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0 0.5 1 1.5 2+ Mortality 71% Improvement Relative Risk Hospitalization time 42% Recovery 71% primary c19ivm.org Gorial et al. Ivermectin for COVID-19 LATE TREATMENT Is late treatment with ivermectin beneficial for COVID-19? Retrospective 87 patients in Iraq Shorter hospitalization with ivermectin (p=0.00005) Gorial et al., medRxiv, doi:10.1101/2020.07.07.20145979 Favors ivermectin Favors control
Effectiveness of Ivermectin as add-on Therapy in COVID-19 Management (Pilot Trial)
Gorial et al., medRxiv, doi:10.1101/2020.07.07.20145979 (Preprint)
Gorial et al., Effectiveness of Ivermectin as add-on Therapy in COVID-19 Management (Pilot Trial), medRxiv, doi:10.1101/2020.07.07.20145979 (Preprint)
Jul 2020   Source   PDF  
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Small trial of hospitalized patients with 16 of 87 patients being treated with ivermectin, showing a significantly lower mean hospital stay with ivermectin: 7.62 vs. 13.22 days, p=0.00005. 0 of 16 ivermectin patients died vs. 2 of 71 control patients.
risk of death, 71.0% lower, RR 0.29, p = 1.00, treatment 0 of 16 (0.0%), control 2 of 71 (2.8%), NNT 36, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
hospitalization time, 42.0% lower, relative time 0.58, p < 0.001, treatment 16, control 71.
risk of no recovery, 71.0% lower, RR 0.29, p = 1.00, treatment 0 of 16 (0.0%), control 2 of 71 (2.8%), NNT 36, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Gorial et al., 8 Jul 2020, retrospective, Iraq, preprint, 9 authors, dosage 200μg/kg single dose.
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This PaperIvermectinAll
Abstract: medRxiv preprint doi: https://doi.org/10.1101/2020.07.07.20145979; this version posted July 8, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license . Effectiveness of Ivermectin as add-on Therapy in COVID-19 Management (Pilot Trial) Faiq I Gorial 1*, Sabeeh Mashhadani 2 , Hend M Sayaly 3, Basim Dhawi Dakhil 4, Marwan M.AlMashhadani5 , Adnan M Aljabory 6 , Hassan M Abbas 7 , Mohammed Ghanim 8, Jawad I Rasheed 9 1, 2, 6 Department of Medicine, College of Medicine, University of Baghdad, Baghdad, Iraq 3,4,5,7,8,9 Medical City Teaching Hospital, Baghdad, Iraq • Corresponding author email: faiqig@gmail.com Abstract Background: To date no effective therapy has been demonstrated for COVID-19. In vitro, studies indicated that ivermectin (IVM) has antiviral effect. Objectives: To assess the effectiveness of ivermectin (IVM) as add-on therapy to hydroxychloroquine (HCQ) and azithromycin (AZT) in treatment of COVID-19. Methods: This Pilot clinical trial conducted on hospitalized adult patients with mild to moderate COVID-19 diagnosed according to WHO interim guidance. Sixteen Patients received a single dose of IVM 200Mcg /kg on admission day as add on therapy to hydroxychloroquine ( HCQ)and Azithromycin (AZT) and were compared with 71 controls received HCQ and AZT matched in age, gender, clinical features, and comorbidities. The primary outcome was percentage of cured patients, defined as symptoms free to be discharged from the hospital and 2 consecutive negative PCR test from nasopharyngeal swabs at least 24 hours apart. The secondary outcomes were time to cure in both groups and evaluated by measuring time from admission of the patient to the hospital till discharge. Results: Of 87 patients included in the study,t he mean age ± SD (range) of patients in the IVM group was similar to controls [44.87 ± 10.64 (28-60) vs 45.23 ± 18.47 (8-80) years, p=0.78] Majority of patients in both groups were male but statistically not significant [11(69%) versus 52 (73%), with male: female ratio 2.21 versus 2.7-, p=0.72) All the patients of IVM group were cured compared with the controls [ 16 (100 %) vs 69 (97.2 %)]. Two patients died in the controls. The mean time to stay in the hospital was significantly lower in IVM group compared with the controls (7.62 ± 2.75 versus 13.22 ±5.90 days, p=0.00005, effect size= 0.82). No adverse events were observed Conclusions : Add-on use of IVM to HCQ and AZT had better effectiveness, shorter hospital stay, and relatively safe compared with controls. however, a larger prospective study with longer follow up may be needed to validate these results. Keywords: Ivermectin, hydroxychloroquine, azithromycin, COVID-19,
Late treatment
is less effective
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