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0 0.5 1 1.5 2+ Viral clearance 82% primary Improvement Relative Risk Viral clearance (b) 39% c19ivm.org Bukhari et al. NCT04392713 Ivermectin RCT EARLY TREATMENT Favors ivermectin Favors control
Efficacy of Ivermectin in COVID-19 Patients with Mild to Moderate Disease
Bukhari et al., medRxiv, doi:10.1101/2021.02.02.21250840 (results 1/16) (Preprint), NCT04392713 (history)
16 Jan 2021    Source   PDF   Share   Tweet
RCT of relatively low risk hospitalized patients with 50 ivermectin and 50 control patients showing significantly faster viral clearance with treatment. 9 patients in the treatment arm were lost to followup compared with 5 in the control arm, which could be in part due to faster recovery with treatment. There were no safety concerns. No mortality was reported. The numbers in Table 3 are the number of patients that became negative on that day, i.e., non-cumulative. SOC included vitamin C and vitamin D. NCT04392713 (history).
risk of no viral clearance, 82.4% lower, RR 0.18, p < 0.001, treatment 4 of 41 (9.8%), control 25 of 45 (55.6%), NNT 2.2, day 7, primary outcome.
risk of no viral clearance, 38.7% lower, RR 0.61, p < 0.001, treatment 24 of 41 (58.5%), control 43 of 45 (95.6%), NNT 2.7, day 3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bukhari et al., 16 Jan 2021, Randomized Controlled Trial, Pakistan, preprint, 10 authors, dosage 12mg single dose, trial NCT04392713 (history).
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