69 residents of a French care home, median age 90, were treated with ivermectin for a scabies outbreak. 3,062 residents in 45 nearby comparable homes were used as controls. 7 of 69 treated patients had probable or certain COVID-19, with no serious cases and no deaths. In comparable care homes in the same district, matched by age and socio-economic level, there was 22.6% COVID-19 and 5% death.
This is the
23rd of 99 COVID-19 controlled studies for ivermectin, which collectively show efficacy with
p<0.0000000001 (1 in 2 sextillion).
46 studies are RCTs, which show efficacy with
p=0.00000014.
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risk of death, 99.4% lower, RR 0.006, p = 0.08, treatment 0 of 69 (0.0%), control 150 of 3,062 (4.9%), NNT 20, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
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risk of case, 55.1% lower, RR 0.45, p = 0.01, treatment 7 of 69 (10.1%), control 692 of 3,062 (22.6%), NNT 8.0.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Bernigaud et al., 28 Nov 2020, retrospective, France, peer-reviewed, 12 authors, dosage 200μg/kg days 1, 8, 15, 400μg/kg days 1, 8, 15, two different dosages.
C Bernigaud, D Guillemot, A Ahmed-Belkacem, L Grimaldi-Bensouda, A Lespine, F Berry, L Softic, C Chenost, G Do-Pham, B Giraudeau, S Fourati, O Chosidow, Ap-Hp Dermatologie
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