Effectiveness and safety of Ivermectin in COVID‐19 patients: A prospective study at a safety‐net hospital
M.D. Muhammet Ozer, Suleyman Yasin Goksu, Reena Conception, MD Esad Ulker, Rodolfo Magallanes Balderas, MD Mohammed Mahdi, MD Zulfiya Manning, PharmD, BCPS, BCIDP Kim To, Muhammad Effendi, MD Rajashree Anandakrishnan, MD Marc Whitman, MD Manish Gugnani
Journal of Medical Virology, doi:10.1002/jmv.27469
Background: Ivermectin has been found to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in vitro. It is unknown whether this inhibition of SARS-CoV-2 replication correlates with improved clinical outcomes. Objective: To assess the effectiveness and safety of ivermectin in hospitalized patients with COVID-19. Methods and Materials: A total of 286 patients with COVID-19 were included in the study. Univariate analysis of the primary mortality outcome and comparisons between treatment groups were determined. Logistic regression and propensity score matching (PSM) was used to adjust for confounders. Results: Patients in the ivermectin group received 2 doses of ivermectin at 200 μg/kg in addition to usual clinical care on hospital days 1 and 3. The ivermectin group had a
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