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All Studies   Meta Analysis    Recent:   

Efficacy and Safety of Ivermectin for Treatment and prophylaxis of COVID-19 Pandemic

Elgazzar et al., Research Square, doi:10.21203/rs.3.rs-100956/v2, NCT 04668469
Nov 2020  
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Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
 
*, now known with p < 0.00000000001 from 100 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19ivm.org
This study was withdrawn.
Elgazzar et al., 13 Nov 2020, preprint, 6 authors, trial NCT 04668469.
This PaperIvermectinAll
Abstract: Efficacy and Safety of Ivermectin for Treatment and prophylaxis of COVID-19 Pandemic Ahmed Elgazzar (  dr_ahmed_elgazzar@yahoo.com ) Banha University Abdelaziz Eltaweel Benha University Shaimaa Abo Youssef Banha University Basma Hany Community Medicine Department, Faculty of Medicine, Benha University, Egypt. Mohy Hafez Benha Faculty of medicine Hany Moussa Kafr Elsheikh University, Faculty of medicine, Chest department Article Keywords: Ivermectin, COVID-19, Hydroxychloroquine Posted Date: December 28th, 2020 DOI: https://doi.org/10.21203/rs.3.rs-100956/v3 License:   This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License EDITORIAL NOTE: Research Square withdrew this preprint on 14 July, 2021 due to an expression of concern communicated directly to our staff. These concerns are now under formal investigation. Detailed information on the reasons for this withdrawal can be found here. (note updated 12 March, 2022) Page 1/10 Abstract Background: Up-to-date, there is no recognized effective treatment or vaccine for the treatment of COVID-19 that emphasize urgency around distinctive effective therapies. This study aims to evaluate the anti-parasitic medication efficacy "Ivermectin" plus standard care in the treatment of mild/moderate and severely ill cases with COVID 19 infection, as well as prophylaxis of health care and/ or household contacts. Subject and methods: 600 subjects; 400 symptomatic confirmed COVID-19 patients and 200 health care and household contacts distributed over 6 groups; Group I: 100 patients with mild/moderate COVID-19 infection received a 4-days course of Ivermectin plus standard of care; Group II: 100 patients with mild/moderate COVID-19 infection received hydroxychloroquine plus standard care; Group III: 100 patients with severe COVID-19 infection received Ivermectin plus standar care; Group IV: 100 patients with Severe COVID-19 infection received hydroxychloroquine plus standard care. Routine laboratory investigations and rT-PCR, were reported before and after initiation of treatment. Group V stick to personal protective measures (PPM ) plus Ivermectin o.4mg / kg on empty stomach to be repeated after one week, and group VI stick to PPM only .Both groups V&VI were followed for two weeks .. Results: Patients received ivermectin early reported substantial recovery of laboratory investigations; and significant reduction in rT-PCR conversion days. A substantial improvement and reduction in mortality rate in Ivermectin treated groups; group I (99% & 0.0%, respectively) and group III (94% & 2.0% respectively) versus hydroxychloroquine plus standard care treated groups; group II (74% and 4%, respectively) and group IV (50% and 20%, respectively). Ivermectin had significantly reduced the incidence of infection in health care and household contacts up to 2% compared to 10% in non ivermectin group when used as a prophylaxis. Conclusion: Early addition of Ivermectin to standard care is very effective drug for treatment of COVID-19 patients with significant reduction in mortality,rt-PCR conversion days , recovery time hospital stay compared to Hydroxychloroquine plus standard care. Early use of Ivermectin is very useful for controlling COVID 19 infections; prophylaxis and improving cytokines storm
Late treatment
is less effective
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