Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All ivermectin studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19ivm.org COVID-19 treatment researchIvermectinIvermectin (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Identification of the shared gene signatures between pulmonary fibrosis and pulmonary hypertension using bioinformatics analysis

Zhao et al., Frontiers in Immunology, doi:10.3389/fimmu.2023.1197752
Sep 2023  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
 
*, now known with p < 0.00000000001 from 103 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19ivm.org
In Silico study identifying IGF1 as a shared gene between pulmonary fibrosis and hypertension that promotes inflammation, fibrosis, and cell proliferation when overactivated. Molecular docking analysis demonstrated ivermectin directly binds IGF1 through multiple binding modes. This suggests ivermectin may inhibit IGF1 signaling. Since uncontrolled inflammation and lung fibrosis are major issues in severe COVID-19, ivermectin's ability to bind IGF1 indicates it may be able to reduce IGF1-mediated inflammation and fibrosis. By binding and inhibiting IGF1, ivermectin could potentially attenuate damaging effects of hyperactive IGF1 signaling on lung tissues observed in critical COVID-19 cases. This proposed mechanism of action via IGF1 binding provides a rationale for how ivermectin could protect lungs against inflammatory damage in severe COVID-19.
Ivermectin, better known for antiparasitic activity, is a broad spectrum antiviral with activity against many viruses including H7N7 Götz, Dengue Jitobaom, Tay, Wagstaff, HIV-1 Wagstaff, Simian virus 40 Wagstaff (B), Zika Barrows, Jitobaom, Yang, West Nile Yang, Yellow Fever Mastrangelo, Varghese, Japanese encephalitis Mastrangelo, Chikungunya Varghese, Semliki Forest virus Varghese, Human papillomavirus Li, Epstein-Barr Li, BK Polyomavirus Bennett, and Sindbis virus Varghese.
Ivermectin inhibits importin-α/β-dependent nuclear import of viral proteins Götz, Kosyna, Wagstaff, Wagstaff (B), shows spike-ACE2 disruption at 1nM with microfluidic diffusional sizing Fauquet, binds to glycan sites on the SARS-CoV-2 spike protein preventing interaction with blood and epithelial cells and inhibiting hemagglutination Boschi, Scheim, shows dose-dependent inhibition of wildtype and omicron variants Shahin, exhibits dose-dependent inhibition of lung injury Abd-Elmawla, Ma, may inhibit SARS-CoV-2 via IMPase inhibition Jitobaom, may inhibit SARS-CoV-2 induced formation of fibrin clots resistant to degradation Vottero, inhibits SARS-CoV-2 3CLpro Mody, may inhibit SARS-CoV-2 RdRp activity Parvez (B), may minimize viral myocarditis by inhibiting NF-κB/p65-mediated inflammation in macrophages Gao, may be beneficial for COVID-19 ARDS by blocking GSDMD and NET formation Liu (C), shows protection against inflammation, cytokine storm, and mortality in an LPS mouse model sharing key pathological features of severe COVID-19 DiNicolantonio, Zhang, may be beneficial in severe COVID-19 by binding IGF1 to inhibit the promotion of inflammation, fibrosis, and cell proliferation that leads to lung damage Zhao, may minimize SARS-CoV-2 induced cardiac damage Liu, Liu (B), increases Bifidobacteria which play a key role in the immune system Hazan, has immunomodulatory Munson and anti-inflammatory DiNicolantonio (B), Yan properties, and has an extensive and very positive safety profile Descotes.
Zhao et al., 4 Sep 2023, peer-reviewed, 12 authors. Contact: wenhui5621006@126.com, pandyyuan@tongji.edu.cn, gongsugang@tongji.edu.cn.
In Silico studies are an important part of preclinical research, however results may be very different in vivo.
This PaperIvermectinAll
Identification of the shared gene signatures between pulmonary fibrosis and pulmonary hypertension using bioinformatics analysis
Hui Zhao, Lan Wang, Yi Yan, Qin-Hua Zhao, Jing He, Rong Jiang, Ci-Jun Luo, Hong-Ling Qiu, Yu-Qing Miao, Su-Gang Gong, Ping Yuan, Wen-Hui Wu
Frontiers in Immunology, doi:10.3389/fimmu.2023.1197752
Pulmonary fibrosis (PF) and pulmonary hypertension (PH) have common pathophysiological features, such as the significant remodeling of pulmonary parenchyma and vascular wall. There is no effective specific drug in clinical treatment for these two diseases, resulting in a worse prognosis and higher mortality. This study aimed to screen the common key genes and immune characteristics of PF and PH by means of bioinformatics to find new common therapeutic targets. Expression profiles are
Ethics statement The studies involving humans were approved by the Ethics Committee of Shanghai Pulmonary Hospital (numbers: K22-137Y). The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study. Author contributions HZ, LW, and YY investigated the literature research, got the data, and analyzed the data. Q-HZ and JH wrote the article. RJ and C-JL modified the figures. H-LQ and Y-QM revised the article. W-HW, PY, and S-GG conceived the idea of the study, designed the steps of the study, and directed the data analysis. All authors contributed to the article and approved the submitted version. Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Supplementary material The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1197752/ full#supplementary-material
References
Azuaje, Zhang, Jeanty, Puhl, Rodius et al., Analysis of a gene co-expression network establishes robust association between Col5a2 and ischemic heart disease, BMC Med Genomics, doi:10.1186/1755-8794-6-13
Bilbao, Luciani, Johannesson, Piszczek, Rosenthal, Insulin-like growth factor-1 stimulates regulatory T cells and suppresses autoimmune disease, EMBO Mol Med, doi:10.15252/emmm.201303376
Bindea, Mlecnik, Hackl, Charoentong, Tosolini et al., ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks, Bioinformatics, doi:10.1093/bioinformatics/btp101
Birjandi, Palchevskiy, Xue, Nunez, Kern et al., CD4(+) CD25(hi)Foxp3(+) cells exacerbate bleomycin-induced pulmonary fibrosis, Am J Pathol, doi:10.1016/j.ajpath.2016.03.020
Bloor, Knight, Kedia, Spiteri, Allen, Differential mRNA expression of insulin-like growth factor-1 splice variants in patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis, Am J Respir Crit Care Med, doi:10.1164/ajrccm.164.2.2003114
Bourgeois, Bonnet, Breuils-Bonnet, Habbout, Paradis et al., Inhibition of CHK 1 (Checkpoint kinase 1) elicits therapeutic effects in pulmonary arterial hypertension, Arterioscler Thromb Vasc Biol, doi:10.1161/ATVBAHA.119.312537
Brummelman, Pilipow, Lugli, The single-cell phenotypic identity of human CD8(+) and CD4(+) T cells, Int Rev Cell Mol Biol, doi:10.1016/bs.ircmb.2018.05.007
Celada, Kropski, Herazo-Maya, Luo, Creecy et al., PD-1 up-regulation on CD4(+) T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-b1 production, Sci Transl Med, doi:10.1126/scitranslmed.aar8356
Chen, Collum, Luo, Weng, Le et al., Macrophage bone morphogenic protein receptor 2 depletion in idiopathic pulmonary fibrosis and Group III pulmonary hypertension, Am J Physiol Lung Cell Mol Physiol, doi:10.1152/ajplung.00142.2016
Chen, Liu, Sun, Zeng, Cai et al., Foxf2 and Smad6 co-regulation of collagen 5A2 transcription is involved in the pathogenesis of intrauterine adhesion, J Cell Mol Med, doi:10.1111/jcmm.14708
Choi, Lee, Sunde, Huizar, Haugk et al., Insulinlike growth factor-I receptor blockade improves outcome in mouse model of lung injury, Am J Respir Crit Care Med, doi:10.1164/rccm.200802-228OC
Collum, Amione-Guerra, As, Difrancesco, Hernandez et al., Pulmonary hypertension associated with idiopathic pulmonary fibrosis: current and future perspectives, Can Respir J, doi:10.1155/2017/1430350
Depianto, Chandriani, Abbas, Jia, 'diaye et al., Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis, Thorax, doi:10.1136/thoraxjnl-2013-204596
Echeverria-Esnal, Martıń-Ontiyuelo, Navarrete-Rouco, Barcelo-Vidal, Conde-Estevez et al., Pharmacological management of antifungal agents in pulmonary aspergillosis: an updated review, Expert Rev Anti Infect Ther, doi:10.1080/14787210.2021.1962292
Formiga, Leblanc, De Souza Reboucas, Farias, De Oliveira et al., Ivermectin: an award-winning drug with expected antiviral activity against COVID-19, J Control Release, doi:10.1016/j.jconrel.2020.10.009
Garibaldi, 'alessio, Mock, Files, Chau et al., Regulatory T cells reduce acute lung injury fibroproliferation by decreasing fibrocyte recruitment, Am J Respir Cell Mol Biol, doi:10.1165/rcmb.2012-0198OC
George, Patterson, Reed, Thillai, Lung transplantation for idiopathic pulmonary fibrosis, Lancet Respir Med, doi:10.1016/S2213-2600(18)30502-2
Gilani, Vuga, Lindell, Gibson, Xue et al., CD28 down-regulation on circulating CD4 T-cells is associated with poor prognoses of patients with idiopathic pulmonary fibrosis, PloS One, doi:10.1371/journal.pone.0008959
Govindarajan, Duraiyan, Kaliyappan, Palanisamy, Microarray and its applications, J Pharm Bioallied Sci, doi:10.4103/0975-7406.100283
Grant, Mimche, Paine R 3rd, Liou, Qian et al., Enhanced epithelial sodium channel activity in neonatal Scnn1b mouse lung attenuates high oxygen-induced lung injury, Am J Physiol Lung Cell Mol Physiol, doi:10.1152/ajplung.00538.2020
Gu, Kumar, Lee, Mickael, Graham, Common genetic variants in pulmonary arterial hypertension, Lancet Respir Med, doi:10.1016/S2213-2600(18)30448-X
Hautefort, Girerd, Montani, Cohen-Kaminsky, Price et al., T-helper 17 cell polarization in pulmonary arterial hypertension, Chest, doi:10.1378/chest.14-1678
Heukels, Moor, Der Thüsen, Wijsenbeek, Kool, Inflammation and immunity in IPF pathogenesis and treatment, Respir Med, doi:10.1016/j.rmed.2018.12.015
Humbert, Kovacs, Hoeper, Badagliacca, Berger et al., ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension, Eur Respir J, doi:10.1183/13993003.00879-2022
Ichikawa, Hirahara, Kokubo, Kiuchi, Aoki et al., CD103 (hi) T(reg) cells constrain lung fibrosis induced by CD103(lo) tissue-resident pathogenic CD4 T cells, Nat Immunol, doi:10.1038/s41590-019-0494-y
Kolahian, Fernandez, Eickelberg, Hartl, Immune mechanisms in pulmonary fibrosis, Am J Respir Cell Mol Biol, doi:10.1165/rcmb.2016-0121TR
Kotsianidis, Nakou, Bouchliou, Tzouvelekis, Spanoudakis et al., Global impairment of CD4+CD25+FOXP3+ regulatory T cells in idiopathic pulmonary fibrosis, Am J Respir Crit Care Med, doi:10.1164/rccm.200812-1936OC
Kundranda, Gracian, Zafar, Meiri, Bendell et al., Randomized, double-blind, placebo-controlled phase II study of istiratumab (MM-141) plus nab-paclitaxel and gemcitabine versus nab-paclitaxel and gemcitabine in front-line metastatic pancreatic cancer (CARRIE), Ann Oncol, doi:10.1016/j.annonc.2019.09.004
Langfelder, Horvath, WGCNA: an R package for weighted correlation network analysis, BMC Bioinf, doi:10.1186/1471-2105-9-559
Lettieri, Nathan, Barnett, Ahmad, Shorr, Prevalence and outcomes of pulmonary arterial hypertension in advanced idiopathic pulmonary fibrosis, Chest, doi:10.1378/chest.129.3.746
Liu, Huang, Li, Li, Zhang, The cardiac glycoside deslanoside exerts anticancer activity in prostate cancer cells by modulating multiple signaling pathways, Cancers, doi:10.3390/cancers13225809
Liu, Shi, Jiang, Liu, He et al., Regulatory T cellrelated gene indicators in pulmonary hypertension, Front Pharmacol, doi:10.3389/fphar.2022.908783
Lu, Li, Hu, Wang, Expression of immune related genes and possible regulatory mechanisms in Alzheimer's disease, Front Immunol, doi:10.3389/fimmu.2021.768966
Ma, Qin, Zhong, Liao, Su et al., Flavine adenine dinucleotide inhibits pathological cardiac hypertrophy and fibrosis through activating short chain acyl-CoA dehydrogenase, Biochem Pharmacol, doi:10.1016/j.bcp.2020.114100
Martinez, Collard, Pardo, Raghu, Richeldi et al., Idiopathic pulmonary fibrosis, Nat Rev Dis Primers, doi:10.1038/nrdp.2017.74
Meng, Shi, Zeng, Chen, Wu, The role of COL5A2 in patients with muscle-invasive bladder cancer: A bioinformatics analysis of public datasets involving 787 subjects and 29 cell lines, Front Oncol, doi:10.3389/fonc.2018.00659
Milara, Ballester, Morell, Ortiz, Escriváj et al., JAK2 mediates lung fibrosis, pulmonary vascular remodelling and hypertension in idiopathic pulmonary fibrosis: an experimental study, Thorax, doi:10.1136/thoraxjnl-2017-210728
Mirdamadi, Bommhardt, Goihl, Guttek, Zouboulis et al., Insulin and Insulin-like growth factor-1 can activate the phosphoinositide-3-kinase /Akt/FoxO1 pathway in T cells in vitro, Dermatoendocrinol, doi:10.1080/19381980.2017.1356518
Mura, Cecchini, Joseph, Granton, Osteopontin lung gene expression is a marker of disease severity in pulmonary arterial hypertension, Respirology, doi:10.1111/resp.13557
Murphy, Durum, Longo, Human growth hormone promotes engraftment of murine or human T cells in severe combined immunodeficient mice, Proc Natl Acad Sci U.S.A, doi:10.1073/pnas.89.10.4481
Nathan, Barbera, Gaine, Harari, Martinez et al., Pulmonary hypertension in chronic lung disease and hypoxia, Eur Respir J, doi:10.1183/13993003.01914-2018
Nathan, Waxman, Rajagopal, Case, Johri et al., Inhaled treprostinil and forced vital capacity in patients with interstitial lung disease and associated pulmonary hypertension: a post-hoc analysis of the INCREASE study, Lancet Respir Med, doi:10.1016/S2213-2600(21)00165-X
No, Imam, Nadeem, Al-Harbi, Korashy et al., Riboflavin attenuates lipopolysaccharide-induced lung injury in rats, Toxicol Mech Methods, doi:10.3109/15376516.2015.1045662
Oherle, Acker, Bonfield, Wang, Gray et al., Insulin-like growth factor 1 supports a pulmonary niche that promotes type 3 innate lymphoid cell development in newborn lungs, Immunity, doi:10.1016/j.immuni.2020.01.005
Pahal, Sharma, Idiopathic Pulmonary Artery Hypertension
Raghu, Amatto, Behr, Stowasser, Comorbidities in idiopathic pulmonary fibrosis patients: a systematic literature review, Eur Respir J, doi:10.1183/13993003.02316-2014
Rajagopal, Bryant, Sahay, Wareing, Zhou et al., Idiopathic pulmonary fibrosis and pulmonary hypertension: Heracles meets the Hydra, Br J Pharmacol, doi:10.1111/bph.15036
Rajkumar, Konishi, Richards, Ishizawar, Wiechert et al., Genomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension, Am J Physiol Heart Circ Physiol, doi:10.1152/ajpheart.00254.2009
Savai, Pullamsetti, Kolbe, Bieniek, Voswinckel et al., Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension, Am J Respir Crit Care Med, doi:10.1164/rccm.201202-0335OC
Sharma, Maclean, Pinto, Kradin, The effect of an anti-CD3 monoclonal antibody on bleomycin-induced lymphokine production and lung injury, Am J Respir Crit Care Med, doi:10.1164/ajrccm.154.1.8680680
Stacher, Graham, Hunt, Gandjeva, Groshong et al., Modern age pathology of pulmonary arterial hypertension, Am J Respir Crit Care Med, doi:10.1164/rccm.201201-0164OC
Sun, Ramchandran, Chen, Yang, Raj, Smooth muscle insulin-like growth factor-1 mediates hypoxia-induced pulmonary hypertension in neonatal mice, Am J Respir Cell Mol Biol, doi:10.1165/rcmb.2015-0388OC
Tamosiuniene, Manouvakhova, Mesange, Saito, Qian et al., Dominant role for regulatory T cells in protecting females against pulmonary hypertension, Circ Res, doi:10.1161/CIRCRESAHA.117.312058
Tamosiuniene, Tian, Dhillon, Wang, Sung et al., Regulatory T cells limit vascular endothelial injury and prevent pulmonary hypertension, Circ Res, doi:10.1161/CIRCRESAHA.110.236927
Teodoro, De, Queiroz, Santos, Catanozi et al., Proposition of a novel animal model of systemic sclerosis induced by type V collagen in C57BL/6 mice that reproduces fibrosis, vasculopathy and autoimmunity, Arthritis Res Ther, doi:10.1186/s13075-019-2052-2
Tian, Jiang, Jiang, Tamosiuniene, Kim et al., The role of regulatory T cells in pulmonary arterial hypertension, Front Immunol, doi:10.3389/fimmu.2021.684657
Tomaszewski, Bębnowska, Hrynkiewicz, Dworzyński, Niedzẃiedzka-Rystwej et al., Role of the immune system elements in pulmonary arterial hypertension, J Clin Med, doi:10.3390/jcm10163757
Vanderbeke, Janssen, Bergmans, Bourgeois, Buil et al., Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial, Intensive Care Med, doi:10.1007/s00134-021-06431-0
Vaz, Hwang, Kagiampakis, Phallen, Patil et al., Chronic cigarette smoke-induced epigenomic changes precede sensitization of bronchial epithelial cells to single-step transformation by KRAS mutations, Cancer Cell, doi:10.1016/j.ccell.2017.08.006
Vignali, Collison, Workman, How regulatory T cells work, Nat Rev Immunol, doi:10.1038/nri2343
Wang, Lee, Dhandapani, Baek, Kim et al., 8-paradol from ginger exacerbates PINK1/Parkin mediated mitophagy to induce apoptosis in human gastric adenocarcinoma, Pharmacol Res, doi:10.1016/j.phrs.2022.106610
Weigel, Malempati, Reid, Voss, Cho et al., Phase 2 trial of cixutumumab in children, adolescents, and young adults with refractory solid tumors: a report from the Children's Oncology Group, Pediatr Blood Cancer, doi:10.1002/pbc.24605
Wu, Bonnet, Shimauchi, Toro, Grobs et al., Potential for inhibition of checkpoint kinases 1/2 in pulmonary fibrosis and secondary pulmonary hypertension, Thorax, doi:10.1136/thoraxjnl-2021-217377
Xu, Janocha, Erzurum, Metabolism in pulmonary hypertension, Annu Rev Physiol, doi:10.1146/annurev-physiol-031620-123956
Yan, Ci, Chen, Chen, Li et al., Anti-inflammatory effects of ivermectin in mouse model of allergic asthma, Inflammation Res, doi:10.1007/s00011-011-0307-8
Yan, He, Jiang, Wang, Chen et al., DNA methyltransferase 3B deficiency unveils a new pathological mechanism of pulmonary hypertension, Sci Adv, doi:10.1126/sciadv.aba2470
Yang, Sun, Ramchandran, Raj, IGF-1 signaling in neonatal hypoxiainduced pulmonary hypertension: Role of epigenetic regulation, Vascul Pharmacol, doi:10.1016/j.vph.2015.04.005
Yao, Zhang, Gao, Wang, Dai et al., Exploration of the shared gene signatures and molecular mechanisms between systemic lupus erythematosus and pulmonary arterial hypertension: evidence from transcriptome data, Front Immunol, doi:10.3389/fimmu.2021.658341
Zeng, Liu, Zhang, Identification of potential biomarkers and immune infiltration characteristics in idiopathic pulmonary arterial hypertension using bioinformatics analysis, Front Cardiovasc Med, doi:10.3389/fcvm.2021.624714
Zhang, Song, Ci, Ju, Li, Ivermectin inhibits LPS-induced production of inflammatory cytokines and improves LPS-induced survival in mice, Inflammation Res, doi:10.1007/s00011-008-8007-8
Zhu, Liu, Hao, Feng, Chen et al., Dietary geranylgeranyl pyrophosphate counteracts the benefits of statin therapy in experimental pulmonary h y p e r t e n s i o n . C i r c u l a t i o n ( 2 0 2 1 ), 1, doi:10.1161/CIRCULATIONAHA.120.046542
{ 'DOI': '10.3389/fimmu.2023.1197752', 'ISSN': ['1664-3224'], 'URL': 'http://dx.doi.org/10.3389/fimmu.2023.1197752', 'abstract': '<jats:p>Pulmonary fibrosis (PF) and pulmonary hypertension (PH) have common ' 'pathophysiological features, such as the significant remodeling of pulmonary parenchyma and ' 'vascular wall. There is no effective specific drug in clinical treatment for these two ' 'diseases, resulting in a worse prognosis and higher mortality. This study aimed to screen the ' 'common key genes and immune characteristics of PF and PH by means of bioinformatics to find ' 'new common therapeutic targets. Expression profiles are downloaded from the Gene Expression ' 'Database. Weighted gene co-expression network analysis is used to identify the co-expression ' 'modules related to PF and PH. We used the ClueGO software to enrich and analyze the common ' 'genes in PF and PH and obtained the protein–protein interaction (PPI) network. Then, the ' 'differential genes were screened out in another cohort of PF and PH, and the shared genes ' 'were crossed. Finally, RT-PCR verification and immune infiltration analysis were performed on ' 'the intersection genes. In the result, the positive correlation module with the highest ' 'correlation between PF and PH was determined, and it was found that lymphocyte activation is ' 'a common feature of the pathophysiology of PF and PH. Eight common characteristic genes ' '(<jats:italic>ACTR2, COL5A2, COL6A3, CYSLTR1, IGF1, RSPO3, SCARNA17</jats:italic> and ' '<jats:italic>SEL1L</jats:italic>) were gained. Immune infiltration showed that compared with ' 'the control group, resting CD4 memory T cells were upregulated in PF and PH. Combining the ' 'results of crossing characteristic genes in ImmPort database and RT-PCR, the important gene ' '<jats:italic>IGF1</jats:italic> was obtained. Knocking down <jats:italic>IGF1</jats:italic> ' 'could significantly reduce the proliferation and apoptosis resistance in pulmonary ' 'microvascular endothelial cells, pulmonary smooth muscle cells, and fibroblasts induced by ' 'hypoxia, platelet-derived growth factor-BB (PDGF-BB), and transforming growth factor-β1 ' '(TGF-β1), respectively. Our work identified the common biomarkers of PF and PH and provided a ' 'new candidate gene for the potential therapeutic targets of PF and PH in the future.</jats:p>', 'alternative-id': ['10.3389/fimmu.2023.1197752'], 'author': [ {'affiliation': [], 'family': 'Zhao', 'given': 'Hui', 'sequence': 'first'}, {'affiliation': [], 'family': 'Wang', 'given': 'Lan', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Yan', 'given': 'Yi', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Zhao', 'given': 'Qin-Hua', 'sequence': 'additional'}, {'affiliation': [], 'family': 'He', 'given': 'Jing', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Jiang', 'given': 'Rong', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Luo', 'given': 'Ci-Jun', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Qiu', 'given': 'Hong-Ling', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Miao', 'given': 'Yu-Qing', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Gong', 'given': 'Su-Gang', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Yuan', 'given': 'Ping', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Wu', 'given': 'Wen-Hui', 'sequence': 'additional'}], 'container-title': 'Frontiers in Immunology', 'container-title-short': 'Front. Immunol.', 'content-domain': {'crossmark-restriction': True, 'domain': ['frontiersin.org']}, 'created': {'date-parts': [[2023, 9, 4]], 'date-time': '2023-09-04T08:54:51Z', 'timestamp': 1693817691000}, 'deposited': { 'date-parts': [[2023, 9, 4]], 'date-time': '2023-09-04T08:54:57Z', 'timestamp': 1693817697000}, 'indexed': {'date-parts': [[2023, 9, 7]], 'date-time': '2023-09-07T21:09:21Z', 'timestamp': 1694120961713}, 'is-referenced-by-count': 0, 'issued': {'date-parts': [[2023, 9, 4]]}, 'license': [ { 'URL': 'https://creativecommons.org/licenses/by/4.0/', 'content-version': 'vor', 'delay-in-days': 0, 'start': { 'date-parts': [[2023, 9, 4]], 'date-time': '2023-09-04T00:00:00Z', 'timestamp': 1693785600000}}], 'link': [ { 'URL': 'https://www.frontiersin.org/articles/10.3389/fimmu.2023.1197752/full', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'member': '1965', 'original-title': [], 'prefix': '10.3389', 'published': {'date-parts': [[2023, 9, 4]]}, 'published-online': {'date-parts': [[2023, 9, 4]]}, 'publisher': 'Frontiers Media SA', 'reference': [ { 'DOI': '10.1183/13993003.00879-2022', 'article-title': 'ESC/ERS Guidelines for the diagnosis and treatment of pulmonary ' 'hypertension', 'author': 'Humbert', 'doi-asserted-by': 'publisher', 'first-page': '2200879', 'journal-title': 'Eur Respir J', 'key': 'B1', 'volume': '61', 'year': '2022'}, { 'DOI': '10.1183/13993003.01914-2018', 'article-title': 'Pulmonary hypertension in chronic lung disease and hypoxia', 'author': 'Nathan', 'doi-asserted-by': 'publisher', 'first-page': '1801914', 'journal-title': 'Eur Respir J', 'key': 'B2', 'volume': '53', 'year': '2019'}, { 'DOI': '10.1183/13993003.02316-2014', 'article-title': 'Comorbidities in idiopathic pulmonary fibrosis patients: a systematic ' 'literature review', 'author': 'Raghu', 'doi-asserted-by': 'publisher', 'journal-title': 'Eur Respir J', 'key': 'B3', 'volume': '46', 'year': '2015'}, { 'article-title': 'Idiopathic Pulmonary Artery Hypertension', 'author': 'Pahal', 'key': 'B4', 'volume-title': 'StatPearls', 'year': '2022'}, { 'DOI': '10.1038/nrdp.2017.74', 'article-title': 'Idiopathic pulmonary fibrosis', 'author': 'Martinez', 'doi-asserted-by': 'publisher', 'first-page': '17074', 'journal-title': 'Nat Rev Dis Primers', 'key': 'B5', 'volume': '3', 'year': '2017'}, { 'DOI': '10.1111/bph.15036', 'article-title': 'Idiopathic pulmonary fibrosis and pulmonary hypertension: Heracles ' 'meets the Hydra', 'author': 'Rajagopal', 'doi-asserted-by': 'publisher', 'journal-title': 'Br J Pharmacol', 'key': 'B6', 'volume': '178', 'year': '2021'}, { 'DOI': '10.1016/S2213-2600(18)30502-2', 'article-title': 'Lung transplantation for idiopathic pulmonary fibrosis', 'author': 'George', 'doi-asserted-by': 'publisher', 'journal-title': 'Lancet Respir Med', 'key': 'B7', 'volume': '7', 'year': '2019'}, { 'DOI': '10.1378/chest.129.3.746', 'article-title': 'Prevalence and outcomes of pulmonary arterial hypertension in advanced ' 'idiopathic pulmonary fibrosis', 'author': 'Lettieri', 'doi-asserted-by': 'publisher', 'journal-title': 'Chest', 'key': 'B8', 'volume': '129', 'year': '2006'}, { 'DOI': '10.1155/2017/1430350', 'article-title': 'Pulmonary hypertension associated with idiopathic pulmonary fibrosis: ' 'current and future perspectives', 'author': 'Collum', 'doi-asserted-by': 'publisher', 'first-page': '1430350', 'journal-title': 'Can Respir J', 'key': 'B9', 'volume': '2017', 'year': '2017'}, { 'DOI': '10.1136/thoraxjnl-2017-210728', 'article-title': 'JAK2 mediates lung fibrosis, pulmonary vascular remodelling and ' 'hypertension in idiopathic pulmonary fibrosis: an experimental study', 'author': 'Milara', 'doi-asserted-by': 'publisher', 'journal-title': 'Thorax', 'key': 'B10', 'volume': '73', 'year': '2018'}, { 'DOI': '10.1152/ajplung.00142.2016', 'article-title': 'Macrophage bone morphogenic protein receptor 2 depletion in idiopathic ' 'pulmonary fibrosis and Group III pulmonary hypertension', 'author': 'Chen', 'doi-asserted-by': 'publisher', 'journal-title': 'Am J Physiol Lung Cell Mol Physiol', 'key': 'B11', 'volume': '311', 'year': '2016'}, { 'DOI': '10.1152/ajpheart.00254.2009', 'article-title': 'Genomewide RNA expression profiling in lung identifies distinct ' 'signatures in idiopathic pulmonary arterial hypertension and secondary ' 'pulmonary hypertension', 'author': 'Rajkumar', 'doi-asserted-by': 'publisher', 'journal-title': 'Am J Physiol Heart Circ Physiol', 'key': 'B12', 'volume': '298', 'year': '2010'}, { 'DOI': '10.1136/thoraxjnl-2021-217377', 'article-title': 'Potential for inhibition of checkpoint kinases 1/2 in pulmonary ' 'fibrosis and secondary pulmonary hypertension', 'author': 'Wu', 'doi-asserted-by': 'publisher', 'journal-title': 'Thorax', 'key': 'B13', 'volume': '77', 'year': '2022'}, { 'DOI': '10.1161/ATVBAHA.119.312537', 'article-title': 'Inhibition of CHK 1 (Checkpoint kinase 1) elicits therapeutic effects ' 'in pulmonary arterial hypertension', 'author': 'Bourgeois', 'doi-asserted-by': 'publisher', 'journal-title': 'Arterioscler Thromb Vasc Biol', 'key': 'B14', 'volume': '39', 'year': '2019'}, { 'DOI': '10.4103/0975-7406.100283', 'article-title': 'Microarray and its applications', 'author': 'Govindarajan', 'doi-asserted-by': 'publisher', 'journal-title': 'J Pharm Bioallied Sci', 'key': 'B15', 'volume': '4', 'year': '2012'}, { 'DOI': '10.3389/fimmu.2021.658341', 'article-title': 'Exploration of the shared gene signatures and molecular mechanisms ' 'between systemic lupus erythematosus and pulmonary arterial ' 'hypertension: evidence from transcriptome data', 'author': 'Yao', 'doi-asserted-by': 'publisher', 'journal-title': 'Front Immunol', 'key': 'B16', 'volume': '12', 'year': '2021'}, { 'DOI': '10.1186/1471-2105-9-559', 'article-title': 'WGCNA: an R package for weighted correlation network analysis', 'author': 'Langfelder', 'doi-asserted-by': 'publisher', 'first-page': '559', 'journal-title': 'BMC Bioinf', 'key': 'B17', 'volume': '9', 'year': '2008'}, { 'DOI': '10.1093/bioinformatics/btp101', 'article-title': 'ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ' 'ontology and pathway annotation networks', 'author': 'Bindea', 'doi-asserted-by': 'publisher', 'journal-title': 'Bioinformatics', 'key': 'B18', 'volume': '25', 'year': '2009'}, { 'DOI': '10.3389/fimmu.2021.768966', 'article-title': 'Expression of immune related genes and possible regulatory mechanisms ' "in Alzheimer's disease", 'author': 'Lu', 'doi-asserted-by': 'publisher', 'journal-title': 'Front Immunol', 'key': 'B19', 'volume': '12', 'year': '2021'}, { 'DOI': '10.1136/thoraxjnl-2013-204596', 'article-title': 'Heterogeneous gene expression signatures correspond to distinct lung ' 'pathologies and biomarkers of disease severity in idiopathic pulmonary ' 'fibrosis', 'author': 'DePianto', 'doi-asserted-by': 'publisher', 'first-page': '48', 'journal-title': 'Thorax', 'key': 'B20', 'volume': '70', 'year': '2015'}, { 'DOI': '10.1111/resp.13557', 'article-title': 'Osteopontin lung gene expression is a marker of disease severity in ' 'pulmonary arterial hypertension', 'author': 'Mura', 'doi-asserted-by': 'publisher', 'journal-title': 'Respirology', 'key': 'B21', 'volume': '24', 'year': '2019'}, { 'DOI': '10.1016/j.phrs.2022.106610', 'article-title': '8-paradol from ginger exacerbates PINK1/Parkin mediated mitophagy to ' 'induce apoptosis in human gastric adenocarcinoma', 'author': 'Wang', 'doi-asserted-by': 'publisher', 'first-page': '106610', 'journal-title': 'Pharmacol Res', 'key': 'B22', 'volume': '187', 'year': '2023'}, { 'DOI': '10.1016/S2213-2600(21)00165-X', 'article-title': 'Inhaled treprostinil and forced vital capacity in patients with ' 'interstitial lung disease and associated pulmonary hypertension: a ' 'post-hoc analysis of the INCREASE study', 'author': 'Nathan', 'doi-asserted-by': 'publisher', 'journal-title': 'Lancet Respir Med', 'key': 'B23', 'volume': '9', 'year': '2021'}, { 'DOI': '10.3389/fcvm.2021.624714', 'article-title': 'Identification of potential biomarkers and immune infiltration ' 'characteristics in idiopathic pulmonary arterial hypertension using ' 'bioinformatics analysis', 'author': 'Zeng', 'doi-asserted-by': 'publisher', 'journal-title': 'Front Cardiovasc Med', 'key': 'B24', 'volume': '8', 'year': '2021'}, { 'DOI': '10.1016/S2213-2600(18)30448-X', 'article-title': 'Common genetic variants in pulmonary arterial hypertension', 'author': 'Gu', 'doi-asserted-by': 'publisher', 'journal-title': 'Lancet Respir Med', 'key': 'B25', 'volume': '7', 'year': '2019'}, { 'DOI': '10.1146/annurev-physiol-031620-123956', 'article-title': 'Metabolism in pulmonary hypertension', 'author': 'Xu', 'doi-asserted-by': 'publisher', 'journal-title': 'Annu Rev Physiol', 'key': 'B26', 'volume': '83', 'year': '2021'}, { 'DOI': '10.1126/sciadv.aba2470', 'article-title': 'DNA methyltransferase 3B deficiency unveils a new pathological ' 'mechanism of pulmonary hypertension', 'author': 'Yan', 'doi-asserted-by': 'publisher', 'first-page': 'eaba2470', 'journal-title': 'Sci Adv', 'key': 'B27', 'volume': '6', 'year': '2020'}, { 'DOI': '10.1016/j.ccell.2017.08.006', 'article-title': 'Chronic cigarette smoke-induced epigenomic changes precede ' 'sensitization of bronchial epithelial cells to single-step ' 'transformation by KRAS mutations', 'author': 'Vaz', 'doi-asserted-by': 'publisher', 'first-page': '360', 'journal-title': 'Cancer Cell', 'key': 'B28', 'volume': '32', 'year': '2017'}, { 'DOI': '10.1161/CIRCULATIONAHA.120.046542', 'article-title': 'Dietary geranylgeranyl pyrophosphate counteracts the benefits of statin ' 'therapy in experimental pulmonary hypertension', 'author': 'Zhu', 'doi-asserted-by': 'publisher', 'journal-title': 'Circulation', 'key': 'B29', 'volume': '143', 'year': '2021'}, { 'DOI': '10.1164/rccm.201201-0164OC', 'article-title': 'Modern age pathology of pulmonary arterial hypertension', 'author': 'Stacher', 'doi-asserted-by': 'publisher', 'journal-title': 'Am J Respir Crit Care Med', 'key': 'B30', 'volume': '186', 'year': '2012'}, { 'DOI': '10.1165/rcmb.2016-0121TR', 'article-title': 'Immune mechanisms in pulmonary fibrosis', 'author': 'Kolahian', 'doi-asserted-by': 'publisher', 'journal-title': 'Am J Respir Cell Mol Biol', 'key': 'B31', 'volume': '55', 'year': '2016'}, { 'DOI': '10.1164/ajrccm.154.1.8680680', 'article-title': 'The effect of an anti-CD3 monoclonal antibody on bleomycin-induced ' 'lymphokine production and lung injury', 'author': 'Sharma', 'doi-asserted-by': 'publisher', 'first-page': '193', 'journal-title': 'Am J Respir Crit Care Med', 'key': 'B32', 'volume': '154', 'year': '1996'}, { 'DOI': '10.1016/bs.ircmb.2018.05.007', 'article-title': 'The single-cell phenotypic identity of human CD8(+) and CD4(+) T cells', 'author': 'Brummelman', 'doi-asserted-by': 'publisher', 'first-page': '63', 'journal-title': 'Int Rev Cell Mol Biol', 'key': 'B33', 'volume': '341', 'year': '2018'}, { 'DOI': '10.1378/chest.14-1678', 'article-title': 'T-helper 17 cell polarization in pulmonary arterial hypertension', 'author': 'Hautefort', 'doi-asserted-by': 'publisher', 'journal-title': 'Chest', 'key': 'B34', 'volume': '147', 'year': '2015'}, { 'DOI': '10.1371/journal.pone.0008959', 'article-title': 'CD28 down-regulation on circulating CD4 T-cells is associated with poor ' 'prognoses of patients with idiopathic pulmonary fibrosis', 'author': 'Gilani', 'doi-asserted-by': 'publisher', 'journal-title': 'PloS One', 'key': 'B35', 'volume': '5', 'year': '2010'}, { 'DOI': '10.3389/fimmu.2021.684657', 'article-title': 'The role of regulatory T cells in pulmonary arterial hypertension', 'author': 'Tian', 'doi-asserted-by': 'publisher', 'journal-title': 'Front Immunol', 'key': 'B36', 'volume': '12', 'year': '2021'}, { 'DOI': '10.1164/rccm.201202-0335OC', 'article-title': 'Immune and inflammatory cell involvement in the pathology of idiopathic ' 'pulmonary arterial hypertension', 'author': 'Savai', 'doi-asserted-by': 'publisher', 'first-page': '897', 'journal-title': 'Am J Respir Crit Care Med', 'key': 'B37', 'volume': '186', 'year': '2012'}, { 'DOI': '10.1126/scitranslmed.aar8356', 'article-title': 'PD-1 up-regulation on CD4(+) T cells promotes pulmonary fibrosis ' 'through STAT3-mediated IL-17A and TGF-β1 production', 'author': 'Celada', 'doi-asserted-by': 'publisher', 'first-page': 'eaar8356', 'journal-title': 'Sci Transl Med', 'key': 'B38', 'volume': '10', 'year': '2018'}, { 'DOI': '10.3390/jcm10163757', 'article-title': 'Role of the immune system elements in pulmonary arterial hypertension', 'author': 'Tomaszewski', 'doi-asserted-by': 'publisher', 'first-page': '3757', 'journal-title': 'J Clin Med', 'key': 'B39', 'volume': '10', 'year': '2021'}, { 'DOI': '10.1161/CIRCRESAHA.117.312058', 'article-title': 'Dominant role for regulatory T cells in protecting females against ' 'pulmonary hypertension', 'author': 'Tamosiuniene', 'doi-asserted-by': 'publisher', 'journal-title': 'Circ Res', 'key': 'B40', 'volume': '122', 'year': '2018'}, { 'DOI': '10.1161/CIRCRESAHA.110.236927', 'article-title': 'Regulatory T cells limit vascular endothelial injury and prevent ' 'pulmonary hypertension', 'author': 'Tamosiuniene', 'doi-asserted-by': 'publisher', 'journal-title': 'Circ Res', 'key': 'B41', 'volume': '109', 'year': '2011'}, { 'DOI': '10.3389/fphar.2022.908783', 'article-title': 'Regulatory T cell-related gene indicators in pulmonary hypertension', 'author': 'Liu', 'doi-asserted-by': 'publisher', 'journal-title': 'Front Pharmacol', 'key': 'B42', 'volume': '13', 'year': '2022'}, { 'DOI': '10.1016/j.rmed.2018.12.015', 'article-title': 'Inflammation and immunity in IPF pathogenesis and treatment', 'author': 'Heukels', 'doi-asserted-by': 'publisher', 'first-page': '79', 'journal-title': 'Respir Med', 'key': 'B43', 'volume': '147', 'year': '2019'}, { 'DOI': '10.1038/nri2343', 'article-title': 'How regulatory T cells work', 'author': 'Vignali', 'doi-asserted-by': 'publisher', 'journal-title': 'Nat Rev Immunol', 'key': 'B44', 'volume': '8', 'year': '2008'}, { 'DOI': '10.1164/rccm.200812-1936OC', 'article-title': 'Global impairment of CD4+CD25+FOXP3+ regulatory T cells in idiopathic ' 'pulmonary fibrosis', 'author': 'Kotsianidis', 'doi-asserted-by': 'publisher', 'journal-title': 'Am J Respir Crit Care Med', 'key': 'B45', 'volume': '179', 'year': '2009'}, { 'DOI': '10.1165/rcmb.2012-0198OC', 'article-title': 'Regulatory T cells reduce acute lung injury fibroproliferation by ' 'decreasing fibrocyte recruitment', 'author': 'Garibaldi', 'doi-asserted-by': 'publisher', 'first-page': '35', 'journal-title': 'Am J Respir Cell Mol Biol', 'key': 'B46', 'volume': '48', 'year': '2013'}, { 'DOI': '10.1038/s41590-019-0494-y', 'article-title': 'CD103(hi) T(reg) cells constrain lung fibrosis induced by CD103(lo) ' 'tissue-resident pathogenic CD4 T cells', 'author': 'Ichikawa', 'doi-asserted-by': 'publisher', 'journal-title': 'Nat Immunol', 'key': 'B47', 'volume': '20', 'year': '2019'}, { 'DOI': '10.1016/j.ajpath.2016.03.020', 'article-title': 'CD4(+)CD25(hi)Foxp3(+) cells exacerbate bleomycin-induced pulmonary ' 'fibrosis', 'author': 'Birjandi', 'doi-asserted-by': 'publisher', 'journal-title': 'Am J Pathol', 'key': 'B48', 'volume': '186', 'year': '2016'}, { 'DOI': '10.1073/pnas.89.10.4481', 'article-title': 'Human growth hormone promotes engraftment of murine or human T cells in ' 'severe combined immunodeficient mice', 'author': 'Murphy', 'doi-asserted-by': 'publisher', 'journal-title': 'Proc Natl Acad Sci U.S.A.', 'key': 'B49', 'volume': '89', 'year': '1992'}, { 'DOI': '10.1080/19381980.2017.1356518', 'article-title': 'Insulin and Insulin-like growth factor-1 can activate the ' 'phosphoinositide-3-kinase /Akt/FoxO1 pathway in T cells in vitro', 'author': 'Mirdamadi', 'doi-asserted-by': 'publisher', 'journal-title': 'Dermatoendocrinol', 'key': 'B50', 'volume': '9', 'year': '2017'}, { 'DOI': '10.15252/emmm.201303376', 'article-title': 'Insulin-like growth factor-1 stimulates regulatory T cells and ' 'suppresses autoimmune disease', 'author': 'Bilbao', 'doi-asserted-by': 'publisher', 'journal-title': 'EMBO Mol Med', 'key': 'B51', 'volume': '6', 'year': '2014'}, { 'DOI': '10.1016/j.immuni.2020.01.005', 'article-title': 'Insulin-like growth factor 1 supports a pulmonary niche that promotes ' 'type 3 innate lymphoid cell development in newborn lungs', 'author': 'Oherle', 'doi-asserted-by': 'publisher', 'first-page': '275', 'journal-title': 'Immunity', 'key': 'B52', 'volume': '52', 'year': '2020'}, { 'DOI': '10.1164/ajrccm.164.2.2003114', 'article-title': 'Differential mRNA expression of insulin-like growth factor-1 splice ' 'variants in patients with idiopathic pulmonary fibrosis and pulmonary ' 'sarcoidosis', 'author': 'Bloor', 'doi-asserted-by': 'publisher', 'journal-title': 'Am J Respir Crit Care Med', 'key': 'B53', 'volume': '164', 'year': '2001'}, { 'DOI': '10.1016/j.vph.2015.04.005', 'article-title': 'IGF-1 signaling in neonatal hypoxia-induced pulmonary hypertension: ' 'Role of epigenetic regulation', 'author': 'Yang', 'doi-asserted-by': 'publisher', 'first-page': '20', 'journal-title': 'Vascul Pharmacol', 'key': 'B54', 'volume': '73', 'year': '2015'}, { 'DOI': '10.1165/rcmb.2015-0388OC', 'article-title': 'Smooth muscle insulin-like growth factor-1 mediates hypoxia-induced ' 'pulmonary hypertension in neonatal mice', 'author': 'Sun', 'doi-asserted-by': 'publisher', 'journal-title': 'Am J Respir Cell Mol Biol', 'key': 'B55', 'volume': '55', 'year': '2016'}, { 'DOI': '10.1164/rccm.200802-228OC', 'article-title': 'Insulin-like growth factor-I receptor blockade improves outcome in ' 'mouse model of lung injury', 'author': 'Choi', 'doi-asserted-by': 'publisher', 'journal-title': 'Am J Respir Crit Care Med', 'key': 'B56', 'volume': '179', 'year': '2009'}, { 'DOI': '10.1002/pbc.24605', 'article-title': 'Phase 2 trial of cixutumumab in children, adolescents, and young adults ' "with refractory solid tumors: a report from the Children's Oncology " 'Group', 'author': 'Weigel', 'doi-asserted-by': 'publisher', 'journal-title': 'Pediatr Blood Cancer', 'key': 'B57', 'volume': '61', 'year': '2014'}, { 'DOI': '10.1016/j.annonc.2019.09.004', 'article-title': 'Randomized, double-blind, placebo-controlled phase II study of ' 'istiratumab (MM-141) plus nab-paclitaxel and gemcitabine versus ' 'nab-paclitaxel and gemcitabine in front-line metastatic pancreatic ' 'cancer (CARRIE)', 'author': 'Kundranda', 'doi-asserted-by': 'publisher', 'first-page': '79', 'journal-title': 'Ann Oncol', 'key': 'B58', 'volume': '31', 'year': '2020'}, { 'DOI': '10.1111/jcmm.14708', 'article-title': 'Foxf2 and Smad6 co-regulation of collagen 5A2 transcription is involved ' 'in the pathogenesis of intrauterine adhesion', 'author': 'Chen', 'doi-asserted-by': 'publisher', 'journal-title': 'J Cell Mol Med', 'key': 'B59', 'volume': '24', 'year': '2020'}, { 'DOI': '10.1186/s13075-019-2052-2', 'article-title': 'Proposition of a novel animal model of systemic sclerosis induced by ' 'type V collagen in C57BL/6 mice that reproduces fibrosis, vasculopathy ' 'and autoimmunity', 'author': 'Teodoro', 'doi-asserted-by': 'publisher', 'first-page': '278', 'journal-title': 'Arthritis Res Ther', 'key': 'B60', 'volume': '21', 'year': '2019'}, { 'DOI': '10.3389/fonc.2018.00659', 'article-title': 'The role of COL5A2 in patients with muscle-invasive bladder cancer: A ' 'bioinformatics analysis of public datasets involving 787 subjects and ' '29 cell lines', 'author': 'Meng', 'doi-asserted-by': 'publisher', 'journal-title': 'Front Oncol', 'key': 'B61', 'volume': '8', 'year': '2018'}, { 'DOI': '10.1186/1755-8794-6-13', 'article-title': 'Analysis of a gene co-expression network establishes robust association ' 'between Col5a2 and ischemic heart disease', 'author': 'Azuaje', 'doi-asserted-by': 'publisher', 'first-page': '13', 'journal-title': 'BMC Med Genomics', 'key': 'B62', 'volume': '6', 'year': '2013'}, { 'DOI': '10.3390/cancers13225809', 'article-title': 'The cardiac glycoside deslanoside exerts anticancer activity in ' 'prostate cancer cells by modulating multiple signaling pathways', 'author': 'Liu', 'doi-asserted-by': 'publisher', 'first-page': '5809', 'journal-title': 'Cancers (Basel)', 'key': 'B63', 'volume': '13', 'year': '2021'}, { 'DOI': '10.1152/ajplung.00538.2020', 'article-title': 'Enhanced epithelial sodium channel activity in neonatal Scnn1b mouse ' 'lung attenuates high oxygen-induced lung injury', 'author': 'Grant', 'doi-asserted-by': 'publisher', 'first-page': 'L29', 'journal-title': 'Am J Physiol Lung Cell Mol Physiol', 'key': 'B64', 'volume': '321', 'year': '2021'}, { 'DOI': '10.1016/j.bcp.2020.114100', 'article-title': 'Flavine adenine dinucleotide inhibits pathological cardiac hypertrophy ' 'and fibrosis through activating short chain acyl-CoA dehydrogenase', 'author': 'Ma', 'doi-asserted-by': 'publisher', 'first-page': '114100', 'journal-title': 'Biochem Pharmacol', 'key': 'B65', 'volume': '178', 'year': '2020'}, { 'DOI': '10.3109/15376516.2015.1045662', 'article-title': 'Riboflavin attenuates lipopolysaccharide-induced lung injury in rats', 'author': 'Al-Harbi', 'doi-asserted-by': 'publisher', 'journal-title': 'Toxicol Mech Methods', 'key': 'B66', 'volume': '25', 'year': '2015'}, { 'DOI': '10.1016/j.jconrel.2020.10.009', 'article-title': 'Ivermectin: an award-winning drug with expected antiviral activity ' 'against COVID-19', 'author': 'Formiga', 'doi-asserted-by': 'publisher', 'journal-title': 'J Control Release', 'key': 'B67', 'volume': '329', 'year': '2021'}, { 'DOI': '10.1007/s00011-011-0307-8', 'article-title': 'Anti-inflammatory effects of ivermectin in mouse model of allergic ' 'asthma', 'author': 'Yan', 'doi-asserted-by': 'publisher', 'journal-title': 'Inflammation Res', 'key': 'B68', 'volume': '60', 'year': '2011'}, { 'DOI': '10.1007/s00011-008-8007-8', 'article-title': 'Ivermectin inhibits LPS-induced production of inflammatory cytokines ' 'and improves LPS-induced survival in mice', 'author': 'Zhang', 'doi-asserted-by': 'publisher', 'journal-title': 'Inflammation Res', 'key': 'B69', 'volume': '57', 'year': '2008'}, { 'DOI': '10.1007/s00134-021-06431-0', 'article-title': 'Posaconazole for prevention of invasive pulmonary aspergillosis in ' 'critically ill influenza patients (POSA-FLU): a randomised, open-label, ' 'proof-of-concept trial', 'author': 'Vanderbeke', 'doi-asserted-by': 'publisher', 'journal-title': 'Intensive Care Med', 'key': 'B70', 'volume': '47', 'year': '2021'}, { 'DOI': '10.1080/14787210.2021.1962292', 'article-title': 'Pharmacological management of antifungal agents in pulmonary ' 'aspergillosis: an updated review', 'author': 'Echeverria-Esnal', 'doi-asserted-by': 'publisher', 'journal-title': 'Expert Rev Anti Infect Ther', 'key': 'B71', 'volume': '20', 'year': '2022'}], 'reference-count': 71, 'references-count': 71, 'relation': {}, 'resource': {'primary': {'URL': 'https://www.frontiersin.org/articles/10.3389/fimmu.2023.1197752/full'}}, 'score': 1, 'short-title': [], 'source': 'Crossref', 'subject': ['Immunology', 'Immunology and Allergy'], 'subtitle': [], 'title': 'Identification of the shared gene signatures between pulmonary fibrosis and pulmonary ' 'hypertension using bioinformatics analysis', 'type': 'journal-article', 'update-policy': 'http://dx.doi.org/10.3389/crossmark-policy', 'volume': '14'}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit