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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 33% Improvement Relative Risk Improvement at day 10 43% Improvement at day 5 16% primary Viral clearance 80% Ivermectin  Okumuş et al.  LATE TREATMENT  DB RCT Is late treatment with ivermectin beneficial for COVID-19? Double-blind RCT 60 patients in Turkey (May - September 2020) Improved viral clearance with ivermectin (p=0.021) c19ivm.org Okumuş et al., BMC Infectious Diseases, Jan 2021 Favors ivermectin Favors control

Evaluation of the Effectiveness and Safety of Adding Ivermectin to Treatment in Severe COVID-19 Patients

Okumuş et al., BMC Infectious Diseases, doi:10.1186/s12879-021-06104-9 (date from preprint), NCT04646109
Jan 2021  
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Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
 
*, now known with p < 0.00000000001 from 100 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19ivm.org
Small RCT for severe COVID-19 comparing the addition of ivermectin to SOC (low dose HCQ+AZ+favipiravir), with 30 treatment and 30 control patients in Turkey, showing lower mortality and faster clinical recovery. Authors also investigate the presence of gene mutations that alter ivermectin metabolism, predicting that ivermectin can be used safely without serious side effects in patients without MDR-1/ABCB1 and/or CYP3A4 gene mutation, and recommending monitoring and appropriate treatment if necessary when sequencing is unavailable. NCT04646109 (history).
This is the 13th of 47 COVID-19 RCTs for ivermectin, which collectively show efficacy with p=0.0000002.
This is the 32nd of 100 COVID-19 controlled studies for ivermectin, which collectively show efficacy with p<0.0000000001 (1 in 1 sextillion).
risk of death, 33.3% lower, RR 0.67, p = 0.55, treatment 6 of 30 (20.0%), control 9 of 30 (30.0%), NNT 10.
risk of no improvement at day 10, 42.9% lower, RR 0.57, p = 0.18, treatment 8 of 30 (26.7%), control 14 of 30 (46.7%), NNT 5.0.
risk of no improvement at day 5, 15.8% lower, RR 0.84, p = 0.60, treatment 16 of 30 (53.3%), control 19 of 30 (63.3%), NNT 10, primary outcome.
risk of no viral clearance, 80.0% lower, RR 0.20, p = 0.02, treatment 2 of 16 (12.5%), control 5 of 8 (62.5%), NNT 2.0, day 10.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Okumuş et al., 12 Jan 2021, Double Blind Randomized Controlled Trial, Turkey, peer-reviewed, 15 authors, study period May 2020 - September 2020, dosage 200μg/kg days 1-5, 36-50kg - 9mg, 51-65kg - 12mg, 66-79kg - 15mg, >80kg 200μg/kg, trial NCT04646109 (history).
This PaperIvermectinAll
Evaluation of the effectiveness and safety of adding ivermectin to treatment in severe COVID-19 patients
Nurullah Okumuş, Neşe Demirtürk, Rıza Aytaç Çetinkaya, Rahmet Güner, İsmail Yaşar Avcı, Semiha Orhan, Petek Konya, Bengü Şaylan, Ayşegül Karalezli, Levent Yamanel, Bircan Kayaaslan, Gülden Yılmaz, Ümit Savaşçı, Fatma Eser, Gürhan Taşkın
BMC Infectious Diseases, doi:10.1186/s12879-021-06104-9
Background and objectives: An effective treatment option is not yet available for SARS-CoV2, which causes the COVID-19 pandemic and whose effects are felt more and more every day. Ivermectin is among the drugs whose effectiveness in treatment has been investigated. In this study; it was aimed to investigate the presence of gene mutations that alter ivermectin metabolism and cause toxic effects in patients with severe COVID-19 pneumonia, and to evaluate the effectiveness and safety of ivermectin use in the treatment of patients without mutation. Materials and methods: Patients with severe COVID19 pneumonia were included in the study, which was planned as a prospective, randomized, controlled, single-blind phase 3 study. Two groups, the study group and the control group, took part in the study. Ivermectin 200 mcg/kg/day for 5 days in the form of a solution prepared for enteral use added to the reference treatment protocol -hydroxychloroquine + favipiravir + azithromycin-of patients included in the study group. Patients in the control group were given only reference treatment with 3 other drugs without ivermectin. The presence of mutations was investigated by performing sequence analysis in the mdr1/ abcab1 gene with the Sanger method in patients included in the study group according to randomization. Patients with mutations were excluded from the study and ivermectin treatment was not continued. Patients were followed for 5 days after treatment. At the end of the treatment and follow-up period, clinical response and changes in laboratory parameters were evaluated.
Supplementary Information The online version contains supplementary material available at https://doi. org/10.1186/s12879-021-06104-9. Additional file 1: Supplementary Table 1 . Laboratory parameter changes. Declarations Ethics approval and consent to participate Ethics board approval (Afyonkarahisar Health Science University, Local Ethical Commitee 03.04.2020/139). All participants provided informed consent prior to study enrollment. Consent for publication Not applicable. Competing interests The authors declare that they have neither financial nor non-financial competing interests. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Late treatment
is less effective
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