Conv. Plasma
Nigella Sativa

All ivermectin studies
Meta analysis
study COVID-19 treatment researchIvermectinIvermectin (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 25% primary Improvement Relative Risk Ventilation 0% Hospitalization time 20% Ivermectin  Abd-Elsalam et al.  LATE TREATMENT  RCT Is late treatment with ivermectin beneficial for COVID-19? RCT 164 patients in Egypt (March - October 2020) Shorter hospitalization with ivermectin (not stat. sig., p=0.085) Abd-Elsalam et al., J. Medical Virology, Jun 2021 Favors ivermectin Favors control

Clinical Study Evaluating the Efficacy of Ivermectin in COVID-19 Treatment: A Randomized Controlled Study

Abd-Elsalam et al., Journal of Medical Virology, doi:10.1002/jmv.27122
Jun 2021  
  Source   PDF   All   Meta
Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
*, now known with p < 0.00000000001 from 102 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
RCT 164 hospitalized patients in Egypt showing lower mortality and shorter hospitalization, but without statistical significance. There were no serious adverse effects. Authors suggest the low dosage may have resulted in lower efficacy than other trials, and recommend increased dosage in future trials. Time from symptom onset is not specified. The trial was retrospectively registered and the recruitment start date in the trial registration (June 2020) differs from the paper (March 2020) For other concerns see
This is the 25th of 49 COVID-19 RCTs for ivermectin, which collectively show efficacy with p=0.00000038.
This is the 55th of 102 COVID-19 controlled studies for ivermectin, which collectively show efficacy with p<0.0000000001 (1 in 560 quintillion).
risk of death, 25.0% lower, RR 0.75, p = 0.70, treatment 3 of 82 (3.7%), control 4 of 82 (4.9%), NNT 82, odds ratio converted to relative risk, logistic regression, primary outcome.
risk of mechanical ventilation, no change, RR 1.00, p = 1.00, treatment 3 of 82 (3.7%), control 3 of 82 (3.7%).
hospitalization time, 19.6% lower, relative time 0.80, p = 0.09, treatment 82, control 82.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Abd-Elsalam et al., 2 Jun 2021, Randomized Controlled Trial, Egypt, peer-reviewed, 16 authors, study period March 2020 - October 2020, dosage 12mg days 1-3.
This PaperIvermectinAll
Clinical study evaluating the efficacy of ivermectin in COVID‐19 treatment: A randomized controlled study
Sherief Abd‐elsalam, Rasha A Noor, Rehab Badawi, Mai Khalaf, Eslam S Esmail, Shaimaa Soliman, Mohamed S Abd El Ghafar, Mohamed Elbahnasawy, Ehab F Moustafa, Sahar M Hassany, Mohammed A Medhat, Haidi Karam‐allah Ramadan, Maii A S Eldeen, Mohamed Alboraie, Ahmed Cordie, Gamal Esmat
Journal of Medical Virology, doi:10.1002/jmv.27122
Researchers around the world are working at record speed to find the best ways to treat and prevent coronavirus disease 2019 (COVID-19). This study aimed to evaluate the efficacy of ivermectin for the treatment of hospitalized mild to moderate COVID-19 infected patients. This was a randomized open-label controlled study that included 164 patients with COVID-19. Patients were randomized into
Abd-Elsalam, Esmail, Khalaf, Hydroxychloroquine in the treatment of COVID-19: a multicenter randomized controlled study, Am J Trop Med Hyg
Abd-Elsalam, Esmail, Khalaf, Tanta protocol for management of COVID-19: perspectives from a developing country
Ahmed, Karim, Ross, A five day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness, Int J Infect Dis
Babalola, Bode, Ajayi, Ivermectin shows clinical benefits in mild to moderate COVID19: A randomised controlled double blind dose response study in Lagos, QJM
Behera, Patro, Singh, Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: a matched case-control study, J Med Virol
Caccour, Casellas, Blanco-Di Matteo, The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with non-severe COVID-19: a pilot, doubleblind, placebo-controlled, randomized clinical trial, EClinicalMedicine
Caly, Druce, Catton, Jans, Wagstaff, The FDAapproved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro, Antiviral Res
Cappello, Marchetti, Parlanti, Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import, Sci Rep
Chaccour, Hammann, Ramón-García, Rabinovich, Ivermectin and COVID-19: keeping rigor in times of urgency, Am J Trop Med Hyg
Chachar, Khan, Asif, Tanveer, Khaqan et al., Effectiveness of ivermectin in SARS-CoV-2/COVID-19 patients, Int J Sci
Elgazzar, Eltaweel, Youssef, Hany, Hafez et al., Efficacy and safety of ivermectin for treatment and prophylaxis of COVID-19 pandemic
Faul, Erdfelder, Lang, Buchner, Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences, Behav Res Methods
Galan, Santos, Asato, Phase 2 randomized study on chloroquine, hydroxychloroquine or ivermectin in hospitalized patients with severe manifestations of SARS-CoV-2 infection, Pathog Glob Health, doi:10.1080/20477724.2021.1890887
Gallegos, WHO Declares Public Health Emergency for Novel Coronavirus, Medscape Medical News
Gandhi, Lynch, Del Rio, Mild or moderate COVID-19, N Engl J Med
Gorial, Mashhadani, Sayaly, Effectiveness of Ivermectin as add-on Therapy in COVID-19 Management (Pilot Trial)
Jans, Martin, Wagstaff, Inhibitors of nuclear transport, Curr Opin Cell Biol
Khan, Khan, Debnath, Ivermectin treatment may improve the prognosis of patients with COVID-19, Arch Bronconeumol, doi:10.1016/j.arbres.2020.08.007
Lundberg, Pinkham, Baer, Nuclear import and export inhibitors alter capsid protein distribution in mammalian cells and reduce Venezuelan equine encephalitis virus replication, Antiviral Res
Masoud, Elassal, Zaky, Management Protocol for COVID-19 Patients
Mccreary, Pogue, Coronavirus disease 2019 treatment: a review of early and emerging options, Open Forum Infect Dis
Mohamed, Mohamed, Mohamoud, SARS-CoV-2: the path of prevention and control
Momekov, Momekova, Ivermectin as a potential COVID-19 treatment from the pharmacokinetic point of view: antiviral levels are not likely attainable with known dosing regimens, Biotechnol Biotechnol Equip
Podder, Chowdhury, Mohim, Haque, Outcome of ivermectin treated mild to moderate COVID-19 cases: a single-centre, open-label, randomized controlled study, IMC J Med Sci
Pott-Junior, Paoliello, Miguel, Use of ivermectin in the treatment of Covid-19: a pilot trial, Toxicol Rep
Prokop, Van Everdingen, Vellinga, CO-RADS: a categorical CT assessment scheme for patients suspected of having COVID-19 definition and evaluation, Radiology
Rajter, Sherman, Vogel, Sacks, Rajter, Use of ivermectin is associated with lower mortality in hospitalized patients with coronavirus disease 2019: the ivermectin in COVID nineteen study, Chest
Sharun, Dhama, Patel, Ivermectin, a new candidate therapeutic against SARS-CoV-2/COVID-19, Clin Microbiol Antimicrob, doi:10.1186/s12941-020-00368-w
Struyf, Deeks, Dinnes, Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19 disease, Cochrane Database Syst Rev
Tay, Fraser, Chan, Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor ivermectin, Antiviral Res
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop