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0 0.5 1 1.5 2+ Adjusted risk of viral+ at.. 64% Improvement Relative Risk ∆Spo2 (unadjusted) 41% Viral clearance 58% Viral clearance (b) 40% Time to viral- 49% primary Time to viral- (b) 34% Babalola et al. Ivermectin for COVID-19 RCT EARLY Is early treatment with ivermectin beneficial for COVID-19? Double-blind RCT 60 patients in Nigeria Trial compares with lopinavir/ritonavir, results vs. placebo may differ Improved viral clearance (p=0.11) and recovery (p=0.073), not stat. sig. Babalola et al., QJM: An Int. J. Medicine, doi:10.1093/qjmed/hcab035 Favors ivermectin Favors lopinavir/ri..

Ivermectin shows clinical benefits in mild to moderate COVID19: A randomised controlled double-blind, dose-response study in Lagos

Babalola et al., QJM: An International Journal of Medicine, doi:10.1093/qjmed/hcab035 (date from earlier preprint)
Babalola et al., Ivermectin shows clinical benefits in mild to moderate COVID19: A randomised controlled double-blind,.., QJM: An International Journal of Medicine, doi:10.1093/qjmed/hcab035 (date from earlier preprint)
Jan 2021   Source   PDF  
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Small RCT comparing ivermectin 6mg & 12mg q84hr with lopinavir/ritonavir, showing a statistically significant and dose dependent effect of ivermectin on reducing the time to PCR-.
The study does not report mortality, hospitalization, progression, recovery, etc. The paper does report change in SpO2 (Figure 3, ∆SpO2), where a similar improvement with a smaller p value is seen with ivermectin, however this result is unadjusted and there are large differences between groups. Specifically, baseline SpO2 is lower in the control group, giving the control group more room to improve, therefore the actual benefit of ivermectin is likely to be even larger than the benefit in ∆SpO2 shown.
See also [].
This is the 10th of 46 COVID-19 RCTs for ivermectin, which collectively show efficacy with p=0.00000014.
This is the 29th of 97 COVID-19 controlled studies for ivermectin, which collectively show efficacy with p<0.0000000001 (1 in 2 sextillion).
adjusted risk of viral+ at day 5, 63.9% lower, RR 0.36, p = 0.11, treatment 40, control 20, adjusted per study, inverted to make RR<1 favor treatment.
relative ∆SpO2 (unadjusted), 41.5% better, RR 0.59, p = 0.07, treatment 38, control 18, figure 3.
risk of no viral clearance, 58.0% lower, HR 0.42, p = 0.01, treatment 20, control 20, inverted to make HR<1 favor treatment, 12mg - Cox proportional hazard model.
risk of no viral clearance, 40.5% lower, HR 0.60, p = 0.12, treatment 20, control 20, inverted to make HR<1 favor treatment, 6mg - Cox proportional hazard model.
time to viral-, 49.2% lower, relative time 0.51, p = 0.02, treatment 20, control 20, 12mg, primary outcome.
time to viral-, 34.4% lower, relative time 0.66, p = 0.08, treatment 20, control 20, 6mg.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Babalola et al., 6 Jan 2021, Double Blind Randomized Controlled Trial, Nigeria, peer-reviewed, baseline oxygen required 8.3%, 10 authors, dosage 12mg or 6mg q84h for two weeks, this trial compares with another treatment - results may be better when compared to placebo.
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Ivermectin shows clinical benefits in mild to moderate COVID19: a randomized controlled double-blind, dose-response study in Lagos
Prof O E Babalola, C O Bode, A A Ajayi, F M Alakaloko, I E Akase, E Otrofanowei, O B Salu, W L Adeyemo, A O Ademuyiwa, S Omilabu
QJM: An International Journal of Medicine, doi:10.1093/qjmed/hcab035
Introduction: In vitro studies have shown the efficacy of Ivermectin (IV) to inhibit the SARS-CoV-2 viral replication, but questions remained as to in-vivo applications. We set out to explore the efficacy and safety of Ivermectin in persons infected with COVID19. Methods: We conducted a translational proof of concept randomized, double blind placebo controlled, dose response and parallel group study of IV efficacy in RT-polymerase chain reaction proven COVID 19 positive patients. Sixty-two patients were randomized to three treatment groups. (A) IV 6 mg regime, (B) IV 12 mg regime (given Q84 h for 2 weeks) (C, control) Lopinavir/Ritonavir. All groups plus standard of Care. Results: The Days to COVID negativity (DTN) was significantly and dose dependently reduced by IV (P ¼ 0.0066). The DTN for Control were, ¼ 9.1þ/-5.2, for A 6.0 þ/-2.9 and for B 4.6 þ/-3.2. Two way repeated measures ANOVA of ranked COVID 19 þ/scores at 0, 84, 168 and252h showed a significant IV treatment effect (P ¼ 0.035) and time effect (P < 0.0001). IV also tended to increase SPO2% compared to controls, P ¼ 0.073, 95% CI-0.39 to 2.59 and increased platelet count compared to C (P ¼ 0.037) 95%CI 5.55-162.55 Â 10 3 /ml. The platelet count increase was inversely correlated to DTN (r ¼ -0.52, P ¼ 0.005). No SAE was reported.
Conflict of interest. None declared.
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