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0 0.5 1 1.5 2+ Ventilation -152% Improvement Relative Risk Progression -4% Viral decay rate 66% primary c19ivm.org Krolewiecki et al. NCT004381884 Ivermectin RCT EARLY Favors ivermectin Favors control
Antiviral effect of high-dose ivermectin in adults with COVID-19: A proof-of-concept randomized trial
Krolewiecki et al., EClinicalMedicine, doi:10.1016/j.eclinm.2021.100959, NCT004381884 (history)
18 Jun 2021    Source   PDF   Share   Tweet
Proof of concept RCT with 30 ivermectin patients and 15 control patients, showing a concentration dependent antiviral activity, but no significant difference in clinical outcomes. There was no significant difference in viral load reduction between groups overall, but a significant difference was found in patients with higher median plasma ivermectin levels (72% vs. 42%, p=0.004). Mean ivermectin plasma concentration levels correlated with viral decay rate (r=0.47, p=0.02). The change in viral load is provided for the <160ng/mL and >160ng/mL groups, but not the overall treatment group. The corrigendum provides individual viral decay rates for computing the overall treatment group viral decay rate. Authors published a corrigendum: [sciencedirect.com].
risk of mechanical ventilation, 151.9% higher, RR 2.52, p = 1.00, treatment 1 of 27 (3.7%), control 0 of 14 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of progression, 3.7% higher, RR 1.04, p = 1.00, treatment 2 of 27 (7.4%), control 1 of 14 (7.1%).
viral decay rate, RR 0.34, p = 0.09, treatment 20, control 14, relative mean viral decay rate (corrigendum table 2, all treatment patients vs. all control patients), primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Krolewiecki et al., 18 Jun 2021, Randomized Controlled Trial, Argentina, peer-reviewed, 23 authors, average treatment delay 3.5 days, dosage 600μg/kg days 1-5, trial NCT004381884 (history).
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