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A Case Series of 100 COVID-19 Positive Patients Treated with Combination of Ivermectin and Doxycycline

Alam et al., Journal of Bangladesh College of Physicians and Surgeons, doi:10.3329/jbcps.v38i0.47512
Jul 2020  
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Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
*, now known with p < 0.00000000001 from 103 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments.
Case study of 100 patients treated with ivermectin and doxycycline, with no ICU admission, deaths, or serious side effects reported.
Alam et al., 31 Jul 2020, preprint, 4 authors.
This PaperIvermectinAll
Ivermectin as Pre-exposure Prophylaxis for COVID-19 among Healthcare Providers in a Selected Tertiary Hospital in Dhaka – An Observational Study
Mohammed Tarek Alam, Rubaiul Murshed, Pauline Francisca Gomes, Zafor Md. Masud, Mainul Sadia Saber, Mainul Alam Chaklader, Fatema Khanam, Monower Hossain, Abdul Basit Ibne Momen Momen, Naz Yasmin, Rafa Faaria Alam, Amrin Sultana, Rishad Choudhury Robin
European Journal of Medical and Health Sciences, doi:10.24018/ejmed.2020.2.6.599
I. BACKGROUND Submerged in the wave of Coronavirus disease 2019 (COVID-19), the world is weeping. Ever since the outbreak was first identified in December 2019 in Wuhan, China the world has not been the same [1] . An ongoing pandemic, the COVID-19 has proved to be the most devastating and unmanageable crisis the world has ever encountered. With the virus proudly lurking around in the atmosphere, millions of lives have already been compromised and many more uncountable innocents are still fighting to survive this war against the invisible rival. The call for an authentic treatment protocol against this virus was made long before
Adedokun, Olarinmoye, Mustapha, Kamorudeen, A close look at the biology of SARS-CoV-2, and the potential influence of weather conditions and seasons on COVID-19 case spread, Infectious Diseases of Poverty
Alam, Murshed, Bhiuyan, Saber, Alam et al., Case Series of 100 COVID-19 Positive Patients Treatedwith Combination of Ivermectin and Doxycycline, Journal of Bangladesh College of Physicians and Surgeons
Azeem, Ashraf, Rasheed, Anjum, Hameed, Evaluation of cytotoxicity and antiviral activity of ivermectin against Newcastle disease virus, Pak J Pharm Sci
Baraka, Mahmoud, Marschke, Geary, Homeida et al., Ivermectin distribution in the plasma and tissues of patients infected with Onchocerca volvulus, Eur J Clin Pharmacol
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Msd, MECTIZAN Donation Program
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Satoshi, None
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{ 'DOI': '10.3329/jbcps.v38i0.47512', 'ISSN': ['1015-0870'], 'URL': '', 'abstract': '<jats:p>Background: A definitive treatment of SARS CoV-2 is yet to arrive and the human death ' 'toll rises exponentially globally. In this health emergency, it might be useful to look into ' 'the old therapies which could be effective against the virus. In vitro research showed ' 'Ivermectin could decrease the concentration of coronavirus 4000 to 5000 folds in living lung ' 'tissue.&#x0D;\n' 'Aim: In this prospective study a combination of Ivermectin and Doxycycline will be evaluated ' 'therapeutically to treat COVID-19 patients. Methods: 100 COVID-19 patients were enrolled in ' 'this study with a predefined inclusion and exclusion criteria. RT- PCR of the SERS-CoV-2 will ' 'be done at designated government hospitals. The clinical features and response to treatment ' 'were noted according to a dedicated protocol.&#x0D;\n' 'Results: In this study male and female were 64 and 36 respectively, the age ranged between 8 ' 'to 84 years. Retesting was done between 4 and 18 days of starting medication. All patients ' 'tested negative and their symptoms improved within 72 hours. There were no noticeable side ' 'effects.&#x0D;\n' 'Conclusion: Combination of Ivermectin and doxycycline was found to be very effective in viral ' 'clearance in mild and moderately sick COVID-19 patients. Medical societies and institutions ' 'should undertake larger multi center studies to validate and recommend this combination ' 'therapy to include in national guidelines.&#x0D;\n' 'J Bangladesh Coll Phys Surg 2020; 38(0): 10-15</jats:p>', 'author': [ {'affiliation': [], 'family': 'Alam', 'given': 'Mohammed Tarek', 'sequence': 'first'}, {'affiliation': [], 'family': 'Murshed', 'given': 'Rubaiul', 'sequence': 'first'}, {'affiliation': [], 'family': 'Bhiuyan', 'given': 'Elias', 'sequence': 'first'}, {'affiliation': [], 'family': 'Saber', 'given': 'Sadia', 'sequence': 'first'}, {'affiliation': [], 'family': 'Alam', 'given': 'Rafa Faaria', 'sequence': 'first'}, {'affiliation': [], 'family': 'Robin', 'given': 'Rishad Choudhury', 'sequence': 'first'}], 'container-title': 'Journal of Bangladesh College of Physicians and Surgeons', 'container-title-short': 'J. Bangladesh Coll. Phys.', 'content-domain': {'crossmark-restriction': False, 'domain': []}, 'created': {'date-parts': [[2020, 7, 31]], 'date-time': '2020-07-31T13:35:25Z', 'timestamp': 1596202525000}, 'deposited': { 'date-parts': [[2020, 7, 31]], 'date-time': '2020-07-31T13:35:32Z', 'timestamp': 1596202532000}, 'indexed': {'date-parts': [[2024, 5, 14]], 'date-time': '2024-05-14T18:02:15Z', 'timestamp': 1715709735109}, 'is-referenced-by-count': 36, 'issued': {'date-parts': [[2020, 6, 12]]}, 'link': [ { 'URL': '', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': '', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'member': '1861', 'original-title': [], 'page': '10-15', 'prefix': '10.3329', 'published': {'date-parts': [[2020, 6, 12]]}, 'published-online': {'date-parts': [[2020, 6, 12]]}, 'publisher': 'Bangladesh Journals Online (JOL)', 'reference-count': 0, 'references-count': 0, 'relation': {}, 'resource': {'primary': {'URL': ''}}, 'score': 1, 'short-title': [], 'source': 'Crossref', 'subject': [], 'subtitle': [], 'title': 'A Case Series of 100 COVID-19 Positive Patients Treated with Combination of Ivermectin and ' 'Doxycycline', 'type': 'journal-article'}
Late treatment
is less effective
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