Meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection
et al., Research Square, doi:10.21203/rs.3.rs-148845/v1 (Preprint) (meta analysis)
, Meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection, Research Square, doi:10.21203/rs.3.rs-148845/v1 (Preprint) (meta analysis)
Meta analysis of 18 ivermectin RCTs with 2,282 patients showing faster viral clearance (dose and duration dependent), improved clinical recovery, and lower hospitalization and mortality. In six RCTs of moderate or severe infection, there was a 75% reduction in mortality, RR 0.25 [0.12-0.52], p = 0.0002.A documentary about the external influences changing the conclusions of this study, and the resulting negative impacts, can be found at [drtesslawrie.substack.com].A sponsor reportedly required the conclusion of this paper to be changed against the wishes of the authors (to suggest that more trials should be done as opposed to the existing evidence being sufficient) [francesoir.fr, reddit.com, youtube.com]. Reportedly, Unitaid had influence over the conclusions [trialsitenews.com, worldcouncilforhealth.org]. See also [roundingtheearth.substack.com].Note that one of the 18 studies in this analysis has since been withdrawn (Elgazzar).Currently there are 97 ivermectin studies and meta analysis shows:
| Outcome | Improvement |
|---|---|
| Mortality | 51% lower [37‑61%] |
| Ventilation | 29% lower [13‑42%] |
| ICU admission | 41% lower [16‑58%] |
| Hospitalization | 34% lower [20‑45%] |
| Cases | 81% fewer [71‑87%] |
|
risk of death, 75.0% lower, RR 0.25, p < 0.001.
|
| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Hill et al., 19 Jan 2021, preprint, 40 authors.
Meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection
doi:10.21203/rs.3.rs-148845/v1
Forum Infectious Diseases published a version of this preprint. The authors subsequently learned that one of the studies on which this analysis was based had been withdrawn due to fraudulent data. An expression of concern was issued on August 9, 2021.
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