PARIPEX INDIAN JOURNAL OF RESEARCH
Dr Naveen Kishoria, Dr S L Mathur, Dr Veeram Parmar, Dr Rimple Jeet Kaur, Dr Harish Agarwal, Dr B S Parihar, Dr Somil Verma
doi:10.36106/paripex
BACKGROUND: A cluster of pneumonia cases of unknown etiology was reported from the city of Wuhan, in the Hubei province of China, in December 2019. A novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the causative agent of the disease which was subsequently termed as the coronavirus disease (COVID-19) by the World Health Organization (WHO). SARS-CoV-2 mainly affects the lower respiratory tract and manifests as 1 pneumonia in humans. The incidence of COVID-19 continues to rise, with 9,653,048 laboratory-confirmed cases and 491,128 deaths worldwide and India has reported 508,953 cases and 15,685 deaths till th 2 27 , June 2020. The clinical manifestations of COVID-19 range from fever, cough, fatigue, sore throat, shortness of breath and less 3,4 common symptoms such as headache, nausea and diarrhea. The most common abnormalities in vital signs are increased temperature and tachypnea. The most common radiological findings are bilateral pulmonary infiltrates, ground glass opacities and consolidation. The most common findings associated with severe disease are older age, d-dimer levels greater, higher SOFA score, elevated IL-6, increased Lactate Dehydrogenase, hyperferritinemia and lymphopenia on 5,6 admission. The most common complications are sepsis, respiratory failure, acute respiratory distress syndrome (ARDS), cardiac injury and acute kidney injury.
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