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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 86% Improvement Relative Risk Hospitalization 93% primary Ivermectin for COVID-19  Hazan et al.  LATE TREATMENT Is late treatment with ivermectin + combined treatments beneficial for COVID-19? Retrospective study in the USA Synthetic control arm Hazan et al., Future Microbiology, Jul 2021 Favors ivermectin Favors control

Effectiveness of ivermectin-based multidrug therapy in severely hypoxic, ambulatory COVID-19 patients

Hazan et al., Future Microbiology, doi:10.2217/fmb-2022-0014 (date from preprint), NCT04949230
Jul 2021  
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Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
*, now known with p < 0.00000000001 from 100 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Small study of 24 consecutive patients in serious condition (9 days post symptoms, mean SpO2 87.4) using combined treatment with ivermectin, doxycycline, zinc, vitamin D, and vitamin C, showing no mortality or hospitalization with treatment. Two patients declined treatment and both died. This study uses a synthetic control arm.
This is the 59th of 100 COVID-19 controlled studies for ivermectin, which collectively show efficacy with p<0.0000000001 (1 in 1 sextillion). 47 studies are RCTs, which show efficacy with p=0.0000002.
This study is excluded in the after exclusion results of meta analysis: study uses a synthetic control arm.
risk of death, 86.2% lower, RR 0.14, p = 0.04, NNT 6.9, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of hospitalization, 93.5% lower, RR 0.07, p = 0.001, NNT 3.3, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hazan et al., 7 Jul 2021, retrospective, USA, peer-reviewed, 7 authors, average treatment delay 9.2 days, dosage 12mg days 1, 4, 8, this trial uses multiple treatments in the treatment arm (combined with doxycycline, zinc, vitamin D, vitamin C) - results of individual treatments may vary, trial NCT04949230 (history).
This PaperIvermectinAll
Effectiveness of ivermectin-based multidrug therapy in severely hypoxic, ambulatory COVID-19 patients
Sabine Hazan, Sonya Dave, Anoja W Gunaratne, Sibasish Dolai, Robert L Clancy, Peter A Mccullough, Thomas J Borody
Future Microbiology, doi:10.2217/fmb-2022-0014
Ivermectin is a safe, inexpensive and effective early COVID-19 treatment validated in 20+ random, controlled trials. Having developed combination therapies for Helicobacter pylori, the authors present a highly effective COVID-19 therapeutic combination, stemming from clinical observations. Patients & methods: In 24 COVID-19 subjects refusing hospitalization with high-risk features, hypoxia and untreated moderate to severe symptoms averaging 9 days, the authors administered this novel combination of ivermectin, doxycycline, zinc and vitamins D and C. Results & conclusions: All subjects resolved symptoms (in 11 days on average), and oxygen saturation improved in 24 h (87.4% to 93.1%; p = 0.001). There were no hospitalizations or deaths, less than (p < 0.002 or 0.05, respectively) background-matched CDC database controls. Triple combination therapy is safe and effective even when used in outpatients with moderate to severe symptoms. Clinical Trial Registration: NCT04949230 (
Conclusion This study builds on extensive literature to provide practical, inexpensive, safe, readily available and highly effective IVM triple therapy aiming to prevent resistance and one that can confidently be used as a routine treatment for outpatient COVID-19. Summary points • The authors observed the effectiveness of a novel combination of ivermectin, doxycycline, zinc and vitamins D and C in 24 COVID-positive subjects with high-risk features/comorbidities. • The majority of the subjects were hypoxic (23 out of 24; oxygen saturation [SpO 2 ] <90%), with 4 below SpO 2 <85% on presentation. Many subjects had related comorbidities (n = 11; 45.8%). The median age of all subjects was 66 years old. • Intervention consisted of 10 days of doxycycline (100 mg twice a day), ivermectin (12 mg on day 1, day 4 and day 8), zinc (25 mg twice a day), vitamin D3 (1500 IU twice a day) and vitamin C (1500 mg twice a day). All treatment was given orally and ceased at the end of 10 days. • One hundred percent of patients accepting treatment survived without the need for hospitalization. All subjects recovered from hypoxic symptoms (SpO 2 >95%) within 10 days of treatment. • The authors report an effective and inexpensive COVID therapy preventing hospitalization and death in all patients and rapid resolution of hypoxia in these ambulatory 'moderately to severely' ill patients. Supplementary data To view the supplementary data that accompany this paper please visit the journal..
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Zithromax R, azithromycin tablets) and (azithromycin for oral suspension
Late treatment
is less effective
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