Abstract: Monaldi Archives for Chest Disease eISSN 2532-5264 https://www.monaldi-archives.org/ Publisher's Disclaimer. E-publishing ahead of print is increasingly important for the rapid dissemination of science. The Monaldi Archives for Chest Disease is, therefore, Epublishing PDF files of an early version of manuscripts that undergone a regular peer review and have been accepted for publication, but have not been through the copyediting, typesetting, pagination and proofreading processes, which may lead to differences between this version and the final one. The final version of the manuscript will then appear on a regular issue of the journal. E-publishing of this PDF file has been approved by the authors. Monaldi Arch Chest Dis 2022 [Online ahead of print] To cite this Article: Zubair SM, Chaudhry MW, Zubairi ABS, et al. The effect of ivermectin on non-severe and severe COVID-19 disease and gender-based difference of its effectiveness. Monaldi Arch Chest Dis doi: 10.4081/monaldi.2022.2062 © the Author(s), 2022 Licensee PAGEPress, Italy Note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries should be directed to the corresponding author for the article. The effect of ivermectin on non-severe and severe COVID-19 disease and gender-based difference of its effectiveness Syed Muhammad Zubair, Muhammad Waleed Chaudhry, Ali Bin Sarwar Zubairi, Talha Shahzad, Aqusa Zahid, Ibrahim Ali Khan, Javaid Ahmed Khan, Muhammad Irfan Section of Pulmonary Medicine, Department of Medicine Aga Khan University Hospital, Karachi, Pakistan Corresponding Author: Muhammad Irfan, Professor, Section of Pulmonary Medicine, Department of Medicine Aga Khan University Hospital, Karachi, Pakistan. Address: Faculty Office Building, National Stadium Road, Aga Khan University Hospital, Karachi, Karachi City, Sindh 74800. Phone: 02134864664 - Cell phone: +923002111459 Email: muhammad.irfan@aku.edu Acknowledgments: None i) Authors Contribution: 1) Syed Muhammad Zubair: Data Collection, statistical analysis, literature review, manuscript writing. 2) Muhammad Waleed Chaudhry: Data Collection, statistical analysis, literature review, manuscript writing. 3) Ali Bin Sarwar Zubairi: Wrote, reviewed and edited the manuscript. 4) Talha Shahzad: Reviewed and edited the manuscript. 5) Aqusa Zahid: Data Collection, reviewed and edited the manuscript. 6) Ibrahim Ali Khan: Reviewed and edited the manuscript. 7) Javaid Ahmed Khan: Reviewed and edited the manuscript. 8) Muhammad Irfan: Conceived the idea, wrote, reviewed and edited the manuscript. Ethics approval: The study protocol was approved by the Ethics Review Committee (ERC) of the Aga Khan University Hospital (Application no: 2021-5902-16610). ii) There is no conflict of interests. iii) There is no funding for this article. The abstract of this article has been scheduled to be presented at the following forum: 1) Abstract title: Role of ivermectin in hospitalized patients with mild to moderate COVID-19. To be presented as an ‘e-poster’ at virtual European Respiratory Society Congress 2021 on 07-09-2021. Abstract The COVID-19 pandemic has led to mortality and morbidity since December 2019. Many possible treatment options have been advised till date. The role of ivermectin in the treatment of COVID19 disease remains controversial. The aim of our study was to evaluate the effect of ivermectin in hospitalized patients with non-severe and severe..