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All Studies   Meta Analysis    Recent:   

Meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection

Hill et al., Research Square, doi:10.21203/rs.3.rs-148845/v1
Jan 2021  
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Mortality 75% Improvement Relative Risk Ivermectin for COVID-19  Hill et al.  META ANALYSIS c19ivm.org Favorsivermectin Favorscontrol 0 0.5 1 1.5 2+
Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
 
*, now with p < 0.00000000001 from 104 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19ivm.org
Meta analysis of 18 ivermectin RCTs with 2,282 patients showing faster viral clearance (dose and duration dependent), improved clinical recovery, and lower hospitalization and mortality. In six RCTs of moderate or severe infection, there was a 75% reduction in mortality, RR 0.25 [0.12-0.52], p = 0.0002.
A documentary about the external influences changing the conclusions of this study, and the resulting negative impacts, can be found at1.
A sponsor reportedly required the conclusion of this paper to be changed against the wishes of the authors (to suggest that more trials should be done as opposed to the existing evidence being sufficient)2-4. Reportedly, Unitaid had influence over the conclusions5,6. See also7.
Note that one of the 18 studies in this analysis has since been withdrawn (Elgazzar).
7 meta analyses show significant improvements with ivermectin for mortality8-13, hospitalization14, recovery10, and cases10.
Currently there are 104 ivermectin for COVID-19 studies, showing 48% lower mortality [35‑59%], 35% lower ventilation [17‑50%], 40% lower ICU admission [12‑58%], 34% lower hospitalization [21‑44%], and 81% fewer cases [71‑87%].
risk of death, 75.0% lower, RR 0.25, p < 0.001.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hill et al., 19 Jan 2021, preprint, 40 authors.
This PaperIvermectinAll
Meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection
Dr Andrew Hill, Ahmed S Abdulamir, Sabeena Ahmed, Asma Asghar, Olufemi Emmanuel Babalola, Rabia Basri, Carlos Chaccour, Aijaz Zeeshan Khan Chachar, Abu Tauib Mohammed Chowdhury, Ahmed Elgazzar, Leah Ellis, Jonathan Falconer, Anna Garratt, Basma M Hany, Hashim A Hashim, Wasim Ul Haque, Arshad Hayat, Shuixiang He, Ramin Jamshidian, Wasif Ali Khan, Ravi Kirti, Alejandro Krolewiecki, Carlos Lanusse, Jacob Levi, Reaz Mahmud, Sermand Ahmed Mangat, Kaitlyn Mccann, Anant Mohan, Mortezza Shakshi Niaee, Nurullah Okumus, Victoria Pilkington, Chinmay Saha Podder, Ambar Qavi, Houssam Raad, Mohammaed Sadegh Rezai, Surapaneni Sasank, Veerapaneni Spoorthi, Tejas Suri, Junzheng Wang, Hannah Wentzel
doi:10.21203/rs.3.rs-148845/v1
Forum Infectious Diseases published a version of this preprint. The authors subsequently learned that one of the studies on which this analysis was based had been withdrawn due to fraudulent data. An expression of concern was issued on August 9, 2021.
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Kirti, Low Low Low Low Low Low Good
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This meta-analysis ' 'investigated ivermectin in 18 randomized clinical trials (2282 patients) identified through ' 'systematic searches of PUBMED, EMBASE, MedRxiv and trial registries. Ivermectin was ' 'associated with reduced inflammatory markers (C-Reactive Protein, d-dimer and ferritin) and ' 'faster viral clearance by PCR. Viral clearance was treatment dose- and duration-dependent. In ' 'six randomized trials of moderate or severe infection, there was a 75% reduction in mortality ' '(Relative Risk=0.25 [95%CI 0.12-0.52]; p=0.0002); 14/650 (2.1%) deaths on ivermectin; 57/597 ' '(9.5%) deaths in controls) with favorable clinical recovery and reduced hospitalization. Many ' 'studies included were not peer reviewed and meta-analyses are prone to confounding issues. ' 'Ivermectin should be validated in larger, appropriately controlled randomized trials before ' 'the results are sufficient for review by regulatory authorities.</p>', 'DOI': '10.21203/rs.3.rs-148845/v1', 'type': 'posted-content', 'created': {'date-parts': [[2021, 1, 19]], 'date-time': '2021-01-19T19:56:12Z', 'timestamp': 1611086172000}, 'source': 'Crossref', 'is-referenced-by-count': 9, 'title': 'Meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection', 'prefix': '10.21203', 'author': [ { 'given': 'Andrew', 'family': 'Hill', 'sequence': 'first', 'affiliation': [{'name': 'University of Liverpool'}]}, { 'given': 'Ahmed', 'family': 'Abdulamir', 'sequence': 'additional', 'affiliation': [{'name': 'College of Medicine, Alnahrain University, Baghdad, Iraq'}]}, { 'given': 'Sabeena', 'family': 'Ahmed', 'sequence': 'additional', 'affiliation': [ { 'name': 'International Centre for Diarrhoeal Disease Research, Dhaka, ' 'Bangladesh,'}]}, { 'given': 'Asma', 'family': 'Asghar', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Medicine, Combined Military Hospital, Lahore, ' 'Pakistan'}]}, { 'given': 'Olufemi Emmanuel', 'family': 'Babalola', 'sequence': 'additional', 'affiliation': [{'name': 'Bingham University / Lagos University, Nigeria'}]}, { 'given': 'Rabia', 'family': 'Basri', 'sequence': 'additional', 'affiliation': [{'name': 'Fatima Memorial Hospital, Lahore, Pakistan'}]}, { 'given': 'Carlos', 'family': 'Chaccour', 'sequence': 'additional', 'affiliation': [ { 'name': 'Barcelona Institute for Global Health, Clinica Universidad de ' 'Navarra, Spain'}]}, { 'given': 'Aijaz Zeeshan Khan', 'family': 'Chachar', 'sequence': 'additional', 'affiliation': [{'name': 'Fatima Memorial Hospital, Lahore, Pakistan'}]}, { 'given': 'Abu Tauib Mohammed', 'family': 'Chowdhury', 'sequence': 'additional', 'affiliation': [ { 'name': "Xi'an Jiaotong University Medical College First Affiliated " 'Hospital, Shaannxi, China'}]}, { 'given': 'Ahmed', 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'Sciences, Patna, India'}]}, { 'given': 'Alejandro', 'family': 'Krolewiecki', 'sequence': 'additional', 'affiliation': [ { 'name': 'Instituto de Investigatiaciones de Enferedades Tropicales, Sede ' 'Regional Oran, Universidad National de Salta, Argentina'}]}, { 'given': 'Carlos', 'family': 'Lanusse', 'sequence': 'additional', 'affiliation': [ { 'name': 'Laboratorio de Farmacologia, Universidad de Buenos Aires, ' 'Argentina'}]}, { 'given': 'Jacob', 'family': 'Levi', 'sequence': 'additional', 'affiliation': [{'name': 'Department of Intensive Care, University College London, UK'}]}, { 'given': 'Reaz', 'family': 'Mahmud', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Neurology, Dhaka Medical College, Dhaka, ' 'Bangladesh'}]}, { 'given': 'Sermand Ahmed', 'family': 'Mangat', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Medicine, Combined Military Hospital, Lahore, ' 'Pakistan'}]}, { 'given': 'Kaitlyn', 'family': 'McCann', 'sequence': 'additional', 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