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All Studies   Meta Analysis    Recent:   

Effects of Ivermectin in Patients With COVID-19: A Multicenter, Double-blind, Randomized, Controlled Clinical Trial

Shahbaznejad et al., Clinical Therapeutics, doi:10.1016/j.clinthera.2021.04.007 (partial results available 1/19), IRCT20111224008507N3
Jan 2021  
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Mortality -197% Improvement Relative Risk Ventilation -94% Recovery time 32% Recovery time (b) 19% primary Hospitalization time 15% Ivermectin  Shahbaznejad et al.  LATE TREATMENT  DB RCT Is late treatment with ivermectin beneficial for COVID-19? Double-blind RCT 69 patients in Iran Faster recovery (p=0.048) and shorter hospitalization (p=0.016) c19ivm.org Shahbaznejad et al., Clinical Therapeu.., Jan 2021 Favorsivermectin Favorscontrol 0 0.5 1 1.5 2+
Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
 
*, now with p < 0.00000000001 from 104 studies, recognized in 23 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19ivm.org
RCT in Iran showing shorter time to recovery and shorter hospitalization time with ivermectin. There were no adverse effects. There was one death in the treatment group, the patient was in critical condition at baseline and died within 24 hours of admission. Also see1 and the author response2.
This is the 15th of 51 COVID-19 RCTs for ivermectin, which collectively show efficacy with p=0.00000015.
This is the 34th of 104 COVID-19 controlled studies for ivermectin, which collectively show efficacy with p<0.0000000001 (1 in 1 sextillion).
risk of death, 197.1% higher, RR 2.97, p = 1.00, treatment 1 of 35 (2.9%), control 0 of 34 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), patient died within 24 hours of admission.
risk of mechanical ventilation, 94.3% higher, RR 1.94, p = 1.00, treatment 2 of 35 (5.7%), control 1 of 34 (2.9%).
recovery time, 31.6% lower, relative time 0.68, p = 0.048, treatment 35, control 34, duration of dsypnea.
recovery time, 19.2% lower, relative time 0.81, p = 0.02, treatment 35, control 34, duration of all symptoms, primary outcome.
hospitalization time, 15.5% lower, relative time 0.85, p = 0.02, treatment 35, control 34.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Shahbaznejad et al., 19 Jan 2021, Double Blind Randomized Controlled Trial, Iran, peer-reviewed, 8 authors, average treatment delay 6.29 days, dosage 200μg/kg single dose, trial IRCT20111224008507N3. Contact: drmsrezaii@yahoo.com.
This PaperIvermectinAll
Effects of Ivermectin in Patients With COVID-19: A Multicenter, Double-blind, Randomized, Controlled Clinical Trial
Leila Shahbaznejad, MD Alireza Davoudi, MD; Gohar Gohar Eslami, PharmD; John S Markowitz, Mohammad Reza Navaeifar, MD Fatemeh Hosseinzadeh, Faeze Sadat Movahedi, MSc Mohammad Sadegh Rezai
Clinical Therapeutics, doi:10.1016/j.clinthera.2021.04.007
Purpose. Given the coronavirus disease-2019 (COVID-19) pandemic, there is a global urgency to discover an effective treatment against this disease. This study aimed to evaluate the effect of the widely used antiparasitic drug ivermectin on COVID-19 patient outcomes. Methods. In this randomized double-blind clinical trial, COVID-19 patients admitted to two referral tertiary hospitals of Mazandaran, north of Iran, were randomly divided into two groups of intervention and control. In addition to standard treatment for COVID-19, the intervention group received a single weight-based dose (0.2 mg/kg) of ivermectin. Demographic, clinical, laboratory and imaging data of participants were recorded at baseline. Patients were daily assessed for clinical complaints and disease progression. The primary clinical outcome measures were duration of hospital stay, fever, dyspnea, cough, and overall clinical improvement. Findings. Sixty-nine patients with the mean age of 47.6±22.2 and 45.2±23.1 years participated in intervention and control groups, respectively (p=0.6). Nineteen patients (54%) in the ivermectin group and 18(53%) in control group were male (p=0.9). The mean duration of dyspnea was 2.4±1.7 days in the ivermectin and 3.7±2.1 days in the control group (p=0.02). Also, persistent cough lasted for 3.1±1.9 days in the ivermectin group compared to 4.8±2.0 days in control group (p=0.00). The mean duration of hospital stay was 6.9±3.1 vs 8.3±3.3 days for the ivermectin and control group, respectively (p=0.01). Also, the frequency of lymphopenia decreased to 14.3% in the ivermectin group and did not change in the control group (p=0.00). Implications. A single dose of ivermectin was well-tolerated in symptomatic COVID-19 patients and improved important clinical features of COVID-19 patients including dyspnea, cough, and lymphopenia. Further studies with larger sample sizes, different drug dosages, dosing intervals and durations, especially in different stages of the disease, may help understanding ivermectin's potential clinical benefits. Trial registration. The current controlled trial was registered in the Iranian Registry of Clinical Trials
Declaration of Competing Interest The authors have declared that no competing interests exist. Authors' Contributions MSR and LSh contributed to study conception and design. ARD, MSR and LSh contributed to data collection and patient sampling. FH and MRN contributed to drafting and editing the manuscript. FSM performed the statistical analysis. MSR, LSh and FH revised the manuscript. MSR and GE provided study supervision. JSM assisted in the drafting and editing the manuscript All authors read and approved the submitted manuscript. Consent for publication Written informed consent was obtained from the patients or their parents prior to manuscript submission for their personal or clinical details in addition to any identifying images to be published in this study. Ethics approval and consent to participate The ethics committee of Mazandaran University of Medical Sciences approved the study protocol (Code: IR.MAZUMS.REC.1399.057) and it was registered in the Iranian Registry of Clinical Trials (code: IRCT20111224008507N3). The patients of this manuscript have not been reported in any other submission by us or anyone else. Availability of data and material All data generated or analyzed during this study are included in this published article. For additional data, please contact the corresponding author (drmsrezaii@yahoo.com). Financial disclosure The authors received no specific funding for this work.
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Late treatment
is less effective
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