Clinical study evaluating the efficacy of ivermectin in COVID‐19 treatment: A randomized controlled study
Sherief Abd‐elsalam, Rasha A Noor, Rehab Badawi, Mai Khalaf, Eslam S Esmail, Shaimaa Soliman, Mohamed S Abd El Ghafar, Mohamed Elbahnasawy, Ehab F Moustafa, Sahar M Hassany, Mohammed A Medhat, Haidi Karam‐allah Ramadan, Maii A S Eldeen, Mohamed Alboraie, Ahmed Cordie, Gamal Esmat
Journal of Medical Virology, doi:10.1002/jmv.27122
Researchers around the world are working at record speed to find the best ways to treat and prevent coronavirus disease 2019 (COVID-19). This study aimed to evaluate the efficacy of ivermectin for the treatment of hospitalized mild to moderate COVID-19 infected patients. This was a randomized open-label controlled study that included 164 patients with COVID-19. Patients were randomized into
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'abstract': '<jats:title>Abstract</jats:title><jats:sec><jats:label /><jats:p>Researchers around the world '
'are working at record speed to find the best ways to treat and prevent coronavirus disease '
'2019 (COVID‐19). This study aimed to evaluate the efficacy of ivermectin for the treatment of '
'hospitalized mild to moderate COVID‐19 infected patients. This was a randomized open‐label '
'controlled study that included 164 patients with COVID‐19. Patients were randomized into two '
'groups where Group 1 (Ivermectin group) included patients who received ivermectin 12\u2009mg '
'once daily for 3 days with standard care and Group 2 (control group) included patients who '
'received standard protocol of treatment alone for 14 days. The main outcomes were mortality, '
'the length of hospital stay, and the need for mechanical ventilation. All patients were '
'followed up for 1 month. Overall, 82 individuals were randomized to receive ivermectin plus '
'standard of care and 82 to receive standard of care alone. Patients in the ivermectin group '
'had a shorter length of hospital stay (8.82\u2009±\u20094.94 days) than the control group '
'(10.97\u2009±\u20095.28 days), but this was not statistically significant '
'(<jats:italic>p</jats:italic>\u2009=\u20090.085). Three patients (3.7%) in each group '
'required mechanical ventilation (<jats:italic>p</jats:italic>\u2009=\u20091.00). The death '
'rate was three patients in the ivermectin group (3.7%) versus four patients (4.9%) in the '
'control group without any significant difference between the two groups '
'(<jats:italic>p</jats:italic>\u2009=\u20091.00). Although there was no statistically '
'significant difference in any endpoints by ivermectin doses (12\u2009mg/day for 3 days); '
'there was an observed trend to reducing hospital stay in the ivermectin‐treated '
'group.</jats:p></jats:sec>',
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