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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 62% Improvement Relative Risk Ivermectin for COVID-19  Bryant et al.  META ANALYSIS c19ivm.org Favors ivermectin Favors control

Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines

Bryant et al., American Journal of Therapeutics, doi:10.1097/MJT.0000000000001402 (date from preprint)
Jun 2021  
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Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
 
*, now known with p < 0.00000000001 from 102 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19ivm.org
Systematic review, meta analysis, and trial sequential analysis of 24 RCTs finding mortality RR 0.38 [0.19-0.73].
An update notes potentially inaccurate data collection and/or reporting in some sources journals.lww.com.
7 meta analyses show significant improvements with ivermectin for mortality Bryant, Hariyanto, Kory, Lawrie, Nardelli, Zein, hospitalization Schwartz, recovery Kory, and cases Kory.
Currently there are 102 ivermectin for COVID-19 studies, showing 49% lower mortality [35‑60%], 29% lower ventilation [12‑42%], 35% lower ICU admission [7‑54%], 34% lower hospitalization [20‑45%], and 81% fewer cases [71‑87%].
risk of death, 62.0% lower, RR 0.38, p = 0.005.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bryant et al., 17 Jun 2021, peer-reviewed, 7 authors.
This PaperIvermectinAll
www.americantherapeutics.com whereas effect estimates for "improvement" and "deterioration" clearly favored ivermectin use. Severe adverse events were rare among treatment trials and evidence of no difference was assessed as low certainty. Evidence on other secondary outcomes was very low certainty. Conclusions: Moderate-certainty evidence finds that large reductions in COVID-19 deaths are possible using ivermectin. Using ivermectin early in the clinical course may reduce numbers progressing to severe disease. The apparent safety and low cost suggest that ivermectin is likely to have a significant impact on the SARS-CoV-2 pandemic globally.
References
Abd-Elsalam, Ivermectin as a Novel Therapy in Covid-19 Treatment
Abd-Elsalam, The Efficacy of Ivermectin and Nitazoxanide in Covid-19 Treatment
Ahmed, Karim, Ross, A five day course of ivermectin for the treatment of covid-19 may reduce the duration of illness, Int J Infect Dis
Alam, Murshe, Bhiuyan, A case series of 100 covid-19 positive patients treatedwith combination of ivermectin and doxycycline, J Bangladesh Coll Physicians Surgeons
Alam, Murshed, Gomes, Ivermectin as pre-exposure prophylaxis for COVID-19 among healthcare providers in a selected tertiary hospital in dhakaan observational study, Eur J Med Health Sci, doi:10.24018/ejmed.2020.2.6.599
Alam, Safety and Efficacy of Ivermectin and Doxycycline in Treatment of Covid-19
Aluko, Graybill, Craig, Chapter 20: economic evidence
Anand, Ziebuhr, Wadhwani, Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs, Science
Arnold, Novel Agents for Treatment of High-Risk Covid-19 Positive Patients
Asghar, Efficacy of Ivermectin in COVID-19
Ashraf, Efficacy of Subcutaneous Ivermectin with or without Zinc and Nigella Sativa in Covid-19 Patients (SINZ-Covid-PK)
Assistencial, Terrassa, Randomised Clinical Trial of Ivermectin for Treatment and Prophylaxis of Covid-19
Ataee, Evaluation of the Effect of Ivermectin in Hospitalized Patients with Covid-19 in Imam Reza Hospital in Mashhad
Babalola, Bode, Ajayi, Ivermectin shows clinical benefits in mild to moderate COV-ID19: a randomised controlled double blind dose response study in Lagos, Int J Med, doi:10.1093/qjmed/hcab035
Banerjee, Nandy, Dalai, The battle against covid 19 pandemic: what we need to know before we "test fire" ivermectin, Drug Res (Stuttg)
Barrows, Campos, Powell, A screen of FDA-approved drugs for inhibitors of zika virus infection, Cell Host Microbe
Behera, Patro, Padhy, Prophylactic role of ivermectin in SARS-CoV-2 infection among healthcare workers, Res Square, doi:10.21203/rs.3.rs-208785/v1
Behera, Patro, Singh, Role of ivermectin in the prevention of covid-19 infection among healthcare workers in India: a matched case-control study, PLoS One
Bernigaud, Guillemot, Ahmed-Belkacem, Oral ivermectin for a scabies outbreak in a long-termcare facility: potential value in preventing COVID-19 and associated mortality?, Br J Dermatol, doi:10.1111/bjd.19821
Bisoffi, COVidIVERmectin: Ivermectin for Treatment of Covid-19
Brok, Thorlund, Gluud, Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses, J Clin Epidemiol
Bryant, Lawrie, Dowsell, Ivermectin for Prevention and Treatment of Covid-19 (Protocol)
Budhiraja, Soni, Jha, Clinical Profile of First 1000 Covid-19 Cases Admitted at Tertiary Care Hospitals and the Correlates of Their Mortality: An Indian Experience, medRxiv, doi:10.1101/2020.11.16.20232223
Bukhari, Asghar, Perveen, Efficacy of Ivermectin in COVID-19 Patients with Mild to Moderate Disease, medRxiv, doi:10.1101/2021.02.02.21250840
Cadegiani, Goren, Wambier, Early covid-19 therapy with azithromycin plus nitazoxanide, ivermectin orHydroxychloroquine in outpatient settings significantly reduced SymptomsCompared to known outcomes in untreated patients, medRxiv, doi:10.1101/2020.10.31.20223883
Cai, Parast, Ryan, Meta-analysis for rare events, Stat Med
Caly, Druce, Catton, The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro, Antivir Res
Campbell, Mckenzie, Sowden, Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline, BMJ
Camprubí, Almuedo-Riera, Martí-Soler, Lack of efficacy of standard doses of ivermectin in severe covid-19 patients, PLoS One
Carvallo, Hirsch, Alkis, Study of the efficacy and safety of topical ivermectin + iona-Carrageenan in the prophylaxis against COVID-19 in health personnel, J Biomed Res Clin Invest
Carvallo, Hirsch, Farinella, Safety and efficacy of the combined use of ivermectin, dexamethasone, enoxaparin and aspirin against covid 19, medRxiv, doi:10.1101/2020.09.10.20191619
Castanẽda-Sabogal, Chambergo-Michilot, Toro-Huamanchumo, Outcomes of Ivermectin in the treatment of covid-19: a systematic review and meta-analysis, medRxiv, doi:10.1101/2021.01.26.21250420
Chaccour, Casellas, Blanco-Di Matteo, The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with nonsevere COVID-19: a pilot, double-blind, placebocontrolled, randomized clinical trial, EClinical Med, doi:10.1016/j.eclinm.2020.100720
Chachar, Khan, Asif, Effectiveness of ivermectin in SARS-CoV-2/COVID-19 patients, Int J Sci
Chahla, Ruiz, Ortega, A randomized trial: intensive treatment based in Ivermectin and iota-Carageenan as pre-exposure prophylaxis for COVID-19 in healthcare agents, medRxiv, doi:10.1101/2021.03.26.21254398
Chamie, Real-world evidence: the case of Peru
Chamie-Quintero, Hibberd, Scheim, Sharp reductions in COVID-19 case fatalities and excess deaths in Peru in close time conjunction, state-by-state, with ivermectin treatments, doi:10.2139/ssrn.3765018
Chen, Chu, Luo, Bayesian analysis on metaanalysis of casecontrol studies accounting for withinstudy correlation, Stat Methods Med Res
Chesler, Letter to Dr Bray at the National Institutes of Health
Chowdhury, Shahbaz, Karim, A randomized trial of ivermectin-doxycycline and hydroxychloroquine-azithromycin therapy on COV-ID19 patients, Res Square, doi:10.21203/rs.3.rs-38896/v1
Conterno, Turchi, Corrêa, Anthelmintic drugs for treating ascariasis, Cochrane Database Syst Rev, doi:10.1002/14651858.CD010599.pub2
Deeks, Altman, Bradburn, and combining results from several studies in meta-analysis
Dersimonian, Laird, Meta-analysis in clinical trials, Controlled Clin Trials
Dinicolantonio, Barroso, Mccarty, Ivermectin may be a clinically useful anti-inflammatory agent for latestage covid-19, Open Heart
Echeverri, Effectiveness and Safety of Ivermectin for the Prevention of Covid-19 Infection in Colombian Health Personnel (IveprofCovid19)
Efthimiou, Practical guide to the meta-analysis of rare events, Evid Based Ment Health
Elalfy, New Antiviral Drugs for Treatment of Covid-19
Elgazzar, Eltaweel, Youssef, Efficacy and safety of ivermectin for treatment and prophylaxis of covid-19 pandemic, Res Square, doi:10.21203/rs.3.rs-100956/v2
Espitia-Hernandez, Munguia, Diaz-Chiguer, Effects of Ivermectin-azithromycin-cholecalciferol combined therapy on COVID-19 infected patients: a proof of concept study, Biomed Res
Exman, Early Treatment with Ivermectin and LosarTAN for Cancer Patients with Covid-19 Infection (TITAN)
Fathalipour, The Efficacy and Safety of Ivermectin in Patients with Covid-19: A Randomized Clinical Trial
Fesler, Stricker, Pre-exposure prophylaxis for covid-19 in pregnant women, Int J Gen Med
Fonseca, The Effect of Chloroquine, Hydroxychloroquine OR Ivermectin in Patients with Severe Manifestations of Coronavirus
Funegra, Randomized Phase IIA Clinical Trial to Evaluate the Efficacy of Ivermectin to Obtain Negative PCR Results in Patients with Early Phase Covid-19
George, A Phase IIB Open Label Randomized Controlled Trial to Evaluate the Efficacy and Safety of Ivermectin in Reducing Viral Loads in Patients with Hematological Disorders Who Are Admitted with Covid 19 Infection
Ghandali, Evaluating the Efficacy and Safety of Ivermectin in the Treatment of Covid-19 Patients: A Double-Blind Randomized Controlled Trial, Phase II
Gheibi, Determination the Therapeutic Effect of Ivermectin and Sovodak on Patients Infected with Covid-19: A Clinical Trial
Gheibi, Dose-Finding Study of Ivermectin Treatment on Patients Infected with Covid-19:A Clinical Trial
Gonzalez, Gámez, Enciso, Efficacy and safety of Ivermectin and Hydroxychloroquine in patients with severe COVID-19. A randomized controlled trial, medRxiv, doi:10.1101/2021.02.18.21252037
Gorial, Mashhadani, Sayaly, Effectiveness of ivermectin as add-on therapy in covid-19 management, medRxiv, doi:10.1101/2020.07.07.20145979
Grade-Decide, The DECIDE Project
Guzzo, Furtek, Porras, Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects, J Clin Pharmacol
Hashim, Maulood, Rasheed, Controlled randomized clinical trial on using Ivermectin with Doxycycline for treating covid-19 patients in Baghdad, Iraq. medRxiv, doi:10.1101/2020.10.26.20219345
Heidary, Gharebaghi, Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen, J Antibiot
Hellwig, A covid-19 Prophylaxis? Lower incidence associated withprophylactic administration of Ivermectin, Int J Antimicrob Agent
Hidalgo, Pragmatic Study "CORIVER": Ivermectin as Antiviral Treatment for Patients Infected by SARS-COV2 (Covid-19)
Higgins, Thomas, Chandler, Cochrane Handbook for Systematic Reviews of Interventions Version
Higgins, Thompson, Deeks, Measuring inconsistency in meta-analyses, BMJ
Hill, Abdulamir, Ahmed, Meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection, doi:10.21203/rs.3.rs-148845/v1
Horby, Lim, Emberson, Dexamethasone in hospitalized patients with covid-19, NEJM
Hospital, Hidalgo, Hydroxychloroquine and Ivermectin for the Treatment of Covid-19 Infection
Jans, Wagstaff, Ivermectin as a broad-spectrum host-directed anti-viral: the real deal?, Cells
Junior, Paoliello, Miguel, Use of ivermectin in the treatment of Covid-19: a pilot trial, Toxicol Rep
Kamal, Ivermectin in Treatment of Covid 19 Patients
Khan, Khan, Debnath, Ivermectin treatment may improve the prognosis of patients with covid-19, Archivos de Bronconeumología
Kircik, Rosso, Layton, Over 25 Years of clinical experience with ivermectin: an overview of safety for an increasing number of indications, J Drugs Dermatol
Kory, Gu, Varon, Review of the emerging evidence demonstrating the efficacy of ivermectin in the prophylaxis and treatment of COVID-19, Am J Ther
Krolewiecki, Lifschitz, Moragas, Antiviral effect of high-dose ivermectin in adults with COVID-19: a pilot randomised, controlled, open label, multicentre trial, doi:10.2139/ssrn.3714649
Lehrer, Rheinstein, Ivermectin docks to the SARS-CoV-2 spike receptor binding domain attached to ACE2
López-Medina, López, Hurtado, Effect of ivermectin on time to resolution of symptoms among adults with mild COVID-19: a randomized clinical trial, J Am Med Assoc
Mody, Ho, Wills, Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents, Nat Commun Biol
Mohan, Tiwari, Suri, Ivermectin in mild and moderate COVID-19 (RIVET-COV): a randomized, placebo-controlled trial, Res Square, doi:10.21203/rs.3.rs-191648/v1
Morgenstern, Redondo, De León, The use of compassionate ivermectin in the management of symptomatic outpatients and hospitalized patients with clinical diagnosis of covid-19 at the medical center bournigal and the medical center punta cana, rescue group, doi:10.1101/2020.10.29.20222505
Nardelli, Zangrillo, Sanchini, Crying wolf in time of Corona: the strange case of ivermectin and hydroxychloroquine. Is the fear of failure withholding potential life-saving treatment from clinical use?, Signa Vitae
Navarro, Camprubí, Requena, Endez, Safety of high-dose ivermectin: a systematic review and meta-analysis, J Antimicrob Chemother
Niaee, Gheibi, Namdar, Ivermectin as an adjunct treatment for hospitalized adult COVID-19 patients: a randomized multi-center clinical trial, Res Square, doi:10.21203/rs.3.rs-109670/v1
Nicolas, Maia, Bassat, Safety of oral ivermectin during pregnancy: a systematic review and meta-analysis, Lancet Glob Health
Ochoa-Jaramillo, Ivermectin in Adults with Severe Covid-19
Okasha, Ivermectin Nasal Spray for Covid19 Patients
Okasha, Ivermectin and Nitazoxanide Combination Therapy for Covid-19
Okumus, Demirtürk, Çetinkaya, Evaluation of the Effectiveness and Safety of Adding Ivermectin to Treatment in Severe COVID-19 Patients, doi:10.21203/rs.3.rs-224203/v1
Owen, Bradbury, Xin, MetaInsight: an interactive web-based tool for analyzing, interrogating, and visualizing network meta-analyses using R-shiny and netmeta, Res Syn Meth
Pathak, Effectiveness of Ivermectin in Preventing Development of Symptomatic Covid-19 Among Primary Contacts of Newly Diagnosed Covid-19 Positive Patients at a Tertiary Care Hospital in North India-an Interventional Study
Perez, Efficacy, Safety and Tolerability of Ivermectin in Subjects Infected with SARS-CoV-2 with or without Symptoms (SILVERBULLET)
Petkov, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Investigating Efficacy
Podder, Chowdhury, Mohim, Outcome of ivermectin treated mild to moderate covid-19 cases: a single-centre, open-label, randomised controlled study, IMC J Med Sci
Portmann-Baracco, Alberti, Accinelli, Antiviral and anti-inflammatory properties ofivermectin and its potential use in Covid-19, Arch Bronconeumol
Prakash, A Clinical Trial to Study the Effects of Hydroxychloroquine, Ciclesonide and Ivermectin in Treatment of Moderate Covid-19 Illness
Progenabiom, Trial of Combination Therapy to Treat Covid-19 Infection
Raad, In Vivo Use of Ivermectin (IVR) for Treatment for Corona Virus Infected Patients (Covid-19): A Randomized Controlled Trial
Rajter, Sherman, Fatteh, Use of ivermectin is associated with lower mortality in hospitalized patients with coronavirus disease 2019, CHEST
Rathi, Study to Efficacy of Ivermectin in Patients of Covid-19
Ravikirti, Pattadar, Ivermectin as a potential treatment for mild to moderate COVID-19 -a double blind randomized placebo-controlled trial, medRxiv, doi:10.1101/2021.01.05.21249310
Rezai, Effectiveness of Ivermectin in the Treatment of Coronavirus Infection in Patients Admitted to Educational Hospitals of Mazandaran in
Roguski, Ivermectin, None
Rücker, Schwarzer, Carpenter, Why add anything to nothing? The arcsine difference as a measure of treatment effect in meta-analysis with zero cells, Stat Med
Rücker, Schwarzer, Krahn, Network Meta-Analysis Using Frequentist Methods
Saibannavar, An Open Label, Prospective Comparative Study to Evaluate the Proposed Therapy in Adults with Mild Symptomatic Covid-19 Patients Receiving the Standard Treatment of Covid Infection
Saxena, Assessment of Response of Ivermectin on Virological Clearance in Covid 19 Patients
Scheim, From cold to killer: how SARS-CoV-2 evolved without hemagglutinin esterase to agglutinate, then clot blood Cells in pulmonary and systemic microvasculature, doi:10.2139/ssrn.3706347
Schmith, Zhou, Lohmer, The approved dose of ivermectin alone is not the ideal dose for the treatment of Covid-19, Clin Pharmacol Ther
Schwartz, Ivermectin Vs, Placebo for the Treatment of Patients with Mild to Moderate Covid-19
Schwartz, Viral load and culture viability in mild COVID-19 patients treated with Ivermectin, New England J Med
Schünemann, Vist, Higgins, Chapter 15: interpreting results and drawing conclusions
Shahbazi, Evaluation Effects of the Standard Regimen along with Ivermectin on Treatment of Corona Virus Type 2 Pneumonia
Shea, Reeves, Wells, AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both, BMJ
Shokati, A Randomized Clinical Trial Study, Comparison of the Therapeutic Effects of Ivermectin, Kaletra and Chloroquine with Kaletra and Chloroquine in the Treatment of Patients with Coronavirus
Shouman, Hegazy, Nafae, Use of ivermectin as a potential chemoprophylaxis for COVID-19 in Egypt: a randomized clinical trial, J Clin Diagn Res
Spoorthi, Sasank, Utility of ivermectin and doxycycline combination for the treatment of SARS-CoV-2, Int Arch Integrated Med
Stein, A Randomized Double-Blind Placebo-Controlled Trial of Oral Ivermectin for Outpatient Treatment of Those at High Risk for Hospitalization Due to Covid-19
Stijnen, Hamza, Ozdemir, Random effects metaanalysis of event outcome in the framework of the generalized linear mixed model with applications in sparse data, Stat Med
Stricker, Fesler, Flattening the risk: pre-exposure prophylaxis for COVID-19, Infect Drug Resist
Suputtamongkol, Ivermectin vs Combined Hydroxychloroquine and Antiretroviral Drugs (ART) Among Asymptomatic Covid-19 Infection (IDRA-Covid19)
Thorlund, Engstrøm, Wetterslev, User Manual for Trial Sequential Analysis
Tian, Cai, Pfeffer, Exact and efficient inference procedure for meta-analysis and its application to the analysis of independent 2 x 2 tables with all available data but without artificial continuity correction, Biostatistics
Trialsitenews, Slovakia Becomes the First EU Nation to Formally Approve Ivermectin for Both Prophylaxis and Treatment for COVID-19 Patients
Wetterslev, Thorlund, Brok, Estimating required information size by quantifying diversity in random-effects model meta-analyses, BMC Med Res Methodol
Yagisawa, Foster, Hanaki, Global trends in clinical studies of ivermectin in COVID-19, Jpn J Antibiot
Yamaoka, Placebo-controlled Randomized, Double-Blind (Evaluator, Patient) Multicenter, Parallel-Group Comparative Study Investigating the Efficacy and Safety of Ivermectin in Patients with Covid-19
Zendehdel, Evaluation of the Effect of Oral Ivermectin on the Outcome of Patients with Covid-19 and Compare it with the Effect of Conucntional Therapics in Patients Admitted to Ziaeian, Baharloo, Imam
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