Clinical Study Evaluating the Efficacy of Ivermectin in COVID-19 Treatment: A Randomized Controlled Study

DOI record: { "DOI": "10.1002/jmv.27122", "ISSN": [ "0146-6615", "1096-9071" ], "URL": "http://dx.doi.org/10.1002/jmv.27122", "abstract": "<jats:title>Abstract</jats:title><jats:sec><jats:label /><jats:p>Researchers around the world are working at record speed to find the best ways to treat and prevent coronavirus disease 2019 (COVID‐19). This study aimed to evaluate the efficacy of ivermectin for the treatment of hospitalized mild to moderate COVID‐19 infected patients. This was a randomized open‐label controlled study that included 164 patients with COVID‐19. Patients were randomized into two groups where Group 1 (Ivermectin group) included patients who received ivermectin 12 mg once daily for 3 days with standard care and Group 2 (control group) included patients who received standard protocol of treatment alone for 14 days. The main outcomes were mortality, the length of hospital stay, and the need for mechanical ventilation. All patients were followed up for 1 month. Overall, 82 individuals were randomized to receive ivermectin plus standard of care and 82 to receive standard of care alone. Patients in the ivermectin group had a shorter length of hospital stay (8.82 ± 4.94 days) than the control group (10.97 ± 5.28 days), but this was not statistically significant (<jats:italic>p</jats:italic> = 0.085). Three patients (3.7%) in each group required mechanical ventilation (<jats:italic>p</jats:italic> = 1.00). The death rate was three patients in the ivermectin group (3.7%) versus four patients (4.9%) in the control group without any significant difference between the two groups (<jats:italic>p</jats:italic> = 1.00). Although there was no statistically significant difference in any endpoints by ivermectin doses (12 mg/day for 3 days); there was an observed trend to reducing hospital stay in the ivermectin‐treated group.</jats:p></jats:sec>", "alternative-id": [ "10.1002/jmv.27122" ], "assertion": [ { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Received", "name": "received", "order": 0, "value": "2021-05-29" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Accepted", "name": "accepted", "order": 1, "value": "2021-05-31" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Published", "name": "published", "order": 2, "value": "2021-06-07" } ], "author": [ { "ORCID": "http://orcid.org/0000-0003-4366-2218", "affiliation": [ { "name": "Department of Tropical Medicine and Infectious diseases, Faculty of Medicine Tanta University Tanta Egypt" } ], "authenticated-orcid": false, "family": "Abd‐Elsalam", "given": "Sherief", "sequence": "first" }, { "affiliation": [ { "name": "Department of Internal Medicine, Faculty of Medicine Tanta University Tanta Egypt" } ], "family": "Noor", "given": "Rasha A.", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Tropical Medicine and Infectious diseases, Faculty of Medicine Tanta University Tanta Egypt" } ], "family": "Badawi", "given": "Rehab", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Tropical Medicine and Infectious diseases, Faculty of Medicine Tanta University Tanta Egypt" } ], "family": "Khalaf", "given": "Mai", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Tropical Medicine and Infectious diseases, Faculty of Medicine Tanta University Tanta Egypt" } ], "family": "Esmail", "given": "Eslam S.", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Public health and Community Medicine, Faculty of Medicine Menoufia University Menoufia Egypt" } ], "family": "Soliman", "given": "Shaimaa", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Anesthesia, Surgical Intensive Care, and Pain Medicine, Faculty of Medicine Tanta University Tanta Egypt" } ], "family": "Abd El Ghafar", "given": "Mohamed S.", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0001-8706-4389", "affiliation": [ { "name": "Department of Emergency Medicine and traumatology, Faculty of Medicine Tanta University Tanta Egypt" } ], "authenticated-orcid": false, "family": "Elbahnasawy", "given": "Mohamed", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Tropical Medicine and Gastroenterology, Faculty of Medicine Assiut University Assiut Egypt" } ], "family": "Moustafa", "given": "Ehab F.", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Tropical Medicine and Gastroenterology, Faculty of Medicine Assiut University Assiut Egypt" } ], "family": "Hassany", "given": "Sahar M.", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Tropical Medicine and Gastroenterology, Faculty of Medicine Assiut University Assiut Egypt" } ], "family": "Medhat", "given": "Mohammed A.", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Tropical Medicine and Gastroenterology, Faculty of Medicine Assiut University Assiut Egypt" } ], "family": "Ramadan", "given": "Haidi Karam‐Allah", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Microbiology and Immunology Tanta University Tanta Egypt" } ], "family": "Eldeen", "given": "Maii A. S.", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Internal Medicine Al‐Azhar University Cairo Egypt" } ], "family": "Alboraie", "given": "Mohamed", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Endemic Medicine, Kasr Alainy School of Medicine Cairo University Cairo Egypt" } ], "family": "Cordie", "given": "Ahmed", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Endemic Medicine, Kasr Alainy School of Medicine Cairo University Cairo Egypt" } ], "family": "Esmat", "given": "Gamal", "sequence": "additional" } ], "container-title": "Journal of Medical Virology", "container-title-short": "Journal of Medical Virology", "content-domain": { "crossmark-restriction": true, "domain": [ "onlinelibrary.wiley.com" ] }, "created": { "date-parts": [ [ 2021, 6, 2 ] ], "date-time": "2021-06-02T17:42:09Z", "timestamp": 1622655729000 }, "deposited": { "date-parts": [ [ 2023, 8, 25 ] ], "date-time": "2023-08-25T22:54:29Z", "timestamp": 1693004069000 }, "indexed": { "date-parts": [ [ 2024, 4, 8 ] ], "date-time": "2024-04-08T20:33:19Z", "timestamp": 1712608399790 }, "is-referenced-by-count": 70, "issue": "10", "issued": { "date-parts": [ [ 2021, 6, 7 ] ] }, "journal-issue": { "issue": "10", "published-print": { "date-parts": [ [ 2021, 10 ] ] } }, "language": "en", "license": [ { "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2021, 6, 7 ] ], "date-time": "2021-06-07T00:00:00Z", "timestamp": 1623024000000 } } ], "link": [ { "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.27122", "content-type": "application/pdf", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jmv.27122", "content-type": "application/xml", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.27122", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "311", "original-title": [], "page": "5833-5838", "prefix": "10.1002", "published": { "date-parts": [ [ 2021, 6, 7 ] ] }, "published-online": { "date-parts": [ [ 2021, 6, 7 ] ] }, "published-print": { "date-parts": [ [ 2021, 10 ] ] }, "publisher": "Wiley", "reference": [ { "key": "e_1_2_7_2_1", "unstructured": "GallegosA. 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