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0 0.5 1 1.5 2+ Mortality 99% Improvement Relative Risk Case 55% c19ivm.org Bernigaud et al. Ivermectin for COVID-19 Prophylaxis Favors ivermectin Favors control
Ivermectin benefit: from scabies to COVID-19, an example of serendipity
Bernigaud et al., Annals of Dermatology and Venereology, doi:10.1016/j.annder.2020.09.231
28 Nov 2020    Source   PDF   Share   Tweet
69 residents of a French care home, median age 90, were treated with ivermectin for a scabies outbreak. 3,062 residents in 45 nearby comparable homes were used as controls. 7 of 69 treated patients had probable or certain COVID-19, with no serious cases and no deaths. In comparable care homes in the same district, matched by age and socio-economic level, there was 22.6% COVID-19 and 5% death.
risk of death, 99.4% lower, RR 0.006, p = 0.08, treatment 0 of 69 (0.0%), control 150 of 3,062 (4.9%), NNT 20, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of case, 55.1% lower, RR 0.45, p = 0.01, treatment 7 of 69 (10.1%), control 692 of 3,062 (22.6%), NNT 8.0.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bernigaud et al., 28 Nov 2020, retrospective, France, peer-reviewed, 12 authors, dosage 200μg/kg days 1, 8, 15, 400μg/kg days 1, 8, 15, two different dosages.
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