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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 100% Improvement Relative Risk Ventilator free days 48% primary Ventilation time 38% ICU free days 43% ICU time 38% GI complications while ve.. 78% c19ivm.org Shimizu et al. Ivermectin for COVID-19 LATE TREATMENT Favors ivermectin Favors control
Ivermectin administration is associated with lower gastrointestinal complications and greater ventilator-free days in ventilated patients with COVID-19: A propensity score analysis
Shimizu et al., Journal of Infection and Chemotherapy, doi:10.1016/j.jiac.2021.12.024
31 Dec 2021    Source   PDF   Share   Tweet
Retrospective 88 ventilated COVID-19 patients in Japan, 39 treated with ivermectin within 3 days of admission, showing significantly reduced incidence of GI complications and mortality, and increased ventilator-free days with treatment.
risk of death, 99.9% lower, HR 0.001, p < 0.001, treatment 0 of 39 (0.0%), control 8 of 49 (16.3%), NNT 6.1, adjusted per study, Cox proportional hazard regression.
ventilator free days, 47.9% lower, OR 0.52, p = 0.03, treatment 39, control 49, adjusted per study, inverted to make OR<1 favor treatment, proportional odds logistic regression, primary outcome, RR approximated with OR.
ventilation time, 38.5% lower, relative time 0.62, p < 0.001, treatment 39, control 49.
ICU free days, 42.8% lower, OR 0.57, p = 0.06, treatment 39, control 49, adjusted per study, inverted to make OR<1 favor treatment, proportional odds logistic regression, RR approximated with OR.
ICU time, 37.5% lower, relative time 0.62, p < 0.001, treatment 39, control 49.
GI complications while ventilated, 77.9% lower, RR 0.22, p = 0.03, treatment 39, control 49, adjusted per study, Cox proportional hazard regression.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Shimizu et al., 31 Dec 2021, retrospective, Japan, peer-reviewed, 11 authors, study period December 2020 - May 2021, dosage 200μg/kg days 1, 14.
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This PaperIvermectinAll
Late treatment
is less effective
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