Sharp Reductions in COVID-19 Case Fatalities and Excess Deaths in Peru in Close Time Conjunction, State-By-State, with Ivermectin Treatments

{ 'indexed': {'date-parts': [[2023, 11, 1]], 'date-time': '2023-11-01T17:00:52Z', 'timestamp': 1698858052737}, 'reference-count': 119, 'publisher': 'Elsevier BV', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'DOI': '10.2139/ssrn.3765018', 'type': 'journal-article', 'created': {'date-parts': [[2021, 1, 22]], 'date-time': '2021-01-22T05:48:44Z', 'timestamp': 1611294524000}, 'source': 'Crossref', 'is-referenced-by-count': 6, 'title': 'Sharp Reductions in COVID-19 Case Fatalities and Excess Deaths in Peru in Close Time ' 'Conjunction, State-By-State, with Ivermectin Treatments', 'prefix': '10.2139', 'author': [ {'given': 'Juan', 'family': 'Chamie-Quintero', 'sequence': 'first', 'affiliation': []}, {'given': 'Jennifer', 'family': 'Hibberd', 'sequence': 'additional', 'affiliation': []}, {'given': 'David', 'family': 'Scheim', 'sequence': 'additional', 'affiliation': []}], 'member': '78', 'reference': [ { 'key': 'ref1', 'journal-title': 'Primer caso de coronavirus en Per�: Los detalles del contagio del ' 'piloto | PERU'}, { 'key': 'ref2', 'article-title': 'Ministerio De Salud', 'year': '2020', 'journal-title': 'Resolucion Ministerial #270-2020'}, { 'key': 'ref3', 'doi-asserted-by': 'publisher', 'first-page': '92', 'DOI': '10.1016/s2214-109x(19)30453-x', 'volume': '8', 'author': 'P Nicolas', 'year': '2020', 'journal-title': 'Safety of oral ivermectin during pregnancy: a systematic review and ' 'meta-analysis. The Lancet Global Health'}, { 'issue': '5', 'key': 'ref4', 'doi-asserted-by': 'publisher', 'first-page': '495', 'DOI': '10.1038/ja.2017.11', 'article-title': "Ivermectin: enigmatic multifaceted 'wonder' drug continues to surprise " 'and exceed expectations', 'volume': '70', 'author': 'A Crump', 'year': '2017', 'journal-title': 'J Antibiot (Tokyo)'}, { 'issue': '5', 'key': 'ref5', 'doi-asserted-by': 'publisher', 'DOI': '10.1371/journal.pntd.0003507', 'article-title': 'Growth, Challenges, and Solutions over 25 Years of Mectizan and the ' 'Impact on Onchocerciasis Control', 'volume': '9', 'author': 'J Lawrence', 'year': '2015', 'journal-title': 'PLoS Negl Trop Dis'}, { 'issue': '8', 'key': 'ref6', 'doi-asserted-by': 'publisher', 'first-page': '2236', 'DOI': '10.1016/j.xphs.2018.03.026', 'article-title': 'The Repurposing of Ivermectin for Malaria: A Prospective ' 'PharmacokineticsBased Virtual Clinical Trials Assessment of Dosing ' 'Regimen Options', 'volume': '107', 'author': 'R Badhan', 'year': '2018', 'journal-title': 'Journal of Pharmaceutical Sciences'}, { 'key': 'ref7', 'year': '1993', 'journal-title': 'Constituci�n Pol�tica Del Per�, 29 de diciembre de'}, { 'key': 'ref8', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.antiviral.2020.104787', 'article-title': 'The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 ' 'in vitro', 'volume': '178', 'author': 'L Caly', 'year': '2020', 'journal-title': 'Antiviral Res'}, { 'key': 'ref9', 'author': 'C Offord', 'year': '2020', 'journal-title': 'Surgisphere Sows Confusion About Another Unproven COVID-19 Drug. The ' 'Scientist'}, { 'issue': '1', 'key': 'ref10', 'doi-asserted-by': 'publisher', 'first-page': '469', 'DOI': '10.1080/13102818.2020.1775118', 'article-title': 'Ivermectin as a potential COVID-19 treatment from the pharmacokinetic ' 'point of view: antiviral levels are not likely attainable with known ' 'dosing regimens', 'volume': '34', 'author': 'G Momekov', 'year': '2020', 'journal-title': 'Biotechnology & Biotechnological Equipment'}, { 'issue': '4', 'key': 'ref11', 'doi-asserted-by': 'publisher', 'first-page': '762', 'DOI': '10.1002/cpt.1889', 'article-title': 'The Approved Dose of Ivermectin Alone is not the Ideal Dose for the ' 'Treatment of COVID-19', 'volume': '108', 'author': 'V D Schmith', 'year': '2020', 'journal-title': 'Clin Pharmacol Ther'}, { 'key': 'ref12', 'doi-asserted-by': 'publisher', 'author': 'C Chaccour', 'journal-title': 'The effect of early treatment with ivermectin on viral load, symptoms ' 'and humoral response in patients with non-severe COVID-19: A pilot, ' 'double-blind, placebo-controlled', 'DOI': '10.1016/j.eclinm.2020.100720'}, { 'key': 'ref13', 'year': '2020', 'journal-title': 'Watanabe Award Ceremony, presentation by Dr. Satoshi Omura, video ' 'segment beginning at 50:00'}, { 'key': 'ref14', 'article-title': 'Scheim and others, cc. Dr. Satoshi Omura, conveying this video greeting ' 'from Dr. Omura for a videoconference on ivermection for COVID-19 ' 'sponsored by Medincell', 'volume': '18', 'author': 'Satoshi Dr', 'year': '2020', 'journal-title': 'video segment beginning at 1:07. October'}, { 'key': 'ref15', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.chest.2020.10.009', 'article-title': 'Use of Ivermectin is Associated with Lower Mortality in Hospitalized ' 'Patients with COVID-19 (ICON study)', 'author': 'J C Rajter', 'year': '2020', 'journal-title': 'CHEST'}, { 'key': 'ref16', 'doi-asserted-by': 'publisher', 'DOI': '10.1101/2020.10.26.20219345', 'article-title': 'Controlled randomized clinical trial on using Ivermectin with ' 'Doxycycline for treating COVID-19 patients in Baghdad', 'author': 'H A Hashim', 'year': '2020', 'journal-title': 'Iraq. medRxiv'}, { 'key': 'ref17', 'doi-asserted-by': 'publisher', 'DOI': '10.21203/rs.3.rs-100956/v1', 'article-title': 'Efficacy and Safety of Ivermectin for Treatment and prophylaxis of ' 'COVID-19 Pandemic', 'author': 'A Elgzazzar', 'year': '2020', 'journal-title': 'Research Square'}, { 'key': 'ref18', 'doi-asserted-by': 'publisher', 'DOI': '10.21203/rs.3.rs-109670/v1', 'article-title': 'Ivermectin as an adjunct treatment for hospitalized adult COVID-19 ' 'patients; A randomized multi-center clinical trial', 'author': 'M S Niaee', 'year': '2020', 'journal-title': 'Research Square'}, { 'key': 'ref19', 'author': 'R Mahmud', 'year': '2020', 'journal-title': 'Clinical Trial of Ivermectin Plus Doxycycline for the Treatment of ' 'Confirmed Covid-19 Infection'}, { 'key': 'ref20', 'doi-asserted-by': 'publisher', 'DOI': '10.1101/2020.09.10.20191619', 'article-title': 'Safety and Efficacy of the combined use of ivermectin, dexamethasone, ' 'enoxaparin and aspirin against COVID-19', 'author': 'H E Carvallo', 'year': '2020', 'journal-title': 'medRxiv'}, { 'key': 'ref21', 'doi-asserted-by': 'publisher', 'author': 'F I Gorial', 'journal-title': 'Effectiveness of Ivermectin as add-on Therapy in COVID-19', 'DOI': '10.1101/2020.07.07.20145979'}, { 'key': 'ref22', 'doi-asserted-by': 'publisher', 'year': '2020', 'journal-title': 'Management (Pilot Trial). medRxiv', 'DOI': '10.1101/2020.07.07.20145979'}, { 'key': 'ref23', 'doi-asserted-by': 'publisher', 'DOI': '10.3329/jbcps.v38i0.47512', 'article-title': 'A Case Series of 100 COVID-19 Positive Patients Treated with ' 'Combination of Ivermectin and Doxycycline', 'volume': '38', 'author': 'M Alam', 'year': '2020', 'journal-title': 'Journal of Bangladesh College of Physicians and Surgeons'}, { 'key': 'ref24', 'author': 'A T Chowdhury', 'year': '2020', 'journal-title': 'A comparative study on Ivermectin-Doxycycline and ' 'Hydroxychloroquine-Azithromycin therapy on COVID19 patients'}, { 'issue': '5', 'key': 'ref25', 'first-page': '129', 'article-title': 'Effects of Ivermectin-azithromycin-cholecalciferol combined therapy on ' 'COVID-19 infected patients: A proof of concept study', 'volume': '31', 'author': 'G Espitia-Hernandez', 'year': '2020', 'journal-title': 'Biomedical Research'}, { 'key': 'ref26', 'author': 'W Shouman', 'journal-title': 'Use of Ivermectin as a Prophylactic Option in Asymptomatic Family Close ' 'Contacts with Patients of COVID-19 (NCT number: 04422561)'}, { 'key': 'ref27', 'doi-asserted-by': 'publisher', 'DOI': '10.20944/preprints202005.0020.v1', 'article-title': '2019-nCoV) Deactivation via Spike Glycoprotein Shielding by Old Drugs', 'author': 'M Dayer', 'year': '2020', 'journal-title': 'Bioinformatic Study. Preprints.org'}, { 'key': 'ref28', 'doi-asserted-by': 'publisher', 'DOI': '10.26434/chemrxiv.12630539.v1', 'article-title': 'A Combination of Ivermectin and Doxycycline Possibly Blocks the Viral ' 'Entry and Modulate the Innate Immune Response in COVID-19 Patients', 'author': 'D Maurya', 'year': '2020', 'journal-title': 'ChemRxiv'}, { 'issue': '1', 'key': 'ref29', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s13721-020-00263-6', 'article-title': 'Molecular docking suggests repurposing of brincidofovir as a potential ' 'drug targeting SARS-CoV-2 ACE2 receptor and main protease', 'volume': '9', 'author': 'M A Hussien', 'year': '2020', 'journal-title': 'Network Modeling Analysis in Health Informatics and Bioinformatics'}, { 'key': 'ref30', 'doi-asserted-by': 'publisher', 'DOI': '10.20944/preprints202005.0439.v2', 'article-title': 'Comparative Docking Studies on Curcumin with COVID-19 Proteins', 'author': 'R Suravajhala', 'year': '2020', 'journal-title': 'Preprints.org'}, { 'key': 'ref31', 'doi-asserted-by': 'publisher', 'DOI': '10.21203/rs.3.rs-31834/v1', 'article-title': 'Shortlisting Phytochemicals Exhibiting Inhibitory Activity against ' 'Major Proteins of SARS-CoV-2 through Virtual Screening', 'author': 'S Nallusamy', 'year': '2020', 'journal-title': 'Research Square'}, { 'issue': '5', 'key': 'ref32', 'doi-asserted-by': 'publisher', 'first-page': '3023', 'DOI': '10.21873/invivo.12134', 'article-title': 'Ivermectin Docks to the SARS-CoV-2 Spike Receptor-binding Domain ' 'Attached to ACE2', 'volume': '34', 'author': 'S Lehrer', 'year': '2020', 'journal-title': 'In Vivo'}, { 'key': 'ref33', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/07391102.2020.1824816:1-16', 'article-title': 'Repurposing of the approved small molecule drugs in order to inhibit ' 'SARS-CoV-2 S protein and human ACE2 interaction through virtual ' 'screening approaches', 'author': 'H Kalhor', 'year': '2020', 'journal-title': 'Journal of Biomolecular Structure and Dynamics'}, { 'key': 'ref34', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41577-020-00480-0', 'article-title': 'Viral targets for vaccines against COVID-19', 'author': 'L Dai', 'year': '2020', 'journal-title': 'Nature Reviews Immunology'}, { 'key': 'ref35', 'doi-asserted-by': 'publisher', 'DOI': '10.2139/ssrn.3706347', 'volume': '12', 'author': 'D Scheim', 'year': '2020', 'journal-title': 'From cold to killer: How SARS-CoV-2 evolved without hemagglutinin ' 'esterase to agglutinate, then clot blood cells in pulmonary and ' 'systemic microvasculature'}, { 'key': 'ref36', 'doi-asserted-by': 'publisher', 'first-page': '122', 'DOI': '10.1016/j.biologicals.2020.08.010', 'article-title': 'SARS-CoV-2 and the safety margins of cell-based biological medicinal ' 'products', 'volume': '68', 'author': 'J Modrof', 'year': '2020', 'journal-title': 'Biologicals'}, { 'key': 'ref37', 'doi-asserted-by': 'publisher', 'DOI': '10.1101/2020.05.20.20104398', 'article-title': 'Erythrocytes Reveal Complement Activation in Patients with COVID-19', 'author': 'L M Lam', 'year': '2020', 'journal-title': 'medRxiv'}, { 'issue': '11', 'key': 'ref38', 'doi-asserted-by': 'publisher', 'first-page': '2046', 'DOI': '10.1021/acscentsci.0c00855', 'article-title': 'The SARS-COV-2 Spike Protein Binds Sialic Acids and Enables Rapid ' 'Detection in a Lateral Flow Point of Care Diagnostic Device', 'volume': '6', 'author': 'A N Baker', 'year': '2020', 'journal-title': 'ACS Central Science'}, { 'key': 'ref39', 'journal-title': 'Mazzetti informa que se retirar� hidroxicloroquina de gu�a de ' 'tratamiento covid-19. Andina, Agencia Peruana de Noticias'}, { 'key': 'ref40', 'author': 'Carillo Rojas', 'journal-title': 'Grupo de m�dicos recomiendan descontinuar uso no supervisado de ' 'hidroxicloroquina e ivermectina'}, { 'key': 'ref41', 'volume': '2020', 'journal-title': 'Era insostenible: Minsa actualiza su gu�a de tratamiento Covid-19 y ' 'retira a hidroxicloroquina'}, { 'key': 'ref42', 'journal-title': 'Gobierno inicia Operaci�n TAYTA para proteger a la poblaci�n vulnerable ' 'ante COVID-19 en zonas de riesgo'}, { 'key': 'ref43', 'journal-title': 'Alcalde de Lima debe convocar a empresariado y gobierno para aplicar ' 'cercos familiares masivos; Lampadia'}, { 'key': 'ref44', 'author': 'A Yumbato', 'journal-title': 'Ivermectina: Testimonios de personas que utilizaron este medicamento en ' 'tiempo de coronavirus'}, { 'key': 'ref45', 'author': 'A Yumbato', 'journal-title': 'Coronavirus en Per�: Experiencia m�dica funcion� en pacientes peruanos'}, { 'key': 'ref46', 'journal-title': 'Se recuperaron: Cinco congresistas de Podemos Per� ya est�n ' 'pr�cticamente libres del COVID-19'}, { 'issue': '2020', 'key': 'ref47', 'article-title': 'Ivermectina: Lo que debes saber sobre este medicamento en tiempo de ' 'coronavirus', 'volume': '11', 'author': '�mpetu', 'journal-title': 'Pucallpa'}, { 'key': 'ref48', 'article-title': 'Polic�a asegura que f�rmaco lo sac� de cuadro cr�tico de COVID-19: ' 'Youtube', 'journal-title': 'Polic�a asegura que f�rmaco lo sac� de cuadro cr�tico de COVID-19. ' 'Panamericana Televisi�n. 2020/05/18'}, { 'key': 'ref49', 'article-title': 'Updated 2020/05/17. Accessed 12/29/2020. 55. Santa Cruz I. Testimonio ' 'del Sub Oficial Darvin Condezo', 'journal-title': 'Polic�a fil�ntropo con Covid19 cuenta su testimonio y recuperaci�n ' 'gracias a f�rmaco. Herson Alc�ntara'}, { 'key': 'ref50', 'author': 'M Leon', 'journal-title': 'No mata al COVID-19, pero lo detiene'}, { 'key': 'ref51', 'author': 'Exitosa Noticias -Noticias Del Peru Y El Mundo', 'journal-title': 'COVID-19: Dr. Mass� indic� en qu� momento es m�s efectiva consumir ' 'ivermectina'}, { 'key': 'ref52', 'journal-title': 'Ivermectina: crece la demanda de f�rmaco antiparasitario para casos de ' 'covid-19. Realidad.pe | Noticias relevantes del Per� | Francisco ' 'Sagasti, Elecciones 2021, COVID-19, Reactiva Per�, Arranca Per�, ' 'Cuarentena focalizada'}, { 'key': 'ref53', 'journal-title': 'Piura: Detienen a dos personas con m�s de 200 dosis de ivermectina de ' 'contrabando; coronavirus; COVID-19; nnpp; PERU. El Comercio Per�. ' '2020/06/19'}, { 'key': 'ref54', 'doi-asserted-by': 'publisher', 'journal-title': 'Porres: incautan 20,000 frascos de ivermectina y detienen a 12 ' 'personas. Andina. Agencia Peruana de Noticias. 2020/05/27', 'DOI': '10.24265/campus.2016.v20n20.08'}, {'key': 'ref55', 'journal-title': 'Peru bet on cheap COVID antibody tests'}, { 'key': 'ref56', 'article-title': 'Covid-19: segundo informe para actualizar cifra de fallecidos se ' 'conocer� esta semana. Andina. Agencia Peruana de Noticias', 'author': 'Minsa', 'journal-title': 'Peru: PM announces new COVID-19 prevalence study. Andina. Agencia ' 'Peruana de Noticias. 2020/09/26'}, { 'key': 'ref57', 'author': 'T Welsh', 'year': '2020', 'journal-title': 'Inequality and corruption: Why Peru is losing its COVID-19 battle. ' 'Devex'}, { 'key': 'ref58', 'doi-asserted-by': 'publisher', 'first-page': '1247', 'DOI': '10.1016/s1473-3099(20)30553-3', 'volume': '20', 'author': 'H S Badr', 'year': '2020', 'journal-title': 'Association between mobility patterns and COVID-19 transmission in the ' 'USA: a mathematical modelling study. The Lancet Infectious Diseases'}, { 'key': 'ref59', 'doi-asserted-by': 'publisher', 'DOI': '10.1101/2020.10.05.20206888', 'article-title': 'The relative effects of non-pharmaceutical interventions on early ' 'Covid-19 mortality: natural experiment in 130 countries', 'author': 'J Stokes', 'year': '2020', 'journal-title': 'medRxiv'}, { 'key': 'ref60', 'doi-asserted-by': 'publisher', 'DOI': '10.1101/2020.10.29.20222414', 'article-title': 'How well does societal mobility restriction help control the COVID-19 ' 'pandemic? Evidence from real-time evaluation', 'author': 'J Oh', 'year': '2020', 'journal-title': 'medRxiv'}, { 'issue': '1', 'key': 'ref61', 'article-title': 'State-level tracking of COVID-19 in the United States', 'volume': '11', 'author': 'Hjt Unwin', 'year': '2020', 'journal-title': 'Nature Communications'}, { 'key': 'ref62', 'volume': '74', 'year': '2020', 'journal-title': 'Worldometer Coronavirus statistics'}, { 'key': 'ref63', 'doi-asserted-by': 'publisher', 'author': 'Worldometer Coronavirus Statistics', 'year': '2020', 'journal-title': 'Accessed', 'DOI': '10.47395/sjvd.13.2021.2.1.04'}, { 'key': 'ref64', 'volume': '2020', 'journal-title': 'Secretar�a de Gobierno Digital Presidencia del Consejo de Ministros'}, { 'key': 'ref65', 'volume': '2020', 'journal-title': 'National Death Information System (SINADEF). ' 'cloud.minsa.gob.pe/s/NctBnHXDnocgWAg/download'}, { 'key': 'ref66', 'doi-asserted-by': 'publisher', 'journal-title': 'Datos Abiertos de COVID', 'DOI': '10.1787/888933415882'}, { 'key': 'ref67', 'volume': '2020', 'journal-title': 'Secretar�a de Gobierno Digital Presidencia del Consejo de Ministros'}, { 'key': 'ref68', 'doi-asserted-by': 'publisher', 'journal-title': 'JHS COVID-19 Map. Johns Hopkins Coronavirus Resource Center', 'DOI': '10.1787/04440101-en'}, { 'key': 'ref69', 'article-title': 'Moquegua: llegan otros 45 m�dicos desde Lima para reforzar lucha contra ' 'el coronavirus', 'author': 'Editora Epdsesa', 'journal-title': 'Covid-19: a m�s de 22,000 personas atendi� Operaci�n Tayta-Yo Me Apunto ' 'en Cajamarca. Andina, Agencia Peruana de Noticias. 2020/08/02'}, { 'key': 'ref70', 'journal-title': 'Equipo del Ministerio de Salud realiza Operaci�n Tayta y brinda ' 'asistencia t�cnica en Moquegua'}, { 'key': 'ref71', 'author': 'C Llantoy', 'journal-title': 'Mediante empadronamiento ejecutado por 60 brigadistas de la mph y ' '"amachay'}, { 'key': 'ref72', 'article-title': 'Puno: Desde ma�ana implementar�n la operaci�n Tayta liderado por el ' 'Ej�rcito peruano. Radio Onda Azul', 'journal-title': 'Operaci�n Tayta permite fortalecer la atenci�n primaria de casos de ' 'COVID-19'}, { 'key': 'ref73', 'journal-title': 'Operaci�n tayta lleg� a hu�nuco para fortalecer lucha contra COVID-19. ' 'Gobierno Regional de Hu�nuco'}, { 'issue': '1', 'key': 'ref74', 'article-title': 'A pilot study of hydroxychloroquine in treatment of patients with ' 'common coronavirus disease-19 (COVID-19)', 'volume': '49', 'author': 'J Chen', 'year': '2020', 'journal-title': 'J Zhejiang Univ (Med Sci)'}, { 'key': 'ref75', 'journal-title': 'Gobierno entrega a Huancavelica m�s de 17 000 unidades de EPP y ' 'medicamentos para luchar contra el Covid-19. Ministerio de la ' 'Producci�n'}, { 'key': 'ref76', 'journal-title': 'Inician plan mega tayta 2020 en ayacucho para diagnosticar, tratar, ' 'aislar y asistir con alimentos a los casos positivos'}, { 'key': 'ref77', 'journal-title': 'Covid-19: inici� operaci�n Tayta con aplicaci�n de 3,000 pruebas de ' 'descarte'}, { 'key': 'ref78', 'journal-title': 'Jun�n: gobierno regional elabora ivermectina para tratamiento temprano ' 'de covid-19. Andina, Agencia Peruana de Noticias'}, { 'key': 'ref79', 'journal-title': 'Hospital Unanue mantiene producci�n regular de ivermectina. Gobierno ' 'Regional de Tacna'}, { 'key': 'ref80', 'journal-title': 'M�s de 500 adultos mayores son atendidos por el Mimp durante Operaci�n ' 'Tayta en Pasco'}, {'key': 'ref81', 'journal-title': 'Provincial de Pasco'}, {'key': 'ref82', 'journal-title': 'Provincial de Pasco'}, {'key': 'ref83', 'author': 'Covid Google', 'journal-title': 'Community Mobility Reports'}, { 'key': 'ref84', 'doi-asserted-by': 'publisher', 'DOI': '10.1101/2020.09.14.296814', 'article-title': 'Phylogenomics reveals multiple introductions and early spread of ' 'SARS-CoV-2 into Peru', 'author': 'E Juscamayta-L�pez', 'year': '2020', 'journal-title': 'bioRxiv'}, { 'key': 'ref85', 'journal-title': 'Covid-19: seroprevalencia en la ciudad de Iquitos es de 75 por ciento. ' 'Andina. Agencia Peruana de Noticias'}, { 'key': 'ref86', 'article-title': 'Global Human Settlement, Urban centres database 2018 visualisation; ' 'Urban Centre Database UCDB R2019A. 2020/11', 'volume': '30', 'year': '2017', 'journal-title': 'Instituto Nacional de Estad�stica e Inform�tica (INEI), Censos ' 'Nacionales'}, { 'key': 'ref87', 'author': 'P Fonseca', 'year': '2020', 'journal-title': 'Exclusive: Study suggests dengue may provide some immunity against ' 'COVID-19. Reuters'}, { 'key': 'ref88', 'doi-asserted-by': 'publisher', 'author': 'Salud Ministerio De', 'DOI': '10.4067/s0716-10182013000300004'}, { 'issue': '1', 'key': 'ref89', 'doi-asserted-by': 'publisher', 'first-page': '146', 'DOI': '10.17843/rpmesp.2015.321.1587', 'article-title': 'Dengue en el Per�: a un cuarto de siglo de su reemergencia', 'volume': '32', 'author': 'C Cabezas', 'year': '2015', 'journal-title': 'Revista Peruana de Medicina Experimental y Salud Publica'}, { 'key': 'ref90', 'doi-asserted-by': 'publisher', 'author': 'C Luna', 'journal-title': 'Repartir�n 10 mil kits con Ivermectina para combatir Covid-19 en ' 'Tuxtla. El Sie7e de Chiapas. 2020/07/03', 'DOI': '10.1787/4752b583-es'}, { 'issue': '6522', 'key': 'ref91', 'doi-asserted-by': 'publisher', 'first-page': '1277', 'DOI': '10.1126/science.abf5084', 'article-title': 'COVID-19 vaccine trial ethics once we have efficacious vaccines', 'volume': '370', 'author': 'D Wendler', 'year': '2020', 'journal-title': 'Science'}, { 'key': 'ref92', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/nejmoa2034577', 'article-title': 'Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine', 'author': 'F P Polack', 'year': '2020', 'journal-title': 'N Engl J Med'}, { 'key': 'ref93', 'doi-asserted-by': 'publisher', 'first-page': '191', 'DOI': '10.1056/nejmoa2034577', 'article-title': 'Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine (study ' 'protocol)', 'author': 'F P Polack', 'year': '2020', 'journal-title': 'N Engl J Med'}, { 'key': 'ref94', 'year': '2020', 'journal-title': 'The authors are indebted for this analysis to Dr. Peter McCullough, who ' 'communicated these observations in an email of December 14'}, { 'issue': '10', 'key': 'ref95', 'doi-asserted-by': 'publisher', 'first-page': '1122', 'DOI': '10.1177/009127002401382731', 'article-title': 'Safety, tolerability, and pharmacokinetics of escalating high doses of ' 'ivermectin in healthy adult subjects', 'volume': '42', 'author': 'C A Guzzo', 'year': '2002', 'journal-title': 'J Clin Pharmacol'}, { 'key': 'ref96', 'doi-asserted-by': 'publisher', 'author': 'A Krolewiecki', 'year': '2020', 'journal-title': 'Antiviral effect of high-dose ivermectin in adults with COVID-19: a ' 'pilot randomised, controlled, open label, multicentre trial', 'DOI': '10.2139/ssrn.3714649'}, { 'key': 'ref97', 'doi-asserted-by': 'publisher', 'author': 'D Scheim', 'year': '2020', 'journal-title': 'Ivermectin for COVID-19 treatment: clinical response at quasi-threshold ' 'doses via hypothesized alleviation of CD147-mediated vascular occlusion', 'DOI': '10.2139/ssrn.3636557'}, { 'key': 'ref98', 'doi-asserted-by': 'publisher', 'first-page': '51', 'DOI': '10.1002/9781118156391.ebcp001003', 'article-title': 'Professional issues and evidence-based practice: The quality problem in ' 'behavioral health care', 'volume': '1', 'author': 'W T O'donohue', 'year': '2005', 'journal-title': 'Child and adolescent disorders'}, { 'key': 'ref99', 'doi-asserted-by': 'publisher', 'author': 'B Marshall', 'journal-title': 'Helicobacter Connections', 'DOI': '10.1002/chin.200642258'}, {'key': 'ref100', 'author': 'Nobel Prize Lecture', 'year': '2005'}, { 'key': 'ref101', 'doi-asserted-by': 'publisher', 'first-page': '1437', 'DOI': '10.1016/s0140-6736(88)90929-4', 'article-title': 'Prospective double-blind trial of duodenal ulcer relapse after ' 'eradication of Campylobacter pylori', 'volume': '2', 'author': 'B J Marshall', 'year': '1988', 'journal-title': 'Lancet'}, { 'issue': '3', 'key': 'ref102', 'doi-asserted-by': 'publisher', 'first-page': '145', 'DOI': '10.5694/j.1326-5377.1990.tb136833.x', 'article-title': 'Cure of duodenal ulcer after eradication of Helicobacter pylori', 'volume': '153', 'author': 'L L George', 'year': '1990', 'journal-title': 'Med J Aust'}, { 'key': 'ref103', 'first-page': '242', 'author': 'A Corsig', 'year': '1995', 'journal-title': 'Glaxo Holdings PLC: Zantac. In: Thomas R, ed. New Product Success ' 'Stories'}, { 'issue': '13', 'key': 'ref104', 'doi-asserted-by': 'publisher', 'first-page': '1489', 'DOI': '10.1001/archinte.1997.00440340131013', 'article-title': 'Time trends of physician visits and treatment patterns of peptic ulcer ' 'disease in the United States', 'volume': '157', 'author': 'S Munnangi', 'year': '1997', 'journal-title': 'Arch Intern Med'}, { 'key': 'ref105', 'year': '2020', 'journal-title': 'Australian GPs urged to prescribe ivermectin triple therapy to fight ' 'COVID-19. Thepharmaletter'}, { 'issue': '5', 'key': 'ref106', 'doi-asserted-by': 'publisher', 'first-page': '343', 'DOI': '10.1111/myc.12599', 'article-title': 'A re-appraisal of the conventional history of antibiosis and Penicillin', 'volume': '60', 'author': 'S N Arseculeratne', 'year': '2017', 'journal-title': 'Mycoses'}, { 'key': 'ref107', 'doi-asserted-by': 'publisher', 'first-page': '163', 'DOI': '10.1016/s0065-2164(01)49013-7', 'article-title': 'Alexander Fleming and the discovery of penicillin', 'volume': '49', 'author': 'J W Bennett', 'year': '2001', 'journal-title': 'Advances in Applied Microbiology'}, { 'issue': '6239', 'key': 'ref108', 'doi-asserted-by': 'publisher', 'first-page': '387', 'DOI': '10.1016/s0140-6736(00)41962-8', 'article-title': 'General and local administration of penicillin', 'volume': '241', 'author': 'M E Florey', 'year': '1943', 'journal-title': 'The Lancet'}, { 'issue': '16', 'key': 'ref109', 'doi-asserted-by': 'publisher', 'first-page': '1007', 'DOI': '10.1001/jama.1943.02840510001001', 'article-title': 'Penicillin therapy of surgical infections in the US Army: A report', 'volume': '123', 'author': 'C Lyons', 'year': '1943', 'journal-title': 'Journal of the American Medical Association'}, { 'issue': '18', 'key': 'ref110', 'doi-asserted-by': 'publisher', 'first-page': '1217', 'DOI': '10.1001/jama.1943.02840350001001', 'article-title': 'Penicillin in the treatment of infections; 500 cases', 'volume': '122', 'author': 'C S Keefer', 'year': '1943', 'journal-title': 'Journal of the American Medical Association'}, { 'issue': '1', 'key': 'ref111', 'doi-asserted-by': 'publisher', 'first-page': '52', 'DOI': '10.1053/j.spid.2004.02.001', 'article-title': 'Penicillin: its discovery and early development', 'volume': '15', 'author': 'B L Ligon', 'year': '2004', 'journal-title': 'Seminars in Pediatric Infectious Diseases'}, { 'issue': '6', 'key': 'ref112', 'doi-asserted-by': 'publisher', 'first-page': '679', 'DOI': '10.1016/s0048-7333(99)00045-1', 'article-title': 'Antibiotics, invention and innovation', 'volume': '29', 'author': 'W Kingston', 'year': '2000', 'journal-title': 'Research Policy'}, { 'issue': '4918', 'key': 'ref113', 'doi-asserted-by': 'publisher', 'first-page': '441', 'DOI': '10.1038/201441a0', 'article-title': 'Production of Penicillin in the United States (1941-1946)', 'volume': '201', 'author': 'A N Richards', 'year': '1964', 'journal-title': 'Nature'}, { 'key': 'ref114', 'doi-asserted-by': 'publisher', 'DOI': '10.1101/2021.01.18.426984', 'article-title': 'Neutralization of SARS-CoV-2 lineage B.1.1.7 pseudovirus by BNT162b2 ' 'vaccine-elicited human sera', 'author': 'A Muik', 'year': '2021', 'journal-title': 'bioRxiv'}, { 'key': 'ref115', 'doi-asserted-by': 'publisher', 'DOI': '10.1101/2021.01.18.427166', 'article-title': 'SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 ' 'donor plasma', 'author': 'C K Wibmer', 'year': '2021', 'journal-title': 'bioRxiv'}, { 'key': 'ref116', 'doi-asserted-by': 'publisher', 'DOI': '10.1101/2020.12.31.425021', 'article-title': 'Comprehensive mapping of mutations to the SARS-CoV-2 receptor-binding ' 'domain that affect recognition by polyclonal human serum antibodies', 'author': 'A J Greaney', 'year': '2021', 'journal-title': 'bioRxiv'}, { 'key': 'ref117', 'author': 'K Wu', 'journal-title': 'mRNA-1273 vaccine induces neutralizing antibodies against spike mutants ' 'from global SARS-CoV-2 variants'}, { 'key': 'ref118', 'doi-asserted-by': 'crossref', 'DOI': '10.7554/eLife.61312', 'article-title': 'Escape from neutralizing antibodies by SARS-CoV-2 spike protein ' 'variants', 'volume': '9', 'author': 'Y Weisblum', 'year': '2020', 'journal-title': 'eLife'}, { 'issue': '1', 'key': 'ref119', 'doi-asserted-by': 'publisher', 'first-page': '44', 'DOI': '10.1016/j.chom.2020.11.007', 'article-title': 'Complete Mapping of Mutations to the SARS-CoV-2 Spike ReceptorBinding ' 'Domain that Escape Antibody Recognition', 'volume': '29', 'author': 'A J Greaney', 'year': '2021', 'journal-title': 'Cell Host & Microbe'}], 'container-title': 'SSRN Electronic Journal', 'original-title': [], 'language': 'en', 'deposited': { 'date-parts': [[2021, 2, 5]], 'date-time': '2021-02-05T10:47:27Z', 'timestamp': 1612522047000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.ssrn.com/abstract=3765018'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021]]}, 'references-count': 119, 'URL': 'http://dx.doi.org/10.2139/ssrn.3765018', 'relation': {}, 'ISSN': ['1556-5068'], 'subject': [], 'published-other': {'date-parts': [[2021]]}, 'container-title-short': 'SSRN Journal', 'published': {'date-parts': [[2021]]}}