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0 0.5 1 1.5 2+ Recovery at day 7 10% primary Improvement Relative Risk Ivermectin  Chachar et al.  LATE TREATMENT  RCT Is late treatment with ivermectin beneficial for COVID-19? RCT 50 patients in India Improved recovery with ivermectin (not stat. sig., p=0.5) Chachar et al., Int. J. Sciences-35, Sep 2020 Favors ivermectin Favors control

Effectiveness of Ivermectin in SARS-CoV-2/COVID-19 Patients

Chachar et al., International Journal of Sciences, 9:31-35, doi:10.18483/ijSci.2378
Sep 2020  
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Small RCT with 25 ivermectin and 25 control patients, not finding a significant difference in recovery at day 7.
This is the 5th of 46 COVID-19 RCTs for ivermectin, which collectively show efficacy with p=0.00000014.
This is the 9th of 99 COVID-19 controlled studies for ivermectin, which collectively show efficacy with p<0.0000000001 (1 in 2 sextillion).
risk of no recovery at day 7, 10.0% lower, RR 0.90, p = 0.50, treatment 9 of 25 (36.0%), control 10 of 25 (40.0%), NNT 25, primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chachar et al., 30 Sep 2020, Randomized Controlled Trial, India, peer-reviewed, 6 authors, dosage 36mg, 12mg stat, 12mg after 12 hours, 12mg after 24 hours.
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Effectiveness of Ivermectin in SARS-CoV-2/COVID-19 Patients
Aijaz Zeeshan Khan Chachar, Khurshid Ahmad Khan, Mohsin Asif, Khushbakht Tanveer, Arous Khaqan, Rabia Basri
International Journal of Sciences, doi:10.18483/ijsci.2378
Background:The first case of Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were diagnosed in Wuhan, China in 2019. In the first half of 2020 this disease has already converted into a global pandemic. Objectives: To assess the efficacy of Ivermectin in mild cases of COVID-19 patients on the basis of predefined assessment criteria. Study Settings: Fatima Memorial Hospital, Lahore Study Design: Open label randomized control trial. Duration of Study: From 1 st May, 2020 to 30 th June, 2020.Patients & Methods: Sample size and technique: Sample size was 50 patients; 25 patients were kept in control group and 25 patients were kept in experimental group. Results: There were total 50 patients, divided into two groups case and control group.The mean age of the participants was 40.60 ± 17 and out of those 31 (62%) were male and 19 (38%) were females. Cough was observed more in case group (p= 0.049). Fever, myalgias and dyspnea were the commonest symptoms in both the groups (p= 1.000). Diarrhea and vomiting were more common in control group (p=0.0001, p= 0.042 respectively). On follow up at day 7, patients were stratified as asymptomatic and symptomatic. Amongst the case group, out of 25 patients, 16(64%) patients were asymptomatic and rest of the 9(36%) patients was asymptomatic. In control group, out of 25 patients, 15(60%) patients were asymptomatic and rest of the 10(40%) patients was asymptomatic. p-value (0.500). Statistically there was no significant difference between case group who were given ivermectin along with symptomatic treatment and control group who were only given symptomatic treatment without ivermectin, being asymptomatic on day 7 at follow up. p-value (0.500
Bai, Yao, Wei, Tian, Jin et al., Presumed asymptomatic carrier transmission of COVID-19, Jama, doi:10.1001/jama.2020.2565
Caly, Druce, Catton, Jans, Wagstaff, The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro, Antiviral research, doi:10.1016/j.antiviral.2020.104787
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Lu, Stratton, Tang, Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle, Journal of medical virology, doi:10.1002/jmv.25678
Patel, Usefulness of Ivermectin in COVID-19 Illness, doi:10.1101/2020.06.06.20124461
Rajter, Sherman, Fatteh, Vogel, Sacks et al., ICON (Ivermectin in COvid Nineteen) study: Use of Ivermectin is Associated with Lower Mortality in Hospitalized Patients with COVID19, medRxiv, doi:10.26434/chemrxiv.11875446.v1
Sohrabi, Alsafi, Neill, Khan, Kerwan et al., World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19), International Journal of Surgery, doi:10.1016/j.ijsu.2020.03.036
Yavuz, Ünal, Antiviral treatment of COVID-19, Turkish Journal of Medical Sciences, doi:10.3906/sag-2004-145
Late treatment
is less effective
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