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0 0.5 1 1.5 2+ Moderate/severe case 95% Improvement Relative Risk Case 84% primary Ivermectin  Chahla et al.  Prophylaxis  RCT Is prophylaxis with ivermectin + iota-carrageenan beneficial for COVID-19? RCT 234 patients in Argentina (October - December 2020) Fewer moderate/severe cases (p=0.0016) and cases (p=0.004) Chahla et al., American J. Therapeutics, Jan 2021 Favors ivermectin Favors control

Intensive Treatment With Ivermectin and Iota-Carrageenan as Pre-exposure Prophylaxis for COVID-19 in Health Care Workers From Tucuman, Argentina

Chahla et al., American Journal of Therapeutics, doi:10.1097/MJT.0000000000001433, NCT04701710
Jan 2021  
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Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
*, now known with p < 0.00000000001 from 102 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Prophylaxis RCT for ivermectin and iota-carrageenan in Argentina, 117 healthcare workers treated with ivermectin and iota-carrageenan, and 117 controls, showing significantly lower cases with treatment. There were no moderate/severe cases with treatment vs. 10 in the control group. There were 4 cases with treatment (all mild) vs. 25 for the control group.
5 studies use direct respiratory tract administration Aref, Aref (B), Carvallo, Carvallo (B), Chahla
Targeted administration to the respiratory tract provides treatment directly to the typical source of initial SARS-CoV-2 infection and replication, and allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects.
This is the 12th of 49 COVID-19 RCTs for ivermectin, which collectively show efficacy with p=0.00000038.
This is the 31st of 102 COVID-19 controlled studies for ivermectin, which collectively show efficacy with p<0.0000000001 (1 in 560 quintillion).
Study covers iota-carrageenan and ivermectin.
risk of moderate/severe case, 95.2% lower, RR 0.05, p = 0.002, treatment 0 of 117 (0.0%), control 10 of 117 (8.5%), NNT 12, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), moderate/severe COVID-19.
risk of case, 84.0% lower, RR 0.16, p = 0.004, treatment 4 of 117 (3.4%), control 25 of 117 (21.4%), NNT 5.6, adjusted per study, odds ratio converted to relative risk, all cases, primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chahla et al., 11 Jan 2021, Randomized Controlled Trial, Argentina, peer-reviewed, 11 authors, study period 15 October, 2020 - 31 December, 2020, dosage 12mg weekly, this trial uses multiple treatments in the treatment arm (combined with iota-carrageenan) - results of individual treatments may vary, trial NCT04701710 (history).
This PaperIvermectinAll
Intensive Treatment With Ivermectin and Iota-Carrageenan as Pre-exposure Prophylaxis for COVID-19 in Health Care Workers From Tucuman, Argentina
tive effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes.
Rossana E. Chahla, MD, PhD 1 Luis Medina Ruiz, MD 2 Eugenia S. Ortega, MSc 3 Marcelo F. Morales, RN 4 Francisco Barreiro, MD 5 Alexia George, MD 5 Cesar Mancilla, RN 4 Sylvia D' Amato, RN 4 Guillermo Barrenechea, MSc 3 Daniel G. Goroso, PhD
Abd-Elsalam, Noor, Badawi, Clinical study evaluating the efficacy of ivermectin in COVID-19 treatment: A randomized controlled study
Alam, Murshed, Gomes, Ivermectin as pre-exposure prophylaxis for COVID-19 among healthcare providers in a selected tertiary hospital in dhakaan observational study, Eur J Med Heal Sci
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Chaccour, Casellas, Matteo, The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with nonsevere COVID-19: a pilot, double-blind, placebocontrolled, randomized clinical trial, EClinicalMedicine
Chaccour, Ruiz-Castillo, Richardson, The sars-cov-2 ivermectin navarra-isglobal trial (saint) to evaluate the potential of ivermectin to reduce covid-19 transmission in low risk, non-severe covid-19 patients in the first 48 hours after symptoms onset: a structured summary of a study protocol, Trials
Chahla, Prophylaxis covid-19 in health workers through intensive treatment with ivermectin and iotacarrageenan (Ivercar-Tuc), ClinicalTrials
Chong, Sullivan, New uses for old drugs, Nature
H Ector, Roberto, Psaltis, Study of the efficacy and safety of topical ivermectin + iota-carrageenan in the prophylaxis against COVID-19 in health personnel, J Biomed Res Clin Investig
Hirsch, Hector, Covid 19 and ivermectin prevention and treatment update, J Infect Dis Trav Med
Kory, Meduri, Varon, Review of the emerging evidence demonstrating the efficacy of ivermectin in the prophylaxis and treatment of COVID-19, Am J Ther
Krolewiecki, Lifschitz, Moragas, Antiviral effect of high-dose ivermectin in adults with COVID-19: A proof-of-concept randomized trial, EClinicalMedicine
Liu, Fang, Reagan, In silico drug repositioning: what we need to know, Drug Discov Today
Shouman, Hegazy, Nafae, Use of ivermectin as a potential chemoprophylaxis for COVID-19 in Egypt: a randomized clinical trial, J Clin Diagn Res
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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