. Biosci. J.", "key": "10.1016/j.heliyon.2020.e05820_bib19", "volume": "19", "year": "2003" }, { "article-title": "Morphological, cytochemical, and ultrastructural study of thrombocytes and leukocytes in Neotropical fish, Brycon orbignyanus Valenciannes, 1850 (Characidae, Bryconinae)", "author": "Tavares-Dias", "first-page": "209", "journal-title": "J. Submicr. Cytol. Pathol.", "key": "10.1016/j.heliyon.2020.e05820_bib20", "volume": "38", "year": "2006" }, { "DOI": "10.1016/j.crvi.2017.12.001", "article-title": "Infestation by Ergasilus coatiarus (Copepoda: Ergasilidae) in two Amazonian cichlids with new host record from Peru: an ectoparasites natural control approach", "author": "Mathews", "doi-asserted-by": "crossref", "first-page": "16", "journal-title": "Comptes Rendus Biol.", "key": "10.1016/j.heliyon.2020.e05820_bib21", "volume": "341", "year": "2018" }, { "DOI": "10.1007/s10499-019-00474-3", "article-title": "Histopathology associated with infection by Procamallanus (Spirocamallanus) inopinatus (Nematoda) in farmed Brycon cephalus (Characiformes) from Peru: a potential fish health problem", "author": "Rivadeneyra", "doi-asserted-by": "crossref", "first-page": "449", "journal-title": "Aquacult. Int.", "key": "10.1016/j.heliyon.2020.e05820_bib22", "volume": "28", "year": "2020" }, { "DOI": "10.1111/j.1439-0264.2007.00816.x", "article-title": "Glycoproteins in the epithelium of lips and associated structures of a hill stream fish Garra lamta (Cyprinidae, Cyprinoformes): a histochemical investigation", "author": "Pinky", "doi-asserted-by": "crossref", "first-page": "101", "journal-title": "Anat. Histol. Embryol.", "key": "10.1016/j.heliyon.2020.e05820_bib23", "volume": "37", "year": "2008" }, { "DOI": "10.1038/srep12312", "article-title": "Myo5b knockout mice as a model of microvillus inclusion disease", "author": "Cartón-García", "doi-asserted-by": "crossref", "first-page": "12312", "journal-title": "Sci. Rep.", "key": "10.1016/j.heliyon.2020.e05820_bib24", "volume": "5", "year": "2015" }, { "DOI": "10.1016/j.carbpol.2016.10.071", "article-title": "Dispersion of chitosan in liquid crystalline lamellar phase: production of biofriendly hydrogel of nanocubic topology", "author": "Mathews", "doi-asserted-by": "crossref", "first-page": "850", "journal-title": "Carbohydr. Polym.", "key": "10.1016/j.heliyon.2020.e05820_bib25", "volume": "157", "year": "2017" }, { "DOI": "10.1080/14756366.2019.1655406", "article-title": "Design and application of oral colon administration system", "author": "Cheng", "doi-asserted-by": "crossref", "first-page": "1590", "journal-title": "J. Enzym. Inhib. Med. Chem.", "key": "10.1016/j.heliyon.2020.e05820_bib26", "volume": "34", "year": "2019" }, { "DOI": "10.1016/j.heliyon.2019.e02916", "article-title": "Formulation of alginate based hydrogel from brown seaweed, Turbinaria conoides for biomedical applications", "author": "Kavitha", "doi-asserted-by": "crossref", "journal-title": "Heliyon", "key": "10.1016/j.heliyon.2020.e05820_bib27", "volume": "5", "year": "2019" }, { "DOI": "10.1021/acs.macromol.8b00609", "article-title": "pH-responsive saloplastics based on weak polyelectrolytes: from molecular processes to material scale properties", "author": "Rydzek", "doi-asserted-by": "crossref", "first-page": "4424", "journal-title": "Macromolecules", "key": "10.1016/j.heliyon.2020.e05820_bib28", "volume": "51", "year": "2018" }, { "DOI": "10.1039/D0TA05901C", "article-title": "Saloplastics as multiresponsive ion exchange reservoirs and catalyst supports", "author": "Sciortino", "doi-asserted-by": "crossref", "first-page": "17713", "journal-title": "J. Math. Chem. A", "key": "10.1016/j.heliyon.2020.e05820_bib29", "volume": "8", "year": "2020" }, { "DOI": "10.1111/j.1471-4159.1980.tb06604.x", "article-title": "Studies on the mechanisms of action of avermectin B1a: stimulation of release of gamma amino butyric acid from brain synaptosomes", "author": "Pony", "doi-asserted-by": "crossref", "first-page": "351", "journal-title": "J. Neurochem.", "key": "10.1016/j.heliyon.2020.e05820_bib30", "volume": "34", "year": "1980" }, { "DOI": "10.1111/tra.12131", "article-title": "Microvillus inclusion disease: loss of Myosin Vb disrupts intracellular traffic and cell polarity", "author": "Thoeni", "doi-asserted-by": "crossref", "first-page": "22", "journal-title": "Traffic", "key": "10.1016/j.heliyon.2020.e05820_bib31", "volume": "15", "year": "2014" }, { "DOI": "10.1091/mbc.12.6.1843", "article-title": "Myosin Vb is associated with plasma membrane recycling systems", "author": "Lapierre", "doi-asserted-by": "crossref", "first-page": "1843", "journal-title": "Mol. Biol. Cell", "key": "10.1016/j.heliyon.2020.e05820_bib32", "volume": "12", "year": "2001" }, { "DOI": "10.1074/jbc.M209270200", "article-title": "Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling", "author": "Hales", "doi-asserted-by": "crossref", "first-page": "50415", "journal-title": "J. Biol. Chem.", "key": "10.1016/j.heliyon.2020.e05820_bib33", "volume": "277", "year": "2002" }, { "DOI": "10.1073/pnas.1010754108", "article-title": "Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization", "author": "Roland", "doi-asserted-by": "crossref", "first-page": "2789", "journal-title": "Proc. Natl. Acad. Sci. U.S.A.", "key": "10.1016/j.heliyon.2020.e05820_bib34", "volume": "108", "year": "2011" }, { "article-title": "Myosin Vb and Rab11a regulate phosphorylation of ezrin in enterocytes", "author": "Dhekne", "first-page": "1007", "journal-title": "J. Cell Sci.", "key": "10.1016/j.heliyon.2020.e05820_bib35", "volume": "127", "year": "2014" }, { "DOI": "10.1073/pnas.1516672112", "article-title": "An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking", "author": "Schneeberger", "doi-asserted-by": "crossref", "first-page": "12408", "journal-title": "Proc. Natl. Acad. Sci. U.S.A.", "key": "10.1016/j.heliyon.2020.e05820_bib36", "volume": "112", "year": "2015" }, { "DOI": "10.1242/bio.20148532", "article-title": "Rab11a is required for apical protein localization in the intestine", "author": "Sobajima", "doi-asserted-by": "crossref", "first-page": "86", "journal-title": "Biol. Open", "key": "10.1016/j.heliyon.2020.e05820_bib37", "volume": "4", "year": "2014" }, { "DOI": "10.1016/j.jid.2018.12.021", "article-title": "The actin-based motor Myosin Vb is crucial to maintain epidermal barrier integrity", "author": "Reynier", "doi-asserted-by": "crossref", "first-page": "1430", "journal-title": "J. Invest. Dermatol.", "key": "10.1016/j.heliyon.2020.e05820_bib38", "volume": "139", "year": "2019" }, { "DOI": "10.1007/s10695-019-00661-2", "article-title": "DNA damage and physiological responses in an indian major carp Labeo Rohita exposed to an antimicrobial agent triclosan", "author": "Hemalatha", "doi-asserted-by": "crossref", "first-page": "1463", "journal-title": "Fish Physiol. Biochem.", "key": "10.1016/j.heliyon.2020.e05820_bib39", "volume": "45", "year": "2019" }, { "DOI": "10.1080/02772248.2019.1691554", "article-title": "Acute hematological toxicity of ivermectin to juvenile Clarias gariepinus", "author": "Ogueji", "doi-asserted-by": "crossref", "first-page": "300", "journal-title": "Toxicol. Environ. Chem.", "key": "10.1016/j.heliyon.2020.e05820_bib40", "volume": "101", "year": "2019" }, { "DOI": "10.1016/j.scitotenv.2019.03.275", "article-title": "Multidisciplinary haematology as prognostic device in environmental and xenobiotic stress-induced response in fish", "author": "Burgos-Aceves", "doi-asserted-by": "crossref", "first-page": "1170", "journal-title": "Sci. Total Environ.", "key": "10.1016/j.heliyon.2020.e05820_bib41", "volume": "670", "year": "2019" }, { "DOI": "10.1371/journal.pntd.0006454", "article-title": "Adverse events following single dose treatment of lymphatic filariasis: observations from a review of the literature", "author": "Budge", "doi-asserted-by": "crossref", "journal-title": "PLoS Neglected Trop. Dis.", "key": "10.1016/j.heliyon.2020.e05820_bib42", "volume": "12", "year": "2018" }, { "DOI": "10.1186/s12936-017-1803-2", "article-title": "Ivermectin to reduce malaria transmission III. Considerations regarding regulatory and policy pathways", "author": "Chaccour", "doi-asserted-by": "crossref", "first-page": "162", "journal-title": "Malar. J.", "key": "10.1016/j.heliyon.2020.e05820_bib43", "volume": "16", "year": "2017" }, { "DOI": "10.1016/S0035-9203(99)90305-X", "article-title": "The effects of high-dose ivermectin regimens on Onchocerca volvulus in onchocerciasis patients", "author": "Awadzi", "doi-asserted-by": "crossref", "first-page": "189", "journal-title": "Trans. R. Soc. Trop. Med. Hyg.", "key": "10.1016/j.heliyon.2020.e05820_bib44", "volume": "93", "year": "1999" } ], "reference-count": 43, "references-count": 43, "relation": {}, "resource": { "primary": { "URL": "https://linkinghub.elsevier.com/retrieve/pii/S2405844020326633" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [], "subtitle": [], "title": "Safety of oral administration of high doses of ivermectin by means of biocompatible polyelectrolytes formulation", "type": "journal-article", "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy", "volume": "7" }