Outcome of Different Therapeutic Interventions in Mild COVID-19 Patients in a Single OPD Clinic of West Bengal: A Retrospective study

DOI record: { "DOI": "10.1101/2021.03.08.21252883", "URL": "http://dx.doi.org/10.1101/2021.03.08.21252883", "abstract": "<jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>With over 87,273,380 cases being reported and 1,899,440 deaths worldwide as of 9th January 2021, Coronavirus disease 2019 (COVID-19) has become the worst-hit pandemic till date. Every day clinicians are bombarded with many new treatment options that claim to be better than the others.</jats:p></jats:sec><jats:sec><jats:title>Materials and methods</jats:title><jats:p>After screening the electronic database of COVID-19 patients retrospectively, 56 patients with mild COVID-19 infection matched the inclusion criteria and were divided into the four following groups - group having used Hydroxychloroquine (HCQ), group using doxycycline (DOX) + Ivermectin (IVR) combination, group receiving only azithromycin (AZ) and, group receiving only symptomatic treatment. The study’s primary objective was to see Clinical response of well-being (CRWB) reporting time after initiating treatment onset between the four different treatment arms.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>CRWB did not differ between the four groups receiving four different managements (p-value 0.846). There was significant correlation between blood levels of LDH (p-value 0.001), CRP (p-value 0.03) and D-dimer (p-value 0.04) with CRWB in IVR+DOX group and, between LDH (p-value 0.001), CRP (p-value 0.01) and age (p-value 0.035) with CRWB in the symptomatic management group.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Mild COVID-19 infection in patients having low-risk to progress can be managed symptomatically without any specific drug intervention.</jats:p></jats:sec>", "accepted": { "date-parts": [ [ 2021, 3, 22 ] ] }, "author": [ { "ORCID": "http://orcid.org/0000-0002-6185-9375", "affiliation": [], "authenticated-orcid": false, "family": "Roy", "given": "Sayak", "sequence": "first" }, { "affiliation": [], "family": "Samajdar", "given": "Shambo Samrat", "sequence": "additional" }, { "affiliation": [], "family": "Tripathi", "given": "Santanu K", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0001-9524-1525", "affiliation": [], "authenticated-orcid": false, "family": "Mukherjee", "given": "Shatavisa", "sequence": "additional" }, { "affiliation": [], "family": "Bhattacharjee", "given": "Kingshuk", "sequence": "additional" } ], "container-title": [], "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2021, 3, 12 ] ], "date-time": "2021-03-12T14:40:23Z", "timestamp": 1615560023000 }, "deposited": { "date-parts": [ [ 2022, 12, 21 ] ], "date-time": "2022-12-21T09:03:55Z", "timestamp": 1671613435000 }, "group-title": "Infectious Diseases (except HIV/AIDS)", "indexed": { "date-parts": [ [ 2022, 12, 22 ] ], "date-time": "2022-12-22T05:31:07Z", "timestamp": 1671687067555 }, "institution": [ { "name": "medRxiv" } ], "is-referenced-by-count": 1, "issued": { "date-parts": [ [ 2021, 3, 12 ] ] }, "link": [ { "URL": "https://syndication.highwire.org/content/doi/10.1101/2021.03.08.21252883", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "246", "original-title": [], "posted": { "date-parts": [ [ 2021, 3, 12 ] ] }, "prefix": "10.1101", "published": { "date-parts": [ [ 2021, 3, 12 ] ] }, "publisher": "Cold Spring Harbor Laboratory", "reference": [ { "key": "2021032410001188000_2021.03.08.21252883v2.1", "unstructured": "Who.int. 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