PARIPEX INDIAN JOURNAL OF RESEARCH
Dr Naveen Kishoria, Dr S L Mathur, Dr Veeram Parmar, Dr Rimple Jeet Kaur, Dr Harish Agarwal, Dr B S Parihar, Dr Somil Verma
doi:10.36106/paripex
BACKGROUND: A cluster of pneumonia cases of unknown etiology was reported from the city of Wuhan, in the Hubei province of China, in December 2019. A novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the causative agent of the disease which was subsequently termed as the coronavirus disease (COVID-19) by the World Health Organization (WHO). SARS-CoV-2 mainly affects the lower respiratory tract and manifests as 1 pneumonia in humans. The incidence of COVID-19 continues to rise, with 9,653,048 laboratory-confirmed cases and 491,128 deaths worldwide and India has reported 508,953 cases and 15,685 deaths till th 2 27 , June 2020. The clinical manifestations of COVID-19 range from fever, cough, fatigue, sore throat, shortness of breath and less 3,4 common symptoms such as headache, nausea and diarrhea. The most common abnormalities in vital signs are increased temperature and tachypnea. The most common radiological findings are bilateral pulmonary infiltrates, ground glass opacities and consolidation. The most common findings associated with severe disease are older age, d-dimer levels greater, higher SOFA score, elevated IL-6, increased Lactate Dehydrogenase, hyperferritinemia and lymphopenia on 5,6 admission. The most common complications are sepsis, respiratory failure, acute respiratory distress syndrome (ARDS), cardiac injury and acute kidney injury.
References
Bray, Rayner, Noël, Jans, Wagstaff, Ivermectin and COVID-19: A report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors' responses, r i n t
Colson, Rolain, Lagier, Brouqui, Raoult, Chloroquine and hydroxychloroquine as available weapons to fight COVID-19, Int J Antimicrob Agents
Colson, Rolain, Raoult, Chloroquine for the 2019 novel coronavirus SARS-CoV2. Inter national Jour nal, of Antimicrobial Agents
Gotz, Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import, Sci. Rep
Guan, Ni, Hu, Clinical Characteristics of Coronavirus Disease 2 0 1 9 i n C h i n a, N E n g l J M e,
doi:10.1056/NEJMoa2002032Jiang, Deng, Zhang, Review of the Clinical Characteristics of Coronavirus Disease 2019 (COVID-19), J GEN INTERN MED Published Online First,
doi:10.1007/s11606-020-05762-wKetkar, Yang, Wormser, Wang, Lack of e cacy of ivermectin for prevention of a lethal Zika virus infection in a murine system, Diagnostic Microbiology and Infectious Disease,
doi:10.1016/j.diagmicrobio.2019.03.012Lundberg, Pinkham, Baer, Nuclear import and export inhibitors alter capsid protein distribution in mammalian cells and reduce Venezuelan Equine Encephalitis Virus replication, Antiviral Res,
doi:10.1016/j.antiviral.2013.10.004Patrì, Fabbrocini, Hydroxychloroquine and ivermectin: A synergistic combination for COVID-19 chemoprophylaxis and treatment?, Journal of the American Academy of Dermatology
Smit, Pharmacokinetics-Pharmacodynamics of High-Dose Ivermectin with Dihydroartemisinin-Piperaquine on Mosquitocidal Activity and QT-Prolongation (IVERMAL) ClinPharmacolTher
Tay, Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin, Antivir. Res
Wagstaff, Ivermectin is a specific inhibitor of importin alpha/beta-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus, Biochem. J
Wang, Hu, Hu, Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, C h i n a . J A M A P u b l i s h e d O n l i n e F i r s t, Fe b r u a r y,
doi:10.1001/jama.2020.1585Who, None
Who, None
Zhou, Yu, Du, Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, The Lancet,
doi:10.1016/S0140-6736(20)30566-3
