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All Studies   Meta Analysis    Recent:   

SIT1 transporter as a potential novel target in treatment of COVID-19

Semiz, S., Biomolecular Concepts, doi:10.1515/bmc-2021-0017
Dec 2021  
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Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
 
*, now with p < 0.00000000001 from 105 studies, recognized in 23 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 95 treatments. c19ivm.org
Review of the potential connections between SLC6A20/SIT1, ACE2, Type 2 Diabetes, and COVID-19 severity. This provides another potential mechanism of action for ivermectin as a partial agonist of glycine-gated chloride channels, interfering with cytokine storm by inducing activation of glycine receptors. Author recommends investigating targeting of the SIT1 transporter and glycine levels in the treatment of COVID-19, particularly for severe cases associated with hyperglycemia, inflammation, and T2D.
Reviews covering ivermectin for COVID-19 include1-44.
Semiz et al., 30 Dec 2021, peer-reviewed, 1 author.
This PaperIvermectinAll
SIT1 transporter as a potential novel target in treatment of COVID-19
Sabina Semiz
Biomolecular Concepts, doi:10.1515/bmc-2021-0017
Studies published earlier this year demonstrated the association of the solute carrier SLC6A20 gene with the risk and severity of COVID-19. The SLC6A20 protein product (Sodium-dependent Imino Transporter 1 (SIT1)) is involved in the transport of amino acids, including glycine. Here we summarized the results of recent studies demonstrating the interaction of SIT1 with the ACE2 receptor for SARS-CoV-2 as well as an observed association of SLC6A20 with the risk and traits of Type 2 diabetes (T2D). Recently, it was also proposed that SLC6A20 represents the novel regulator of glycine levels and that glycine has beneficial effects against the proinflammatory cytokine secretion induced by SARS-CoV-2 infection. Ivermectin, as a partial agonist of glycine-gated chloride channels, was also recently suggested to interfere with the COVID-19 cytokine storm by inducing the activation of glycine receptors. Furthermore, plasma glycine levels are found to be decreased in diabetic patients. Thus, further clinical trials are warranted to confirm the potential favorable effects of targeting the SIT1 transporter and glycine levels in the treatment of COVID-19, particularly for the severe case of disease associated with hyperglycemia, inflammation, and T2D. These findings suggest that SIT1 may potentially represent one of the missing pieces in the complex puzzle observed between these two pandemic diseases and the potential novel target for their efficient treatment.
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Here we ' 'summarized the results of recent studies demonstrating the interaction of SIT1 with the ACE2 ' 'receptor for SARS-CoV-2 as well as an observed association of ' '<jats:italic>SLC6A20</jats:italic> with the risk and traits of Type 2 diabetes (T2D). ' 'Recently, it was also proposed that <jats:italic>SLC6A20</jats:italic> represents the novel ' 'regulator of glycine levels and that glycine has beneficial effects against the ' 'proinflammatory cytokine secretion induced by SARS-CoV-2 infection. Ivermectin, as a partial ' 'agonist of glycine-gated chloride channels, was also recently suggested to interfere with the ' 'COVID-19 cytokine storm by inducing the activation of glycine receptors. Furthermore, plasma ' 'glycine levels are found to be decreased in diabetic patients. Thus, further clinical trials ' 'are warranted to confirm the potential favorable effects of targeting the SIT1 transporter ' 'and glycine levels in the treatment of COVID-19, particularly for the severe case of disease ' 'associated with hyperglycemia, inflammation, and T2D. 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' '2004;42(2):277–88.'}], 'container-title': ['Biomolecular Concepts'], 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.degruyter.com/document/doi/10.1515/bmc-2021-0017/xml', 'content-type': 'application/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://www.degruyter.com/document/doi/10.1515/bmc-2021-0017/pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2021, 12, 30]], 'date-time': '2021-12-30T18:41:53Z', 'timestamp': 1640889713000}, 'score': 1, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 1, 1]]}, 'references-count': 92, 'journal-issue': { 'issue': '1', 'published-online': {'date-parts': [[2021, 2, 2]]}, 'published-print': {'date-parts': [[2021, 1, 1]]}}, 'alternative-id': ['10.1515/bmc-2021-0017'], 'URL': 'http://dx.doi.org/10.1515/bmc-2021-0017', 'relation': {}, 'ISSN': ['1868-503X', '1868-5021'], 'issn-type': [{'value': '1868-503X', 'type': 'electronic'}, {'value': '1868-5021', 'type': 'print'}], 'subject': [ 'Cellular and Molecular Neuroscience', 'General Biochemistry, Genetics and Molecular Biology', 'General Medicine'], 'published': {'date-parts': [[2021, 1, 1]]}}
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