M-Motif, a potential non-conventional NLS in YAP/TAZ and other cellular and viral proteins that inhibits classic protein import
Michael Kofler, Shruthi Venugopal, Gary Gill, Caterina Di Ciano-Oliveira, András Kapus
iScience, doi:10.1016/j.isci.2025.112105
iScience M-Motif, a potential non-conventional NLS in YAP/ TAZ and other cellular and viral proteins that inhibits classic protein import
AUTHOR CONTRIBUTIONS M.K. participated in the conceptualization of the project, developed the experimental approaches, generated the majority of the reagents, designed, and performed the majority of the experiments, analyzed the results, and wrote iScience 28, 112105, April 18, 2025
DECLARATION OF INTERESTS The authors declare no competing interests.
STAR+METHODS Detailed methods are provided in the online version of this paper and include the following:
Cells Tissue culture media and reagents were from Thermo Fisher/Life Technologies. Culture media was supplemented with 10% fetal bovine serum and 1% penicillin/streptomycin, and cells were grown in a humidified atmosphere containing 5% CO2. LLC-PK1, a kidney tubule epithelial cell line (male) was a gift from R.C. Harris, Vanderbilt University School of Medicine and was cultured in low-glucose DMEM as described in. 58 HEK (HEK293T Cat# CRL-3216, RRID:CVCL_0063), a human epitheliallike embryonic kidney cell line (female) was a gift from Gagan Gupta (Toronto Metropolitan University). These cells were cultured in high-glucose DMEM. hTERT RPE cells, a Telomerase immortalized human retina pigmented epithelial cell line (female) were obtained from the American Type Culture Collection (ATCC Cat# CRL-4000, RRID:CVCL_4388). RPE cells were cultured in DMEM-F12. Where indicated, cells were treated with LMB (20 ng/ml), Rapamycin (1 nM), TNFa (20 ng/ml) or ivermectin (25 mM, or with indicated concentrations) for varying times..
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"short-title": [],
"source": "Crossref",
"subject": [],
"subtitle": [],
"title": "M-Motif, a potential non-conventional NLS in YAP/TAZ and other cellular and viral proteins that inhibits classic protein import",
"type": "journal-article",
"update-policy": "https://doi.org/10.1016/elsevier_cm_policy",
"volume": "28"
}
