Microbiome-Based Hypothesis on Ivermectin’s Mechanism in COVID-19: Ivermectin Feeds Bifidobacteria to Boost Immunity
Hazan,
Microbiome-Based Hypothesis on Ivermectin’s Mechanism in COVID-19: Ivermectin Feeds Bifidobacteria to Boost..,
, S., Frontiers in Microbiology, doi:10.3389/fmicb.2022.952321 (Theory)
Hypothesis for an additional mechanism of action for ivermectin: inhibition of pro-inflammatory cytokines due to enhanced replication of Bifidobacterium. The journal notes the submission of a concern, which may be political. No details on the issue of concern are provided, and the article only provides a hypothesis, while noting that supporting data is forthcoming.
Hazan et al., 11 Jul 2022, peer-reviewed, 1 author.
Contact:
drhazan@progenabiome.com.
Abstract: HYPOTHESIS AND THEORY
published: 11 July 2022
doi: 10.3389/fmicb.2022.952321
Microbiome-Based Hypothesis on
Ivermectin’s Mechanism in
COVID-19: Ivermectin Feeds
Bifidobacteria to Boost Immunity
Sabine Hazan*
Progenabiome, LLC, Ventura, CA, United States
Edited by:
Mohammad Yousef Alikhani,
Hamadan University of Medical
Sciences, Iran
Reviewed by:
Amir Khodavirdipour,
University of Tabriz, Iran
Piyush Baindara,
University of Missouri, United States
*Correspondence:
Sabine Hazan
DrHazan@progenabiome.com
Specialty section:
This article was submitted to
Infectious Agents and Disease,
a section of the journal
Frontiers in Microbiology
Received: 25 May 2022
Accepted: 10 June 2022
Published: 11 July 2022
Citation:
Hazan S (2022)
Microbiome-Based Hypothesis on
Ivermectin’s Mechanism in COVID-19:
Ivermectin Feeds Bifidobacteria to
Boost Immunity.
Front. Microbiol. 13:952321.
doi: 10.3389/fmicb.2022.952321
Ivermectin is an anti-parasitic agent that has gained attention as a potential
COVID-19 therapeutic. It is a compound of the type Avermectin, which is a
fermented by-product of Streptomyces avermitilis. Bifidobacterium is a member
of the same phylum as Streptomyces spp., suggesting it may have a symbiotic
relation with Streptomyces. Decreased Bifidobacterium levels are observed in COVID19 susceptibility states, including old age, autoimmune disorder, and obesity. We
hypothesize that Ivermectin, as a by-product of Streptomyces fermentation, is
capable of feeding Bifidobacterium, thereby possibly preventing against COVID-19
susceptibilities. Moreover, Bifidobacterium may be capable of boosting natural immunity,
offering more direct COVID-19 protection. These data concord with our study, as well
as others, that show Ivermectin protects against COVID-19.
Keywords: microbiome, COVID-19, SARS-CoV-2, Bifidobacterium, TNF-α (tumor necrosis factor a), ivermectin
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