Crying wolf in time of Corona: the strange case of ivermectin and hydroxychloroquine. Is the fear of failure withholding potential life-saving treatment from clinical use?
et al., Signa Vitae, doi:10.22514/sv.2021.043 (meta analysis)
, Crying wolf in time of Corona: the strange case of ivermectin and hydroxychloroquine. Is the fear of failure.., Signa Vitae, doi:10.22514/sv.2021.043 (meta analysis)
Meta analysis of RCT mortality results showing RR 0.19, p < 0.00001.Currently there are 95 ivermectin studies and meta analysis shows:
| Outcome | Improvement |
|---|---|
| Mortality | 51% lower [37‑62%] |
| Ventilation | 29% lower [13‑42%] |
| ICU admission | 41% lower [16‑58%] |
| Hospitalization | 34% lower [20‑45%] |
| Cases | 78% fewer [67‑85%] |
|
risk of death, 79.5% lower, RR 0.21, p < 0.001, treatment 14 of 703 (2.0%), control 57 of 620 (9.2%), NNT 14, odds ratio converted to relative risk.
|
| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Nardelli et al., 11 Mar 2021, peer-reviewed, 8 authors.
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