Meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection
Dr Andrew Hill, Ahmed S Abdulamir, Sabeena Ahmed, Asma Asghar, Olufemi Emmanuel Babalola, Rabia Basri, Carlos Chaccour, Aijaz Zeeshan Khan Chachar, Abu Tauib Mohammed Chowdhury, Ahmed Elgazzar, Leah Ellis, Jonathan Falconer, Anna Garratt, Basma M Hany, Hashim A Hashim, Wasim Ul Haque, Arshad Hayat, Shuixiang He, Ramin Jamshidian, Wasif Ali Khan, Ravi Kirti, Alejandro Krolewiecki, Carlos Lanusse, Jacob Levi, Reaz Mahmud, Sermand Ahmed Mangat, Kaitlyn Mccann, Anant Mohan, Mortezza Shakshi Niaee, Nurullah Okumus, Victoria Pilkington, Chinmay Saha Podder, Ambar Qavi, Houssam Raad, Mohammaed Sadegh Rezai, Surapaneni Sasank, Veerapaneni Spoorthi, Tejas Suri, Junzheng Wang, Hannah Wentzel
doi:10.21203/rs.3.rs-148845/v1
Forum Infectious Diseases published a version of this preprint. The authors subsequently learned that one of the studies on which this analysis was based had been withdrawn due to fraudulent data. An expression of concern was issued on August 9, 2021.
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doi:10.1073/pnas.052713799{ 'institution': [{'name': 'Research Square'}],
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'posted': {'date-parts': [[2021, 1, 19]]},
'group-title': 'In Review',
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'abstract': '<title>Abstract</title>\n'
' <p>Ivermectin is an antiparasitic drug being investigated for repurposing to '
'SARS-CoV-2. In-vitro, ivermectin showed limited antiviral activity and a COVID-19 animal '
'model demonstrated pathological benefits but no effect on viral RNA. This meta-analysis '
'investigated ivermectin in 18 randomized clinical trials (2282 patients) identified through '
'systematic searches of PUBMED, EMBASE, MedRxiv and trial registries. Ivermectin was '
'associated with reduced inflammatory markers (C-Reactive Protein, d-dimer and ferritin) and '
'faster viral clearance by PCR. Viral clearance was treatment dose- and duration-dependent. In '
'six randomized trials of moderate or severe infection, there was a 75% reduction in mortality '
'(Relative Risk=0.25 [95%CI 0.12-0.52]; p=0.0002); 14/650 (2.1%) deaths on ivermectin; 57/597 '
'(9.5%) deaths in controls) with favorable clinical recovery and reduced hospitalization. Many '
'studies included were not peer reviewed and meta-analyses are prone to confounding issues. '
'Ivermectin should be validated in larger, appropriately controlled randomized trials before '
'the results are sufficient for review by regulatory authorities.</p>',
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