The effect of ivermectin on non-severe and severe COVID-19 disease and gender-based difference of its effectiveness

Zubair et al., Monaldi Archives for Chest Disease, doi:10.4081/monaldi.2022.2062

Jan 2022

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Retrospective 188 hospitalized patients in Pakistan, 90 treated with ivermectin, showing no significant differences with treatment. The ivermectin group had more severe disease (66% vs 58%, with 6x higher risk for severe disease patients), and more male patients (70% vs. 65%). Higher use of remdesivir and steroids in the ivermectin group also suggests that ivermectin was more likely to be given to patients in more severe condition. There were no side effects seen with ivermectin. Authors note that significantly improved ferritin levels were seen with treatment. Authors state that ivermectin patients received 2 12mg doses, 24 hours apart, but later state that the dosage was not standardized.

This is the 76th of 99 COVID-19 controlled studies for ivermectin, which collectively show efficacy with p<0.0000000001 (1 in 2 sextillion). 46 studies are RCTs, which show efficacy with p=0.00000014. This study is excluded in the after exclusion results of meta analysis: substantial unadjusted confounding by indication likely; unadjusted results with no group details.

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risk of death, 9.0% higher, RR 1.09, p = 1.00, treatment 5 of 90 (5.6%), control 5 of 98 (5.1%), unadjusted.

hospitalization time, 8.0% higher, relative time 1.08, p = 0.40, treatment 90, control 98, unadjusted, Table 3, mean number of days.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Zubair et al., 18 Jan 2022, retrospective, Pakistan, peer-reviewed, 8 authors, study period October 2020 - February 2021, dosage 12mg single dose.

Contact: muhammad.irfan@aku.edu.

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The effect of ivermectin on non-severe and severe COVID-19 disease and gender-based difference of its effectiveness

Syed Muhammad Zubair, Muhammad Waleed Chaudhry, Ali Bin Sarwar Zubairi, Talha Shahzad, Aqusa Zahid, Ibrahim Ali Khan, Javaid Ahmed Khan, Muhammad Irfan

Monaldi Archives for Chest Disease, doi:10.4081/monaldi.2022.2062

Role of ivermectin in hospitalized patients with mild to moderate COVID-19. To be presented as an 'e-poster' at virtual European Respiratory Society Congress 2021 on 07-09-2021.

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