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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Symptoms 96% Improvement Relative Risk Viral load 95% Viral clearance 8% primary c19ivm.org Chaccour et al. NCT04390022 Ivermectin RCT EARLY TREATMENT Favors ivermectin Favors control
The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with non-severe COVID-19: A pilot, double-blind, placebo-controlled, randomized clinical trial
Chaccour et al., EClinicalMedicine, doi:10.1016/j.eclinm.2020.100720 (date from earlier preprint), NCT04390022 (history)
7 Dec 2020    Source   PDF   Share   Tweet
Tiny RCT for early treatment of mild COVID-19 in low risk patients, with 12 400mcg/kg single dose ivermectin patients and 12 control patients, showing significantly faster viral load reduction and symptom improvement with ivermectin. Average median viral load for gene E and gene N mid-viral recovery at day 7: Ivermectin: 1637, control: 30175 (supplementary appendix). NCT04390022 (history).
See also: [doyourownresearch.substack.com].
risk of symptoms, 96.0% lower, OR 0.04, p < 0.05, treatment 12, control 12, logistic regression, chance of presenting any symptom, RR approximated with OR.
viral load, 94.6% lower, relative load 0.05, p < 0.01, treatment 12, control 12, day 7 mid-recovery, average of gene E and gene N, data in supplementary appendix.
risk of no viral clearance, 8.0% lower, RR 0.92, p = 1.00, treatment 12, control 12, primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chaccour et al., 7 Dec 2020, Double Blind Randomized Controlled Trial, Spain, peer-reviewed, 23 authors, average treatment delay 1.0 days, dosage 400μg/kg single dose, trial NCT04390022 (history).
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