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Coating of Remdesivir and Ivermectin on Silver Nanoparticles: First Principle Study

Morad, R., Elsevier BV, doi:10.2139/ssrn.5021494
Nov 2024  
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Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020, now with p < 0.00000000001 from 105 studies, recognized in 23 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 110 treatments. c19ivm.org
In Silico study showing that silver nanoparticles could be used as a therapeutic drug delivery mechanism for remdesivir and ivermectin against SARS-CoV-2. Using Density Functional Theory calculations, authors find that both drugs bond strongly to the Ag(111) surface, with interaction energies of -2.16 eV for ivermectin and -2.03 eV for remdesivir. Molecular dynamics simulations show that the most electronegative atoms in each drug molecule have the strongest attraction to the silver atoms on the nanoparticle surface. The findings suggest silver nanoparticles coated with remdesivir or ivermectin could improve the efficacy and reduce the dosage requirements of these antiviral drugs for treating COVID-19.
70 preclinical studies support the efficacy of ivermectin for COVID-19:
Ivermectin, better known for antiparasitic activity, is a broad spectrum antiviral with activity against many viruses including H7N768, Dengue34,69,70, HIV-170, Simian virus 4071, Zika34,72,73, West Nile73, Yellow Fever74,75, Japanese encephalitis74, Chikungunya75, Semliki Forest virus75, Human papillomavirus54, Epstein-Barr54, BK Polyomavirus76, and Sindbis virus75.
Ivermectin inhibits importin-α/β-dependent nuclear import of viral proteins68,70,71,77, shows spike-ACE2 disruption at 1nM with microfluidic diffusional sizing35, binds to glycan sites on the SARS-CoV-2 spike protein preventing interaction with blood and epithelial cells and inhibiting hemagglutination38,78, shows dose-dependent inhibition of wildtype and omicron variants33, exhibits dose-dependent inhibition of lung injury58,63, may inhibit SARS-CoV-2 via IMPase inhibition34, may inhibit SARS-CoV-2 induced formation of fibrin clots resistant to degradation7, inhibits SARS-CoV-2 3CLpro51, may inhibit SARS-CoV-2 RdRp activity26, may minimize viral myocarditis by inhibiting NF-κB/p65-mediated inflammation in macrophages57, may be beneficial for COVID-19 ARDS by blocking GSDMD and NET formation79, may interfere with SARS-CoV-2's immune evasion via ORF8 binding2, may inhibit SARS-CoV-2 by disrupting CD147 interaction80-83, shows protection against inflammation, cytokine storm, and mortality in an LPS mouse model sharing key pathological features of severe COVID-1956,84, may be beneficial in severe COVID-19 by binding IGF1 to inhibit the promotion of inflammation, fibrosis, and cell proliferation that leads to lung damage6, may minimize SARS-CoV-2 induced cardiac damage37,45, increases Bifidobacteria which play a key role in the immune system85, has immunomodulatory48 and anti-inflammatory67,86 properties, and has an extensive and very positive safety profile87.
Study covers ivermectin and remdesivir.
Morad et al., 15 Nov 2024, preprint, 1 author. Contact: rmorad@tlabs.ac.za.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
This PaperIvermectinAll
Coating of Remdesivir and Ivermectin on silver nanoparticles: First principle study
Razieh Morad
The rapid emergence of SARS-CoV-2 has necessitated the repurposing of existing drugs to manage the COVID-19 pandemic effectively. This study explores the potential of using silver nanoparticles as a delivery system for the antiviral drugs Remdesivir and Ivermectin, which are effective against the SARS-CoV-2 virus. Utilizing quantum chemistry computational methods, specifically Density Functional Theory (DFT) and Molecular Dynamics (MD), I investigated the interaction dynamics of these drugs when coated onto silver nanoparticles. This approach promises to improve the efficacy and reduce the dosage requirements for these antiviral drugs, offering a novel therapeutic strategy against viral infections like COVID-19.
Competing interests The authors declare no competing interests. Author contributions R. Morad performed the DFT, and MD simulations, analyzed the results, and wrote the manuscript.
References
Abraham, Murtola, Schulz, Páll, Smith et al., GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers, SoftwareX
Adcock, Mccammon, Molecular dynamics: survey of methods for simulating the activity of proteins, Chemical reviews
Akbari, Morad, Coating of favipiravir (FVP) on silver nanoparticles: First principle study, Materials Today: Proceedings
Akbari, Morad, Maaza, Effect of silver nanoparticle size on interaction with artemisinin: first principle study, Results in Surfaces and Interfaces
Akbari, Morad, Maaza, First principle study of silver nanoparticle interactions with antimalarial drugs extracted from Artemisia annua plant, Journal of Nanoparticle Research
Artemisinin: Huang, Yang, Liu, New clinical application prospects of artemisinin and its derivatives: a scoping review, Infect Dis Poverty, doi:10.1186/s40249-023-01152-6
Athar, Das, Therapeutic nanoparticles: State-of-the-art of nanomedicine, Adv. Mater. Rev
Caly, Druce, Catton, Jans, Wagstaff, The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro, Antiviral research
Chaccour, Hammann, Ramón-García, Rabinovich, Ivermectin and COVID-19: keeping rigor in times of urgency, The American journal of tropical medicine and hygiene
Essmann, Perera, Berkowitz, Darden, Lee et al., A smooth particle mesh Ewald method, The Journal of chemical physics
Giannozzi, Baroni, Bonini, Calandra, Car et al., QUANTUM ESPRESSO: a modular and open-source software project for quantum simulations of materials, Journal of physics: Condensed matter
Grimme, Ehrlich, Goerigk, Effect of the damping function in dispersion corrected density functional theory, Journal of computational chemistry
Hess, Bekker, Berendsen, Fraaije, LINCS: A linear constraint solver for molecular simulations, Journal of computational chemistry
Huang, Mackerell, CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data, Journal of computational chemistry
Humphrey, Dalke, Schulten, VMD: visual molecular dynamics, Journal of molecular graphics
Jorgensen, Chandrasekhar, Madura, Impey, Klein, Comparison of simple potential functions for simulating liquid water, The Journal of chemical physics
Khambholja, Asudani, Potential repurposing of Favipiravir in COVID-19 outbreak based on current evidence, Travel medicine and infectious disease
Kyrychenko, Pasko, Kalugin, Poly (vinyl alcohol) as a water protecting agent for silver nanoparticles: The role of polymer size and structure, Physical Chemistry Chemical Physics
Morad, Akbari, Maaza, Theoretical study of chemical reactivity descriptors of some repurposed drugs for COVID-19, Mrs Advances
Morad, Akbari, Rezaee, Koochaki, Maaza et al., First principle simulation of coated hydroxychloroquine on Ag, Au and Pt nanoparticles, Scientific Reports
Perdew, Burke, Ernzerhof, Generalized gradient approximation made simple, Physical review letters
Pushpalatha, Selvamuthukumar, Kilimozhi, Nanocarrier mediated combination drug delivery for chemotherapy-A review, Journal of Drug Delivery Science and Technology
Sohraby, Soltanabad, Bagheri, Javan, Moghadam et al., Application of molecular dynamics in coating Ag-conjugated nanoparticles with potential therapeutic applications, Nano Biomed Eng
Van Den Boogaard, Kibiki, Kisanga, Boeree, Aarnoutse, New drugs against tuberculosis: problems, progress, and evaluation of agents in clinical development, Antimicrobial agents and chemotherapy
Vanachayangkul, Im-Erbsin, Tungtaeng, Kodchakorn, Roth et al., Safety, pharmacokinetics, and activity of highdose ivermectin and chloroquine against the liver stage of Plasmodium cynomolgi infection in rhesus macaques, Antimicrobial agents and chemotherapy
Vanommeslaeghe, Mackerell, Automation of the CHARMM General Force Field (CGenFF) I: bond perception and atom typing, Journal of chemical information and modeling
Wang, Cao, Zhang, Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro, Cell Res, doi:10.1038/s41422-020-0282-0
Wang, Zhang, Du, Du, Zhao et al., Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial, The lancet
Wang, Zhang, Du, Du, Zhao et al., Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial, The lancet
Yao, Ye, Zhang, Cui, Huang et al., In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Clinical infectious diseases
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