Effectiveness of a multidrug therapy consisting of ivermectin, azithromycin, montelukast and acetylsalicylic acid to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico

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antioxidant therapy on endothelium-dependent coronary vasomotion", "author": "Anderson", "doi-asserted-by": "crossref", "first-page": "488", "issue": "February (8)", "journal-title": "N Engl J Med", "key": "10.1016/j.ijid.2021.02.014_bib0015", "volume": "332", "year": "1995" }, { "DOI": "10.1016/j.ijid.2020.06.099", "article-title": "Treatment with Hydroxychloroquine, Azithromycin, and combination in patients hospitalized with COVID-19", "author": "Arshad", "doi-asserted-by": "crossref", "first-page": "396", "issue": "August", "journal-title": "Int J Infect Dis", "key": "10.1016/j.ijid.2021.02.014_bib0020", "volume": "97", "year": "2020" }, { "DOI": "10.1016/j.phrs.2020.105250", "article-title": "Meta-analysis on outcome-worsening comorbidities of COVID-19 and related potential drug-drug interactions", "author": "Awortwe", "doi-asserted-by": "crossref", "journal-title": "Pharmacol Res", "key": "10.1016/j.ijid.2021.02.014_bib0025", "year": "2020" }, { "article-title": "COVID-19 treatment in patients with comorbidities: Awareness of drug–drug interactions", "author": "Back", "issue": "May", "journal-title": "Br J Clin Pharmacol", "key": "10.1016/j.ijid.2021.02.014_bib0030", "year": "2020" }, { "DOI": "10.1016/S1473-3099(20)30195-X", "article-title": "Real estimates of mortality following COVID-19 infection", "author": "Baud", "doi-asserted-by": "crossref", "first-page": "773", "issue": "July (7)", "journal-title": "Lancet Infect Dis", "key": "10.1016/j.ijid.2021.02.014_bib0035", "volume": "20", "year": "2020" }, { "article-title": "Remdesivir for the treatment of Covid-19—Preliminary report", "author": "Beigel", "issue": "May", "journal-title": "N Engl J Med", "key": "10.1016/j.ijid.2021.02.014_bib0040", "year": "2020" }, { "article-title": "Is acetylsalicylic acid a safe and potentially useful choice for adult patients with cOVID-19?", "author": "Bianconi", "first-page": "1", "issue": "July", "journal-title": "Drugs", "key": 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Documentos", "year": "2016" }, { "DOI": "10.1002/cpt.1857", "article-title": "Clinical pharmacology perspectives on the antiviral activity of azithromycin and use in COVID-19", "author": "Damle", "doi-asserted-by": "crossref", "first-page": "201", "issue": "August (2)", "journal-title": "Clin Pharmacol Ther", "key": "10.1016/j.ijid.2021.02.014_bib0090", "volume": "108", "year": "2020" }, { "article-title": "Anti–tumor necrosis factor-α treatment improves endothelial function in patients with rheumatoid arthritis", "author": "David", "first-page": "2184", "issue": "October (17)", "journal-title": "Circulation", "key": "10.1016/j.ijid.2021.02.014_bib0095", "volume": "106", "year": "2002" }, { "DOI": "10.1016/S2213-2600(20)30116-8", "article-title": "Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?", "author": "Fang", "doi-asserted-by": "crossref", "first-page": "e21", "journal-title": "Lancet Resp Med", "key": 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"journal-title": "Circulation", "key": "10.1016/j.ijid.2021.02.014_bib0115", "volume": "117", "year": "2008" }, { "DOI": "10.5582/bst.2020.01047", "article-title": "Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies", "author": "Gao", "doi-asserted-by": "crossref", "first-page": "72", "issue": "March (1)", "journal-title": "Biosci Trends", "key": "10.1016/j.ijid.2021.02.014_bib0120", "volume": "14", "year": "2020" }, { "author": "Gobierno de México", "first-page": "1", "key": "10.1016/j.ijid.2021.02.014_bib0125", "series-title": "Datos Abiertos de México — Información Referente a Casos COVID-19 en México – Bases de Datos COVID-19", "year": "2020" }, { "DOI": "10.1056/NEJMoa2002032", "article-title": "Clinical characteristics of coronavirus disease 2019 in China", "author": "Guan", "doi-asserted-by": "crossref", "first-page": "1708", "issue": "February (18)", "journal-title": "N Engl J Med", "key": "10.1016/j.ijid.2021.02.014_bib0130", "volume": "382", "year": "2020" }, { "DOI": "10.1016/j.bjid.2020.06.002", "article-title": "Ivermectin: Potential candidate for the treatment of Covid 19", "author": "Gupta", "doi-asserted-by": "crossref", "journal-title": "Braz J Infect Dis", "key": "10.1016/j.ijid.2021.02.014_bib0135", "year": "2020" }, { "DOI": "10.1016/S0140-6736(20)30183-5", "article-title": "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China", "author": "Huang", "doi-asserted-by": "crossref", "first-page": "497", "issue": "February (10223)", "journal-title": "Lancet", "key": "10.1016/j.ijid.2021.02.014_bib0140", "volume": "395", "year": "2020" }, { "DOI": "10.1016/S0140-6736(20)31042-4", "article-title": "Triple combination of interferon beta-1b, lopinavir–2013; ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: An open-label, randomised, phase 2 trial", "author": "Hung", "doi-asserted-by": "crossref", "first-page": "1695", "issue": "May (10238)", "journal-title": "Lancet", "key": "10.1016/j.ijid.2021.02.014_bib0145", "volume": "395", "year": "2020" }, { "DOI": "10.22159/ajpcr.2020.v13i8.38357", "article-title": "A review on the antiparasitic drug ivermectin for various viral infections and possibilities of using it for novel Severe Acute Respiratory Syndrome Coronavirus 2: New hope to treat coronavirus disease-2019", "author": "Jabeen", "doi-asserted-by": "crossref", "first-page": "21", "issue": "June", "journal-title": "Asian J Pharm Clin Res", "key": "10.1016/j.ijid.2021.02.014_bib0150", "volume": "13", "year": "2020" }, { "DOI": "10.12688/f1000research.26707.1", "article-title": "The worldwide clinical trial research response to the COVID-19 pandemic — The first 100 days", "author": "Janiaud", "doi-asserted-by": "crossref", "first-page": "1193", "journal-title": "F1000Research", "key": "10.1016/j.ijid.2021.02.014_bib0155", "volume": "9", "year": "2020" }, { "DOI": "10.1016/j.jmii.2020.03.034", "article-title": "Treatment options for COVID-19: The reality and challenges", "author": "Jean", "doi-asserted-by": "crossref", "first-page": "436", "issue": "June (3)", "journal-title": "J Microbiol Immunol Infect", "key": "10.1016/j.ijid.2021.02.014_bib0160", "volume": "53", "year": "2020" }, { "article-title": "SARS-CoV-2 infection-induced immune responses: Friends or foes?", "author": "Li", "issue": "August (2)", "journal-title": "Scand J Immunol", "key": "10.1016/j.ijid.2021.02.014_bib0165", "volume": "92", "year": "2020" }, { "article-title": "Understanding severe acute respiratory syndrome coronavirus 2 replication to design efficient drug combination therapies", "author": "Ortega", "first-page": "1", "issue": "October", "journal-title": "Intervirology", "key": "10.1016/j.ijid.2021.02.014_bib0170", "year": "2020" }, { "DOI": "10.1016/j.ijantimicag.2020.106053", "article-title": "Macrolides and viral infections: Focus on Azithromycin in COVID-19 pathology", "author": "Pani", "doi-asserted-by": "crossref", "first-page": "106053", "journal-title": "Int J Antimicrob Agents", "key": "10.1016/j.ijid.2021.02.014_bib0175", "volume": "56", "year": "2020" }, { "DOI": "10.1016/j.cellsig.2020.109721", "article-title": "Drugs targeting various stages of the SARS-CoV-2 life cycle: Exploring promising drugs for the treatment of Covid-19", "author": "Poduri", "doi-asserted-by": "crossref", "first-page": "109721", "issue": "October", "journal-title": "Cell Signal", "key": "10.1016/j.ijid.2021.02.014_bib0180", "volume": "74", "year": "2020" }, { "article-title": "Antiviral and anti-inflammatory of Ivermectin and its potential use in COVID-19", "author": "Portmann-Baracco", "journal-title": "Arch Bronchomeunol", "key": "10.1016/j.ijid.2021.02.014_bib0185", "year": "2020" }, { "article-title": "ICON (Ivermectin in COvid Nineteen) study: Use of Ivermectin is associated with lower mortality in hospitalized patients with COVID19", "author": "Rajter", "issue": "January", "journal-title": "medRxiv", "key": "10.1016/j.ijid.2021.02.014_bib0190", "year": "2020" }, { "DOI": "10.1001/jama.2020.8630", "article-title": "Association of treatment with Hydroxychloroquine or Azithromycin with in-hospital mortality in patients with COVID-19 in New York State", "author": "Rosenberg", "doi-asserted-by": "crossref", "first-page": "2493", "issue": "June (24)", "journal-title": "JAMA", "key": "10.1016/j.ijid.2021.02.014_bib0195", "volume": "323", "year": "2020" }, { "article-title": "Pharmacologic treatments for coronavirus disease 2019 (COVID-19): A review", "author": "Sanders", "issue": "April", "journal-title": "JAMA", "key": "10.1016/j.ijid.2021.02.014_bib0200", "year": "2020" }, { "author": "Secretaría de Salud", "key": "10.1016/j.ijid.2021.02.014_bib0205", "series-title": "NORMA Oficial Mexicana NOM-017-SSA2-2012", "year": "2013" }, { "author": "Secretaría de Salud-Gobierno de México", "key": "10.1016/j.ijid.2021.02.014_bib0210", "series-title": "Lineamiento Estandarizado para la Vigilancia Epidemiológica y por Laboratorio de la Enfermedad Respiratoria Viral", "year": "2020" }, { "DOI": "10.1097/00004872-199816040-00006", "article-title": "Effects of angiotensin converting enzyme inhibition on endothelium-dependent vasodilatation in essential hypertensive patients", "author": "Taddei", "doi-asserted-by": "crossref", "first-page": "447", "issue": "April (4)", "journal-title": "J Hypertens", "key": "10.1016/j.ijid.2021.02.014_bib0215", "volume": "16", "year": "1998" }, { "DOI": "10.1111/jth.14768", "article-title": "Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia", "author": "Tang", "doi-asserted-by": "crossref", "first-page": "844", "issue": "April (4)", "journal-title": "J Thromb Haemost", "key": "10.1016/j.ijid.2021.02.014_bib0220", "volume": "18", "year": "2020" }, { "article-title": "An update on COVID-19 pandemic: The epidemiology, pathogenesis, prevention and treatment strategies", "author": "Tsang", "first-page": "1", "issue": "December", "journal-title": "Expert Rev Anti Infect Ther", "key": "10.1016/j.ijid.2021.02.014_bib0225", "year": "2020" }, { "DOI": "10.1016/S0140-6736(20)30937-5", "article-title": "Endothelial cell infection and endotheliitis in COVID-19", "author": "Varga", "doi-asserted-by": "crossref", "first-page": "1417", "issue": "May (10234)", "journal-title": "Lancet (London, England)", "key": "10.1016/j.ijid.2021.02.014_bib0230", "volume": "395", "year": "2020" }, { "DOI": "10.1016/j.phrs.2020.104950", "article-title": "Enhanced platelet inhibition treatment improves hypoxemia in patients with severe Covid-19 and hypercoagulability. 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