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Ivermectin and mortality in patients with COVID-19: A systematic review, meta-analysis, and meta-regression of randomized controlled trials

Zein et al., Diabetes & Metabolic Syndrome: Clinical Research & Reviews, doi:10.1016/j.dsx.2021.102186

Jul 2021

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Ivermectin for COVID-19

4th treatment shown to reduce risk in August 2020

^*, now known with p < 0.00000000001 from 102 studies, recognized in 22 countries.

Lower risk for mortality, ventilation, ICU admission, hospitalization, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine complementary and synergistic treatments. ^* >10% efficacy in meta analysis with ≥3 clinical studies.

4,100+ studies for 60+ treatments. c19ivm.org

Systematic review and meta analysis showing lower mortality with ivermectin.

7 meta analyses show significant improvements with ivermectin for mortality Bryant, Hariyanto, Kory, Lawrie, Nardelli, Zein, hospitalization Schwartz, recovery Kory, and cases Kory.

Currently there are 102 ivermectin for COVID-19 studies, showing 49% lower mortality [35‑60%], 29% lower ventilation [12‑42%], 35% lower ICU admission [7‑54%], 34% lower hospitalization [20‑45%], and 81% fewer cases [71‑87%].

1. Bryant et al., Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines, American Journal of Therapeutics, doi:10.1097/MJT.0000000000001402.lww.com, doi.org.

2. Hariyanto et al., Ivermectin and outcomes from Covid-19 pneumonia: A systematic review and meta-analysis of randomized clinical trial studies, Reviews In Medical Virology, doi:10.1002/rmv.2265.wiley.com, doi.org.

3. Kory et al., Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19, American Journal of Therapeutics, doi:10.1097/MJT.0000000000001377.lww.com, doi.org.

4. Lawrie et al., Ivermectin reduces the risk of death from COVID-19 – a rapid review and meta-analysis in support of the recommendation of the Front Line COVID-19 Critical Care Alliance, Preprint, b3d2650e-e929-4448-a527-4eeb59304c7f.filesusr.com/ugd/593c4f_8cb655bd21b1448ba6cf1f4c59f0d73d.pdf.filesusr.com.

5. Nardelli et al., Crying wolf in time of Corona: the strange case of ivermectin and hydroxychloroquine. Is the fear of failure withholding potential life-saving treatment from clinical use?, Signa Vitae, doi:10.22514/sv.2021.043.signavitae.com, doi.org.

6. Schwartz, E., Does ivermectin have a place in the treatment of mild Covid-19?, New Microbes and New Infections, doi:10.1016/j.nmni.2022.100989.sciencedirect.com, doi.org.

7. Zein et al., Ivermectin and mortality in patients with COVID-19: A systematic review, meta-analysis, and meta-regression of randomized controlled trials, Diabetes & Metabolic Syndrome: Clinical Research & Reviews, doi:10.1016/j.dsx.2021.102186.sciencedirect.com, doi.org.

Important missing comments or errors? Let us know.

risk of death, 61.0% lower, RR 0.39, p = 0.005.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Zein et al., 31 Jul 2021, peer-reviewed, 4 authors. Contact: fariz_zein_dr@yahoo.com, wilsonkores@gmail.com, pranata@hotmail.com.

This Paper Ivermectin All

Ivermectin and mortality in patients with COVID-19: A systematic review, meta-analysis, and meta-regression of randomized controlled trials

Ahmad Fariz Malvi Zamzam Zein, Catur Setiya Sulistiyana, Wilson Matthew Raffaelo, Raymond Pranata

Diabetes & Metabolic Syndrome: Clinical Research & Reviews, doi:10.1016/j.dsx.2021.102186

Aims: This systematic review and meta-analysis aims to investigate the effect of ivermectin on mortality in patients with COVID-19. Methods: A comprehensive systematic literature search was performed using PubMed, Scopus, Embase, and Clinicaltrials.gov from the inception of databases up until April 9, 2021. The intervention group was ivermectin and the control group was standard of care or placebo. The primary outcome was mortality reported as risk ratio (RR). Results: There were 9 RCTs comprising of 1788 patients included in this meta-analysis. Ivermectin was associated with decreased mortality (RR 0.39 [95% 0.20e0.74], p ¼ 0.004; I 2 : 58.2%, p ¼ 0.051). Subgroup analysis in patients with severe COVID-19 showed borderline statistical significance towards mortality reduction (RR 0.42 [95% 0.18e1.00], p ¼ 0.052; I 2 : 68.3, p ¼ 0.013). The benefit of ivermectin and mortality was reduced by hypertension (RR 1.08 [95% CI 1.03e1.13], p ¼ 0.001); but was not influenced by age (p ¼ 0.657), sex (p ¼ 0.466), diabetes (p ¼ 0.429). Sensitivity analysis using fixed-effect model showed that ivermectin decreased mortality in general (RR 0.43 [95% CI 0.29e0.62], p < 0.001) and severe COVID-19 subgroup (RR 0.48 [95% CI 0.32e0.72], p < 0.001). Conclusions: Ivermectin was associated with decreased mortality in COVID-19 with a low certainty of evidence. Further adequately powered double-blinded placebo-controlled RCTs are required for definite conclusion.

References

Ashraf, Chaudhry, Raza, Ghosh, Zhao, In vitro activity of ivermectin against Staphylococcus aureus clinical isolates, Antimicrob Resist Infect Contr, doi:10.1186/s13756-018-0314-4

Ashraf, Prichard, Ivermectin exhibits potent anti-mitotic activity, Vet Parasitol, doi:10.1016/j.vetpar.2016.06.015

Barrows, Campos, Powell, Prasanth, Schott-Lerner et al., A screen of FDA-approved drugs for inhibitors of zika virus infection, Cell Host Microbe, doi:10.1016/j.chom.2016.07.004

Caly, Druce, Catton, Jans, Wagstaff, The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro, Antivir Res, doi:10.1016/j.antiviral.2020.104787

Caly, Wagstaff, Jans, Nuclear trafficking of proteins from RNA viruses: potential target for antivirals?, Antivir Res, doi:10.1016/j.antiviral.2012.06.008

Canga, Prieto, Li Ebana, Martínez, Vega et al., The pharmacokinetics and interactions of ivermectin in humans -a mini-review, AAPS J, doi:10.1208/s12248-007-9000-9

Cordova, Deserno, Gelbart, Ben-Shaul, Osmotic shock and the strength of viral capsids, Biophys J, doi:10.1016/S0006-3495(03)74455-5

Crump, Ivermectin: enigmatic multifaceted "wonder" drug continues to surprise and exceed expectations, J Antibiot (Tokyo), doi:10.1038/ja.2017.11

Elgazzar, Eltaweel, Youssef, Hany, Hafez, Efficacy and safety of ivermectin for treatment and prophylaxis of COVID-19 pandemic, Res Sq, doi:10.21203/rs.3.rs-100956/v3

Galan, Santos Nm Dos, Asato, Araújo, De Lima Moreira et al., Phase 2 randomized study on chloroquine, hydroxychloroquine or ivermectin in hospitalized patients with severe manifestations of SARS-CoV-2 infection, Pathog Glob Health, doi:10.1080/20477724.2021.1890887

Gonzalez, Gonz Alez G Amez, Enciso, Maldonado, Efficacy and safety of Ivermectin and Hydroxychloroquine in patients with severe COVID-19. A randomized controlled trial Corresponding Authors, MedRxiv, doi:10.1101/2021.02.18.21252037

G€ Otz, Magar, Dornfeld, Giese, Pohlmann et al., Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import, Sci Rep, doi:10.1038/srep23138

Handayani, Juliastuti, Nawangsih, Kusmala, Rakhmat et al., Prognostic value of fasting hyperglycemia in patients with COVID-19 e diagnostic test accuracy meta-analysis, Obes Med, doi:10.1016/j.obmed.2021.100333

Hashim, Maulood, Rasheed, Fatak, Kabah et al., Controlled randomized clinical trial on using Ivermectin with Doxycycline for treating COVID-19 patients in Baghdad, Iraq. MedRxiv, doi:10.1101/2020.10.26.20219345

Huang, Pranata, Lim, Oehadian, Alisjahbana, C-reactive protein, procalcitonin, D-dimer, and ferritin in severe coronavirus disease-2019: a meta-analysis, Ther Adv Respir Dis, doi:10.1177/1753466620937175

Intuyod, Hahnvajanawong, Pinlaor, Pinlaor, Anti-parasitic drug ivermectin exhibits potent anticancer activity against gemcitabine-resistant cholangiocarcinoma in vitro, Anticancer Res, doi:10.21873/anticanres.13669

Juarez, Schcolnik-Cabrera, Dueñas-Gonzalez, The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug, Am J Cancer Res

Klotz, Ogbuokiri, Okonkwo, Ivermectin binds avidly to plasma proteins, Eur J Clin Pharmacol, doi:10.1007/BF00316107

Lim, Pranata, Huang, Yonas, Soeroto et al., Multiorgan failure with emphasis on acute kidney injury and severity of COVID-19: systematic review and meta-analysis, Can J Kidney Heal Dis, doi:10.1177/2054358120938573

Lim, Vilch Eze, Ng, Jacobs, On-García et al., Anthelmintic avermectins kill mycobacterium tuberculosis, including multidrugresistant clinical strains, Antimicrob Agents Chemother, doi:10.1128/AAC.01696-12

Lukito, Pranata, Henrina, Lim, Lawrensia et al., The effect of metformin consumption on mortality in hospitalized COVID-19 patients: a systematic review and meta-analysis, Diabetes Metab Syndr Clin Res Rev, doi:10.1016/j.dsx.2020.11.006

Martha, Pranata, Lim, Wibowo, Akbar, Active prescription of low-dose aspirin during or prior to hospitalization and mortality in COVID-19: a systematic review and meta-analysis of adjusted effect estimates, Int J Infect Dis, doi:10.1016/j.ijid.2021.05.016

Niaee, Gheibi, Namdar, Allami, Zolghadr et al., Ivermectin as an adjunct treatment for hospitalized adult COVID-19 patients: a randomized multi-center clinical trial, Res Sq, doi:10.21203/rs.3.rs-109670/v1

Opez-Medina, Hurtado, Ramirez, Martínez, Effect of ivermectin on time to resolution of symptoms among adults with mild COVID-19: a randomized clinical trial, JAMA, J Am Med Assoc, doi:10.1001/jama.2021.3071

Portmann-Baracco, Alberti, Accinelli, Antiviral and antiinflammatory properties of ivermectin and its potential use in COVID-19, Arch Bronconeumol, doi:10.1016/j.arbres.2020.06.011

Pranata, Henrina, Raffaello, Lawrensia, Huang, Diabetes and COVID-19: the past, the present, and the future, Metabolism, doi:10.1016/j.metabol.2021.154814

Pranata, Huang, Lim, Yonas, Vania et al., Delirium and mortality in coronavirus disease 2019 (COVID-19) e a systematic review and meta-analysis, Arch Gerontol Geriatr, doi:10.1016/j.archger.2021.104388

Pranata, Huang, Raharjo, Incidence and impact of cardiac arrhythmias in coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis, Indian Pacing Electrophysiol J, doi:10.1016/j.ipej.2020.08.001

Pranata, Lim, Huang, Raharjo, Lukito, Hypertension is associated with increased mortality and severity of disease in COVID-19 pneumonia: a systematic review, meta-analysis and meta-regression, JRAAS -J Renin-Angiotensin-Aldosterone Syst, doi:10.1177/1470320320926899

Pranata, Permana, Huang, Lim, Soetedjo et al., The use of renin angiotensin system inhibitor on mortality in patients with coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis, Diabetes Metab Syndr Clin Res Rev, doi:10.1016/j.dsx.2020.06.047

Rajter, Sherman, Fatteh, Vogel, Sacks et al., Use of ivermectin is associated with lower mortality in hospitalized patients with coronavirus disease 2019: the ivermectin in COVID nineteen study, Chest, doi:10.1016/j.chest.2020.10.009

Rakhmat, Kusmala, Handayani, Juliastuti, Nawangsih et al., Dipeptidyl peptidase-4 (DPP-4) inhibitor and mortality in coronavirus disease 2019 (COVID-19) e a systematic review, meta-analysis, and meta-regression, Diabetes Metab Syndr Clin Res Rev, doi:10.1016/j.dsx.2021.03.027

Rizzo, Ivermectin, antiviral properties and COVID-19: a possible new mechanism of action, doi:10.1007/s00210-020-01902-5

Roy, Pattadar, Raj, Agarwal, Biswas, Ivermectin as a potential treatment for mild to moderate COVID-19 e a double blind randomized placebo-controlled trial, MedRxiv, doi:10.1101/2021.01.05.21249310

Sharun, Dhama, Patel, Pathak, Tiwari et al., Ivermectin, a new candidate therapeutic against SARS-CoV-2/COVID-19, Ann Clin Microbiol Antimicrob, doi:10.1186/s12941-020-00368-w

Sigrist, Bridge, Mercier, A potential role for integrins in host cell entry by SARS-CoV-2, Antivir Res, doi:10.1016/j.antiviral.2020.104759

Tay, Fraser, Chan, Moreland, Rathore et al., Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin, Antivir Res, doi:10.1016/j.antiviral.2013.06.002

Ventre, Rozi Eres, Lenief, Albert, Rossio et al., Topical ivermectin improves allergic skin inflammation, Allergy Eur J Allergy Clin Immunol, doi:10.1111/all.13118

Wagstaff, Sivakumaran, Heaton, Harrich, Jans, Ivermectin is a specific inhibitor of importin a/b-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus, Biochem J, doi:10.1042/BJ20120150

Who, Weekly epidemiological update -2

Yan, Ci, Chen, Chen, Li et al., Anti-inflammatory effects of ivermectin in mouse model of allergic asthma, Inflamm Res, doi:10.1007/s00011-011-0307-8

Yang, Atkinson, Wang, Lee, Bogoyevitch et al., The broad spectrum antiviral ivermectin targets the host nuclear transport importin a/b1 heterodimer, Antivir Res, doi:10.1016/j.antiviral.2020.104760

Yonas, Alwi, Pranata, Huang, Lim et al., Elevated interleukin levels are associated with higher severity and mortality in COVID 19 e a systematic review, meta-analysis, and meta-regression, Diabetes Metab Syndr Clin Res Rev, doi:10.1016/j.dsx.2020.11.011

Zhang, Song, Ci, Ju, Li, Ivermectin inhibits LPS-induced production of inflammatory cytokines and improves LPS-induced survival in mice, Inflamm Res, doi:10.1007/s00011-008-8007-8

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