Ivermectin in combination with doxycycline for treating COVID-19 symptoms: a randomized trial
Reaz Mahmud, Md. Mujibur Rahman, Iftikher Alam, Kazi Gias Uddin Ahmed, A K M Humayon Kabir, S K Jakaria Been Sayeed, Mohammad Aftab Rassel, Farhana Binte Monayem, Md Shahidul Islam, Mohammad Monirul Islam, Anindita Das Barshan, Mohammad Mahfuzul Hoque, MD Md. Uzzal Mallik, Mohammad Abdullah Yusuf, Mohammad Zaid Hossain
Journal of International Medical Research, doi:10.1177/03000605211013550
Objective: We evaluated whether ivermectin combined with doxycycline reduced the clinical recovery time in adults with COVID-19 infection. Methods: This was a randomized, blinded, placebo-controlled trial in patients with mild-tomoderate COVID-19 symptoms randomly assigned to treatment (n ¼ 200) and placebo (n ¼ 200) groups. The primary outcome was duration from treatment to clinical recovery. Secondary outcomes were disease progression and persistent COVID-19 positivity by RT-PCR.
Declaration of conflicting interest The authors declare that there is no conflict of interest. Popular Pharmaceuticals Limited, Bangladesh provided ivermectin, doxycycline, and placebo. The company was not involved in the planning or design of the study and had no role in the collection, analysis, or interpretation of the data.
Author contributions
Appendix
References
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'categories': ['FOS: Health sciences', 'FOS: Health sciences'],
'language': 'en',
'author': [ {'family': 'Reaz', 'given': 'Mahmud'}, {'family': 'Rahman', 'given': 'Mujibur'},
{'family': 'Iftikher', 'given': 'Alam'}, {'family': 'Ahmed', 'given': 'Kazi Gias Uddin'},
{'family': 'Kabir', 'given': 'A. K. M. Humayon'},
{'family': 'S. K. Jakaria Been', 'given': 'Sayeed'},
{'family': 'Mohammad Aftab', 'given': 'Rassel'}, {'family': 'Monayem', 'given': 'Farhana'},
{'family': 'Shahidul', 'given': 'Islam'}, {'family': 'Mohammad Monirul', 'given': 'Islam'},
{'family': 'Anindita Das', 'given': 'Barshan'},
{'family': 'Mohammad Mahfuzul', 'given': 'Hoque'}, {'family': 'Uzzal', 'given': 'Mallik'},
{'family': 'Mohammad Abdullah', 'given': 'Yusuf'},
{'family': 'Hossain', 'given': 'Mohammad Zaid'}],
'issued': {'date-parts': [[2021, 4, 25]]},
'abstract': 'Objective: We evaluated whether ivermectin combined with doxycycline\n'
' reduced the time to clinical recovery in adults with COVID-19 infection.\n'
' Methods: This was a randomized, blinded, placebo-controlled trial in\n'
' patients with mild-to-moderate COVID-19 symptoms randomly assigned to\n'
' treatment (n = 200) and placebo groups (n = 200). The primary outcome was\n'
' duration from treatment to clinical recovery. Secondary outcomes included\n'
' disease progression and persistent COVID-19 positivity by RT-PCR. Results:\n'
' Among 556 screened patients, 400 were enrolled and 363 completed\n'
' follow-up. The mean patient age was 40 years, and 59% were men. The median\n'
' recovery time was 7 (4–10) and 9 (5–12) days in the treatment and placebo\n'
' groups, respectively (hazard ratio, 0.73; 95% confidence interval,\n'
' 0.60–0.90). The number of patients who recovered within 7 days was 61% and\n'
' 44% in the treatment and placebo groups, respectively (hazard ratio, 0.06;\n'
' 95% confidence interval, 0.04–0.09). The proportion of patients who\n'
' remained RT-PCR positive on day 14 and whose disease did not progress was\n'
' significantly lower in the treatment group than in the placebo group.\n'
' Conclusions: Patients with mild-to-moderate COVID-19 infection treated\n'
' with ivermectin plus doxycycline recovered earlier, were less likely to\n'
' progress to more serious disease, and were more likely to be COVID-19\n'
' negative by RT-PCR on day 14.',
'DOI': '10.5061/DRYAD.QJQ2BVQF6',
'publisher': 'Dryad',
'title': 'Ivermectin in combination with doxycycline for treating COVID-19 symptoms: a randomized trial',
'URL': 'https://datadryad.org/stash/dataset/doi:10.5061/dryad.qjq2bvqf6',
'copyright': 'Creative Commons Zero v1.0 Universal',
'version': '3'}
