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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Recovery 43% Improvement Relative Risk Recovery time 15% Viral clearance, day 14 5% primary Viral clearance, day 7 3% Ivermectin  Manomaipiboon et al.  EARLY TREATMENT  DB RCT Is early treatment with ivermectin beneficial for COVID-19? Double-blind RCT 72 patients in Thailand (October - December 2021) Improved recovery with ivermectin (not stat. sig., p=0.26) c19ivm.org Manomaipiboon et al., Trials, February 2022 Favors ivermectin Favors control

Efficacy and safety of ivermectin in the treatment of mild-to-moderate COVID-19 infection: A randomized, double blind, placebo, controlled trial

Manomaipiboon et al., Trials, doi:10.1186/s13063-022-06649-3 (date from preprint), NCT05076253
Feb 2022  
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Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
 
*, now known with p < 0.00000000001 from 100 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19ivm.org
Small RCT with 72 low-risk patients in Thailand, showing improved recovery with ivermectin, without statistical significance. All patients recovered and there was no escalation of care in either group. There were no adverse events.
This is the 33rd of 47 COVID-19 RCTs for ivermectin, which collectively show efficacy with p=0.0000002.
This is the 78th of 100 COVID-19 controlled studies for ivermectin, which collectively show efficacy with p<0.0000000001 (1 in 1 sextillion).
risk of no recovery, 43.5% lower, RR 0.57, p = 0.26, treatment 3 of 36 (8.3%), control 6 of 36 (16.7%), NNT 12, adjusted per study, odds ratio converted to relative risk, resolution of symptoms, Table S2, day 28.
recovery time, 15.3% lower, RR 0.85, p = 0.56, treatment 36, control 36, inverted to make RR<1 favor treatment, time to resolution of symptoms.
risk of no viral clearance, 5.0% lower, RR 0.95, p = 1.00, treatment 19 of 36 (52.8%), control 20 of 36 (55.6%), NNT 36, day 14, primary outcome.
risk of no viral clearance, 3.3% lower, RR 0.97, p = 1.00, treatment 29 of 36 (80.6%), control 30 of 36 (83.3%), NNT 36, day 7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Manomaipiboon et al., 2 Feb 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Thailand, peer-reviewed, mean age 48.6, 8 authors, study period 10 October, 2021 - 15 December, 2021, dosage 12mg days 1-5, trial NCT05076253 (history). Contact: thananda@hotmail.com (corresponding author).
This PaperIvermectinAll
Efficacy and safety of ivermectin in the treatment of mild to moderate COVID-19 infection: a randomized, double-blind, placebo-controlled trial
Anan Manomaipiboon, Kittisak Pholtawornkulchai, Sujaree Poopipatpab, Swangjit Suraamornkul, Jakravoot Maneerit, Wiroj Ruksakul, Uraporn Phumisantiphong, Thananda Trakarnvanich
Trials, doi:10.1186/s13063-022-06649-3
Background: The emergent outbreak of coronavirus disease , caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emphasized the requirement for therapeutic opportunities to overcome this pandemic. Ivermectin is an antiparasitic drug that has shown effectiveness against various agents, including SARS-CoV-2. This study aimed to assess the efficacy of ivermectin treatment compared with the standard of care (SOC) among people with mild to moderate COVID-19 symptoms. Methods: In this randomized, double-blind, placebo-controlled, single-center, parallel-arm, superiority trial among adult hospitalized patients with mild to moderate COVID-19, 72 patients (mean age 48.57 ± 14.80 years) were randomly assigned to either the ivermectin (n=36) or placebo (n=36) group, along with receiving standard care. We aimed to compare the negativity of reverse transcription polymerase chain reaction (RT-PCR) result at days 7 and 14 of enrolment as the primary outcome. The secondary outcomes were duration of hospitalization, frequency of clinical worsening, survival on day 28, and adverse events. Results: At days 7 and 14, no differences were observed in the proportion of PCR-positive patients (RR 0.97 at day 7 (p=0.759) and 0.95 at day 14 (p=0.813). No significant differences were found between the groups for any of the secondary endpoints, and no adverse events were reported. Conclusion: No difference was found in the proportion of PCR-positive cases after treatment with ivermectin compared with standard care among patients with mild to moderate COVID-19 symptoms. However, early symptomatic recovery was observed without side effects. Trial registration: ClinicalTrials.gov NCT05076253. Registered on 8 October 2021, prospectively.
Supplementary Information The online version contains supplementary material available at https:// doi. org/ 10. 1186/ s13063-022-06649-3. Additional file 1. Authors' contributions AM: supervised the project, had full access to the data in the study, and contributed to the study design. KP: contributed to data collection and conceived and designed the study. SS: collected and interpreted the data. JM: contributed in reviewing the design of the study and acquiring the data. WR: coordinated sample collection and oversaw data collection. UP: conducted and analyzed the laboratory results. TT: designed the study, analyzed, and interpreted the data and contributed towards the writing of the manuscript. All authors approve the final version of the manuscript for submission. Declarations Ethics approval and consent to participate The study was conducted according to the guidelines of the Declaration of Helsinki and Good Clinical Practice Guidelines. The trial was approved by the Vajira Ethics Committee, approval no 171/64. Written informed consent was obtained from all subjects involved in the study. Consent for publication Consent for publication is not applicable. Competing interests The authors declare they have no competing interests. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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