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0 0.5 1 1.5 2+ Moderate/severe case 95% Improvement Relative Risk Case 84% primary c19ivm.org Chahla et al. NCT04701710 Ivermectin RCT Prophylaxis Favors ivermectin Favors control
Intensive Treatment With Ivermectin and Iota-Carrageenan as Pre-exposure Prophylaxis for COVID-19 in Health Care Workers From Tucuman, Argentina
Chahla et al., American Journal of Therapeutics, doi:10.1097/MJT.0000000000001433, NCT04701710 (history)
11 Jan 2021    Source   PDF   Share   Tweet
Prophylaxis RCT for ivermectin and iota-carrageenan in Argentina, 117 healthcare workers treated with ivermectin and iota-carrageenan, and 117 controls, showing significantly lower cases with treatment. There were no moderate/severe cases with treatment vs. 10 in the control group. There were 4 cases with treatment (all mild) vs. 25 for the control group.
risk of moderate/severe case, 95.2% lower, RR 0.05, p = 0.002, treatment 0 of 117 (0.0%), control 10 of 117 (8.5%), NNT 12, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), moderate/severe COVID-19.
risk of case, 84.0% lower, RR 0.16, p = 0.004, treatment 4 of 117 (3.4%), control 25 of 117 (21.4%), NNT 5.6, adjusted per study, odds ratio converted to relative risk, all cases, primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chahla et al., 11 Jan 2021, Randomized Controlled Trial, Argentina, peer-reviewed, 11 authors, dosage 12mg weekly, this trial uses multiple treatments in the treatment arm (combined with iota-carrageenan) - results of individual treatments may vary, trial NCT04701710 (history).
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